Health Experts Call for Greater Investment in Women-Led TB Solutions 04/08/2025 Health Policy Watch Women leadership in TB (illustrative) As South Africa marks Women’s Month this August, the global health community is preparing to spotlight the vital role women play in tackling tuberculosis—often in overlooked and underfunded areas of research, care, and advocacy. A special webinar, hosted by Global Health Strategies, the Bhekisisa Centre for Health Journalism, and Health Policy Watch, will recognize and amplify the voices of women transforming TB research, policy, and community engagement. The event aims to inspire action, call for increased investment, and promote a future that is TB-free, equitable, and inclusive—driven by those most impacted by the disease. Register Now According to the organizers, TB remains one of the world’s deadliest infectious diseases. In 2023, approximately 8.2 million people were newly diagnosed with TB—the highest number recorded since the World Health Organization began tracking global cases in 1995. In South Africa alone, around 280,000 people are diagnosed with TB each year. From the lab to the frontlines, women are shaping a more inclusive and effective response to the disease. But their contributions are often overlooked and underfunded. Celebrating these efforts isn’t just symbolic—it’s about opening the door to leadership, sharing knowledge, and driving real systems change. Register to join the conversation Image Credits: Erinbetzk from Pixabay. Indian Study Calls for Air Quality Index to Be Linked to Health Risk 04/08/2025 Chetan Bhattacharji Every winter, Delhi is covered in a cloud of thick smog, with air quality as bad as smoking 50 cigarettes in a day. Delhi and other Indian cities should replace the one-size-fits-all air quality index (AQI) with a city-specific health index focused on premature death risks, a new study recommends. NEW DELHI – Almost three-quarters of the world’s top 100 most-polluted cities are in India, but does its widely used air quality index (AQI) adequately warn people of short-term health risks, especially death? It is an established scientific fact that air pollution can lead to premature death, particularly amongst vulnerable groups, like the elderly and ill, in the short and long term; it is the second highest risk factor for non-communicable diseases (NCDs). But the AQI, which is meant to effectively communicate the short-term health risks, doesn’t reflect this. Instead, the current warnings are relatively benign, ranging from “minor breathing discomfort to sensitive people” when pollution is low, to “affects healthy people and seriously impacts those with existing diseases” for severe pollution. A new study proposes adding the risk of death, which could make the AQI a lot more compelling, and calling it the Air Quality Health Index (AQHI). Short-term Risk of Death as Air Pollution Rises AQHI Health risk category AQHI values Rise in excess mortality Good 0–16 – Satisfactory 17–33 – Moderate 34–50 2% Poor 51–67 6% Very Poor 68–84 9% Severe >84 16% Source: Dr Santu Ghosh, St Johns Medical College, Bangalore. When air quality is categorised as ‘moderate’, the AQHI has a risk of 2% excess mortality in a day due to air pollution. This moves to 6% for ‘poor’, 9% for ‘very poor’ and jumps to 16% excess mortality per day when the air pollution is poor. “That is, in a day if the average mortality in Delhi is 250, in a ‘severe’ AQHI day, 40 additional deaths could be added on that day attributed to air pollution,” Dr Santu Ghosh, one of the authors and a biostatistics professor at Bangalore’s St John’s Medical College, explained to Health Policy Watch. The other authors are Franciosalgeo George from St John’s National Academy of Health Sciences, Pallavi Joshi and Sagnik Dey from the Indian Institute of Technology in Delhi, and RK Mall from Banaras Hindu University in Varanasi. The study, A Framework For City-Specific Air Quality Health Index, builds on earlier research, which shows how every small increase in pollution, 10 micrograms in fine particulate matter (PM2.5), increases the risk of death by a fraction of a percentage point. As the table shows, these fractions can add up devastatingly fast, especially in places in northern India with a chronic air pollution crisis. Air Quality Health Index explained The table is for Delhi so it uses an AQHI classification exclusively for Delhi. This is a key difference between AQHI and AQI. To be effective, AQHI should be tailored for each locality to “accurately communicate” health risks posed by air pollution, the researchers argue. In contrast, the national AQI, launched in 2015, has a single index for the entire country. But India is demographically and epidemologically diverse, and has different climate zones so there cannot be a one-size-fits-all AQI, according to the authors. The AQHI is based on a different framework for each city or locality. For the study, mortality and air pollution data from two cities were analysed – Delhi, a megacity, and Varanasi, a small city. Both are politically relevant. Delhi is India’s capital and often ranked as the world’s most polluted capital. Varanasi is Prime Minister Narendra Modi’s constituency. From a communication point of view, the major change is that the AQI uses numbers from 0-500, while the AQHI uses a range of 0-100. The AQHI authors say that the AQI’s thresholds are not supported by any health studies, and a 2015 government document on AQI acknowledges this, asserting that “in view of no specific studies in India”, the US Environmntal Protection Agency’s (EPA) health advisories, or breakpoints, can be adopted. Indices can vary greatly, unlike measurements of pollutants. An AQI transforms complex air quality data of various pollutants into a single number, that is, the index value. Using a stock market analogy, a pollutant is like a stock; it is measured by its concentration, which largely remains the same if similar instruments are used to measure it in the same area, like one stock’s price is roughly the same in different stock markets. But an air quality index depends on the formula it uses, like different stock market indices for the same country. For those who track AQI regularly, the table below shows how the older one compares to the proposed health index. If the concentration of PM2.5, a fine, toxic particulate matter, is 120, then the AQI would be 300, but AQHI would be 46 in Delhi and 64 in Varanasi. India’s air pollution: AQHI vs AQI PM2.5 O3 NO2 Existing AQI Proposed AQHI, Delhi Proposed AQHI, Varanasi AQI category Delhi AQHI category Varanasi AQHI category 120 35 65 300 46 64 Very Poor Moderate Poor Source: Report authors As the authors only focused on mortality due to exposure to high pollution, the report does not list health warnings or breakpoints for asthma, cardio-respiratory illness and other ailments for each category. However, despite the differences, the authors say they don’t want the AQI to be abandoned, but updated. “Policy makers need to understand that air pollution is a risk factor. It is not a disease,” says Dey. If a person dies of high blood pressure, a stroke, heart failure or something else, especially when air pollution is high, then investigate the link with pollutants; look at existing data and gather more data at a country-wide level. Air pollution deaths: Government pushback The Indian government has consistently maintained in Parliament that there’s “no conclusive data available in the country” to establish that death or disease is exclusively due to air pollution. Dr Dey, one of the authors, told Health Policy Watch that he can understand why they are hesitant, using the analogy of smoking: “[If] I can put the onus on the individual: ‘why did you smoke?’, so my responsibility goes down. But for air pollution… we can reduce our own footprint, but that may be a tiny fraction. Ultimately, the government has to step in.” Developing an AQHI for hundreds of Indian cities should not take more than a few months, Dey says, and there is “hardly any cost”. All that is required is city-specific data, which is then put through the framework code that already exists to calculate the city-specific AQHI cut-offs. But the challenge is data, which is very difficult to access, according to Dey. The mortality data is available with the health ministry and the National Centre for Disease Control (NCDC). The 11-year-old AQI has in recent years made it to common parlance, even as fodder for stand-up comedians. But there is little evidence that people follow the few, brief warnings it provides. With the risk of death added, the air quality health index may be taken more seriously by the public and government. Image Credits: Raunaq Chopra/ Climate Outreach. Call for Global Strategy to Counter ‘Vaccine Misinformation from US’ 01/08/2025 Kerry Cullinan A baby is being vaccinated in Gonzagueville, Côte d’Ivoire. A clear global strategy is needed to “counter vaccine misinformation from the United States” (US), Heidi Larson and Simon Piatek write in The Lancet this week. This should be based on ensuring the independence of scientific institutions that deal with vaccines and the regulation of digital platforms to “address cross-border health harms”, they argue. Global immunisation programmes are already being being undermined by a lack of resources, with the global vaccine alliance, Gavi, reporting this week that it is facing a $3 billion shortfall that will result in “a slowdown” in some of the immunisation programmes it supports. Meanwhile, “the USA, long a cornerstone of global health leadership, has become an unexpected source of global instability in vaccination confidence”, argue Larsen, who heads the Vaccine Confidence Project at the London School of Hygiene, and Piatek, founder of New Imagination Lab, which researches digital influence. “An analysis of 316 million vaccine-related tweets from October 2019 to March 2021 across 18 languages found that the US functioned as a major exporter of COVID-19 vaccine misinformation, with American accounts disproportionately represented as central hubs in global misinformation networks”, they report. Kennedy: Misinformation ‘super-spreader’ A separate longitudinal analysis of almost 300 million tweets on Twitter (now X) in 2021 found that 800 “superspreader” accounts were responsible for a third of all vaccine misinformation retweets – and the most prominent of these accounts belonged to Robert F Kennedy Jr, appointed US Health Secretary earlier this year. Kennedy was responsible “for more than 13% of these retweets”, while most of the other super-spreader accounts also “operated primarily within the US digital ecosystem but had global reach, reinforcing the role of American-origin misinformation as a destabilising force in international vaccination confidence”, they report. The impact of the US misinformation has been global. In 2023, UNICEF reported that in West Africa, particularly Nigeria and Ghana, “viral social media posts from the USA promoting conspiracy theories” eroded trust and reduced demand for COVID-19 and childhood vaccines. Similarly, in Eastern Europe, particularly Romania and Bulgaria, misinformation has translated in lower vaccine uptake, write Larsen and Piatek. Aid cuts undermines vaccines They also argue that the US defunding of “substantial portions of international funding for science as well as vaccine delivery” has also allowed “conspiracy and misinformation to flourish globally”. Countering “US vaccine misinformation” should rest primarily on the protection of “scientific independence within federal health agencies”. “Political appointees should not interfere with technical guidance. Congressional mechanisms must guarantee the autonomy of bodies such as the CDC and NIH, irrespective of the incumbent administration,” they argue. Secondly, the regulation of digital platforms should take the form of “a binding international code on digital health integrity”, which could be developed by the World Health Organization and regional organisations such as the African Union and the Association of Southeast Asian Nations (ASEAN). “Central to such a framework must be algorithmic transparency,” they argue, pointing to the European Union’s Digital Services Act as an example of what could be possible. “Coordinated fact-checking infrastructure should be built into platform operations, not outsourced or voluntary, and must be adaptable to local languages and sociocultural contexts,” they assert, noting that while digital platforms operate globally, “regulatory responses remain national and fragmented”. “A world fragmented by health #misinformation is ill-prepared to respond to the next pandemic threat.”@ProfHeidiLarson & @sjpiatek in @TheLancet on impact of US leadership/politics on global health & #vaccine confidence.https://t.co/OggRnqAc8z — London School of Hygiene & Tropical Medicine (@LSHTM) August 1, 2025 Next pandemic is incubating “The urgency is compounded by what lies ahead. With climate-linked disease emergence, conflict-driven displacement, and increasing zoonotic risk, the next pandemic might already be incubating. A world fragmented by health misinformation is ill-prepared to respond to the next pandemic threat,” they conclude. “There is still time to act. But it requires confronting uncomfortable truths about the role of the USA in fuelling mistrust, and the political choices that have allowed it. The world cannot afford another crisis in which lives are lost not for lack of vaccines, but for lack of truth.” Image Credits: UNICEF. Oral Health Left Out Again? Why the UN’s NCD Declaration Must Not Repeat Past Mistakes 01/08/2025 Habib Benzian Children in the Philippines brushing their teeth. Some 3.7 billion people have oral diseases. Amid protests over the weakening of the political declaration for the UN High Level Meeting on NCDs, one huge issue was omitted from the start: oral health. As United Nations (UN) Member States navigate negotiations for the political declaration of the 2025 United Nations (UN) High-Level Meeting (HLM) on Non-communicable Diseases (NCDs), a familiar and troubling omission reappears: oral health is absent from the zero draft. This exclusion is neither new nor accidental – but it is increasingly indefensible. Oral diseases are the most prevalent NCDs globally, affecting nearly 3.7 billion people. They are preventable, deeply inequitable, and carry significant social and economic costs. Yet they remain excluded from the core political commitments that will shape global NCD and health priorities through 2030 and beyond. The zero draft, released around the 2025 World Health Assembly, omits oral health entirely—not in the preamble, not in the goals, not even in passing. This silence has raised concern among advocates, stakeholders, and Member States. Since then, at least a dozen countries, including major regional blocs, have called for its inclusion in the next draft. Previous UN HLM declarations, starting in 2011, offered only token two-word references to oral diseases, usually buried in broader commitments on NCDs or Universal Health Coverage. Given the major policy progress over the past five years, such minimal language no longer reflects the reality. Member states have made clear their collective commitment to act; the Declaration must now do the same. This is not a bold or unreasonable demand. It is a call for fairness and for recognition of a disease burden that touches half the world’s population and undermines education, livelihoods, and wellbeing. The burden is vast and rising. Untreated caries, periodontal disease, tooth loss, and oral cancers are among the most common health conditions worldwide. The highest burden is in middle-income countries, where health systems face growing needs but limited capacity. Annual global spending on oral health exceeds $390 billion, most of it out-of-pocket and concentrated in high-income countries. In many lower-income settings, even basic treatment is unaffordable. With few public services, most systems rely on a privatized, commercialized model that deepens inequality and leaves billions behind. Adding to this imbalance is a critical advocacy gap. Unlike other major health issues, oral health lacks strong civil society mobilisation. The absence of patient-led organisations and grassroots movements means there is little community pressure to drive policy change. As a result, those most affected by oral diseases remain largely unheard in global health debates. A dentist in Kurdistan checks the teeth of school children. In many developing countries, even basic dental treatment is out of reach for most people. Fragile moment of transition at WHO The omission of oral health comes at a precarious time. In recent years, the global oral health community has achieved major milestones: a 2021 World Health Assembly resolution, the Global Oral Health Status Report, a Global Strategy and Action Plan, and the Bangkok Declaration – No Health without Oral Health – endorsed by over 100 countries. Yet these advances remain largely under the radar of the broader global health community. At the same time, WHO is navigating internal turbulence and leadership gaps, particularly in NCDs. This weakens its presence in critical policy spaces, where influence depends as much on relationships and coordination as on technical input. The UNHLM is a UN-led process, and WHO’s role is limited. Influence flows through mechanisms like the Interagency Task Force and the Global Coordinating Mechanism, which dilute technical leadership and can shift focus toward political compromise. Compounding this, resistance to integrating oral health exists within the WHO itself. Traditional departmental silos, rigid program structures, and donor-driven priorities can hinder progress. Despite recent gains, systemic inertia continues to slow fuller inclusion. NCD Alliance and the limits of ‘5×5’ model The NCD Alliance’s response to the zero draft has been underwhelming. Despite counting major oral health organisations among its members, it failed to support the inclusion of oral diseases – likely to avoid expanding beyond the traditional “5×5” focus of five diseases and five risk factors. This narrow, mortality-based framework excludes conditions like oral diseases that cause long-term disability and deepen inequities. But chronic diseases are not defined by lethality alone. They require lifelong care and can often be managed successfully with the right support. Oral diseases begin early and last a lifetime. They cause pain, stigma, and exclusion—especially among the poor. Any political declaration that claims to advance equity must reflect today’s realities, not yesterday’s frameworks. Ignoring oral health means ignoring the lived experience of billions. A call for concrete commitments The inclusion of oral health in the Political Declaration is not about symbolism. It is about creating the conditions for action—national policies, budgets, and accountability frameworks that can translate global commitments into local change. At a minimum, this means: Recognizing oral diseases in the Declaration as part of the global NCD burden; Reaffirming existing commitments made by Member States through WHO instruments; Supporting the integration of essential oral health services into UHC and primary care delivery; Addressing the commercial determinants of oral diseases—especially the role of sugar and ultra-processed foods; and Ensuring that oral health is included in global monitoring and accountability systems. Anything less risks undermining the credibility of the declaration and leaving billions of people once again outside the promise of “health for all.” A quiet crisis, a global test Oral health affects nearly every household but remains low on political agendas. It lacks visibility, donor attention, and strong public advocacy, despite being a major source of avoidable pain and inequality. Recent progress has been real but remains fragile. Without political recognition, it risks stalling. The UN HLM is a test of global health priorities and our commitment to equity. Oral diseases are the most common NCDs. Excluding them would be indefensible. Oral health is not optional. This time, the Declaration must get it right. Habib Benzian is Professor of Epidemiology and Global Health at NYU College of Dentistry and a member of the Lancet Commission on Oral Health. He advises governments and international organizations on oral health policy and equity. Image Credits: Manila Water Foundation, Kurdistan Dental Health Organization. Health Taxes Offer Solution to Africa’s ‘Burning Platform’ of NCDs 31/07/2025 Kerry Cullinan South Africans campaign in favour of a tax on sugary drinks in 2017. Taxes on tobacco, alcohol and sugary drinks offer African countries the opportunity to regain their “sovereignty” in response to the collapse of donor funding, according to a new report on health financing compiled by Vital Strategies. Vital CEO Mary-Ann Etiebet described the rise of non-communicable diseases (NCDs) fueled by these unhealthy products as a “burning platform” – already accounting for a third of Africa’s deaths and set to surpass the burden of infectious disease within five years. “Low- and middle-income countries are at risk of losing up to $21 trillion by 2030 if no action is taken on the prevention and control of NCDs,” Etiebet told the launch of the report this week. “External health aid is falling sharply and is projected to fall even further, tightening fiscal space and reducing budgets available to support country health needs,” she added. Official development assistance (ODA) for health in Africa has fallen by a massive 70% since 2021 – from $80 billion to $24 billion – mostly as a result of the US’s abrupt cancellation of longstanding donor commitments earlier this year. Serah Makka, ONE’s executive director for Africa, said that the African Union agenda for 2063 and other continental plans call for “self-financing, resilient health systems”. But where are governments going to get funds from when 24 African countries are at risk of debt distress and 34 countries pay more to service their debt than to health and education combined, she asked. “This is where the innovation of taxes comes in, because, again, it’s been proven to provide more resources and health benefits,” said Makka. The launch of the Vital Strategies report was moderated by Adam Karpati (top left), and addressed by Jeff Drope, Mary-Ann Etiebet, Serah Makka and Corne van Walbeek. Specific tax works best Professor Jeffrey Drope, director of the Economics for Health team at Johns Hopkins University, described the lack of health taxes in many African countries as “untapped potential” to raise revenues and improve public health. Vietnam was an example of what is possible, added Drope. In the past few months, it has restructured its tobacco tax, which will “raise rates significantly” and imposed a tax on sugary drinks for the first time. Ethiopia and Cabo Verde are also increasing their taxation of unhealthy products. “Health taxes work,” he stressed. “When the taxes go up, the prices go up and consumption of these products goes down. “ We know that, for example, for tobacco and alcohol, a 10% increase in price will lead to around a 5% decrease in consumption. That’s a lot. And if you think about the fact that a lot of these countries are raising their taxes and prices a lot more than 10% you can see that the effects on consumption are going to be enormous and that the public health rewards are also going to be enormous as well.” The revenue can be used to fund education and health services, including programmes to help people quit smoking or alcohol, added Drope. Corne van Walbeek, director of the Research Unit on the Economics of Excisable Products (REEP) at the University of Cape Town, said that the best tax is a “specific tax”. In the case of cigarettes, this would be a certain amount of dollars per pack of cigarettes – rather than a tax based on the value or length of the cigarette (known as an ad valorem tax). For alcohol and sugary drinks, the most effective tax would tax the harmful ingredient – the alcohol or sugar content. This provided suppliers with an incentive to reduce the volume of the harmful substance, which has happened in South Africa, where some producers of sugary drinks and beer have reduced sugar and alcohol content respectively, he said. Scare-mongering However, the unhealthy industries are pushing back against taxes, Etiebet pointed out. This has emerged in negotiations on the political declaration, which is due to be adopted at the UN High-Level Meeting (HLM) on NCDs in September. The latest draft has “weakened commitments with regard to health taxes,” she said. The NCD Alliance has described the weaker language in the declaration as evidence of lobbying by “big tobacco, alcohol, junk food, and fossil fuels”. “At a time of fiscal pressures, shrinking global health funding, and increased emphasis on domestic resource mobilisation, health taxes are a golden opportunity to both generate revenue and reduce the burden of NCDs and associated healthcare costs,” said Alison Cox, director of policy and advocacy at the NCD Alliance. Vital Strategies has urged the negotiators to “reinstate explicit commitment to health taxes” on tobacco, alcohol and sugar-sweetened beverages. It has also urged negotiators to put back references to the World Health Organization’s (WHO) “Best Buy” policy recommendations for reducing alcohol consumption and related diseases, which include raising taxes, restricting marketing and regulating availability. However, sources close to the negotiations told Health Policy Watch that the United States had insisted that references to the WHO in the declaration to be scrapped. The Trump administration has withdrawn from the WHO. But Makka said that West African governments and the West African Health Organisation are “looking at how we can increase health security through health taxes for universal health coverage”. “Regional action and health taxes are going to be very important for Africa. And finally, there is political alignment. So this is the time. This is the moment. We’ve seen countries like South Africa, Nigeria and Kenya, already exploring and implementing excise taxes.” Image Credits: Kerry Cullinan. Addressing Alzheimer’s: Speech and Smell Tests May Help to Detect Cognitive Decline 30/07/2025 Kerry Cullinan New tests based on speech and smell may help to identify people at risk of dementia earlier Digital tests based on speech and smell are being developed to screen for cognitive decline, researchers told the Alzheimer’s Association International Conference in Toronto. Two speech apps are already some way down the road, testing several markers including speech speed, vocabulary and rhythm in different languages to establish a baseline for testing, a session convened by the Davos Alzheimer’s Collaboration (DAC) heard. A third initiative using smell is also in the mix, primarily testing people’s ability to smell certain scents via inhalers. DAC supports an innovation ecosystem to accelerate healthcare solutions to end Alzheimer’s disease globally, and DAC-supported projects in Kenya, India, Egypt and Chile have afforded the companies access to multicultural groups to refine their innovations. Better screening tests are essential as an estimated three-quarters of people with Alzheimer’s are never diagnosed and, as the burden grows in the global South, tests for low-resource settings as crucial. TELL’s Adolfo Garcia described his company’s product as “a digital speech biomarker app” that can run on multiple platforms, based on a collection of speech tasks ranging from spontaneous to non-spontaneous tasks. Several speech features “are very revealing about your mental health status”, said Garcia. Using speech timing metrics, for example, the app can measure “the rhythm with which people speak; the number of pauses that they make, how long those pauses are, how variable they are, how long the syllables that they produced are”, said Garcia. TELL has been tested in over 20 countries with over 40,000 hours of data from around 9000 participants. But Garcia describes the in-depth research with the DAC-supported researchers headed by Dr Karen Blackmon at Agha Khan University in Kenya, as “phenomenal, instructive and fulfilling.” Blackmon’s team has been testing Swahili-speaking Kenyans for cognitive decline based on simple speech timing metrics, while TELL has trained a machine learning regressor with various speech metrics. There has been a “moderate to strong correlation” between the results from TELL’s machine model and the real-time scores from people that Blackmon’s team has tested on “simple speech timing metrics, which are quite scalable across different languages”, Garcia noted. Nicklas Linz of Ki Elements said his speech app aims to find “something that works across languages, across cultural contexts, so that we have something that is culturally fair, neutral and usable in all of these contexts”. His group has worked with DAC teams in Egypt, India, Kenya and Chile who speak Arabic, Hindi, English, Swahili and Spanish. Loss of smell and neurodegeneration Subhanjan Mondal of Sensify said that the idea to use olfaction (smell) as a measure for neurodegeneration “came from COVID”, where many people who contracted the virus lost their sense of smell. People with the ApoE e4 allele, the gene variant that increases the risk of developing late-onset Alzheimer’s disease, also have an increased risk of olfactory decline. “There is an anatomical connection between olfaction and neurodegeneration for Alzheimer’s and Parkinson’s and many other neurodegenerative diseases,” said Mondal. “And there is also a genetic component, as ApoE carriers have a strong disposition to olfactory decline.” Sensify has developed a digital smell test, ScentAware, with smells contained in different inhalers that are QR-coded. Using an app connected to a mobile phone camera, people can conduct the smell test at home or in a clinical setting. “People found it easy to use, fun, and it can be done in a short time,” said Mondal. But there is some way to go. The field is so new that there are no common smell elements across cultures. “Can this be incorporated somewhere upstream in a screening mechanism in normal individuals with higher risk factors?” Mondal asks. Sensify is developing a smell test, ScentAware, to diagnose cognitive decline. Multicultural challenges “There are a lot of challenges in adapting speech tasks from multilingual contexts like Kenya,” said Aga Khan’s Blackmon. “But these are challenges that we’re going to have to face across as, in the Global South, multilingualism is a norm in most post-colonial settings where… major languages like English are spoken in schools but not necessarily in homes.” “It’s been excellent to work with TELL, Ki Elements and Sensify Aware because, in each of these partnerships, we are identifying problems and we’re proactively solving them,” said Blackmon. For example, an app using automatic speech recognition did not do so well when people were switching languages, she explained. “Although our samples may seem small, the way that we’re approaching this is to solve problems [before the app is] scaled to larger populations.” The end goal is to integrate the apps into health systems to enable affordable and accurate early detection. “These tools are friendlier. Their interfaces have been really well designed. They’re user-friendly. Tools like the olfactory Sensify Aware are fun for patients,” said Blackmon. “It’s very different from a standard neuropsychological test setting that I’m used to, where people are sweating. “It’s an opportunity to do it well and do it differently with input from stakeholders across the global South. We may even discover new speech features that turn out to be diagnostically relevant, like the number of times someone switches language could tell us something about early signs of dementia.” Societal and genetic influences The exposome influencing Alzheimer’s disease. Professor Amy Kind of the University of Wisconsin (UW) addressed how cognitive decline is influenced by both genetic and societal elements, known as the “exposome”. “The term was first coined in 2005, and it means the integrated compilation of physical, chemical, biological and social influences across an entire life course that influence biology,” said Kind. “The environmental exposures are modifiable. These are things that we can intervene upon, over and above individual-level factors, to improve health. And this construct is thought of as precision health, not just precision medicine,” she said. “Individuals who live in adverse exposomes experience poor brain health, and hundreds of studies have shown this,” added Kind. She heads the largest study of the social exposome in the United States, The Neighborhoods Study, which works with large community-based surveys as well as with tissue from people who have donated their brains to the study to better understand the environmental risks influencing Alzheimer’s. “We work with brain tissue, and we link it back to the life-course social exposome,” said Kind. “Across 25 academic institutions, there are over 9,000 descendants’ brain donors in the cohort, and it allows us to link, with some certainty, the association between certain types of exposure – be that occupational, social, toxic, metabolic – to findings within the tissue. Kind and colleagues try to identify and mitigate the risks for people living in adverse exposomes. Factors influences Alzheimer’s, as identified by The Lancet “Are there critical windows of life course across these pathways? “Perhaps all of our future for our brain health is written in our childhood, [so] gestational and early childhood effects could be profound, as we think about late life brain health,” said Kind. “Some of our newest work is focused on lead and heavy metal poisoning, because these metals accumulate in the tissue across the life course, and yet lead exposure is so common in our water supply, in the air that we breathe and in other places.” Kind and colleagues have worked closely with the Inner City Milwaukee Water Works Department in order to decrease the lead line pipe infrastructure to decrease lead in the water supply. Lead exposure has been linked to Alzheimer’s and cognitive decline, and a large study was released at the conference this week identifying the impact of leaded gasoline on the memory of older Americans. Reaching the Global South DAC founder George Vradenburg said one of the motives for collaboration is to link the global north and global South. “The majority of cases, by far, are already in the Global South, and by mid-century, it’s going to be 80% of cases of dementia are in the global South. So we have not fulfilled a patient mission if all we deal with is the top 20% of white people in the United States and Europe,” said Vradenburg. “DAC brings together researchers, healthcare systems, governments and funders to accelerate progress where it’s most needed,” DAC COO Drew Holzapfel told the meeting. It is based on three programmes – global cohort development, global clinical trials, and healthcare system preparedness – to address gaps in Alzheimer’s research and treatment. The cohort development programme aims to “increase the amount of research in diverse populations so that we can find better targets for drug development and associated biomarkers,” said Holzapfel. DAC’s global clinical trials programme aims to do clinical trials “better, faster, cheaper” around pharmacological and non-pharmacological interventions for brain health in parts of the globe that have never had those types of trials, he explained. The third component, healthcare system preparedness, aims to prime health systems to implement the innovations. “Our implementation scientists like to talk about how the time it takes for an innovation to go from availability to full clinical utilisation is about 17 years. We think that’s too long, so we’re trying to take the high-speed train and put it on high-speed tracks so that we can help patients,” said Holzapfel. By the end of this year, DAC will have worked in about 70 healthcare systems, implementing new tools for detection and diagnosis for about 60,000 patients. Image Credits: Cristina Gottardi/ Unsplash. Exposure to Leaded Fuel Affects Memory Loss of Older Americans 29/07/2025 Kerry Cullinan Exposure to leaded gasoline affects the memory loss of older Americans. Americans are about 20% more likely to experience memory problems if they lived in areas with high levels of atmospheric lead, according to a study of over 600,000 adults over the age of 65 released at the Alzheimer’s Association International Conference in Toronto on Tuesday. Researchers examined how exposure to airborne lead between 1960 and 1974, when leaded gasoline use was at its highest, may affect brain health later in life. They calculated exposure to historical atmospheric lead levels (HALL) by area and linked it to self-reported memory problems from two American Community Surveys (conducted between 2012 and 2021) involving over 500,000 people. Some 17-22% of people living in areas with moderate, high or extremely high atmospheric lead reported memory issues. “Our study may help us understand the pathways that contribute to some people developing dementia and Alzheimer’s disease,” said Dr Eric Brown, lead author and associate chief of geriatric psychiatry at the Centre for Addiction and Mental Health in Toronto. Lead was originally added to gasoline to increase performance until researchers determined it posed serious risks to health and the environment. The more than 20-year-long phase-out of leaded gas began in 1975. “When I was a child in 1976, our blood carried 15 times more lead than children’s blood today,” said Esme Fuller-Thomson, senior author of the study and a professor at the University of Toronto’s Faculty of Social Work. “An astonishing 88% of us had levels higher than 10 micrograms per deciliter, which are now considered dangerously high.” While the risk of atmospheric lead has decreased, other sources of exposure remain, such as old lead paint and pipes. Those who have been exposed to atmospheric lead should focus on reducing other risk factors for dementia, including high blood pressure, smoking and social isolation, said Brown. “Research suggests half the US population – more than 170 million people – were exposed to high lead levels in early childhood. This research sheds more light on the toxicity of lead related to brain health in older adults today,” said Dr Maria Carrillo, Alzheimer’s Association chief science officer and medical affairs lead. Another study reported at the conference found that older adults who live about three miles from a lead-releasing facility – such as glass, ready-mixed concrete or computer and electronics manufacturers – are more likely to have memory and thinking problems than those who live farther away. Lifestyle interventions help slow cognitive decline Alzheimer’s disease is the most common type of dementia found in elderly people. Social isolation, diet and lack of exercise affect the progression of the disease. Meanwhile, in better news, older adults at risk for cognitive decline and dementia who were actively encouraged to adopt healthy lifestyles were able to slow memory loss, the conference heard. A study of over 2,000 people compared the impact of a structured lifestyle intervention with a self-guided intervention and found that, while both interventions helped, those in the more intense intervention had better success at slowing cognitive decline. Both interventions focused on physical exercise, nutrition, cognitive challenge and social engagement, and heart health monitoring, but differed in intensity, structure, accountability and support provided. In the structured lifestyle group, participants attended 38 facilitated peer team meetings over two years. They were provided with an activity programme with measurable goals, encouraged to eat according to the MIND diet, given cognitive challenges and other intellectual and social activities. Their progress was reviewed regularly. In the self-guided lifestyle intervention, participants attended six peer team meetings to encourage self-selected lifestyle changes. Participants in the structured intervention showed greater improvement on global cognition, protecting cognition from normal age-related decline for up to two years. The results of the study, called US POINTER, were reported for the first time at the AAIC conference and published in the Journal of the American Medical Association (JAMA). “As the burden of dementia grows worldwide, US POINTER affirms a vital public health message: healthy behaviour has a powerful impact on brain health,” said Dr Joanne Pike, Alzheimer’s Association president and CEO. “This is a critical public health opportunity. The intervention was effective across a broad, representative group – regardless of sex, ethnicity, APOE [gene] genetic risk, or heart health status – demonstrating its applicability and scalability for communities across the country,” added Pike. “The positive results of US POINTER encourage us to look at the potential for a combination of a lifestyle program and drug treatment as the next frontier in our fight against cognitive decline and possibly dementia.” Image Credits: Dawn McDonal/ Unsplash, Photo by Steven HWG on Unsplash. Governments ‘Backslide’ on NCD Commitments After Pressure from Unhealthy Industries 28/07/2025 Kerry Cullinan Few countries are effectively taxing tobacco, alcohol, sugary drinks and ultraprocessed food, in part due to massive industry pushback. Governments have weakened their commitment to addressing non-communicable diseases (NCDs) after pressure from “big tobacco, alcohol, junk food, and fossil fuels”, according to civil society. Their claim centres on the draft political declaration due to be adopted at the UN High-Level Meeting (HLM) on NCDs in September, which no longer calls on countries to implement high taxes on these unhealthy products. Countries are due to wrap up negotiations on the declaration this week, with the final declaration due to be adopted at the HLM on 25 September. “It looks like health-harming industry fingerprints are all over this,” said Alison Cox, director of policy and advocacy at the NCD Alliance. “At a time of fiscal pressures, shrinking global health funding, and increased emphasis on domestic resource mobilisation, health taxes are a golden opportunity to both generate revenue and reduce the burden of NCDs and associated healthcare costs,” she added. “Yet as it stands, the declaration’s text contains weaker language around taxes and lets industry off the hook, prioritising profits over public health,” added Cox, describing the draft as “a backslide”. The language in the current draft has been watered down, and targets have been “flattened”, with active commitments to ‘implement’ and ‘enact’ replaced with the “far more passive language of ‘consider’ and ‘encourage’,” according to the NCD Alliance. ‘Reinstate commitment to taxes’ Vital Strategies, a global public health organisation, urged the negotiators to “reinstate explicit commitment to health taxes” on tobacco, alcohol and sugar-sweetened beverages. “These taxes should increase prices sufficiently to reduce affordability, prevent initiation and support reduction or cessation of use,” said Vital Strategies in a media release. “As outlined by the Task Force for Fiscal Policy on Health, a 50% price increase on tobacco, alcohol, and sugary beverages could raise $2.1 trillion in five years for low- and middle-income countries, revenue equal to 40% of their total health spending,” added the organisation. NCDs, including heart disease, cancer and diabetes, account for 43 million deaths annually, 75% of all deaths worldwide. The burden of NCDs is growing in low- and middle-income countries, driven primarily by smoking and poor diets. Taxes on alcohol, restricting marketing and regulating sales hours are proven interventions to reduce consumption. Vital Strategies also raised alarm about the removal of references to the World Health Organization’s (WHO) “Best Buy” policy recommendations for reducing alcohol consumption and related diseases, including raising taxes, restricting marketing and regulating availability. “The conspicuous deletion of these proven policies from the text strongly suggests undue alcohol industry influence aimed at weakening public health protections. We urge governments to immediately reverse these deletions and fully restore WHO’s recommendations in the final text,” said Vital Strategies. Harmful commercial practices It also wants the declaration to “explicitly tackle harmful commercial practices and strengthen conflict-of-interest protections to safeguard public health policymaking from industry interference”, strengthen commitments to “proven tobacco control measures” including effective taxation, and “recognise unhealthy diets as an urgent priority”. The WHO attributes some 2.8 million deaths a year to obesity and overweight, and Vital wants the declaration to “explicitly state that rising obesity rates are primarily driven by unhealthy diets, emphasising clear interventions like front-of-pack labelling and marketing restrictions targeting children”. The NCD Alliance is also unhappy about “significant backsliding” around social participation and the role of civil society, which is only referred to once. “History has taught us that ignoring the integral role of civil society, communities and people living with diseases weakens any meaningful public health response,” said Cox. With just a week of negotiations remaining, the NCD Alliance is calling on governments to “demonstrate true leadership and resist last-minute compromises that prioritise commercial interests over public health and reflect a genuine commitment to protecting lives”. Image Credits: Leo Zhuang/ Unsplash, Stanislav Ivanitskiy/ Unsplash. Smoke Signals from the Plastics Treaty: Why Geneva Negotiations Can’t Ignore Health Governance 25/07/2025 Deborah Sy Cigarette filters, made from a plastic called cellulose acetate, are world’s most littered plastic item. As negotiators prepare to meet in Geneva, 5-14 August in yet another attempt to finalize the United Nations Global Plastics Treaty addressing a pollution crisis affecting oceans and ecosystems worldwide – a critical linkage between health and environment governance seems to be largely missing from the draft text. After nearly three years of negotiations, the world may be on the verge of finalizing its first legally-binding global instrument to tackle plastic pollution – providing that treaty negotiators overcome massive pressures from the fossil fuel industry to further stall an agreement or weaken provisions aiming to limit plastics production. But as negotiators prepare for the resumed fifth session (INC-5.2), another fundamental flaw threatens the future treaty’s health objectives: the failure to integrate environmental and health governance. This is particularly apparent with regards to cigarette filters – the world’s most littered plastic item – although it extends to cross-sector cooperation on other issues regarding the health harms of other plastics as well. The current draft text makes with only one reference to ‘plastic’ cigarette filters (in draft Annex X) and makes no reference at all to the WHO Framework Convention on Tobacco Control – which could, in fact, be an important nexus for health-environment cooperation on the treaty – once it is approved. The treatment of cigarette filters – largely made of a plastic called cellulose acetate – sends smoke signals about more systematic problems with the treaty text in terms of its approach to environment and health. Health rhetoric vs reality gap Cigarette filters are the world’s most prevalent forms of plastic litter, marring beaches and from there, infiltrating to oceans and fresh water ways. The Chair’s text, the working document guiding final negotiations, acknowledges health extensively in its rhetoric, although much of it remains in brackets, indicating areas where countries have not yet reached agreement. The preamble recognizes plastic pollution as “a serious environmental and human health problem,” while the treaty’s stated objective is “to protect human health and the environment from plastic pollution.” But while the preamble recognizes mutual support with “other international agreements in the field of the environment,” it limits that framework to environmental treaties. Any reference to health instruments, including the WHO Framework Convention on Tobacco Control (FCTC), which has been ratified by 183 countries, are absent from this structure. Draft Plastics Treaty negotiating text – much of language on health remains in brackets. The Chair’s preambular text affirms that the plastics treaty will “not affect… existing treaty obligations,” but this is a non-binding statement that merely avoids direct legal contradictions without promoting substantive policy coherence. In practice, it enables siloed implementation, weakens the ability of health ministries to regulate tobacco product components, and gives the tobacco industry new opportunities to exploit regulatory gaps through the environment ministries. Most tellingly, a standalone health article remains uncertain, reduced to scattered references or a placeholder “pending informal drafting work.” Despite the draft’s stated health objectives, the institutional bridge to health governance is still missing. The ‘safe alternatives’ problem This gap matters because “safe substitutes,” “safe alternatives,” or “safe recycling” are at the heart of solutions throughout the draft treaty. But how can environmental authorities evaluate safety and health impacts without connecting to international or national health standards? The tobacco industry is already exploiting this governance gap by promoting “eco-filters” and “biodegradable” alternatives to plastic cigarette filters. While these products may appear to address plastic pollution, they remain harmful to both health and the environment. Worse, they risk misleading consumers and this kind of product feature substitution is typically assessed by health authorities, not environmental ministries, which may lack the mandate or expertise to evaluate such claims. The cigarette filter test case Cigarette filters are the most littered plastic in the world. Used cigarette filters represent the world’s most littered plastic item, with trillions discarded annually. Each cigarette butt contains toxic lead, cadmium, phthalates, and polycyclic aromatic hydrocarbons that leach into waterways. A single cigarette butt can contaminate 1,000 liters of water, causing $26 billion in annual marine ecosystem damage. The FCTC provides clear guidance on these filters: Parties should prohibit ingredients in tobacco products that may create the impression that they have a health benefit. The WHO study group’s recommendations early this year included that filters should be banned to reduce the palatability and appeal of cigarettes. This would remove consumer misconceptions that filters reduce health harms, and it would also reduce a major source of toxic tobacco waste, including the microplastics deposited by cellulose acetate in filters. Annex X: plastics items recommended for limitations, but not ban or phaseout. Annex Y: proposed ban or phaseout list. Yet the draft plastics treaty only lists “cigarette filters made with plastic” in a priority list for mandatory or voluntary restriction or banning (Annex X), rather than on the ban or phaseout list (Annex Y). The “made with plastic” language for cigarette filters also creates a dangerous loophole that permits biofilters/ eco-filters, contradicting established health guidance. In contrast, Annex Y, the ban/ phase out list, itemizes toys and food containers containing lead, cadmium, and phthalates – the same toxicants found in cigarette filters. Broader governance architecture problem The cigarette filter case reveals systemic weaknesses in the treaty draft’s language around health. Article 2.2 of the FCTC requires Parties to ensure that subsequent international agreements should be compatible with FCTC obligations. However, the negotiating states have yet to provide a mechanism for ensuring this compatibility. When environmental ministries approve product redesigns without health authority input, both agendas suffer. When industries exploit policy gaps to rehabilitate their image while maintaining harmful products, both environmental integrity and health objectives are compromised. Extended Producer Responsibility schemes promoted throughout the draft treaty could also legitimize tobacco industry participation in environmental policy and its greenwashing, directly contradicting FCTC Article 5.3’s requirement to “protect tobacco-related environment policies” from industry interference. The problem extends far beyond tobacco. Plastic substitution decisions made in isolation from health expertise risk creating new health hazards while solving environmental concerns—essentially trading one set of risks for another. Environmental authorities may inadvertently approve alternatives that address plastic pollution while creating health risks. Infrastructure already exists Plastics health impacts in brief. The solution isn’t to build new health systems from scratch, as many countries already have relevant capacity, and global infrastructure exists, including for chemical safety, food standards, and medical devices. For tobacco, global networks like TobLabNet and TobReg provide evidence-based guidance. The real challenge is not global coordination, but national-level inter-agency cooperation. The future plastics treaty can help by explicitly obligating this, ensuring health and environment agencies work together. Without giving due regard to existing health treaties, such coordination will inevitably run up against the different standards these agencies follow on industry engagement. No credible health authority engages with the tobacco industry, which is prohibited globally under the WHO’s Framework of Engagement with Non-State Actors (FENSA) and nationally through Article 5.3 of the FCTC, which covers over 90% of the world’s population. The commitment to binding norms on conflict of interest in the FCTC is essential. It creates space for the broader safeguards called for by civil society, scientists, and the Office of the High Commissioner for Human Rights (OHCHR). Failing to respect existing obligations—especially in the clearest and extreme case of tobacco— effectively precludes any meaningful prevention of conflicts of interest. Integration not isolation The solution lies in strengthening the draft’s health foundation by explicitly recognizing existing health agreements, including the WHO’s FCTC, which was already referenced in previous drafts to promote “cooperation, coordination, and complementarity.” A global coalition focusing on this issue recommends a simple safeguard clause – “Measures taken under this instrument shall be without prejudice to, and aligned with, existing international public health treaties and obligations, (including the WHO FCTC)” – would help prevent regulatory conflicts while provide supportive infrastructures to bolster the authority of environmental ministries to implement the future treaty. For cigarette filters, the recommendation is to eliminate material qualifiers “made of plastic” and move filters to a list for immediate bans. More broadly, the future instrument needs formal mechanisms for health expertise integration—not transferring authority from the environment to health ministries, but creating coordination mechanisms ensuring both objectives are met. The Geneva opportunity The Global Plastics Treaty could model integrated governance for 21st-century planetary health challenges, or represent another missed opportunity for coherent global health governance. Tobacco control shows how weak coordination between health and environmental sectors can backfire. When environmental agencies promote so-called “eco-filters” without health input, they risk legitimizing harmful products. But the reverse is also true. During COVID-19, health-led responses drove a surge in plastic consumption, worsening pollution. Both cases expose the same flaw: without coordination, one sector’s solution can become another’s crisis. The Plastics Treaty offers a rare chance to correct this. The infrastructure exists. The evidence is clear. What’s missing is the political will to connect them through binding legal frameworks. Geneva may be the last, best opportunity, not only to curb plastic pollution, but to safeguard the future of global health governance. Integrating international health agreements into the treaty does more than align with existing obligations. It helps define the treaty’s direction and lays the foundation for a strong, legally binding instrument with robust regulatory measures and comprehensive protections for people and the planet. Deborah Sy is head of Strategy and Global Public Policy at the Global Center for Good Governance in Tobacco Control (GGTC) at Thammasat University in Thailand, the convener of Global Youth Voices and the Stop Tobacco Pollution Alliance (STPA). She is the founder and senior advisor of Health Justice Philippines, an observer to the UN Plastics Treaty negotiations. Image Credits: Dennis Skley, University of Bath , UNEP , Chairs Text, draft UN Plastics Treaty, December 2024, Chairs Text, UN Plastics Treaty, Draft 2024, Ciel.org. US Drafts Plan to Change PEPFAR’s Focus From HIV to Diseases that Could Threaten Americans 24/07/2025 Kerry Cullinan A woman with HIV takes her antiretrovial (ARV) medicine. Until earlier this year, over 20 million people with HIV received ARVs funded by PEPFAR. US State Department officials are developing a plan to transform the President’s Emergency Plan for AIDS Relief (PEPFAR) from an entity that tackles HIV to one that is broadly focused on protecting and promoting American interests. This is according to a report in the New York Times on Thursday, based on leaked planning documents that map out their vision for PEPFAR’s transition in in the next few years. “It would be replaced by ‘bilateral relationships’ with low-income countries focused on the detection of outbreaks that could threaten the United States and the creation of new markets for American drugs and technologies,” the newspaper reports. This is in keeping with the focus of the Trump administration’s first meeting with African health leaders after the US paused all foreign aid for 90 days in January. During the meeting between leaders of the US Centers for Disease Control and Prevention (CDC) and their counterparts in Africa CDC in March, the US officials indicated that they were interested in African business opportunities for American companies. Africa CDC official Dr Ngashi Ngongo told journalists after the meeting that the Trump administration “would like to see health more as a business, rather than something that functions on grants,” and is interested in “exploring how can we go into a partnership that translates into health as a business”. Aggressive transition planning Dr Jirair Ratevosian, a global health expert at Duke and previous PEPFAR chief of staff, said that the Trump administration has “made it very clear that they want to carry on with aggressive transition planning” for PEPFAR. “Transition planning is not a bad idea, but it must be done right, with timetables, developing indicators, matching government buy-in, getting community input etc,” Ratevosian said. While he has not seen the documents referred to by the New York Times, Ratevosian is concerned that the transition plan is being written in Washington rather than in and with the African countries most affected by PEPFAR’s transition. “There needs to be realistic timetables, careful planning and resources to successfully make the transition of HIV programming [from PEPFAR] to national control,” said Ratevosian. “Congress has made clear it rejects the administration’s rushed approach to PEPFAR’s transition, signalling bipartisan concern about protecting the program’s legacy and impact.” He added that the US State Department should also develop plans for US companies to sell their antiretroviral drugs to African countries, the largest market for these products. Brief defunding reprieve Luyengo Clinic in Eswatini. PEPFAR funded 80% of the clinic’s cost, and the HIV treatment of 3,000 people is in jeopardy. Last week, there was a brief moment of hope for PEPFAR recipients after the US Senate agreed to exempt the programme from a planned $400 million reduction, which had been included in a $9.4 billion rescission package put forward by President Donald Trump. The rescission package seeks to claw back federal funds from various programs, including approximately $900 million in global health allocations. Disruptions to US aid for global health including for PEPFAR programmes, have placed millions of lives at risk, particularly in countries heavily dependent on US-supported HIV infrastructure. Carolyn Amole, Clinton Health Access Initiative vice-president for HIV, hepatitis and TB, said PEPFAR’s funding cuts had disrupted commodities procurement, essential systems such as human resources, supply chains, and data infrastructure. Millions more AIDS deaths, infections projected An additional six million new HIV infections and four million AIDS-related deaths could occur between 2025 and 2029 if US-supported HIV treatment and prevention services collapse, according to UNAIDS. “This is not just a funding gap. It’s a ticking time bomb,” said UNAIDS Executive Director Winnie Byanyima at the launch of the organisation’s 2025 global AIDS update earlier this month. “We have seen services vanish overnight. Health workers have been sent home. And people – especially children and key populations – are being pushed out of care.” “Key populations” refer to people most vulnerable to HIV infection, including sex workers, men to have sex with men, people who inject drugs and young women. Some of the immediate effects of the US withdrawal of funds since Donald Trump assumed the presidency in January include the closure of health facilities, healthworker job losses, and disrupted treatment, testing and prevention services. 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Indian Study Calls for Air Quality Index to Be Linked to Health Risk 04/08/2025 Chetan Bhattacharji Every winter, Delhi is covered in a cloud of thick smog, with air quality as bad as smoking 50 cigarettes in a day. Delhi and other Indian cities should replace the one-size-fits-all air quality index (AQI) with a city-specific health index focused on premature death risks, a new study recommends. NEW DELHI – Almost three-quarters of the world’s top 100 most-polluted cities are in India, but does its widely used air quality index (AQI) adequately warn people of short-term health risks, especially death? It is an established scientific fact that air pollution can lead to premature death, particularly amongst vulnerable groups, like the elderly and ill, in the short and long term; it is the second highest risk factor for non-communicable diseases (NCDs). But the AQI, which is meant to effectively communicate the short-term health risks, doesn’t reflect this. Instead, the current warnings are relatively benign, ranging from “minor breathing discomfort to sensitive people” when pollution is low, to “affects healthy people and seriously impacts those with existing diseases” for severe pollution. A new study proposes adding the risk of death, which could make the AQI a lot more compelling, and calling it the Air Quality Health Index (AQHI). Short-term Risk of Death as Air Pollution Rises AQHI Health risk category AQHI values Rise in excess mortality Good 0–16 – Satisfactory 17–33 – Moderate 34–50 2% Poor 51–67 6% Very Poor 68–84 9% Severe >84 16% Source: Dr Santu Ghosh, St Johns Medical College, Bangalore. When air quality is categorised as ‘moderate’, the AQHI has a risk of 2% excess mortality in a day due to air pollution. This moves to 6% for ‘poor’, 9% for ‘very poor’ and jumps to 16% excess mortality per day when the air pollution is poor. “That is, in a day if the average mortality in Delhi is 250, in a ‘severe’ AQHI day, 40 additional deaths could be added on that day attributed to air pollution,” Dr Santu Ghosh, one of the authors and a biostatistics professor at Bangalore’s St John’s Medical College, explained to Health Policy Watch. The other authors are Franciosalgeo George from St John’s National Academy of Health Sciences, Pallavi Joshi and Sagnik Dey from the Indian Institute of Technology in Delhi, and RK Mall from Banaras Hindu University in Varanasi. The study, A Framework For City-Specific Air Quality Health Index, builds on earlier research, which shows how every small increase in pollution, 10 micrograms in fine particulate matter (PM2.5), increases the risk of death by a fraction of a percentage point. As the table shows, these fractions can add up devastatingly fast, especially in places in northern India with a chronic air pollution crisis. Air Quality Health Index explained The table is for Delhi so it uses an AQHI classification exclusively for Delhi. This is a key difference between AQHI and AQI. To be effective, AQHI should be tailored for each locality to “accurately communicate” health risks posed by air pollution, the researchers argue. In contrast, the national AQI, launched in 2015, has a single index for the entire country. But India is demographically and epidemologically diverse, and has different climate zones so there cannot be a one-size-fits-all AQI, according to the authors. The AQHI is based on a different framework for each city or locality. For the study, mortality and air pollution data from two cities were analysed – Delhi, a megacity, and Varanasi, a small city. Both are politically relevant. Delhi is India’s capital and often ranked as the world’s most polluted capital. Varanasi is Prime Minister Narendra Modi’s constituency. From a communication point of view, the major change is that the AQI uses numbers from 0-500, while the AQHI uses a range of 0-100. The AQHI authors say that the AQI’s thresholds are not supported by any health studies, and a 2015 government document on AQI acknowledges this, asserting that “in view of no specific studies in India”, the US Environmntal Protection Agency’s (EPA) health advisories, or breakpoints, can be adopted. Indices can vary greatly, unlike measurements of pollutants. An AQI transforms complex air quality data of various pollutants into a single number, that is, the index value. Using a stock market analogy, a pollutant is like a stock; it is measured by its concentration, which largely remains the same if similar instruments are used to measure it in the same area, like one stock’s price is roughly the same in different stock markets. But an air quality index depends on the formula it uses, like different stock market indices for the same country. For those who track AQI regularly, the table below shows how the older one compares to the proposed health index. If the concentration of PM2.5, a fine, toxic particulate matter, is 120, then the AQI would be 300, but AQHI would be 46 in Delhi and 64 in Varanasi. India’s air pollution: AQHI vs AQI PM2.5 O3 NO2 Existing AQI Proposed AQHI, Delhi Proposed AQHI, Varanasi AQI category Delhi AQHI category Varanasi AQHI category 120 35 65 300 46 64 Very Poor Moderate Poor Source: Report authors As the authors only focused on mortality due to exposure to high pollution, the report does not list health warnings or breakpoints for asthma, cardio-respiratory illness and other ailments for each category. However, despite the differences, the authors say they don’t want the AQI to be abandoned, but updated. “Policy makers need to understand that air pollution is a risk factor. It is not a disease,” says Dey. If a person dies of high blood pressure, a stroke, heart failure or something else, especially when air pollution is high, then investigate the link with pollutants; look at existing data and gather more data at a country-wide level. Air pollution deaths: Government pushback The Indian government has consistently maintained in Parliament that there’s “no conclusive data available in the country” to establish that death or disease is exclusively due to air pollution. Dr Dey, one of the authors, told Health Policy Watch that he can understand why they are hesitant, using the analogy of smoking: “[If] I can put the onus on the individual: ‘why did you smoke?’, so my responsibility goes down. But for air pollution… we can reduce our own footprint, but that may be a tiny fraction. Ultimately, the government has to step in.” Developing an AQHI for hundreds of Indian cities should not take more than a few months, Dey says, and there is “hardly any cost”. All that is required is city-specific data, which is then put through the framework code that already exists to calculate the city-specific AQHI cut-offs. But the challenge is data, which is very difficult to access, according to Dey. The mortality data is available with the health ministry and the National Centre for Disease Control (NCDC). The 11-year-old AQI has in recent years made it to common parlance, even as fodder for stand-up comedians. But there is little evidence that people follow the few, brief warnings it provides. With the risk of death added, the air quality health index may be taken more seriously by the public and government. Image Credits: Raunaq Chopra/ Climate Outreach. Call for Global Strategy to Counter ‘Vaccine Misinformation from US’ 01/08/2025 Kerry Cullinan A baby is being vaccinated in Gonzagueville, Côte d’Ivoire. A clear global strategy is needed to “counter vaccine misinformation from the United States” (US), Heidi Larson and Simon Piatek write in The Lancet this week. This should be based on ensuring the independence of scientific institutions that deal with vaccines and the regulation of digital platforms to “address cross-border health harms”, they argue. Global immunisation programmes are already being being undermined by a lack of resources, with the global vaccine alliance, Gavi, reporting this week that it is facing a $3 billion shortfall that will result in “a slowdown” in some of the immunisation programmes it supports. Meanwhile, “the USA, long a cornerstone of global health leadership, has become an unexpected source of global instability in vaccination confidence”, argue Larsen, who heads the Vaccine Confidence Project at the London School of Hygiene, and Piatek, founder of New Imagination Lab, which researches digital influence. “An analysis of 316 million vaccine-related tweets from October 2019 to March 2021 across 18 languages found that the US functioned as a major exporter of COVID-19 vaccine misinformation, with American accounts disproportionately represented as central hubs in global misinformation networks”, they report. Kennedy: Misinformation ‘super-spreader’ A separate longitudinal analysis of almost 300 million tweets on Twitter (now X) in 2021 found that 800 “superspreader” accounts were responsible for a third of all vaccine misinformation retweets – and the most prominent of these accounts belonged to Robert F Kennedy Jr, appointed US Health Secretary earlier this year. Kennedy was responsible “for more than 13% of these retweets”, while most of the other super-spreader accounts also “operated primarily within the US digital ecosystem but had global reach, reinforcing the role of American-origin misinformation as a destabilising force in international vaccination confidence”, they report. The impact of the US misinformation has been global. In 2023, UNICEF reported that in West Africa, particularly Nigeria and Ghana, “viral social media posts from the USA promoting conspiracy theories” eroded trust and reduced demand for COVID-19 and childhood vaccines. Similarly, in Eastern Europe, particularly Romania and Bulgaria, misinformation has translated in lower vaccine uptake, write Larsen and Piatek. Aid cuts undermines vaccines They also argue that the US defunding of “substantial portions of international funding for science as well as vaccine delivery” has also allowed “conspiracy and misinformation to flourish globally”. Countering “US vaccine misinformation” should rest primarily on the protection of “scientific independence within federal health agencies”. “Political appointees should not interfere with technical guidance. Congressional mechanisms must guarantee the autonomy of bodies such as the CDC and NIH, irrespective of the incumbent administration,” they argue. Secondly, the regulation of digital platforms should take the form of “a binding international code on digital health integrity”, which could be developed by the World Health Organization and regional organisations such as the African Union and the Association of Southeast Asian Nations (ASEAN). “Central to such a framework must be algorithmic transparency,” they argue, pointing to the European Union’s Digital Services Act as an example of what could be possible. “Coordinated fact-checking infrastructure should be built into platform operations, not outsourced or voluntary, and must be adaptable to local languages and sociocultural contexts,” they assert, noting that while digital platforms operate globally, “regulatory responses remain national and fragmented”. “A world fragmented by health #misinformation is ill-prepared to respond to the next pandemic threat.”@ProfHeidiLarson & @sjpiatek in @TheLancet on impact of US leadership/politics on global health & #vaccine confidence.https://t.co/OggRnqAc8z — London School of Hygiene & Tropical Medicine (@LSHTM) August 1, 2025 Next pandemic is incubating “The urgency is compounded by what lies ahead. With climate-linked disease emergence, conflict-driven displacement, and increasing zoonotic risk, the next pandemic might already be incubating. A world fragmented by health misinformation is ill-prepared to respond to the next pandemic threat,” they conclude. “There is still time to act. But it requires confronting uncomfortable truths about the role of the USA in fuelling mistrust, and the political choices that have allowed it. The world cannot afford another crisis in which lives are lost not for lack of vaccines, but for lack of truth.” Image Credits: UNICEF. Oral Health Left Out Again? Why the UN’s NCD Declaration Must Not Repeat Past Mistakes 01/08/2025 Habib Benzian Children in the Philippines brushing their teeth. Some 3.7 billion people have oral diseases. Amid protests over the weakening of the political declaration for the UN High Level Meeting on NCDs, one huge issue was omitted from the start: oral health. As United Nations (UN) Member States navigate negotiations for the political declaration of the 2025 United Nations (UN) High-Level Meeting (HLM) on Non-communicable Diseases (NCDs), a familiar and troubling omission reappears: oral health is absent from the zero draft. This exclusion is neither new nor accidental – but it is increasingly indefensible. Oral diseases are the most prevalent NCDs globally, affecting nearly 3.7 billion people. They are preventable, deeply inequitable, and carry significant social and economic costs. Yet they remain excluded from the core political commitments that will shape global NCD and health priorities through 2030 and beyond. The zero draft, released around the 2025 World Health Assembly, omits oral health entirely—not in the preamble, not in the goals, not even in passing. This silence has raised concern among advocates, stakeholders, and Member States. Since then, at least a dozen countries, including major regional blocs, have called for its inclusion in the next draft. Previous UN HLM declarations, starting in 2011, offered only token two-word references to oral diseases, usually buried in broader commitments on NCDs or Universal Health Coverage. Given the major policy progress over the past five years, such minimal language no longer reflects the reality. Member states have made clear their collective commitment to act; the Declaration must now do the same. This is not a bold or unreasonable demand. It is a call for fairness and for recognition of a disease burden that touches half the world’s population and undermines education, livelihoods, and wellbeing. The burden is vast and rising. Untreated caries, periodontal disease, tooth loss, and oral cancers are among the most common health conditions worldwide. The highest burden is in middle-income countries, where health systems face growing needs but limited capacity. Annual global spending on oral health exceeds $390 billion, most of it out-of-pocket and concentrated in high-income countries. In many lower-income settings, even basic treatment is unaffordable. With few public services, most systems rely on a privatized, commercialized model that deepens inequality and leaves billions behind. Adding to this imbalance is a critical advocacy gap. Unlike other major health issues, oral health lacks strong civil society mobilisation. The absence of patient-led organisations and grassroots movements means there is little community pressure to drive policy change. As a result, those most affected by oral diseases remain largely unheard in global health debates. A dentist in Kurdistan checks the teeth of school children. In many developing countries, even basic dental treatment is out of reach for most people. Fragile moment of transition at WHO The omission of oral health comes at a precarious time. In recent years, the global oral health community has achieved major milestones: a 2021 World Health Assembly resolution, the Global Oral Health Status Report, a Global Strategy and Action Plan, and the Bangkok Declaration – No Health without Oral Health – endorsed by over 100 countries. Yet these advances remain largely under the radar of the broader global health community. At the same time, WHO is navigating internal turbulence and leadership gaps, particularly in NCDs. This weakens its presence in critical policy spaces, where influence depends as much on relationships and coordination as on technical input. The UNHLM is a UN-led process, and WHO’s role is limited. Influence flows through mechanisms like the Interagency Task Force and the Global Coordinating Mechanism, which dilute technical leadership and can shift focus toward political compromise. Compounding this, resistance to integrating oral health exists within the WHO itself. Traditional departmental silos, rigid program structures, and donor-driven priorities can hinder progress. Despite recent gains, systemic inertia continues to slow fuller inclusion. NCD Alliance and the limits of ‘5×5’ model The NCD Alliance’s response to the zero draft has been underwhelming. Despite counting major oral health organisations among its members, it failed to support the inclusion of oral diseases – likely to avoid expanding beyond the traditional “5×5” focus of five diseases and five risk factors. This narrow, mortality-based framework excludes conditions like oral diseases that cause long-term disability and deepen inequities. But chronic diseases are not defined by lethality alone. They require lifelong care and can often be managed successfully with the right support. Oral diseases begin early and last a lifetime. They cause pain, stigma, and exclusion—especially among the poor. Any political declaration that claims to advance equity must reflect today’s realities, not yesterday’s frameworks. Ignoring oral health means ignoring the lived experience of billions. A call for concrete commitments The inclusion of oral health in the Political Declaration is not about symbolism. It is about creating the conditions for action—national policies, budgets, and accountability frameworks that can translate global commitments into local change. At a minimum, this means: Recognizing oral diseases in the Declaration as part of the global NCD burden; Reaffirming existing commitments made by Member States through WHO instruments; Supporting the integration of essential oral health services into UHC and primary care delivery; Addressing the commercial determinants of oral diseases—especially the role of sugar and ultra-processed foods; and Ensuring that oral health is included in global monitoring and accountability systems. Anything less risks undermining the credibility of the declaration and leaving billions of people once again outside the promise of “health for all.” A quiet crisis, a global test Oral health affects nearly every household but remains low on political agendas. It lacks visibility, donor attention, and strong public advocacy, despite being a major source of avoidable pain and inequality. Recent progress has been real but remains fragile. Without political recognition, it risks stalling. The UN HLM is a test of global health priorities and our commitment to equity. Oral diseases are the most common NCDs. Excluding them would be indefensible. Oral health is not optional. This time, the Declaration must get it right. Habib Benzian is Professor of Epidemiology and Global Health at NYU College of Dentistry and a member of the Lancet Commission on Oral Health. He advises governments and international organizations on oral health policy and equity. Image Credits: Manila Water Foundation, Kurdistan Dental Health Organization. Health Taxes Offer Solution to Africa’s ‘Burning Platform’ of NCDs 31/07/2025 Kerry Cullinan South Africans campaign in favour of a tax on sugary drinks in 2017. Taxes on tobacco, alcohol and sugary drinks offer African countries the opportunity to regain their “sovereignty” in response to the collapse of donor funding, according to a new report on health financing compiled by Vital Strategies. Vital CEO Mary-Ann Etiebet described the rise of non-communicable diseases (NCDs) fueled by these unhealthy products as a “burning platform” – already accounting for a third of Africa’s deaths and set to surpass the burden of infectious disease within five years. “Low- and middle-income countries are at risk of losing up to $21 trillion by 2030 if no action is taken on the prevention and control of NCDs,” Etiebet told the launch of the report this week. “External health aid is falling sharply and is projected to fall even further, tightening fiscal space and reducing budgets available to support country health needs,” she added. Official development assistance (ODA) for health in Africa has fallen by a massive 70% since 2021 – from $80 billion to $24 billion – mostly as a result of the US’s abrupt cancellation of longstanding donor commitments earlier this year. Serah Makka, ONE’s executive director for Africa, said that the African Union agenda for 2063 and other continental plans call for “self-financing, resilient health systems”. But where are governments going to get funds from when 24 African countries are at risk of debt distress and 34 countries pay more to service their debt than to health and education combined, she asked. “This is where the innovation of taxes comes in, because, again, it’s been proven to provide more resources and health benefits,” said Makka. The launch of the Vital Strategies report was moderated by Adam Karpati (top left), and addressed by Jeff Drope, Mary-Ann Etiebet, Serah Makka and Corne van Walbeek. Specific tax works best Professor Jeffrey Drope, director of the Economics for Health team at Johns Hopkins University, described the lack of health taxes in many African countries as “untapped potential” to raise revenues and improve public health. Vietnam was an example of what is possible, added Drope. In the past few months, it has restructured its tobacco tax, which will “raise rates significantly” and imposed a tax on sugary drinks for the first time. Ethiopia and Cabo Verde are also increasing their taxation of unhealthy products. “Health taxes work,” he stressed. “When the taxes go up, the prices go up and consumption of these products goes down. “ We know that, for example, for tobacco and alcohol, a 10% increase in price will lead to around a 5% decrease in consumption. That’s a lot. And if you think about the fact that a lot of these countries are raising their taxes and prices a lot more than 10% you can see that the effects on consumption are going to be enormous and that the public health rewards are also going to be enormous as well.” The revenue can be used to fund education and health services, including programmes to help people quit smoking or alcohol, added Drope. Corne van Walbeek, director of the Research Unit on the Economics of Excisable Products (REEP) at the University of Cape Town, said that the best tax is a “specific tax”. In the case of cigarettes, this would be a certain amount of dollars per pack of cigarettes – rather than a tax based on the value or length of the cigarette (known as an ad valorem tax). For alcohol and sugary drinks, the most effective tax would tax the harmful ingredient – the alcohol or sugar content. This provided suppliers with an incentive to reduce the volume of the harmful substance, which has happened in South Africa, where some producers of sugary drinks and beer have reduced sugar and alcohol content respectively, he said. Scare-mongering However, the unhealthy industries are pushing back against taxes, Etiebet pointed out. This has emerged in negotiations on the political declaration, which is due to be adopted at the UN High-Level Meeting (HLM) on NCDs in September. The latest draft has “weakened commitments with regard to health taxes,” she said. The NCD Alliance has described the weaker language in the declaration as evidence of lobbying by “big tobacco, alcohol, junk food, and fossil fuels”. “At a time of fiscal pressures, shrinking global health funding, and increased emphasis on domestic resource mobilisation, health taxes are a golden opportunity to both generate revenue and reduce the burden of NCDs and associated healthcare costs,” said Alison Cox, director of policy and advocacy at the NCD Alliance. Vital Strategies has urged the negotiators to “reinstate explicit commitment to health taxes” on tobacco, alcohol and sugar-sweetened beverages. It has also urged negotiators to put back references to the World Health Organization’s (WHO) “Best Buy” policy recommendations for reducing alcohol consumption and related diseases, which include raising taxes, restricting marketing and regulating availability. However, sources close to the negotiations told Health Policy Watch that the United States had insisted that references to the WHO in the declaration to be scrapped. The Trump administration has withdrawn from the WHO. But Makka said that West African governments and the West African Health Organisation are “looking at how we can increase health security through health taxes for universal health coverage”. “Regional action and health taxes are going to be very important for Africa. And finally, there is political alignment. So this is the time. This is the moment. We’ve seen countries like South Africa, Nigeria and Kenya, already exploring and implementing excise taxes.” Image Credits: Kerry Cullinan. Addressing Alzheimer’s: Speech and Smell Tests May Help to Detect Cognitive Decline 30/07/2025 Kerry Cullinan New tests based on speech and smell may help to identify people at risk of dementia earlier Digital tests based on speech and smell are being developed to screen for cognitive decline, researchers told the Alzheimer’s Association International Conference in Toronto. Two speech apps are already some way down the road, testing several markers including speech speed, vocabulary and rhythm in different languages to establish a baseline for testing, a session convened by the Davos Alzheimer’s Collaboration (DAC) heard. A third initiative using smell is also in the mix, primarily testing people’s ability to smell certain scents via inhalers. DAC supports an innovation ecosystem to accelerate healthcare solutions to end Alzheimer’s disease globally, and DAC-supported projects in Kenya, India, Egypt and Chile have afforded the companies access to multicultural groups to refine their innovations. Better screening tests are essential as an estimated three-quarters of people with Alzheimer’s are never diagnosed and, as the burden grows in the global South, tests for low-resource settings as crucial. TELL’s Adolfo Garcia described his company’s product as “a digital speech biomarker app” that can run on multiple platforms, based on a collection of speech tasks ranging from spontaneous to non-spontaneous tasks. Several speech features “are very revealing about your mental health status”, said Garcia. Using speech timing metrics, for example, the app can measure “the rhythm with which people speak; the number of pauses that they make, how long those pauses are, how variable they are, how long the syllables that they produced are”, said Garcia. TELL has been tested in over 20 countries with over 40,000 hours of data from around 9000 participants. But Garcia describes the in-depth research with the DAC-supported researchers headed by Dr Karen Blackmon at Agha Khan University in Kenya, as “phenomenal, instructive and fulfilling.” Blackmon’s team has been testing Swahili-speaking Kenyans for cognitive decline based on simple speech timing metrics, while TELL has trained a machine learning regressor with various speech metrics. There has been a “moderate to strong correlation” between the results from TELL’s machine model and the real-time scores from people that Blackmon’s team has tested on “simple speech timing metrics, which are quite scalable across different languages”, Garcia noted. Nicklas Linz of Ki Elements said his speech app aims to find “something that works across languages, across cultural contexts, so that we have something that is culturally fair, neutral and usable in all of these contexts”. His group has worked with DAC teams in Egypt, India, Kenya and Chile who speak Arabic, Hindi, English, Swahili and Spanish. Loss of smell and neurodegeneration Subhanjan Mondal of Sensify said that the idea to use olfaction (smell) as a measure for neurodegeneration “came from COVID”, where many people who contracted the virus lost their sense of smell. People with the ApoE e4 allele, the gene variant that increases the risk of developing late-onset Alzheimer’s disease, also have an increased risk of olfactory decline. “There is an anatomical connection between olfaction and neurodegeneration for Alzheimer’s and Parkinson’s and many other neurodegenerative diseases,” said Mondal. “And there is also a genetic component, as ApoE carriers have a strong disposition to olfactory decline.” Sensify has developed a digital smell test, ScentAware, with smells contained in different inhalers that are QR-coded. Using an app connected to a mobile phone camera, people can conduct the smell test at home or in a clinical setting. “People found it easy to use, fun, and it can be done in a short time,” said Mondal. But there is some way to go. The field is so new that there are no common smell elements across cultures. “Can this be incorporated somewhere upstream in a screening mechanism in normal individuals with higher risk factors?” Mondal asks. Sensify is developing a smell test, ScentAware, to diagnose cognitive decline. Multicultural challenges “There are a lot of challenges in adapting speech tasks from multilingual contexts like Kenya,” said Aga Khan’s Blackmon. “But these are challenges that we’re going to have to face across as, in the Global South, multilingualism is a norm in most post-colonial settings where… major languages like English are spoken in schools but not necessarily in homes.” “It’s been excellent to work with TELL, Ki Elements and Sensify Aware because, in each of these partnerships, we are identifying problems and we’re proactively solving them,” said Blackmon. For example, an app using automatic speech recognition did not do so well when people were switching languages, she explained. “Although our samples may seem small, the way that we’re approaching this is to solve problems [before the app is] scaled to larger populations.” The end goal is to integrate the apps into health systems to enable affordable and accurate early detection. “These tools are friendlier. Their interfaces have been really well designed. They’re user-friendly. Tools like the olfactory Sensify Aware are fun for patients,” said Blackmon. “It’s very different from a standard neuropsychological test setting that I’m used to, where people are sweating. “It’s an opportunity to do it well and do it differently with input from stakeholders across the global South. We may even discover new speech features that turn out to be diagnostically relevant, like the number of times someone switches language could tell us something about early signs of dementia.” Societal and genetic influences The exposome influencing Alzheimer’s disease. Professor Amy Kind of the University of Wisconsin (UW) addressed how cognitive decline is influenced by both genetic and societal elements, known as the “exposome”. “The term was first coined in 2005, and it means the integrated compilation of physical, chemical, biological and social influences across an entire life course that influence biology,” said Kind. “The environmental exposures are modifiable. These are things that we can intervene upon, over and above individual-level factors, to improve health. And this construct is thought of as precision health, not just precision medicine,” she said. “Individuals who live in adverse exposomes experience poor brain health, and hundreds of studies have shown this,” added Kind. She heads the largest study of the social exposome in the United States, The Neighborhoods Study, which works with large community-based surveys as well as with tissue from people who have donated their brains to the study to better understand the environmental risks influencing Alzheimer’s. “We work with brain tissue, and we link it back to the life-course social exposome,” said Kind. “Across 25 academic institutions, there are over 9,000 descendants’ brain donors in the cohort, and it allows us to link, with some certainty, the association between certain types of exposure – be that occupational, social, toxic, metabolic – to findings within the tissue. Kind and colleagues try to identify and mitigate the risks for people living in adverse exposomes. Factors influences Alzheimer’s, as identified by The Lancet “Are there critical windows of life course across these pathways? “Perhaps all of our future for our brain health is written in our childhood, [so] gestational and early childhood effects could be profound, as we think about late life brain health,” said Kind. “Some of our newest work is focused on lead and heavy metal poisoning, because these metals accumulate in the tissue across the life course, and yet lead exposure is so common in our water supply, in the air that we breathe and in other places.” Kind and colleagues have worked closely with the Inner City Milwaukee Water Works Department in order to decrease the lead line pipe infrastructure to decrease lead in the water supply. Lead exposure has been linked to Alzheimer’s and cognitive decline, and a large study was released at the conference this week identifying the impact of leaded gasoline on the memory of older Americans. Reaching the Global South DAC founder George Vradenburg said one of the motives for collaboration is to link the global north and global South. “The majority of cases, by far, are already in the Global South, and by mid-century, it’s going to be 80% of cases of dementia are in the global South. So we have not fulfilled a patient mission if all we deal with is the top 20% of white people in the United States and Europe,” said Vradenburg. “DAC brings together researchers, healthcare systems, governments and funders to accelerate progress where it’s most needed,” DAC COO Drew Holzapfel told the meeting. It is based on three programmes – global cohort development, global clinical trials, and healthcare system preparedness – to address gaps in Alzheimer’s research and treatment. The cohort development programme aims to “increase the amount of research in diverse populations so that we can find better targets for drug development and associated biomarkers,” said Holzapfel. DAC’s global clinical trials programme aims to do clinical trials “better, faster, cheaper” around pharmacological and non-pharmacological interventions for brain health in parts of the globe that have never had those types of trials, he explained. The third component, healthcare system preparedness, aims to prime health systems to implement the innovations. “Our implementation scientists like to talk about how the time it takes for an innovation to go from availability to full clinical utilisation is about 17 years. We think that’s too long, so we’re trying to take the high-speed train and put it on high-speed tracks so that we can help patients,” said Holzapfel. By the end of this year, DAC will have worked in about 70 healthcare systems, implementing new tools for detection and diagnosis for about 60,000 patients. Image Credits: Cristina Gottardi/ Unsplash. Exposure to Leaded Fuel Affects Memory Loss of Older Americans 29/07/2025 Kerry Cullinan Exposure to leaded gasoline affects the memory loss of older Americans. Americans are about 20% more likely to experience memory problems if they lived in areas with high levels of atmospheric lead, according to a study of over 600,000 adults over the age of 65 released at the Alzheimer’s Association International Conference in Toronto on Tuesday. Researchers examined how exposure to airborne lead between 1960 and 1974, when leaded gasoline use was at its highest, may affect brain health later in life. They calculated exposure to historical atmospheric lead levels (HALL) by area and linked it to self-reported memory problems from two American Community Surveys (conducted between 2012 and 2021) involving over 500,000 people. Some 17-22% of people living in areas with moderate, high or extremely high atmospheric lead reported memory issues. “Our study may help us understand the pathways that contribute to some people developing dementia and Alzheimer’s disease,” said Dr Eric Brown, lead author and associate chief of geriatric psychiatry at the Centre for Addiction and Mental Health in Toronto. Lead was originally added to gasoline to increase performance until researchers determined it posed serious risks to health and the environment. The more than 20-year-long phase-out of leaded gas began in 1975. “When I was a child in 1976, our blood carried 15 times more lead than children’s blood today,” said Esme Fuller-Thomson, senior author of the study and a professor at the University of Toronto’s Faculty of Social Work. “An astonishing 88% of us had levels higher than 10 micrograms per deciliter, which are now considered dangerously high.” While the risk of atmospheric lead has decreased, other sources of exposure remain, such as old lead paint and pipes. Those who have been exposed to atmospheric lead should focus on reducing other risk factors for dementia, including high blood pressure, smoking and social isolation, said Brown. “Research suggests half the US population – more than 170 million people – were exposed to high lead levels in early childhood. This research sheds more light on the toxicity of lead related to brain health in older adults today,” said Dr Maria Carrillo, Alzheimer’s Association chief science officer and medical affairs lead. Another study reported at the conference found that older adults who live about three miles from a lead-releasing facility – such as glass, ready-mixed concrete or computer and electronics manufacturers – are more likely to have memory and thinking problems than those who live farther away. Lifestyle interventions help slow cognitive decline Alzheimer’s disease is the most common type of dementia found in elderly people. Social isolation, diet and lack of exercise affect the progression of the disease. Meanwhile, in better news, older adults at risk for cognitive decline and dementia who were actively encouraged to adopt healthy lifestyles were able to slow memory loss, the conference heard. A study of over 2,000 people compared the impact of a structured lifestyle intervention with a self-guided intervention and found that, while both interventions helped, those in the more intense intervention had better success at slowing cognitive decline. Both interventions focused on physical exercise, nutrition, cognitive challenge and social engagement, and heart health monitoring, but differed in intensity, structure, accountability and support provided. In the structured lifestyle group, participants attended 38 facilitated peer team meetings over two years. They were provided with an activity programme with measurable goals, encouraged to eat according to the MIND diet, given cognitive challenges and other intellectual and social activities. Their progress was reviewed regularly. In the self-guided lifestyle intervention, participants attended six peer team meetings to encourage self-selected lifestyle changes. Participants in the structured intervention showed greater improvement on global cognition, protecting cognition from normal age-related decline for up to two years. The results of the study, called US POINTER, were reported for the first time at the AAIC conference and published in the Journal of the American Medical Association (JAMA). “As the burden of dementia grows worldwide, US POINTER affirms a vital public health message: healthy behaviour has a powerful impact on brain health,” said Dr Joanne Pike, Alzheimer’s Association president and CEO. “This is a critical public health opportunity. The intervention was effective across a broad, representative group – regardless of sex, ethnicity, APOE [gene] genetic risk, or heart health status – demonstrating its applicability and scalability for communities across the country,” added Pike. “The positive results of US POINTER encourage us to look at the potential for a combination of a lifestyle program and drug treatment as the next frontier in our fight against cognitive decline and possibly dementia.” Image Credits: Dawn McDonal/ Unsplash, Photo by Steven HWG on Unsplash. Governments ‘Backslide’ on NCD Commitments After Pressure from Unhealthy Industries 28/07/2025 Kerry Cullinan Few countries are effectively taxing tobacco, alcohol, sugary drinks and ultraprocessed food, in part due to massive industry pushback. Governments have weakened their commitment to addressing non-communicable diseases (NCDs) after pressure from “big tobacco, alcohol, junk food, and fossil fuels”, according to civil society. Their claim centres on the draft political declaration due to be adopted at the UN High-Level Meeting (HLM) on NCDs in September, which no longer calls on countries to implement high taxes on these unhealthy products. Countries are due to wrap up negotiations on the declaration this week, with the final declaration due to be adopted at the HLM on 25 September. “It looks like health-harming industry fingerprints are all over this,” said Alison Cox, director of policy and advocacy at the NCD Alliance. “At a time of fiscal pressures, shrinking global health funding, and increased emphasis on domestic resource mobilisation, health taxes are a golden opportunity to both generate revenue and reduce the burden of NCDs and associated healthcare costs,” she added. “Yet as it stands, the declaration’s text contains weaker language around taxes and lets industry off the hook, prioritising profits over public health,” added Cox, describing the draft as “a backslide”. The language in the current draft has been watered down, and targets have been “flattened”, with active commitments to ‘implement’ and ‘enact’ replaced with the “far more passive language of ‘consider’ and ‘encourage’,” according to the NCD Alliance. ‘Reinstate commitment to taxes’ Vital Strategies, a global public health organisation, urged the negotiators to “reinstate explicit commitment to health taxes” on tobacco, alcohol and sugar-sweetened beverages. “These taxes should increase prices sufficiently to reduce affordability, prevent initiation and support reduction or cessation of use,” said Vital Strategies in a media release. “As outlined by the Task Force for Fiscal Policy on Health, a 50% price increase on tobacco, alcohol, and sugary beverages could raise $2.1 trillion in five years for low- and middle-income countries, revenue equal to 40% of their total health spending,” added the organisation. NCDs, including heart disease, cancer and diabetes, account for 43 million deaths annually, 75% of all deaths worldwide. The burden of NCDs is growing in low- and middle-income countries, driven primarily by smoking and poor diets. Taxes on alcohol, restricting marketing and regulating sales hours are proven interventions to reduce consumption. Vital Strategies also raised alarm about the removal of references to the World Health Organization’s (WHO) “Best Buy” policy recommendations for reducing alcohol consumption and related diseases, including raising taxes, restricting marketing and regulating availability. “The conspicuous deletion of these proven policies from the text strongly suggests undue alcohol industry influence aimed at weakening public health protections. We urge governments to immediately reverse these deletions and fully restore WHO’s recommendations in the final text,” said Vital Strategies. Harmful commercial practices It also wants the declaration to “explicitly tackle harmful commercial practices and strengthen conflict-of-interest protections to safeguard public health policymaking from industry interference”, strengthen commitments to “proven tobacco control measures” including effective taxation, and “recognise unhealthy diets as an urgent priority”. The WHO attributes some 2.8 million deaths a year to obesity and overweight, and Vital wants the declaration to “explicitly state that rising obesity rates are primarily driven by unhealthy diets, emphasising clear interventions like front-of-pack labelling and marketing restrictions targeting children”. The NCD Alliance is also unhappy about “significant backsliding” around social participation and the role of civil society, which is only referred to once. “History has taught us that ignoring the integral role of civil society, communities and people living with diseases weakens any meaningful public health response,” said Cox. With just a week of negotiations remaining, the NCD Alliance is calling on governments to “demonstrate true leadership and resist last-minute compromises that prioritise commercial interests over public health and reflect a genuine commitment to protecting lives”. Image Credits: Leo Zhuang/ Unsplash, Stanislav Ivanitskiy/ Unsplash. Smoke Signals from the Plastics Treaty: Why Geneva Negotiations Can’t Ignore Health Governance 25/07/2025 Deborah Sy Cigarette filters, made from a plastic called cellulose acetate, are world’s most littered plastic item. As negotiators prepare to meet in Geneva, 5-14 August in yet another attempt to finalize the United Nations Global Plastics Treaty addressing a pollution crisis affecting oceans and ecosystems worldwide – a critical linkage between health and environment governance seems to be largely missing from the draft text. After nearly three years of negotiations, the world may be on the verge of finalizing its first legally-binding global instrument to tackle plastic pollution – providing that treaty negotiators overcome massive pressures from the fossil fuel industry to further stall an agreement or weaken provisions aiming to limit plastics production. But as negotiators prepare for the resumed fifth session (INC-5.2), another fundamental flaw threatens the future treaty’s health objectives: the failure to integrate environmental and health governance. This is particularly apparent with regards to cigarette filters – the world’s most littered plastic item – although it extends to cross-sector cooperation on other issues regarding the health harms of other plastics as well. The current draft text makes with only one reference to ‘plastic’ cigarette filters (in draft Annex X) and makes no reference at all to the WHO Framework Convention on Tobacco Control – which could, in fact, be an important nexus for health-environment cooperation on the treaty – once it is approved. The treatment of cigarette filters – largely made of a plastic called cellulose acetate – sends smoke signals about more systematic problems with the treaty text in terms of its approach to environment and health. Health rhetoric vs reality gap Cigarette filters are the world’s most prevalent forms of plastic litter, marring beaches and from there, infiltrating to oceans and fresh water ways. The Chair’s text, the working document guiding final negotiations, acknowledges health extensively in its rhetoric, although much of it remains in brackets, indicating areas where countries have not yet reached agreement. The preamble recognizes plastic pollution as “a serious environmental and human health problem,” while the treaty’s stated objective is “to protect human health and the environment from plastic pollution.” But while the preamble recognizes mutual support with “other international agreements in the field of the environment,” it limits that framework to environmental treaties. Any reference to health instruments, including the WHO Framework Convention on Tobacco Control (FCTC), which has been ratified by 183 countries, are absent from this structure. Draft Plastics Treaty negotiating text – much of language on health remains in brackets. The Chair’s preambular text affirms that the plastics treaty will “not affect… existing treaty obligations,” but this is a non-binding statement that merely avoids direct legal contradictions without promoting substantive policy coherence. In practice, it enables siloed implementation, weakens the ability of health ministries to regulate tobacco product components, and gives the tobacco industry new opportunities to exploit regulatory gaps through the environment ministries. Most tellingly, a standalone health article remains uncertain, reduced to scattered references or a placeholder “pending informal drafting work.” Despite the draft’s stated health objectives, the institutional bridge to health governance is still missing. The ‘safe alternatives’ problem This gap matters because “safe substitutes,” “safe alternatives,” or “safe recycling” are at the heart of solutions throughout the draft treaty. But how can environmental authorities evaluate safety and health impacts without connecting to international or national health standards? The tobacco industry is already exploiting this governance gap by promoting “eco-filters” and “biodegradable” alternatives to plastic cigarette filters. While these products may appear to address plastic pollution, they remain harmful to both health and the environment. Worse, they risk misleading consumers and this kind of product feature substitution is typically assessed by health authorities, not environmental ministries, which may lack the mandate or expertise to evaluate such claims. The cigarette filter test case Cigarette filters are the most littered plastic in the world. Used cigarette filters represent the world’s most littered plastic item, with trillions discarded annually. Each cigarette butt contains toxic lead, cadmium, phthalates, and polycyclic aromatic hydrocarbons that leach into waterways. A single cigarette butt can contaminate 1,000 liters of water, causing $26 billion in annual marine ecosystem damage. The FCTC provides clear guidance on these filters: Parties should prohibit ingredients in tobacco products that may create the impression that they have a health benefit. The WHO study group’s recommendations early this year included that filters should be banned to reduce the palatability and appeal of cigarettes. This would remove consumer misconceptions that filters reduce health harms, and it would also reduce a major source of toxic tobacco waste, including the microplastics deposited by cellulose acetate in filters. Annex X: plastics items recommended for limitations, but not ban or phaseout. Annex Y: proposed ban or phaseout list. Yet the draft plastics treaty only lists “cigarette filters made with plastic” in a priority list for mandatory or voluntary restriction or banning (Annex X), rather than on the ban or phaseout list (Annex Y). The “made with plastic” language for cigarette filters also creates a dangerous loophole that permits biofilters/ eco-filters, contradicting established health guidance. In contrast, Annex Y, the ban/ phase out list, itemizes toys and food containers containing lead, cadmium, and phthalates – the same toxicants found in cigarette filters. Broader governance architecture problem The cigarette filter case reveals systemic weaknesses in the treaty draft’s language around health. Article 2.2 of the FCTC requires Parties to ensure that subsequent international agreements should be compatible with FCTC obligations. However, the negotiating states have yet to provide a mechanism for ensuring this compatibility. When environmental ministries approve product redesigns without health authority input, both agendas suffer. When industries exploit policy gaps to rehabilitate their image while maintaining harmful products, both environmental integrity and health objectives are compromised. Extended Producer Responsibility schemes promoted throughout the draft treaty could also legitimize tobacco industry participation in environmental policy and its greenwashing, directly contradicting FCTC Article 5.3’s requirement to “protect tobacco-related environment policies” from industry interference. The problem extends far beyond tobacco. Plastic substitution decisions made in isolation from health expertise risk creating new health hazards while solving environmental concerns—essentially trading one set of risks for another. Environmental authorities may inadvertently approve alternatives that address plastic pollution while creating health risks. Infrastructure already exists Plastics health impacts in brief. The solution isn’t to build new health systems from scratch, as many countries already have relevant capacity, and global infrastructure exists, including for chemical safety, food standards, and medical devices. For tobacco, global networks like TobLabNet and TobReg provide evidence-based guidance. The real challenge is not global coordination, but national-level inter-agency cooperation. The future plastics treaty can help by explicitly obligating this, ensuring health and environment agencies work together. Without giving due regard to existing health treaties, such coordination will inevitably run up against the different standards these agencies follow on industry engagement. No credible health authority engages with the tobacco industry, which is prohibited globally under the WHO’s Framework of Engagement with Non-State Actors (FENSA) and nationally through Article 5.3 of the FCTC, which covers over 90% of the world’s population. The commitment to binding norms on conflict of interest in the FCTC is essential. It creates space for the broader safeguards called for by civil society, scientists, and the Office of the High Commissioner for Human Rights (OHCHR). Failing to respect existing obligations—especially in the clearest and extreme case of tobacco— effectively precludes any meaningful prevention of conflicts of interest. Integration not isolation The solution lies in strengthening the draft’s health foundation by explicitly recognizing existing health agreements, including the WHO’s FCTC, which was already referenced in previous drafts to promote “cooperation, coordination, and complementarity.” A global coalition focusing on this issue recommends a simple safeguard clause – “Measures taken under this instrument shall be without prejudice to, and aligned with, existing international public health treaties and obligations, (including the WHO FCTC)” – would help prevent regulatory conflicts while provide supportive infrastructures to bolster the authority of environmental ministries to implement the future treaty. For cigarette filters, the recommendation is to eliminate material qualifiers “made of plastic” and move filters to a list for immediate bans. More broadly, the future instrument needs formal mechanisms for health expertise integration—not transferring authority from the environment to health ministries, but creating coordination mechanisms ensuring both objectives are met. The Geneva opportunity The Global Plastics Treaty could model integrated governance for 21st-century planetary health challenges, or represent another missed opportunity for coherent global health governance. Tobacco control shows how weak coordination between health and environmental sectors can backfire. When environmental agencies promote so-called “eco-filters” without health input, they risk legitimizing harmful products. But the reverse is also true. During COVID-19, health-led responses drove a surge in plastic consumption, worsening pollution. Both cases expose the same flaw: without coordination, one sector’s solution can become another’s crisis. The Plastics Treaty offers a rare chance to correct this. The infrastructure exists. The evidence is clear. What’s missing is the political will to connect them through binding legal frameworks. Geneva may be the last, best opportunity, not only to curb plastic pollution, but to safeguard the future of global health governance. Integrating international health agreements into the treaty does more than align with existing obligations. It helps define the treaty’s direction and lays the foundation for a strong, legally binding instrument with robust regulatory measures and comprehensive protections for people and the planet. Deborah Sy is head of Strategy and Global Public Policy at the Global Center for Good Governance in Tobacco Control (GGTC) at Thammasat University in Thailand, the convener of Global Youth Voices and the Stop Tobacco Pollution Alliance (STPA). She is the founder and senior advisor of Health Justice Philippines, an observer to the UN Plastics Treaty negotiations. Image Credits: Dennis Skley, University of Bath , UNEP , Chairs Text, draft UN Plastics Treaty, December 2024, Chairs Text, UN Plastics Treaty, Draft 2024, Ciel.org. US Drafts Plan to Change PEPFAR’s Focus From HIV to Diseases that Could Threaten Americans 24/07/2025 Kerry Cullinan A woman with HIV takes her antiretrovial (ARV) medicine. Until earlier this year, over 20 million people with HIV received ARVs funded by PEPFAR. US State Department officials are developing a plan to transform the President’s Emergency Plan for AIDS Relief (PEPFAR) from an entity that tackles HIV to one that is broadly focused on protecting and promoting American interests. This is according to a report in the New York Times on Thursday, based on leaked planning documents that map out their vision for PEPFAR’s transition in in the next few years. “It would be replaced by ‘bilateral relationships’ with low-income countries focused on the detection of outbreaks that could threaten the United States and the creation of new markets for American drugs and technologies,” the newspaper reports. This is in keeping with the focus of the Trump administration’s first meeting with African health leaders after the US paused all foreign aid for 90 days in January. During the meeting between leaders of the US Centers for Disease Control and Prevention (CDC) and their counterparts in Africa CDC in March, the US officials indicated that they were interested in African business opportunities for American companies. Africa CDC official Dr Ngashi Ngongo told journalists after the meeting that the Trump administration “would like to see health more as a business, rather than something that functions on grants,” and is interested in “exploring how can we go into a partnership that translates into health as a business”. Aggressive transition planning Dr Jirair Ratevosian, a global health expert at Duke and previous PEPFAR chief of staff, said that the Trump administration has “made it very clear that they want to carry on with aggressive transition planning” for PEPFAR. “Transition planning is not a bad idea, but it must be done right, with timetables, developing indicators, matching government buy-in, getting community input etc,” Ratevosian said. While he has not seen the documents referred to by the New York Times, Ratevosian is concerned that the transition plan is being written in Washington rather than in and with the African countries most affected by PEPFAR’s transition. “There needs to be realistic timetables, careful planning and resources to successfully make the transition of HIV programming [from PEPFAR] to national control,” said Ratevosian. “Congress has made clear it rejects the administration’s rushed approach to PEPFAR’s transition, signalling bipartisan concern about protecting the program’s legacy and impact.” He added that the US State Department should also develop plans for US companies to sell their antiretroviral drugs to African countries, the largest market for these products. Brief defunding reprieve Luyengo Clinic in Eswatini. PEPFAR funded 80% of the clinic’s cost, and the HIV treatment of 3,000 people is in jeopardy. Last week, there was a brief moment of hope for PEPFAR recipients after the US Senate agreed to exempt the programme from a planned $400 million reduction, which had been included in a $9.4 billion rescission package put forward by President Donald Trump. The rescission package seeks to claw back federal funds from various programs, including approximately $900 million in global health allocations. Disruptions to US aid for global health including for PEPFAR programmes, have placed millions of lives at risk, particularly in countries heavily dependent on US-supported HIV infrastructure. Carolyn Amole, Clinton Health Access Initiative vice-president for HIV, hepatitis and TB, said PEPFAR’s funding cuts had disrupted commodities procurement, essential systems such as human resources, supply chains, and data infrastructure. Millions more AIDS deaths, infections projected An additional six million new HIV infections and four million AIDS-related deaths could occur between 2025 and 2029 if US-supported HIV treatment and prevention services collapse, according to UNAIDS. “This is not just a funding gap. It’s a ticking time bomb,” said UNAIDS Executive Director Winnie Byanyima at the launch of the organisation’s 2025 global AIDS update earlier this month. “We have seen services vanish overnight. Health workers have been sent home. And people – especially children and key populations – are being pushed out of care.” “Key populations” refer to people most vulnerable to HIV infection, including sex workers, men to have sex with men, people who inject drugs and young women. Some of the immediate effects of the US withdrawal of funds since Donald Trump assumed the presidency in January include the closure of health facilities, healthworker job losses, and disrupted treatment, testing and prevention services. 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Call for Global Strategy to Counter ‘Vaccine Misinformation from US’ 01/08/2025 Kerry Cullinan A baby is being vaccinated in Gonzagueville, Côte d’Ivoire. A clear global strategy is needed to “counter vaccine misinformation from the United States” (US), Heidi Larson and Simon Piatek write in The Lancet this week. This should be based on ensuring the independence of scientific institutions that deal with vaccines and the regulation of digital platforms to “address cross-border health harms”, they argue. Global immunisation programmes are already being being undermined by a lack of resources, with the global vaccine alliance, Gavi, reporting this week that it is facing a $3 billion shortfall that will result in “a slowdown” in some of the immunisation programmes it supports. Meanwhile, “the USA, long a cornerstone of global health leadership, has become an unexpected source of global instability in vaccination confidence”, argue Larsen, who heads the Vaccine Confidence Project at the London School of Hygiene, and Piatek, founder of New Imagination Lab, which researches digital influence. “An analysis of 316 million vaccine-related tweets from October 2019 to March 2021 across 18 languages found that the US functioned as a major exporter of COVID-19 vaccine misinformation, with American accounts disproportionately represented as central hubs in global misinformation networks”, they report. Kennedy: Misinformation ‘super-spreader’ A separate longitudinal analysis of almost 300 million tweets on Twitter (now X) in 2021 found that 800 “superspreader” accounts were responsible for a third of all vaccine misinformation retweets – and the most prominent of these accounts belonged to Robert F Kennedy Jr, appointed US Health Secretary earlier this year. Kennedy was responsible “for more than 13% of these retweets”, while most of the other super-spreader accounts also “operated primarily within the US digital ecosystem but had global reach, reinforcing the role of American-origin misinformation as a destabilising force in international vaccination confidence”, they report. The impact of the US misinformation has been global. In 2023, UNICEF reported that in West Africa, particularly Nigeria and Ghana, “viral social media posts from the USA promoting conspiracy theories” eroded trust and reduced demand for COVID-19 and childhood vaccines. Similarly, in Eastern Europe, particularly Romania and Bulgaria, misinformation has translated in lower vaccine uptake, write Larsen and Piatek. Aid cuts undermines vaccines They also argue that the US defunding of “substantial portions of international funding for science as well as vaccine delivery” has also allowed “conspiracy and misinformation to flourish globally”. Countering “US vaccine misinformation” should rest primarily on the protection of “scientific independence within federal health agencies”. “Political appointees should not interfere with technical guidance. Congressional mechanisms must guarantee the autonomy of bodies such as the CDC and NIH, irrespective of the incumbent administration,” they argue. Secondly, the regulation of digital platforms should take the form of “a binding international code on digital health integrity”, which could be developed by the World Health Organization and regional organisations such as the African Union and the Association of Southeast Asian Nations (ASEAN). “Central to such a framework must be algorithmic transparency,” they argue, pointing to the European Union’s Digital Services Act as an example of what could be possible. “Coordinated fact-checking infrastructure should be built into platform operations, not outsourced or voluntary, and must be adaptable to local languages and sociocultural contexts,” they assert, noting that while digital platforms operate globally, “regulatory responses remain national and fragmented”. “A world fragmented by health #misinformation is ill-prepared to respond to the next pandemic threat.”@ProfHeidiLarson & @sjpiatek in @TheLancet on impact of US leadership/politics on global health & #vaccine confidence.https://t.co/OggRnqAc8z — London School of Hygiene & Tropical Medicine (@LSHTM) August 1, 2025 Next pandemic is incubating “The urgency is compounded by what lies ahead. With climate-linked disease emergence, conflict-driven displacement, and increasing zoonotic risk, the next pandemic might already be incubating. A world fragmented by health misinformation is ill-prepared to respond to the next pandemic threat,” they conclude. “There is still time to act. But it requires confronting uncomfortable truths about the role of the USA in fuelling mistrust, and the political choices that have allowed it. The world cannot afford another crisis in which lives are lost not for lack of vaccines, but for lack of truth.” Image Credits: UNICEF. Oral Health Left Out Again? Why the UN’s NCD Declaration Must Not Repeat Past Mistakes 01/08/2025 Habib Benzian Children in the Philippines brushing their teeth. Some 3.7 billion people have oral diseases. Amid protests over the weakening of the political declaration for the UN High Level Meeting on NCDs, one huge issue was omitted from the start: oral health. As United Nations (UN) Member States navigate negotiations for the political declaration of the 2025 United Nations (UN) High-Level Meeting (HLM) on Non-communicable Diseases (NCDs), a familiar and troubling omission reappears: oral health is absent from the zero draft. This exclusion is neither new nor accidental – but it is increasingly indefensible. Oral diseases are the most prevalent NCDs globally, affecting nearly 3.7 billion people. They are preventable, deeply inequitable, and carry significant social and economic costs. Yet they remain excluded from the core political commitments that will shape global NCD and health priorities through 2030 and beyond. The zero draft, released around the 2025 World Health Assembly, omits oral health entirely—not in the preamble, not in the goals, not even in passing. This silence has raised concern among advocates, stakeholders, and Member States. Since then, at least a dozen countries, including major regional blocs, have called for its inclusion in the next draft. Previous UN HLM declarations, starting in 2011, offered only token two-word references to oral diseases, usually buried in broader commitments on NCDs or Universal Health Coverage. Given the major policy progress over the past five years, such minimal language no longer reflects the reality. Member states have made clear their collective commitment to act; the Declaration must now do the same. This is not a bold or unreasonable demand. It is a call for fairness and for recognition of a disease burden that touches half the world’s population and undermines education, livelihoods, and wellbeing. The burden is vast and rising. Untreated caries, periodontal disease, tooth loss, and oral cancers are among the most common health conditions worldwide. The highest burden is in middle-income countries, where health systems face growing needs but limited capacity. Annual global spending on oral health exceeds $390 billion, most of it out-of-pocket and concentrated in high-income countries. In many lower-income settings, even basic treatment is unaffordable. With few public services, most systems rely on a privatized, commercialized model that deepens inequality and leaves billions behind. Adding to this imbalance is a critical advocacy gap. Unlike other major health issues, oral health lacks strong civil society mobilisation. The absence of patient-led organisations and grassroots movements means there is little community pressure to drive policy change. As a result, those most affected by oral diseases remain largely unheard in global health debates. A dentist in Kurdistan checks the teeth of school children. In many developing countries, even basic dental treatment is out of reach for most people. Fragile moment of transition at WHO The omission of oral health comes at a precarious time. In recent years, the global oral health community has achieved major milestones: a 2021 World Health Assembly resolution, the Global Oral Health Status Report, a Global Strategy and Action Plan, and the Bangkok Declaration – No Health without Oral Health – endorsed by over 100 countries. Yet these advances remain largely under the radar of the broader global health community. At the same time, WHO is navigating internal turbulence and leadership gaps, particularly in NCDs. This weakens its presence in critical policy spaces, where influence depends as much on relationships and coordination as on technical input. The UNHLM is a UN-led process, and WHO’s role is limited. Influence flows through mechanisms like the Interagency Task Force and the Global Coordinating Mechanism, which dilute technical leadership and can shift focus toward political compromise. Compounding this, resistance to integrating oral health exists within the WHO itself. Traditional departmental silos, rigid program structures, and donor-driven priorities can hinder progress. Despite recent gains, systemic inertia continues to slow fuller inclusion. NCD Alliance and the limits of ‘5×5’ model The NCD Alliance’s response to the zero draft has been underwhelming. Despite counting major oral health organisations among its members, it failed to support the inclusion of oral diseases – likely to avoid expanding beyond the traditional “5×5” focus of five diseases and five risk factors. This narrow, mortality-based framework excludes conditions like oral diseases that cause long-term disability and deepen inequities. But chronic diseases are not defined by lethality alone. They require lifelong care and can often be managed successfully with the right support. Oral diseases begin early and last a lifetime. They cause pain, stigma, and exclusion—especially among the poor. Any political declaration that claims to advance equity must reflect today’s realities, not yesterday’s frameworks. Ignoring oral health means ignoring the lived experience of billions. A call for concrete commitments The inclusion of oral health in the Political Declaration is not about symbolism. It is about creating the conditions for action—national policies, budgets, and accountability frameworks that can translate global commitments into local change. At a minimum, this means: Recognizing oral diseases in the Declaration as part of the global NCD burden; Reaffirming existing commitments made by Member States through WHO instruments; Supporting the integration of essential oral health services into UHC and primary care delivery; Addressing the commercial determinants of oral diseases—especially the role of sugar and ultra-processed foods; and Ensuring that oral health is included in global monitoring and accountability systems. Anything less risks undermining the credibility of the declaration and leaving billions of people once again outside the promise of “health for all.” A quiet crisis, a global test Oral health affects nearly every household but remains low on political agendas. It lacks visibility, donor attention, and strong public advocacy, despite being a major source of avoidable pain and inequality. Recent progress has been real but remains fragile. Without political recognition, it risks stalling. The UN HLM is a test of global health priorities and our commitment to equity. Oral diseases are the most common NCDs. Excluding them would be indefensible. Oral health is not optional. This time, the Declaration must get it right. Habib Benzian is Professor of Epidemiology and Global Health at NYU College of Dentistry and a member of the Lancet Commission on Oral Health. He advises governments and international organizations on oral health policy and equity. Image Credits: Manila Water Foundation, Kurdistan Dental Health Organization. Health Taxes Offer Solution to Africa’s ‘Burning Platform’ of NCDs 31/07/2025 Kerry Cullinan South Africans campaign in favour of a tax on sugary drinks in 2017. Taxes on tobacco, alcohol and sugary drinks offer African countries the opportunity to regain their “sovereignty” in response to the collapse of donor funding, according to a new report on health financing compiled by Vital Strategies. Vital CEO Mary-Ann Etiebet described the rise of non-communicable diseases (NCDs) fueled by these unhealthy products as a “burning platform” – already accounting for a third of Africa’s deaths and set to surpass the burden of infectious disease within five years. “Low- and middle-income countries are at risk of losing up to $21 trillion by 2030 if no action is taken on the prevention and control of NCDs,” Etiebet told the launch of the report this week. “External health aid is falling sharply and is projected to fall even further, tightening fiscal space and reducing budgets available to support country health needs,” she added. Official development assistance (ODA) for health in Africa has fallen by a massive 70% since 2021 – from $80 billion to $24 billion – mostly as a result of the US’s abrupt cancellation of longstanding donor commitments earlier this year. Serah Makka, ONE’s executive director for Africa, said that the African Union agenda for 2063 and other continental plans call for “self-financing, resilient health systems”. But where are governments going to get funds from when 24 African countries are at risk of debt distress and 34 countries pay more to service their debt than to health and education combined, she asked. “This is where the innovation of taxes comes in, because, again, it’s been proven to provide more resources and health benefits,” said Makka. The launch of the Vital Strategies report was moderated by Adam Karpati (top left), and addressed by Jeff Drope, Mary-Ann Etiebet, Serah Makka and Corne van Walbeek. Specific tax works best Professor Jeffrey Drope, director of the Economics for Health team at Johns Hopkins University, described the lack of health taxes in many African countries as “untapped potential” to raise revenues and improve public health. Vietnam was an example of what is possible, added Drope. In the past few months, it has restructured its tobacco tax, which will “raise rates significantly” and imposed a tax on sugary drinks for the first time. Ethiopia and Cabo Verde are also increasing their taxation of unhealthy products. “Health taxes work,” he stressed. “When the taxes go up, the prices go up and consumption of these products goes down. “ We know that, for example, for tobacco and alcohol, a 10% increase in price will lead to around a 5% decrease in consumption. That’s a lot. And if you think about the fact that a lot of these countries are raising their taxes and prices a lot more than 10% you can see that the effects on consumption are going to be enormous and that the public health rewards are also going to be enormous as well.” The revenue can be used to fund education and health services, including programmes to help people quit smoking or alcohol, added Drope. Corne van Walbeek, director of the Research Unit on the Economics of Excisable Products (REEP) at the University of Cape Town, said that the best tax is a “specific tax”. In the case of cigarettes, this would be a certain amount of dollars per pack of cigarettes – rather than a tax based on the value or length of the cigarette (known as an ad valorem tax). For alcohol and sugary drinks, the most effective tax would tax the harmful ingredient – the alcohol or sugar content. This provided suppliers with an incentive to reduce the volume of the harmful substance, which has happened in South Africa, where some producers of sugary drinks and beer have reduced sugar and alcohol content respectively, he said. Scare-mongering However, the unhealthy industries are pushing back against taxes, Etiebet pointed out. This has emerged in negotiations on the political declaration, which is due to be adopted at the UN High-Level Meeting (HLM) on NCDs in September. The latest draft has “weakened commitments with regard to health taxes,” she said. The NCD Alliance has described the weaker language in the declaration as evidence of lobbying by “big tobacco, alcohol, junk food, and fossil fuels”. “At a time of fiscal pressures, shrinking global health funding, and increased emphasis on domestic resource mobilisation, health taxes are a golden opportunity to both generate revenue and reduce the burden of NCDs and associated healthcare costs,” said Alison Cox, director of policy and advocacy at the NCD Alliance. Vital Strategies has urged the negotiators to “reinstate explicit commitment to health taxes” on tobacco, alcohol and sugar-sweetened beverages. It has also urged negotiators to put back references to the World Health Organization’s (WHO) “Best Buy” policy recommendations for reducing alcohol consumption and related diseases, which include raising taxes, restricting marketing and regulating availability. However, sources close to the negotiations told Health Policy Watch that the United States had insisted that references to the WHO in the declaration to be scrapped. The Trump administration has withdrawn from the WHO. But Makka said that West African governments and the West African Health Organisation are “looking at how we can increase health security through health taxes for universal health coverage”. “Regional action and health taxes are going to be very important for Africa. And finally, there is political alignment. So this is the time. This is the moment. We’ve seen countries like South Africa, Nigeria and Kenya, already exploring and implementing excise taxes.” Image Credits: Kerry Cullinan. Addressing Alzheimer’s: Speech and Smell Tests May Help to Detect Cognitive Decline 30/07/2025 Kerry Cullinan New tests based on speech and smell may help to identify people at risk of dementia earlier Digital tests based on speech and smell are being developed to screen for cognitive decline, researchers told the Alzheimer’s Association International Conference in Toronto. Two speech apps are already some way down the road, testing several markers including speech speed, vocabulary and rhythm in different languages to establish a baseline for testing, a session convened by the Davos Alzheimer’s Collaboration (DAC) heard. A third initiative using smell is also in the mix, primarily testing people’s ability to smell certain scents via inhalers. DAC supports an innovation ecosystem to accelerate healthcare solutions to end Alzheimer’s disease globally, and DAC-supported projects in Kenya, India, Egypt and Chile have afforded the companies access to multicultural groups to refine their innovations. Better screening tests are essential as an estimated three-quarters of people with Alzheimer’s are never diagnosed and, as the burden grows in the global South, tests for low-resource settings as crucial. TELL’s Adolfo Garcia described his company’s product as “a digital speech biomarker app” that can run on multiple platforms, based on a collection of speech tasks ranging from spontaneous to non-spontaneous tasks. Several speech features “are very revealing about your mental health status”, said Garcia. Using speech timing metrics, for example, the app can measure “the rhythm with which people speak; the number of pauses that they make, how long those pauses are, how variable they are, how long the syllables that they produced are”, said Garcia. TELL has been tested in over 20 countries with over 40,000 hours of data from around 9000 participants. But Garcia describes the in-depth research with the DAC-supported researchers headed by Dr Karen Blackmon at Agha Khan University in Kenya, as “phenomenal, instructive and fulfilling.” Blackmon’s team has been testing Swahili-speaking Kenyans for cognitive decline based on simple speech timing metrics, while TELL has trained a machine learning regressor with various speech metrics. There has been a “moderate to strong correlation” between the results from TELL’s machine model and the real-time scores from people that Blackmon’s team has tested on “simple speech timing metrics, which are quite scalable across different languages”, Garcia noted. Nicklas Linz of Ki Elements said his speech app aims to find “something that works across languages, across cultural contexts, so that we have something that is culturally fair, neutral and usable in all of these contexts”. His group has worked with DAC teams in Egypt, India, Kenya and Chile who speak Arabic, Hindi, English, Swahili and Spanish. Loss of smell and neurodegeneration Subhanjan Mondal of Sensify said that the idea to use olfaction (smell) as a measure for neurodegeneration “came from COVID”, where many people who contracted the virus lost their sense of smell. People with the ApoE e4 allele, the gene variant that increases the risk of developing late-onset Alzheimer’s disease, also have an increased risk of olfactory decline. “There is an anatomical connection between olfaction and neurodegeneration for Alzheimer’s and Parkinson’s and many other neurodegenerative diseases,” said Mondal. “And there is also a genetic component, as ApoE carriers have a strong disposition to olfactory decline.” Sensify has developed a digital smell test, ScentAware, with smells contained in different inhalers that are QR-coded. Using an app connected to a mobile phone camera, people can conduct the smell test at home or in a clinical setting. “People found it easy to use, fun, and it can be done in a short time,” said Mondal. But there is some way to go. The field is so new that there are no common smell elements across cultures. “Can this be incorporated somewhere upstream in a screening mechanism in normal individuals with higher risk factors?” Mondal asks. Sensify is developing a smell test, ScentAware, to diagnose cognitive decline. Multicultural challenges “There are a lot of challenges in adapting speech tasks from multilingual contexts like Kenya,” said Aga Khan’s Blackmon. “But these are challenges that we’re going to have to face across as, in the Global South, multilingualism is a norm in most post-colonial settings where… major languages like English are spoken in schools but not necessarily in homes.” “It’s been excellent to work with TELL, Ki Elements and Sensify Aware because, in each of these partnerships, we are identifying problems and we’re proactively solving them,” said Blackmon. For example, an app using automatic speech recognition did not do so well when people were switching languages, she explained. “Although our samples may seem small, the way that we’re approaching this is to solve problems [before the app is] scaled to larger populations.” The end goal is to integrate the apps into health systems to enable affordable and accurate early detection. “These tools are friendlier. Their interfaces have been really well designed. They’re user-friendly. Tools like the olfactory Sensify Aware are fun for patients,” said Blackmon. “It’s very different from a standard neuropsychological test setting that I’m used to, where people are sweating. “It’s an opportunity to do it well and do it differently with input from stakeholders across the global South. We may even discover new speech features that turn out to be diagnostically relevant, like the number of times someone switches language could tell us something about early signs of dementia.” Societal and genetic influences The exposome influencing Alzheimer’s disease. Professor Amy Kind of the University of Wisconsin (UW) addressed how cognitive decline is influenced by both genetic and societal elements, known as the “exposome”. “The term was first coined in 2005, and it means the integrated compilation of physical, chemical, biological and social influences across an entire life course that influence biology,” said Kind. “The environmental exposures are modifiable. These are things that we can intervene upon, over and above individual-level factors, to improve health. And this construct is thought of as precision health, not just precision medicine,” she said. “Individuals who live in adverse exposomes experience poor brain health, and hundreds of studies have shown this,” added Kind. She heads the largest study of the social exposome in the United States, The Neighborhoods Study, which works with large community-based surveys as well as with tissue from people who have donated their brains to the study to better understand the environmental risks influencing Alzheimer’s. “We work with brain tissue, and we link it back to the life-course social exposome,” said Kind. “Across 25 academic institutions, there are over 9,000 descendants’ brain donors in the cohort, and it allows us to link, with some certainty, the association between certain types of exposure – be that occupational, social, toxic, metabolic – to findings within the tissue. Kind and colleagues try to identify and mitigate the risks for people living in adverse exposomes. Factors influences Alzheimer’s, as identified by The Lancet “Are there critical windows of life course across these pathways? “Perhaps all of our future for our brain health is written in our childhood, [so] gestational and early childhood effects could be profound, as we think about late life brain health,” said Kind. “Some of our newest work is focused on lead and heavy metal poisoning, because these metals accumulate in the tissue across the life course, and yet lead exposure is so common in our water supply, in the air that we breathe and in other places.” Kind and colleagues have worked closely with the Inner City Milwaukee Water Works Department in order to decrease the lead line pipe infrastructure to decrease lead in the water supply. Lead exposure has been linked to Alzheimer’s and cognitive decline, and a large study was released at the conference this week identifying the impact of leaded gasoline on the memory of older Americans. Reaching the Global South DAC founder George Vradenburg said one of the motives for collaboration is to link the global north and global South. “The majority of cases, by far, are already in the Global South, and by mid-century, it’s going to be 80% of cases of dementia are in the global South. So we have not fulfilled a patient mission if all we deal with is the top 20% of white people in the United States and Europe,” said Vradenburg. “DAC brings together researchers, healthcare systems, governments and funders to accelerate progress where it’s most needed,” DAC COO Drew Holzapfel told the meeting. It is based on three programmes – global cohort development, global clinical trials, and healthcare system preparedness – to address gaps in Alzheimer’s research and treatment. The cohort development programme aims to “increase the amount of research in diverse populations so that we can find better targets for drug development and associated biomarkers,” said Holzapfel. DAC’s global clinical trials programme aims to do clinical trials “better, faster, cheaper” around pharmacological and non-pharmacological interventions for brain health in parts of the globe that have never had those types of trials, he explained. The third component, healthcare system preparedness, aims to prime health systems to implement the innovations. “Our implementation scientists like to talk about how the time it takes for an innovation to go from availability to full clinical utilisation is about 17 years. We think that’s too long, so we’re trying to take the high-speed train and put it on high-speed tracks so that we can help patients,” said Holzapfel. By the end of this year, DAC will have worked in about 70 healthcare systems, implementing new tools for detection and diagnosis for about 60,000 patients. Image Credits: Cristina Gottardi/ Unsplash. Exposure to Leaded Fuel Affects Memory Loss of Older Americans 29/07/2025 Kerry Cullinan Exposure to leaded gasoline affects the memory loss of older Americans. Americans are about 20% more likely to experience memory problems if they lived in areas with high levels of atmospheric lead, according to a study of over 600,000 adults over the age of 65 released at the Alzheimer’s Association International Conference in Toronto on Tuesday. Researchers examined how exposure to airborne lead between 1960 and 1974, when leaded gasoline use was at its highest, may affect brain health later in life. They calculated exposure to historical atmospheric lead levels (HALL) by area and linked it to self-reported memory problems from two American Community Surveys (conducted between 2012 and 2021) involving over 500,000 people. Some 17-22% of people living in areas with moderate, high or extremely high atmospheric lead reported memory issues. “Our study may help us understand the pathways that contribute to some people developing dementia and Alzheimer’s disease,” said Dr Eric Brown, lead author and associate chief of geriatric psychiatry at the Centre for Addiction and Mental Health in Toronto. Lead was originally added to gasoline to increase performance until researchers determined it posed serious risks to health and the environment. The more than 20-year-long phase-out of leaded gas began in 1975. “When I was a child in 1976, our blood carried 15 times more lead than children’s blood today,” said Esme Fuller-Thomson, senior author of the study and a professor at the University of Toronto’s Faculty of Social Work. “An astonishing 88% of us had levels higher than 10 micrograms per deciliter, which are now considered dangerously high.” While the risk of atmospheric lead has decreased, other sources of exposure remain, such as old lead paint and pipes. Those who have been exposed to atmospheric lead should focus on reducing other risk factors for dementia, including high blood pressure, smoking and social isolation, said Brown. “Research suggests half the US population – more than 170 million people – were exposed to high lead levels in early childhood. This research sheds more light on the toxicity of lead related to brain health in older adults today,” said Dr Maria Carrillo, Alzheimer’s Association chief science officer and medical affairs lead. Another study reported at the conference found that older adults who live about three miles from a lead-releasing facility – such as glass, ready-mixed concrete or computer and electronics manufacturers – are more likely to have memory and thinking problems than those who live farther away. Lifestyle interventions help slow cognitive decline Alzheimer’s disease is the most common type of dementia found in elderly people. Social isolation, diet and lack of exercise affect the progression of the disease. Meanwhile, in better news, older adults at risk for cognitive decline and dementia who were actively encouraged to adopt healthy lifestyles were able to slow memory loss, the conference heard. A study of over 2,000 people compared the impact of a structured lifestyle intervention with a self-guided intervention and found that, while both interventions helped, those in the more intense intervention had better success at slowing cognitive decline. Both interventions focused on physical exercise, nutrition, cognitive challenge and social engagement, and heart health monitoring, but differed in intensity, structure, accountability and support provided. In the structured lifestyle group, participants attended 38 facilitated peer team meetings over two years. They were provided with an activity programme with measurable goals, encouraged to eat according to the MIND diet, given cognitive challenges and other intellectual and social activities. Their progress was reviewed regularly. In the self-guided lifestyle intervention, participants attended six peer team meetings to encourage self-selected lifestyle changes. Participants in the structured intervention showed greater improvement on global cognition, protecting cognition from normal age-related decline for up to two years. The results of the study, called US POINTER, were reported for the first time at the AAIC conference and published in the Journal of the American Medical Association (JAMA). “As the burden of dementia grows worldwide, US POINTER affirms a vital public health message: healthy behaviour has a powerful impact on brain health,” said Dr Joanne Pike, Alzheimer’s Association president and CEO. “This is a critical public health opportunity. The intervention was effective across a broad, representative group – regardless of sex, ethnicity, APOE [gene] genetic risk, or heart health status – demonstrating its applicability and scalability for communities across the country,” added Pike. “The positive results of US POINTER encourage us to look at the potential for a combination of a lifestyle program and drug treatment as the next frontier in our fight against cognitive decline and possibly dementia.” Image Credits: Dawn McDonal/ Unsplash, Photo by Steven HWG on Unsplash. Governments ‘Backslide’ on NCD Commitments After Pressure from Unhealthy Industries 28/07/2025 Kerry Cullinan Few countries are effectively taxing tobacco, alcohol, sugary drinks and ultraprocessed food, in part due to massive industry pushback. Governments have weakened their commitment to addressing non-communicable diseases (NCDs) after pressure from “big tobacco, alcohol, junk food, and fossil fuels”, according to civil society. Their claim centres on the draft political declaration due to be adopted at the UN High-Level Meeting (HLM) on NCDs in September, which no longer calls on countries to implement high taxes on these unhealthy products. Countries are due to wrap up negotiations on the declaration this week, with the final declaration due to be adopted at the HLM on 25 September. “It looks like health-harming industry fingerprints are all over this,” said Alison Cox, director of policy and advocacy at the NCD Alliance. “At a time of fiscal pressures, shrinking global health funding, and increased emphasis on domestic resource mobilisation, health taxes are a golden opportunity to both generate revenue and reduce the burden of NCDs and associated healthcare costs,” she added. “Yet as it stands, the declaration’s text contains weaker language around taxes and lets industry off the hook, prioritising profits over public health,” added Cox, describing the draft as “a backslide”. The language in the current draft has been watered down, and targets have been “flattened”, with active commitments to ‘implement’ and ‘enact’ replaced with the “far more passive language of ‘consider’ and ‘encourage’,” according to the NCD Alliance. ‘Reinstate commitment to taxes’ Vital Strategies, a global public health organisation, urged the negotiators to “reinstate explicit commitment to health taxes” on tobacco, alcohol and sugar-sweetened beverages. “These taxes should increase prices sufficiently to reduce affordability, prevent initiation and support reduction or cessation of use,” said Vital Strategies in a media release. “As outlined by the Task Force for Fiscal Policy on Health, a 50% price increase on tobacco, alcohol, and sugary beverages could raise $2.1 trillion in five years for low- and middle-income countries, revenue equal to 40% of their total health spending,” added the organisation. NCDs, including heart disease, cancer and diabetes, account for 43 million deaths annually, 75% of all deaths worldwide. The burden of NCDs is growing in low- and middle-income countries, driven primarily by smoking and poor diets. Taxes on alcohol, restricting marketing and regulating sales hours are proven interventions to reduce consumption. Vital Strategies also raised alarm about the removal of references to the World Health Organization’s (WHO) “Best Buy” policy recommendations for reducing alcohol consumption and related diseases, including raising taxes, restricting marketing and regulating availability. “The conspicuous deletion of these proven policies from the text strongly suggests undue alcohol industry influence aimed at weakening public health protections. We urge governments to immediately reverse these deletions and fully restore WHO’s recommendations in the final text,” said Vital Strategies. Harmful commercial practices It also wants the declaration to “explicitly tackle harmful commercial practices and strengthen conflict-of-interest protections to safeguard public health policymaking from industry interference”, strengthen commitments to “proven tobacco control measures” including effective taxation, and “recognise unhealthy diets as an urgent priority”. The WHO attributes some 2.8 million deaths a year to obesity and overweight, and Vital wants the declaration to “explicitly state that rising obesity rates are primarily driven by unhealthy diets, emphasising clear interventions like front-of-pack labelling and marketing restrictions targeting children”. The NCD Alliance is also unhappy about “significant backsliding” around social participation and the role of civil society, which is only referred to once. “History has taught us that ignoring the integral role of civil society, communities and people living with diseases weakens any meaningful public health response,” said Cox. With just a week of negotiations remaining, the NCD Alliance is calling on governments to “demonstrate true leadership and resist last-minute compromises that prioritise commercial interests over public health and reflect a genuine commitment to protecting lives”. Image Credits: Leo Zhuang/ Unsplash, Stanislav Ivanitskiy/ Unsplash. Smoke Signals from the Plastics Treaty: Why Geneva Negotiations Can’t Ignore Health Governance 25/07/2025 Deborah Sy Cigarette filters, made from a plastic called cellulose acetate, are world’s most littered plastic item. As negotiators prepare to meet in Geneva, 5-14 August in yet another attempt to finalize the United Nations Global Plastics Treaty addressing a pollution crisis affecting oceans and ecosystems worldwide – a critical linkage between health and environment governance seems to be largely missing from the draft text. After nearly three years of negotiations, the world may be on the verge of finalizing its first legally-binding global instrument to tackle plastic pollution – providing that treaty negotiators overcome massive pressures from the fossil fuel industry to further stall an agreement or weaken provisions aiming to limit plastics production. But as negotiators prepare for the resumed fifth session (INC-5.2), another fundamental flaw threatens the future treaty’s health objectives: the failure to integrate environmental and health governance. This is particularly apparent with regards to cigarette filters – the world’s most littered plastic item – although it extends to cross-sector cooperation on other issues regarding the health harms of other plastics as well. The current draft text makes with only one reference to ‘plastic’ cigarette filters (in draft Annex X) and makes no reference at all to the WHO Framework Convention on Tobacco Control – which could, in fact, be an important nexus for health-environment cooperation on the treaty – once it is approved. The treatment of cigarette filters – largely made of a plastic called cellulose acetate – sends smoke signals about more systematic problems with the treaty text in terms of its approach to environment and health. Health rhetoric vs reality gap Cigarette filters are the world’s most prevalent forms of plastic litter, marring beaches and from there, infiltrating to oceans and fresh water ways. The Chair’s text, the working document guiding final negotiations, acknowledges health extensively in its rhetoric, although much of it remains in brackets, indicating areas where countries have not yet reached agreement. The preamble recognizes plastic pollution as “a serious environmental and human health problem,” while the treaty’s stated objective is “to protect human health and the environment from plastic pollution.” But while the preamble recognizes mutual support with “other international agreements in the field of the environment,” it limits that framework to environmental treaties. Any reference to health instruments, including the WHO Framework Convention on Tobacco Control (FCTC), which has been ratified by 183 countries, are absent from this structure. Draft Plastics Treaty negotiating text – much of language on health remains in brackets. The Chair’s preambular text affirms that the plastics treaty will “not affect… existing treaty obligations,” but this is a non-binding statement that merely avoids direct legal contradictions without promoting substantive policy coherence. In practice, it enables siloed implementation, weakens the ability of health ministries to regulate tobacco product components, and gives the tobacco industry new opportunities to exploit regulatory gaps through the environment ministries. Most tellingly, a standalone health article remains uncertain, reduced to scattered references or a placeholder “pending informal drafting work.” Despite the draft’s stated health objectives, the institutional bridge to health governance is still missing. The ‘safe alternatives’ problem This gap matters because “safe substitutes,” “safe alternatives,” or “safe recycling” are at the heart of solutions throughout the draft treaty. But how can environmental authorities evaluate safety and health impacts without connecting to international or national health standards? The tobacco industry is already exploiting this governance gap by promoting “eco-filters” and “biodegradable” alternatives to plastic cigarette filters. While these products may appear to address plastic pollution, they remain harmful to both health and the environment. Worse, they risk misleading consumers and this kind of product feature substitution is typically assessed by health authorities, not environmental ministries, which may lack the mandate or expertise to evaluate such claims. The cigarette filter test case Cigarette filters are the most littered plastic in the world. Used cigarette filters represent the world’s most littered plastic item, with trillions discarded annually. Each cigarette butt contains toxic lead, cadmium, phthalates, and polycyclic aromatic hydrocarbons that leach into waterways. A single cigarette butt can contaminate 1,000 liters of water, causing $26 billion in annual marine ecosystem damage. The FCTC provides clear guidance on these filters: Parties should prohibit ingredients in tobacco products that may create the impression that they have a health benefit. The WHO study group’s recommendations early this year included that filters should be banned to reduce the palatability and appeal of cigarettes. This would remove consumer misconceptions that filters reduce health harms, and it would also reduce a major source of toxic tobacco waste, including the microplastics deposited by cellulose acetate in filters. Annex X: plastics items recommended for limitations, but not ban or phaseout. Annex Y: proposed ban or phaseout list. Yet the draft plastics treaty only lists “cigarette filters made with plastic” in a priority list for mandatory or voluntary restriction or banning (Annex X), rather than on the ban or phaseout list (Annex Y). The “made with plastic” language for cigarette filters also creates a dangerous loophole that permits biofilters/ eco-filters, contradicting established health guidance. In contrast, Annex Y, the ban/ phase out list, itemizes toys and food containers containing lead, cadmium, and phthalates – the same toxicants found in cigarette filters. Broader governance architecture problem The cigarette filter case reveals systemic weaknesses in the treaty draft’s language around health. Article 2.2 of the FCTC requires Parties to ensure that subsequent international agreements should be compatible with FCTC obligations. However, the negotiating states have yet to provide a mechanism for ensuring this compatibility. When environmental ministries approve product redesigns without health authority input, both agendas suffer. When industries exploit policy gaps to rehabilitate their image while maintaining harmful products, both environmental integrity and health objectives are compromised. Extended Producer Responsibility schemes promoted throughout the draft treaty could also legitimize tobacco industry participation in environmental policy and its greenwashing, directly contradicting FCTC Article 5.3’s requirement to “protect tobacco-related environment policies” from industry interference. The problem extends far beyond tobacco. Plastic substitution decisions made in isolation from health expertise risk creating new health hazards while solving environmental concerns—essentially trading one set of risks for another. Environmental authorities may inadvertently approve alternatives that address plastic pollution while creating health risks. Infrastructure already exists Plastics health impacts in brief. The solution isn’t to build new health systems from scratch, as many countries already have relevant capacity, and global infrastructure exists, including for chemical safety, food standards, and medical devices. For tobacco, global networks like TobLabNet and TobReg provide evidence-based guidance. The real challenge is not global coordination, but national-level inter-agency cooperation. The future plastics treaty can help by explicitly obligating this, ensuring health and environment agencies work together. Without giving due regard to existing health treaties, such coordination will inevitably run up against the different standards these agencies follow on industry engagement. No credible health authority engages with the tobacco industry, which is prohibited globally under the WHO’s Framework of Engagement with Non-State Actors (FENSA) and nationally through Article 5.3 of the FCTC, which covers over 90% of the world’s population. The commitment to binding norms on conflict of interest in the FCTC is essential. It creates space for the broader safeguards called for by civil society, scientists, and the Office of the High Commissioner for Human Rights (OHCHR). Failing to respect existing obligations—especially in the clearest and extreme case of tobacco— effectively precludes any meaningful prevention of conflicts of interest. Integration not isolation The solution lies in strengthening the draft’s health foundation by explicitly recognizing existing health agreements, including the WHO’s FCTC, which was already referenced in previous drafts to promote “cooperation, coordination, and complementarity.” A global coalition focusing on this issue recommends a simple safeguard clause – “Measures taken under this instrument shall be without prejudice to, and aligned with, existing international public health treaties and obligations, (including the WHO FCTC)” – would help prevent regulatory conflicts while provide supportive infrastructures to bolster the authority of environmental ministries to implement the future treaty. For cigarette filters, the recommendation is to eliminate material qualifiers “made of plastic” and move filters to a list for immediate bans. More broadly, the future instrument needs formal mechanisms for health expertise integration—not transferring authority from the environment to health ministries, but creating coordination mechanisms ensuring both objectives are met. The Geneva opportunity The Global Plastics Treaty could model integrated governance for 21st-century planetary health challenges, or represent another missed opportunity for coherent global health governance. Tobacco control shows how weak coordination between health and environmental sectors can backfire. When environmental agencies promote so-called “eco-filters” without health input, they risk legitimizing harmful products. But the reverse is also true. During COVID-19, health-led responses drove a surge in plastic consumption, worsening pollution. Both cases expose the same flaw: without coordination, one sector’s solution can become another’s crisis. The Plastics Treaty offers a rare chance to correct this. The infrastructure exists. The evidence is clear. What’s missing is the political will to connect them through binding legal frameworks. Geneva may be the last, best opportunity, not only to curb plastic pollution, but to safeguard the future of global health governance. Integrating international health agreements into the treaty does more than align with existing obligations. It helps define the treaty’s direction and lays the foundation for a strong, legally binding instrument with robust regulatory measures and comprehensive protections for people and the planet. Deborah Sy is head of Strategy and Global Public Policy at the Global Center for Good Governance in Tobacco Control (GGTC) at Thammasat University in Thailand, the convener of Global Youth Voices and the Stop Tobacco Pollution Alliance (STPA). She is the founder and senior advisor of Health Justice Philippines, an observer to the UN Plastics Treaty negotiations. Image Credits: Dennis Skley, University of Bath , UNEP , Chairs Text, draft UN Plastics Treaty, December 2024, Chairs Text, UN Plastics Treaty, Draft 2024, Ciel.org. US Drafts Plan to Change PEPFAR’s Focus From HIV to Diseases that Could Threaten Americans 24/07/2025 Kerry Cullinan A woman with HIV takes her antiretrovial (ARV) medicine. Until earlier this year, over 20 million people with HIV received ARVs funded by PEPFAR. US State Department officials are developing a plan to transform the President’s Emergency Plan for AIDS Relief (PEPFAR) from an entity that tackles HIV to one that is broadly focused on protecting and promoting American interests. This is according to a report in the New York Times on Thursday, based on leaked planning documents that map out their vision for PEPFAR’s transition in in the next few years. “It would be replaced by ‘bilateral relationships’ with low-income countries focused on the detection of outbreaks that could threaten the United States and the creation of new markets for American drugs and technologies,” the newspaper reports. This is in keeping with the focus of the Trump administration’s first meeting with African health leaders after the US paused all foreign aid for 90 days in January. During the meeting between leaders of the US Centers for Disease Control and Prevention (CDC) and their counterparts in Africa CDC in March, the US officials indicated that they were interested in African business opportunities for American companies. Africa CDC official Dr Ngashi Ngongo told journalists after the meeting that the Trump administration “would like to see health more as a business, rather than something that functions on grants,” and is interested in “exploring how can we go into a partnership that translates into health as a business”. Aggressive transition planning Dr Jirair Ratevosian, a global health expert at Duke and previous PEPFAR chief of staff, said that the Trump administration has “made it very clear that they want to carry on with aggressive transition planning” for PEPFAR. “Transition planning is not a bad idea, but it must be done right, with timetables, developing indicators, matching government buy-in, getting community input etc,” Ratevosian said. While he has not seen the documents referred to by the New York Times, Ratevosian is concerned that the transition plan is being written in Washington rather than in and with the African countries most affected by PEPFAR’s transition. “There needs to be realistic timetables, careful planning and resources to successfully make the transition of HIV programming [from PEPFAR] to national control,” said Ratevosian. “Congress has made clear it rejects the administration’s rushed approach to PEPFAR’s transition, signalling bipartisan concern about protecting the program’s legacy and impact.” He added that the US State Department should also develop plans for US companies to sell their antiretroviral drugs to African countries, the largest market for these products. Brief defunding reprieve Luyengo Clinic in Eswatini. PEPFAR funded 80% of the clinic’s cost, and the HIV treatment of 3,000 people is in jeopardy. Last week, there was a brief moment of hope for PEPFAR recipients after the US Senate agreed to exempt the programme from a planned $400 million reduction, which had been included in a $9.4 billion rescission package put forward by President Donald Trump. The rescission package seeks to claw back federal funds from various programs, including approximately $900 million in global health allocations. Disruptions to US aid for global health including for PEPFAR programmes, have placed millions of lives at risk, particularly in countries heavily dependent on US-supported HIV infrastructure. Carolyn Amole, Clinton Health Access Initiative vice-president for HIV, hepatitis and TB, said PEPFAR’s funding cuts had disrupted commodities procurement, essential systems such as human resources, supply chains, and data infrastructure. Millions more AIDS deaths, infections projected An additional six million new HIV infections and four million AIDS-related deaths could occur between 2025 and 2029 if US-supported HIV treatment and prevention services collapse, according to UNAIDS. “This is not just a funding gap. It’s a ticking time bomb,” said UNAIDS Executive Director Winnie Byanyima at the launch of the organisation’s 2025 global AIDS update earlier this month. “We have seen services vanish overnight. Health workers have been sent home. And people – especially children and key populations – are being pushed out of care.” “Key populations” refer to people most vulnerable to HIV infection, including sex workers, men to have sex with men, people who inject drugs and young women. Some of the immediate effects of the US withdrawal of funds since Donald Trump assumed the presidency in January include the closure of health facilities, healthworker job losses, and disrupted treatment, testing and prevention services. 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Oral Health Left Out Again? Why the UN’s NCD Declaration Must Not Repeat Past Mistakes 01/08/2025 Habib Benzian Children in the Philippines brushing their teeth. Some 3.7 billion people have oral diseases. Amid protests over the weakening of the political declaration for the UN High Level Meeting on NCDs, one huge issue was omitted from the start: oral health. As United Nations (UN) Member States navigate negotiations for the political declaration of the 2025 United Nations (UN) High-Level Meeting (HLM) on Non-communicable Diseases (NCDs), a familiar and troubling omission reappears: oral health is absent from the zero draft. This exclusion is neither new nor accidental – but it is increasingly indefensible. Oral diseases are the most prevalent NCDs globally, affecting nearly 3.7 billion people. They are preventable, deeply inequitable, and carry significant social and economic costs. Yet they remain excluded from the core political commitments that will shape global NCD and health priorities through 2030 and beyond. The zero draft, released around the 2025 World Health Assembly, omits oral health entirely—not in the preamble, not in the goals, not even in passing. This silence has raised concern among advocates, stakeholders, and Member States. Since then, at least a dozen countries, including major regional blocs, have called for its inclusion in the next draft. Previous UN HLM declarations, starting in 2011, offered only token two-word references to oral diseases, usually buried in broader commitments on NCDs or Universal Health Coverage. Given the major policy progress over the past five years, such minimal language no longer reflects the reality. Member states have made clear their collective commitment to act; the Declaration must now do the same. This is not a bold or unreasonable demand. It is a call for fairness and for recognition of a disease burden that touches half the world’s population and undermines education, livelihoods, and wellbeing. The burden is vast and rising. Untreated caries, periodontal disease, tooth loss, and oral cancers are among the most common health conditions worldwide. The highest burden is in middle-income countries, where health systems face growing needs but limited capacity. Annual global spending on oral health exceeds $390 billion, most of it out-of-pocket and concentrated in high-income countries. In many lower-income settings, even basic treatment is unaffordable. With few public services, most systems rely on a privatized, commercialized model that deepens inequality and leaves billions behind. Adding to this imbalance is a critical advocacy gap. Unlike other major health issues, oral health lacks strong civil society mobilisation. The absence of patient-led organisations and grassroots movements means there is little community pressure to drive policy change. As a result, those most affected by oral diseases remain largely unheard in global health debates. A dentist in Kurdistan checks the teeth of school children. In many developing countries, even basic dental treatment is out of reach for most people. Fragile moment of transition at WHO The omission of oral health comes at a precarious time. In recent years, the global oral health community has achieved major milestones: a 2021 World Health Assembly resolution, the Global Oral Health Status Report, a Global Strategy and Action Plan, and the Bangkok Declaration – No Health without Oral Health – endorsed by over 100 countries. Yet these advances remain largely under the radar of the broader global health community. At the same time, WHO is navigating internal turbulence and leadership gaps, particularly in NCDs. This weakens its presence in critical policy spaces, where influence depends as much on relationships and coordination as on technical input. The UNHLM is a UN-led process, and WHO’s role is limited. Influence flows through mechanisms like the Interagency Task Force and the Global Coordinating Mechanism, which dilute technical leadership and can shift focus toward political compromise. Compounding this, resistance to integrating oral health exists within the WHO itself. Traditional departmental silos, rigid program structures, and donor-driven priorities can hinder progress. Despite recent gains, systemic inertia continues to slow fuller inclusion. NCD Alliance and the limits of ‘5×5’ model The NCD Alliance’s response to the zero draft has been underwhelming. Despite counting major oral health organisations among its members, it failed to support the inclusion of oral diseases – likely to avoid expanding beyond the traditional “5×5” focus of five diseases and five risk factors. This narrow, mortality-based framework excludes conditions like oral diseases that cause long-term disability and deepen inequities. But chronic diseases are not defined by lethality alone. They require lifelong care and can often be managed successfully with the right support. Oral diseases begin early and last a lifetime. They cause pain, stigma, and exclusion—especially among the poor. Any political declaration that claims to advance equity must reflect today’s realities, not yesterday’s frameworks. Ignoring oral health means ignoring the lived experience of billions. A call for concrete commitments The inclusion of oral health in the Political Declaration is not about symbolism. It is about creating the conditions for action—national policies, budgets, and accountability frameworks that can translate global commitments into local change. At a minimum, this means: Recognizing oral diseases in the Declaration as part of the global NCD burden; Reaffirming existing commitments made by Member States through WHO instruments; Supporting the integration of essential oral health services into UHC and primary care delivery; Addressing the commercial determinants of oral diseases—especially the role of sugar and ultra-processed foods; and Ensuring that oral health is included in global monitoring and accountability systems. Anything less risks undermining the credibility of the declaration and leaving billions of people once again outside the promise of “health for all.” A quiet crisis, a global test Oral health affects nearly every household but remains low on political agendas. It lacks visibility, donor attention, and strong public advocacy, despite being a major source of avoidable pain and inequality. Recent progress has been real but remains fragile. Without political recognition, it risks stalling. The UN HLM is a test of global health priorities and our commitment to equity. Oral diseases are the most common NCDs. Excluding them would be indefensible. Oral health is not optional. This time, the Declaration must get it right. Habib Benzian is Professor of Epidemiology and Global Health at NYU College of Dentistry and a member of the Lancet Commission on Oral Health. He advises governments and international organizations on oral health policy and equity. Image Credits: Manila Water Foundation, Kurdistan Dental Health Organization. Health Taxes Offer Solution to Africa’s ‘Burning Platform’ of NCDs 31/07/2025 Kerry Cullinan South Africans campaign in favour of a tax on sugary drinks in 2017. Taxes on tobacco, alcohol and sugary drinks offer African countries the opportunity to regain their “sovereignty” in response to the collapse of donor funding, according to a new report on health financing compiled by Vital Strategies. Vital CEO Mary-Ann Etiebet described the rise of non-communicable diseases (NCDs) fueled by these unhealthy products as a “burning platform” – already accounting for a third of Africa’s deaths and set to surpass the burden of infectious disease within five years. “Low- and middle-income countries are at risk of losing up to $21 trillion by 2030 if no action is taken on the prevention and control of NCDs,” Etiebet told the launch of the report this week. “External health aid is falling sharply and is projected to fall even further, tightening fiscal space and reducing budgets available to support country health needs,” she added. Official development assistance (ODA) for health in Africa has fallen by a massive 70% since 2021 – from $80 billion to $24 billion – mostly as a result of the US’s abrupt cancellation of longstanding donor commitments earlier this year. Serah Makka, ONE’s executive director for Africa, said that the African Union agenda for 2063 and other continental plans call for “self-financing, resilient health systems”. But where are governments going to get funds from when 24 African countries are at risk of debt distress and 34 countries pay more to service their debt than to health and education combined, she asked. “This is where the innovation of taxes comes in, because, again, it’s been proven to provide more resources and health benefits,” said Makka. The launch of the Vital Strategies report was moderated by Adam Karpati (top left), and addressed by Jeff Drope, Mary-Ann Etiebet, Serah Makka and Corne van Walbeek. Specific tax works best Professor Jeffrey Drope, director of the Economics for Health team at Johns Hopkins University, described the lack of health taxes in many African countries as “untapped potential” to raise revenues and improve public health. Vietnam was an example of what is possible, added Drope. In the past few months, it has restructured its tobacco tax, which will “raise rates significantly” and imposed a tax on sugary drinks for the first time. Ethiopia and Cabo Verde are also increasing their taxation of unhealthy products. “Health taxes work,” he stressed. “When the taxes go up, the prices go up and consumption of these products goes down. “ We know that, for example, for tobacco and alcohol, a 10% increase in price will lead to around a 5% decrease in consumption. That’s a lot. And if you think about the fact that a lot of these countries are raising their taxes and prices a lot more than 10% you can see that the effects on consumption are going to be enormous and that the public health rewards are also going to be enormous as well.” The revenue can be used to fund education and health services, including programmes to help people quit smoking or alcohol, added Drope. Corne van Walbeek, director of the Research Unit on the Economics of Excisable Products (REEP) at the University of Cape Town, said that the best tax is a “specific tax”. In the case of cigarettes, this would be a certain amount of dollars per pack of cigarettes – rather than a tax based on the value or length of the cigarette (known as an ad valorem tax). For alcohol and sugary drinks, the most effective tax would tax the harmful ingredient – the alcohol or sugar content. This provided suppliers with an incentive to reduce the volume of the harmful substance, which has happened in South Africa, where some producers of sugary drinks and beer have reduced sugar and alcohol content respectively, he said. Scare-mongering However, the unhealthy industries are pushing back against taxes, Etiebet pointed out. This has emerged in negotiations on the political declaration, which is due to be adopted at the UN High-Level Meeting (HLM) on NCDs in September. The latest draft has “weakened commitments with regard to health taxes,” she said. The NCD Alliance has described the weaker language in the declaration as evidence of lobbying by “big tobacco, alcohol, junk food, and fossil fuels”. “At a time of fiscal pressures, shrinking global health funding, and increased emphasis on domestic resource mobilisation, health taxes are a golden opportunity to both generate revenue and reduce the burden of NCDs and associated healthcare costs,” said Alison Cox, director of policy and advocacy at the NCD Alliance. Vital Strategies has urged the negotiators to “reinstate explicit commitment to health taxes” on tobacco, alcohol and sugar-sweetened beverages. It has also urged negotiators to put back references to the World Health Organization’s (WHO) “Best Buy” policy recommendations for reducing alcohol consumption and related diseases, which include raising taxes, restricting marketing and regulating availability. However, sources close to the negotiations told Health Policy Watch that the United States had insisted that references to the WHO in the declaration to be scrapped. The Trump administration has withdrawn from the WHO. But Makka said that West African governments and the West African Health Organisation are “looking at how we can increase health security through health taxes for universal health coverage”. “Regional action and health taxes are going to be very important for Africa. And finally, there is political alignment. So this is the time. This is the moment. We’ve seen countries like South Africa, Nigeria and Kenya, already exploring and implementing excise taxes.” Image Credits: Kerry Cullinan. Addressing Alzheimer’s: Speech and Smell Tests May Help to Detect Cognitive Decline 30/07/2025 Kerry Cullinan New tests based on speech and smell may help to identify people at risk of dementia earlier Digital tests based on speech and smell are being developed to screen for cognitive decline, researchers told the Alzheimer’s Association International Conference in Toronto. Two speech apps are already some way down the road, testing several markers including speech speed, vocabulary and rhythm in different languages to establish a baseline for testing, a session convened by the Davos Alzheimer’s Collaboration (DAC) heard. A third initiative using smell is also in the mix, primarily testing people’s ability to smell certain scents via inhalers. DAC supports an innovation ecosystem to accelerate healthcare solutions to end Alzheimer’s disease globally, and DAC-supported projects in Kenya, India, Egypt and Chile have afforded the companies access to multicultural groups to refine their innovations. Better screening tests are essential as an estimated three-quarters of people with Alzheimer’s are never diagnosed and, as the burden grows in the global South, tests for low-resource settings as crucial. TELL’s Adolfo Garcia described his company’s product as “a digital speech biomarker app” that can run on multiple platforms, based on a collection of speech tasks ranging from spontaneous to non-spontaneous tasks. Several speech features “are very revealing about your mental health status”, said Garcia. Using speech timing metrics, for example, the app can measure “the rhythm with which people speak; the number of pauses that they make, how long those pauses are, how variable they are, how long the syllables that they produced are”, said Garcia. TELL has been tested in over 20 countries with over 40,000 hours of data from around 9000 participants. But Garcia describes the in-depth research with the DAC-supported researchers headed by Dr Karen Blackmon at Agha Khan University in Kenya, as “phenomenal, instructive and fulfilling.” Blackmon’s team has been testing Swahili-speaking Kenyans for cognitive decline based on simple speech timing metrics, while TELL has trained a machine learning regressor with various speech metrics. There has been a “moderate to strong correlation” between the results from TELL’s machine model and the real-time scores from people that Blackmon’s team has tested on “simple speech timing metrics, which are quite scalable across different languages”, Garcia noted. Nicklas Linz of Ki Elements said his speech app aims to find “something that works across languages, across cultural contexts, so that we have something that is culturally fair, neutral and usable in all of these contexts”. His group has worked with DAC teams in Egypt, India, Kenya and Chile who speak Arabic, Hindi, English, Swahili and Spanish. Loss of smell and neurodegeneration Subhanjan Mondal of Sensify said that the idea to use olfaction (smell) as a measure for neurodegeneration “came from COVID”, where many people who contracted the virus lost their sense of smell. People with the ApoE e4 allele, the gene variant that increases the risk of developing late-onset Alzheimer’s disease, also have an increased risk of olfactory decline. “There is an anatomical connection between olfaction and neurodegeneration for Alzheimer’s and Parkinson’s and many other neurodegenerative diseases,” said Mondal. “And there is also a genetic component, as ApoE carriers have a strong disposition to olfactory decline.” Sensify has developed a digital smell test, ScentAware, with smells contained in different inhalers that are QR-coded. Using an app connected to a mobile phone camera, people can conduct the smell test at home or in a clinical setting. “People found it easy to use, fun, and it can be done in a short time,” said Mondal. But there is some way to go. The field is so new that there are no common smell elements across cultures. “Can this be incorporated somewhere upstream in a screening mechanism in normal individuals with higher risk factors?” Mondal asks. Sensify is developing a smell test, ScentAware, to diagnose cognitive decline. Multicultural challenges “There are a lot of challenges in adapting speech tasks from multilingual contexts like Kenya,” said Aga Khan’s Blackmon. “But these are challenges that we’re going to have to face across as, in the Global South, multilingualism is a norm in most post-colonial settings where… major languages like English are spoken in schools but not necessarily in homes.” “It’s been excellent to work with TELL, Ki Elements and Sensify Aware because, in each of these partnerships, we are identifying problems and we’re proactively solving them,” said Blackmon. For example, an app using automatic speech recognition did not do so well when people were switching languages, she explained. “Although our samples may seem small, the way that we’re approaching this is to solve problems [before the app is] scaled to larger populations.” The end goal is to integrate the apps into health systems to enable affordable and accurate early detection. “These tools are friendlier. Their interfaces have been really well designed. They’re user-friendly. Tools like the olfactory Sensify Aware are fun for patients,” said Blackmon. “It’s very different from a standard neuropsychological test setting that I’m used to, where people are sweating. “It’s an opportunity to do it well and do it differently with input from stakeholders across the global South. We may even discover new speech features that turn out to be diagnostically relevant, like the number of times someone switches language could tell us something about early signs of dementia.” Societal and genetic influences The exposome influencing Alzheimer’s disease. Professor Amy Kind of the University of Wisconsin (UW) addressed how cognitive decline is influenced by both genetic and societal elements, known as the “exposome”. “The term was first coined in 2005, and it means the integrated compilation of physical, chemical, biological and social influences across an entire life course that influence biology,” said Kind. “The environmental exposures are modifiable. These are things that we can intervene upon, over and above individual-level factors, to improve health. And this construct is thought of as precision health, not just precision medicine,” she said. “Individuals who live in adverse exposomes experience poor brain health, and hundreds of studies have shown this,” added Kind. She heads the largest study of the social exposome in the United States, The Neighborhoods Study, which works with large community-based surveys as well as with tissue from people who have donated their brains to the study to better understand the environmental risks influencing Alzheimer’s. “We work with brain tissue, and we link it back to the life-course social exposome,” said Kind. “Across 25 academic institutions, there are over 9,000 descendants’ brain donors in the cohort, and it allows us to link, with some certainty, the association between certain types of exposure – be that occupational, social, toxic, metabolic – to findings within the tissue. Kind and colleagues try to identify and mitigate the risks for people living in adverse exposomes. Factors influences Alzheimer’s, as identified by The Lancet “Are there critical windows of life course across these pathways? “Perhaps all of our future for our brain health is written in our childhood, [so] gestational and early childhood effects could be profound, as we think about late life brain health,” said Kind. “Some of our newest work is focused on lead and heavy metal poisoning, because these metals accumulate in the tissue across the life course, and yet lead exposure is so common in our water supply, in the air that we breathe and in other places.” Kind and colleagues have worked closely with the Inner City Milwaukee Water Works Department in order to decrease the lead line pipe infrastructure to decrease lead in the water supply. Lead exposure has been linked to Alzheimer’s and cognitive decline, and a large study was released at the conference this week identifying the impact of leaded gasoline on the memory of older Americans. Reaching the Global South DAC founder George Vradenburg said one of the motives for collaboration is to link the global north and global South. “The majority of cases, by far, are already in the Global South, and by mid-century, it’s going to be 80% of cases of dementia are in the global South. So we have not fulfilled a patient mission if all we deal with is the top 20% of white people in the United States and Europe,” said Vradenburg. “DAC brings together researchers, healthcare systems, governments and funders to accelerate progress where it’s most needed,” DAC COO Drew Holzapfel told the meeting. It is based on three programmes – global cohort development, global clinical trials, and healthcare system preparedness – to address gaps in Alzheimer’s research and treatment. The cohort development programme aims to “increase the amount of research in diverse populations so that we can find better targets for drug development and associated biomarkers,” said Holzapfel. DAC’s global clinical trials programme aims to do clinical trials “better, faster, cheaper” around pharmacological and non-pharmacological interventions for brain health in parts of the globe that have never had those types of trials, he explained. The third component, healthcare system preparedness, aims to prime health systems to implement the innovations. “Our implementation scientists like to talk about how the time it takes for an innovation to go from availability to full clinical utilisation is about 17 years. We think that’s too long, so we’re trying to take the high-speed train and put it on high-speed tracks so that we can help patients,” said Holzapfel. By the end of this year, DAC will have worked in about 70 healthcare systems, implementing new tools for detection and diagnosis for about 60,000 patients. Image Credits: Cristina Gottardi/ Unsplash. Exposure to Leaded Fuel Affects Memory Loss of Older Americans 29/07/2025 Kerry Cullinan Exposure to leaded gasoline affects the memory loss of older Americans. Americans are about 20% more likely to experience memory problems if they lived in areas with high levels of atmospheric lead, according to a study of over 600,000 adults over the age of 65 released at the Alzheimer’s Association International Conference in Toronto on Tuesday. Researchers examined how exposure to airborne lead between 1960 and 1974, when leaded gasoline use was at its highest, may affect brain health later in life. They calculated exposure to historical atmospheric lead levels (HALL) by area and linked it to self-reported memory problems from two American Community Surveys (conducted between 2012 and 2021) involving over 500,000 people. Some 17-22% of people living in areas with moderate, high or extremely high atmospheric lead reported memory issues. “Our study may help us understand the pathways that contribute to some people developing dementia and Alzheimer’s disease,” said Dr Eric Brown, lead author and associate chief of geriatric psychiatry at the Centre for Addiction and Mental Health in Toronto. Lead was originally added to gasoline to increase performance until researchers determined it posed serious risks to health and the environment. The more than 20-year-long phase-out of leaded gas began in 1975. “When I was a child in 1976, our blood carried 15 times more lead than children’s blood today,” said Esme Fuller-Thomson, senior author of the study and a professor at the University of Toronto’s Faculty of Social Work. “An astonishing 88% of us had levels higher than 10 micrograms per deciliter, which are now considered dangerously high.” While the risk of atmospheric lead has decreased, other sources of exposure remain, such as old lead paint and pipes. Those who have been exposed to atmospheric lead should focus on reducing other risk factors for dementia, including high blood pressure, smoking and social isolation, said Brown. “Research suggests half the US population – more than 170 million people – were exposed to high lead levels in early childhood. This research sheds more light on the toxicity of lead related to brain health in older adults today,” said Dr Maria Carrillo, Alzheimer’s Association chief science officer and medical affairs lead. Another study reported at the conference found that older adults who live about three miles from a lead-releasing facility – such as glass, ready-mixed concrete or computer and electronics manufacturers – are more likely to have memory and thinking problems than those who live farther away. Lifestyle interventions help slow cognitive decline Alzheimer’s disease is the most common type of dementia found in elderly people. Social isolation, diet and lack of exercise affect the progression of the disease. Meanwhile, in better news, older adults at risk for cognitive decline and dementia who were actively encouraged to adopt healthy lifestyles were able to slow memory loss, the conference heard. A study of over 2,000 people compared the impact of a structured lifestyle intervention with a self-guided intervention and found that, while both interventions helped, those in the more intense intervention had better success at slowing cognitive decline. Both interventions focused on physical exercise, nutrition, cognitive challenge and social engagement, and heart health monitoring, but differed in intensity, structure, accountability and support provided. In the structured lifestyle group, participants attended 38 facilitated peer team meetings over two years. They were provided with an activity programme with measurable goals, encouraged to eat according to the MIND diet, given cognitive challenges and other intellectual and social activities. Their progress was reviewed regularly. In the self-guided lifestyle intervention, participants attended six peer team meetings to encourage self-selected lifestyle changes. Participants in the structured intervention showed greater improvement on global cognition, protecting cognition from normal age-related decline for up to two years. The results of the study, called US POINTER, were reported for the first time at the AAIC conference and published in the Journal of the American Medical Association (JAMA). “As the burden of dementia grows worldwide, US POINTER affirms a vital public health message: healthy behaviour has a powerful impact on brain health,” said Dr Joanne Pike, Alzheimer’s Association president and CEO. “This is a critical public health opportunity. The intervention was effective across a broad, representative group – regardless of sex, ethnicity, APOE [gene] genetic risk, or heart health status – demonstrating its applicability and scalability for communities across the country,” added Pike. “The positive results of US POINTER encourage us to look at the potential for a combination of a lifestyle program and drug treatment as the next frontier in our fight against cognitive decline and possibly dementia.” Image Credits: Dawn McDonal/ Unsplash, Photo by Steven HWG on Unsplash. Governments ‘Backslide’ on NCD Commitments After Pressure from Unhealthy Industries 28/07/2025 Kerry Cullinan Few countries are effectively taxing tobacco, alcohol, sugary drinks and ultraprocessed food, in part due to massive industry pushback. Governments have weakened their commitment to addressing non-communicable diseases (NCDs) after pressure from “big tobacco, alcohol, junk food, and fossil fuels”, according to civil society. Their claim centres on the draft political declaration due to be adopted at the UN High-Level Meeting (HLM) on NCDs in September, which no longer calls on countries to implement high taxes on these unhealthy products. Countries are due to wrap up negotiations on the declaration this week, with the final declaration due to be adopted at the HLM on 25 September. “It looks like health-harming industry fingerprints are all over this,” said Alison Cox, director of policy and advocacy at the NCD Alliance. “At a time of fiscal pressures, shrinking global health funding, and increased emphasis on domestic resource mobilisation, health taxes are a golden opportunity to both generate revenue and reduce the burden of NCDs and associated healthcare costs,” she added. “Yet as it stands, the declaration’s text contains weaker language around taxes and lets industry off the hook, prioritising profits over public health,” added Cox, describing the draft as “a backslide”. The language in the current draft has been watered down, and targets have been “flattened”, with active commitments to ‘implement’ and ‘enact’ replaced with the “far more passive language of ‘consider’ and ‘encourage’,” according to the NCD Alliance. ‘Reinstate commitment to taxes’ Vital Strategies, a global public health organisation, urged the negotiators to “reinstate explicit commitment to health taxes” on tobacco, alcohol and sugar-sweetened beverages. “These taxes should increase prices sufficiently to reduce affordability, prevent initiation and support reduction or cessation of use,” said Vital Strategies in a media release. “As outlined by the Task Force for Fiscal Policy on Health, a 50% price increase on tobacco, alcohol, and sugary beverages could raise $2.1 trillion in five years for low- and middle-income countries, revenue equal to 40% of their total health spending,” added the organisation. NCDs, including heart disease, cancer and diabetes, account for 43 million deaths annually, 75% of all deaths worldwide. The burden of NCDs is growing in low- and middle-income countries, driven primarily by smoking and poor diets. Taxes on alcohol, restricting marketing and regulating sales hours are proven interventions to reduce consumption. Vital Strategies also raised alarm about the removal of references to the World Health Organization’s (WHO) “Best Buy” policy recommendations for reducing alcohol consumption and related diseases, including raising taxes, restricting marketing and regulating availability. “The conspicuous deletion of these proven policies from the text strongly suggests undue alcohol industry influence aimed at weakening public health protections. We urge governments to immediately reverse these deletions and fully restore WHO’s recommendations in the final text,” said Vital Strategies. Harmful commercial practices It also wants the declaration to “explicitly tackle harmful commercial practices and strengthen conflict-of-interest protections to safeguard public health policymaking from industry interference”, strengthen commitments to “proven tobacco control measures” including effective taxation, and “recognise unhealthy diets as an urgent priority”. The WHO attributes some 2.8 million deaths a year to obesity and overweight, and Vital wants the declaration to “explicitly state that rising obesity rates are primarily driven by unhealthy diets, emphasising clear interventions like front-of-pack labelling and marketing restrictions targeting children”. The NCD Alliance is also unhappy about “significant backsliding” around social participation and the role of civil society, which is only referred to once. “History has taught us that ignoring the integral role of civil society, communities and people living with diseases weakens any meaningful public health response,” said Cox. With just a week of negotiations remaining, the NCD Alliance is calling on governments to “demonstrate true leadership and resist last-minute compromises that prioritise commercial interests over public health and reflect a genuine commitment to protecting lives”. Image Credits: Leo Zhuang/ Unsplash, Stanislav Ivanitskiy/ Unsplash. Smoke Signals from the Plastics Treaty: Why Geneva Negotiations Can’t Ignore Health Governance 25/07/2025 Deborah Sy Cigarette filters, made from a plastic called cellulose acetate, are world’s most littered plastic item. As negotiators prepare to meet in Geneva, 5-14 August in yet another attempt to finalize the United Nations Global Plastics Treaty addressing a pollution crisis affecting oceans and ecosystems worldwide – a critical linkage between health and environment governance seems to be largely missing from the draft text. After nearly three years of negotiations, the world may be on the verge of finalizing its first legally-binding global instrument to tackle plastic pollution – providing that treaty negotiators overcome massive pressures from the fossil fuel industry to further stall an agreement or weaken provisions aiming to limit plastics production. But as negotiators prepare for the resumed fifth session (INC-5.2), another fundamental flaw threatens the future treaty’s health objectives: the failure to integrate environmental and health governance. This is particularly apparent with regards to cigarette filters – the world’s most littered plastic item – although it extends to cross-sector cooperation on other issues regarding the health harms of other plastics as well. The current draft text makes with only one reference to ‘plastic’ cigarette filters (in draft Annex X) and makes no reference at all to the WHO Framework Convention on Tobacco Control – which could, in fact, be an important nexus for health-environment cooperation on the treaty – once it is approved. The treatment of cigarette filters – largely made of a plastic called cellulose acetate – sends smoke signals about more systematic problems with the treaty text in terms of its approach to environment and health. Health rhetoric vs reality gap Cigarette filters are the world’s most prevalent forms of plastic litter, marring beaches and from there, infiltrating to oceans and fresh water ways. The Chair’s text, the working document guiding final negotiations, acknowledges health extensively in its rhetoric, although much of it remains in brackets, indicating areas where countries have not yet reached agreement. The preamble recognizes plastic pollution as “a serious environmental and human health problem,” while the treaty’s stated objective is “to protect human health and the environment from plastic pollution.” But while the preamble recognizes mutual support with “other international agreements in the field of the environment,” it limits that framework to environmental treaties. Any reference to health instruments, including the WHO Framework Convention on Tobacco Control (FCTC), which has been ratified by 183 countries, are absent from this structure. Draft Plastics Treaty negotiating text – much of language on health remains in brackets. The Chair’s preambular text affirms that the plastics treaty will “not affect… existing treaty obligations,” but this is a non-binding statement that merely avoids direct legal contradictions without promoting substantive policy coherence. In practice, it enables siloed implementation, weakens the ability of health ministries to regulate tobacco product components, and gives the tobacco industry new opportunities to exploit regulatory gaps through the environment ministries. Most tellingly, a standalone health article remains uncertain, reduced to scattered references or a placeholder “pending informal drafting work.” Despite the draft’s stated health objectives, the institutional bridge to health governance is still missing. The ‘safe alternatives’ problem This gap matters because “safe substitutes,” “safe alternatives,” or “safe recycling” are at the heart of solutions throughout the draft treaty. But how can environmental authorities evaluate safety and health impacts without connecting to international or national health standards? The tobacco industry is already exploiting this governance gap by promoting “eco-filters” and “biodegradable” alternatives to plastic cigarette filters. While these products may appear to address plastic pollution, they remain harmful to both health and the environment. Worse, they risk misleading consumers and this kind of product feature substitution is typically assessed by health authorities, not environmental ministries, which may lack the mandate or expertise to evaluate such claims. The cigarette filter test case Cigarette filters are the most littered plastic in the world. Used cigarette filters represent the world’s most littered plastic item, with trillions discarded annually. Each cigarette butt contains toxic lead, cadmium, phthalates, and polycyclic aromatic hydrocarbons that leach into waterways. A single cigarette butt can contaminate 1,000 liters of water, causing $26 billion in annual marine ecosystem damage. The FCTC provides clear guidance on these filters: Parties should prohibit ingredients in tobacco products that may create the impression that they have a health benefit. The WHO study group’s recommendations early this year included that filters should be banned to reduce the palatability and appeal of cigarettes. This would remove consumer misconceptions that filters reduce health harms, and it would also reduce a major source of toxic tobacco waste, including the microplastics deposited by cellulose acetate in filters. Annex X: plastics items recommended for limitations, but not ban or phaseout. Annex Y: proposed ban or phaseout list. Yet the draft plastics treaty only lists “cigarette filters made with plastic” in a priority list for mandatory or voluntary restriction or banning (Annex X), rather than on the ban or phaseout list (Annex Y). The “made with plastic” language for cigarette filters also creates a dangerous loophole that permits biofilters/ eco-filters, contradicting established health guidance. In contrast, Annex Y, the ban/ phase out list, itemizes toys and food containers containing lead, cadmium, and phthalates – the same toxicants found in cigarette filters. Broader governance architecture problem The cigarette filter case reveals systemic weaknesses in the treaty draft’s language around health. Article 2.2 of the FCTC requires Parties to ensure that subsequent international agreements should be compatible with FCTC obligations. However, the negotiating states have yet to provide a mechanism for ensuring this compatibility. When environmental ministries approve product redesigns without health authority input, both agendas suffer. When industries exploit policy gaps to rehabilitate their image while maintaining harmful products, both environmental integrity and health objectives are compromised. Extended Producer Responsibility schemes promoted throughout the draft treaty could also legitimize tobacco industry participation in environmental policy and its greenwashing, directly contradicting FCTC Article 5.3’s requirement to “protect tobacco-related environment policies” from industry interference. The problem extends far beyond tobacco. Plastic substitution decisions made in isolation from health expertise risk creating new health hazards while solving environmental concerns—essentially trading one set of risks for another. Environmental authorities may inadvertently approve alternatives that address plastic pollution while creating health risks. Infrastructure already exists Plastics health impacts in brief. The solution isn’t to build new health systems from scratch, as many countries already have relevant capacity, and global infrastructure exists, including for chemical safety, food standards, and medical devices. For tobacco, global networks like TobLabNet and TobReg provide evidence-based guidance. The real challenge is not global coordination, but national-level inter-agency cooperation. The future plastics treaty can help by explicitly obligating this, ensuring health and environment agencies work together. Without giving due regard to existing health treaties, such coordination will inevitably run up against the different standards these agencies follow on industry engagement. No credible health authority engages with the tobacco industry, which is prohibited globally under the WHO’s Framework of Engagement with Non-State Actors (FENSA) and nationally through Article 5.3 of the FCTC, which covers over 90% of the world’s population. The commitment to binding norms on conflict of interest in the FCTC is essential. It creates space for the broader safeguards called for by civil society, scientists, and the Office of the High Commissioner for Human Rights (OHCHR). Failing to respect existing obligations—especially in the clearest and extreme case of tobacco— effectively precludes any meaningful prevention of conflicts of interest. Integration not isolation The solution lies in strengthening the draft’s health foundation by explicitly recognizing existing health agreements, including the WHO’s FCTC, which was already referenced in previous drafts to promote “cooperation, coordination, and complementarity.” A global coalition focusing on this issue recommends a simple safeguard clause – “Measures taken under this instrument shall be without prejudice to, and aligned with, existing international public health treaties and obligations, (including the WHO FCTC)” – would help prevent regulatory conflicts while provide supportive infrastructures to bolster the authority of environmental ministries to implement the future treaty. For cigarette filters, the recommendation is to eliminate material qualifiers “made of plastic” and move filters to a list for immediate bans. More broadly, the future instrument needs formal mechanisms for health expertise integration—not transferring authority from the environment to health ministries, but creating coordination mechanisms ensuring both objectives are met. The Geneva opportunity The Global Plastics Treaty could model integrated governance for 21st-century planetary health challenges, or represent another missed opportunity for coherent global health governance. Tobacco control shows how weak coordination between health and environmental sectors can backfire. When environmental agencies promote so-called “eco-filters” without health input, they risk legitimizing harmful products. But the reverse is also true. During COVID-19, health-led responses drove a surge in plastic consumption, worsening pollution. Both cases expose the same flaw: without coordination, one sector’s solution can become another’s crisis. The Plastics Treaty offers a rare chance to correct this. The infrastructure exists. The evidence is clear. What’s missing is the political will to connect them through binding legal frameworks. Geneva may be the last, best opportunity, not only to curb plastic pollution, but to safeguard the future of global health governance. Integrating international health agreements into the treaty does more than align with existing obligations. It helps define the treaty’s direction and lays the foundation for a strong, legally binding instrument with robust regulatory measures and comprehensive protections for people and the planet. Deborah Sy is head of Strategy and Global Public Policy at the Global Center for Good Governance in Tobacco Control (GGTC) at Thammasat University in Thailand, the convener of Global Youth Voices and the Stop Tobacco Pollution Alliance (STPA). She is the founder and senior advisor of Health Justice Philippines, an observer to the UN Plastics Treaty negotiations. Image Credits: Dennis Skley, University of Bath , UNEP , Chairs Text, draft UN Plastics Treaty, December 2024, Chairs Text, UN Plastics Treaty, Draft 2024, Ciel.org. US Drafts Plan to Change PEPFAR’s Focus From HIV to Diseases that Could Threaten Americans 24/07/2025 Kerry Cullinan A woman with HIV takes her antiretrovial (ARV) medicine. Until earlier this year, over 20 million people with HIV received ARVs funded by PEPFAR. US State Department officials are developing a plan to transform the President’s Emergency Plan for AIDS Relief (PEPFAR) from an entity that tackles HIV to one that is broadly focused on protecting and promoting American interests. This is according to a report in the New York Times on Thursday, based on leaked planning documents that map out their vision for PEPFAR’s transition in in the next few years. “It would be replaced by ‘bilateral relationships’ with low-income countries focused on the detection of outbreaks that could threaten the United States and the creation of new markets for American drugs and technologies,” the newspaper reports. This is in keeping with the focus of the Trump administration’s first meeting with African health leaders after the US paused all foreign aid for 90 days in January. During the meeting between leaders of the US Centers for Disease Control and Prevention (CDC) and their counterparts in Africa CDC in March, the US officials indicated that they were interested in African business opportunities for American companies. Africa CDC official Dr Ngashi Ngongo told journalists after the meeting that the Trump administration “would like to see health more as a business, rather than something that functions on grants,” and is interested in “exploring how can we go into a partnership that translates into health as a business”. Aggressive transition planning Dr Jirair Ratevosian, a global health expert at Duke and previous PEPFAR chief of staff, said that the Trump administration has “made it very clear that they want to carry on with aggressive transition planning” for PEPFAR. “Transition planning is not a bad idea, but it must be done right, with timetables, developing indicators, matching government buy-in, getting community input etc,” Ratevosian said. While he has not seen the documents referred to by the New York Times, Ratevosian is concerned that the transition plan is being written in Washington rather than in and with the African countries most affected by PEPFAR’s transition. “There needs to be realistic timetables, careful planning and resources to successfully make the transition of HIV programming [from PEPFAR] to national control,” said Ratevosian. “Congress has made clear it rejects the administration’s rushed approach to PEPFAR’s transition, signalling bipartisan concern about protecting the program’s legacy and impact.” He added that the US State Department should also develop plans for US companies to sell their antiretroviral drugs to African countries, the largest market for these products. Brief defunding reprieve Luyengo Clinic in Eswatini. PEPFAR funded 80% of the clinic’s cost, and the HIV treatment of 3,000 people is in jeopardy. Last week, there was a brief moment of hope for PEPFAR recipients after the US Senate agreed to exempt the programme from a planned $400 million reduction, which had been included in a $9.4 billion rescission package put forward by President Donald Trump. The rescission package seeks to claw back federal funds from various programs, including approximately $900 million in global health allocations. Disruptions to US aid for global health including for PEPFAR programmes, have placed millions of lives at risk, particularly in countries heavily dependent on US-supported HIV infrastructure. Carolyn Amole, Clinton Health Access Initiative vice-president for HIV, hepatitis and TB, said PEPFAR’s funding cuts had disrupted commodities procurement, essential systems such as human resources, supply chains, and data infrastructure. Millions more AIDS deaths, infections projected An additional six million new HIV infections and four million AIDS-related deaths could occur between 2025 and 2029 if US-supported HIV treatment and prevention services collapse, according to UNAIDS. “This is not just a funding gap. It’s a ticking time bomb,” said UNAIDS Executive Director Winnie Byanyima at the launch of the organisation’s 2025 global AIDS update earlier this month. “We have seen services vanish overnight. Health workers have been sent home. And people – especially children and key populations – are being pushed out of care.” “Key populations” refer to people most vulnerable to HIV infection, including sex workers, men to have sex with men, people who inject drugs and young women. Some of the immediate effects of the US withdrawal of funds since Donald Trump assumed the presidency in January include the closure of health facilities, healthworker job losses, and disrupted treatment, testing and prevention services. Image Credits: The Global Fund/ Saiba Sehmi, UNAIDS. Posts navigation Older postsNewer posts This site uses cookies to help give you the best experience on our website. Cookies enable us to collect information that helps us personalise your experience and improve the functionality and performance of our site. By continuing to read our website, we assume you agree to this, otherwise you can adjust your browser settings. Please read our cookie and Privacy Policy. Our Cookies and Privacy Policy Loading Comments... You must be logged in to post a comment.
Health Taxes Offer Solution to Africa’s ‘Burning Platform’ of NCDs 31/07/2025 Kerry Cullinan South Africans campaign in favour of a tax on sugary drinks in 2017. Taxes on tobacco, alcohol and sugary drinks offer African countries the opportunity to regain their “sovereignty” in response to the collapse of donor funding, according to a new report on health financing compiled by Vital Strategies. Vital CEO Mary-Ann Etiebet described the rise of non-communicable diseases (NCDs) fueled by these unhealthy products as a “burning platform” – already accounting for a third of Africa’s deaths and set to surpass the burden of infectious disease within five years. “Low- and middle-income countries are at risk of losing up to $21 trillion by 2030 if no action is taken on the prevention and control of NCDs,” Etiebet told the launch of the report this week. “External health aid is falling sharply and is projected to fall even further, tightening fiscal space and reducing budgets available to support country health needs,” she added. Official development assistance (ODA) for health in Africa has fallen by a massive 70% since 2021 – from $80 billion to $24 billion – mostly as a result of the US’s abrupt cancellation of longstanding donor commitments earlier this year. Serah Makka, ONE’s executive director for Africa, said that the African Union agenda for 2063 and other continental plans call for “self-financing, resilient health systems”. But where are governments going to get funds from when 24 African countries are at risk of debt distress and 34 countries pay more to service their debt than to health and education combined, she asked. “This is where the innovation of taxes comes in, because, again, it’s been proven to provide more resources and health benefits,” said Makka. The launch of the Vital Strategies report was moderated by Adam Karpati (top left), and addressed by Jeff Drope, Mary-Ann Etiebet, Serah Makka and Corne van Walbeek. Specific tax works best Professor Jeffrey Drope, director of the Economics for Health team at Johns Hopkins University, described the lack of health taxes in many African countries as “untapped potential” to raise revenues and improve public health. Vietnam was an example of what is possible, added Drope. In the past few months, it has restructured its tobacco tax, which will “raise rates significantly” and imposed a tax on sugary drinks for the first time. Ethiopia and Cabo Verde are also increasing their taxation of unhealthy products. “Health taxes work,” he stressed. “When the taxes go up, the prices go up and consumption of these products goes down. “ We know that, for example, for tobacco and alcohol, a 10% increase in price will lead to around a 5% decrease in consumption. That’s a lot. And if you think about the fact that a lot of these countries are raising their taxes and prices a lot more than 10% you can see that the effects on consumption are going to be enormous and that the public health rewards are also going to be enormous as well.” The revenue can be used to fund education and health services, including programmes to help people quit smoking or alcohol, added Drope. Corne van Walbeek, director of the Research Unit on the Economics of Excisable Products (REEP) at the University of Cape Town, said that the best tax is a “specific tax”. In the case of cigarettes, this would be a certain amount of dollars per pack of cigarettes – rather than a tax based on the value or length of the cigarette (known as an ad valorem tax). For alcohol and sugary drinks, the most effective tax would tax the harmful ingredient – the alcohol or sugar content. This provided suppliers with an incentive to reduce the volume of the harmful substance, which has happened in South Africa, where some producers of sugary drinks and beer have reduced sugar and alcohol content respectively, he said. Scare-mongering However, the unhealthy industries are pushing back against taxes, Etiebet pointed out. This has emerged in negotiations on the political declaration, which is due to be adopted at the UN High-Level Meeting (HLM) on NCDs in September. The latest draft has “weakened commitments with regard to health taxes,” she said. The NCD Alliance has described the weaker language in the declaration as evidence of lobbying by “big tobacco, alcohol, junk food, and fossil fuels”. “At a time of fiscal pressures, shrinking global health funding, and increased emphasis on domestic resource mobilisation, health taxes are a golden opportunity to both generate revenue and reduce the burden of NCDs and associated healthcare costs,” said Alison Cox, director of policy and advocacy at the NCD Alliance. Vital Strategies has urged the negotiators to “reinstate explicit commitment to health taxes” on tobacco, alcohol and sugar-sweetened beverages. It has also urged negotiators to put back references to the World Health Organization’s (WHO) “Best Buy” policy recommendations for reducing alcohol consumption and related diseases, which include raising taxes, restricting marketing and regulating availability. However, sources close to the negotiations told Health Policy Watch that the United States had insisted that references to the WHO in the declaration to be scrapped. The Trump administration has withdrawn from the WHO. But Makka said that West African governments and the West African Health Organisation are “looking at how we can increase health security through health taxes for universal health coverage”. “Regional action and health taxes are going to be very important for Africa. And finally, there is political alignment. So this is the time. This is the moment. We’ve seen countries like South Africa, Nigeria and Kenya, already exploring and implementing excise taxes.” Image Credits: Kerry Cullinan. Addressing Alzheimer’s: Speech and Smell Tests May Help to Detect Cognitive Decline 30/07/2025 Kerry Cullinan New tests based on speech and smell may help to identify people at risk of dementia earlier Digital tests based on speech and smell are being developed to screen for cognitive decline, researchers told the Alzheimer’s Association International Conference in Toronto. Two speech apps are already some way down the road, testing several markers including speech speed, vocabulary and rhythm in different languages to establish a baseline for testing, a session convened by the Davos Alzheimer’s Collaboration (DAC) heard. A third initiative using smell is also in the mix, primarily testing people’s ability to smell certain scents via inhalers. DAC supports an innovation ecosystem to accelerate healthcare solutions to end Alzheimer’s disease globally, and DAC-supported projects in Kenya, India, Egypt and Chile have afforded the companies access to multicultural groups to refine their innovations. Better screening tests are essential as an estimated three-quarters of people with Alzheimer’s are never diagnosed and, as the burden grows in the global South, tests for low-resource settings as crucial. TELL’s Adolfo Garcia described his company’s product as “a digital speech biomarker app” that can run on multiple platforms, based on a collection of speech tasks ranging from spontaneous to non-spontaneous tasks. Several speech features “are very revealing about your mental health status”, said Garcia. Using speech timing metrics, for example, the app can measure “the rhythm with which people speak; the number of pauses that they make, how long those pauses are, how variable they are, how long the syllables that they produced are”, said Garcia. TELL has been tested in over 20 countries with over 40,000 hours of data from around 9000 participants. But Garcia describes the in-depth research with the DAC-supported researchers headed by Dr Karen Blackmon at Agha Khan University in Kenya, as “phenomenal, instructive and fulfilling.” Blackmon’s team has been testing Swahili-speaking Kenyans for cognitive decline based on simple speech timing metrics, while TELL has trained a machine learning regressor with various speech metrics. There has been a “moderate to strong correlation” between the results from TELL’s machine model and the real-time scores from people that Blackmon’s team has tested on “simple speech timing metrics, which are quite scalable across different languages”, Garcia noted. Nicklas Linz of Ki Elements said his speech app aims to find “something that works across languages, across cultural contexts, so that we have something that is culturally fair, neutral and usable in all of these contexts”. His group has worked with DAC teams in Egypt, India, Kenya and Chile who speak Arabic, Hindi, English, Swahili and Spanish. Loss of smell and neurodegeneration Subhanjan Mondal of Sensify said that the idea to use olfaction (smell) as a measure for neurodegeneration “came from COVID”, where many people who contracted the virus lost their sense of smell. People with the ApoE e4 allele, the gene variant that increases the risk of developing late-onset Alzheimer’s disease, also have an increased risk of olfactory decline. “There is an anatomical connection between olfaction and neurodegeneration for Alzheimer’s and Parkinson’s and many other neurodegenerative diseases,” said Mondal. “And there is also a genetic component, as ApoE carriers have a strong disposition to olfactory decline.” Sensify has developed a digital smell test, ScentAware, with smells contained in different inhalers that are QR-coded. Using an app connected to a mobile phone camera, people can conduct the smell test at home or in a clinical setting. “People found it easy to use, fun, and it can be done in a short time,” said Mondal. But there is some way to go. The field is so new that there are no common smell elements across cultures. “Can this be incorporated somewhere upstream in a screening mechanism in normal individuals with higher risk factors?” Mondal asks. Sensify is developing a smell test, ScentAware, to diagnose cognitive decline. Multicultural challenges “There are a lot of challenges in adapting speech tasks from multilingual contexts like Kenya,” said Aga Khan’s Blackmon. “But these are challenges that we’re going to have to face across as, in the Global South, multilingualism is a norm in most post-colonial settings where… major languages like English are spoken in schools but not necessarily in homes.” “It’s been excellent to work with TELL, Ki Elements and Sensify Aware because, in each of these partnerships, we are identifying problems and we’re proactively solving them,” said Blackmon. For example, an app using automatic speech recognition did not do so well when people were switching languages, she explained. “Although our samples may seem small, the way that we’re approaching this is to solve problems [before the app is] scaled to larger populations.” The end goal is to integrate the apps into health systems to enable affordable and accurate early detection. “These tools are friendlier. Their interfaces have been really well designed. They’re user-friendly. Tools like the olfactory Sensify Aware are fun for patients,” said Blackmon. “It’s very different from a standard neuropsychological test setting that I’m used to, where people are sweating. “It’s an opportunity to do it well and do it differently with input from stakeholders across the global South. We may even discover new speech features that turn out to be diagnostically relevant, like the number of times someone switches language could tell us something about early signs of dementia.” Societal and genetic influences The exposome influencing Alzheimer’s disease. Professor Amy Kind of the University of Wisconsin (UW) addressed how cognitive decline is influenced by both genetic and societal elements, known as the “exposome”. “The term was first coined in 2005, and it means the integrated compilation of physical, chemical, biological and social influences across an entire life course that influence biology,” said Kind. “The environmental exposures are modifiable. These are things that we can intervene upon, over and above individual-level factors, to improve health. And this construct is thought of as precision health, not just precision medicine,” she said. “Individuals who live in adverse exposomes experience poor brain health, and hundreds of studies have shown this,” added Kind. She heads the largest study of the social exposome in the United States, The Neighborhoods Study, which works with large community-based surveys as well as with tissue from people who have donated their brains to the study to better understand the environmental risks influencing Alzheimer’s. “We work with brain tissue, and we link it back to the life-course social exposome,” said Kind. “Across 25 academic institutions, there are over 9,000 descendants’ brain donors in the cohort, and it allows us to link, with some certainty, the association between certain types of exposure – be that occupational, social, toxic, metabolic – to findings within the tissue. Kind and colleagues try to identify and mitigate the risks for people living in adverse exposomes. Factors influences Alzheimer’s, as identified by The Lancet “Are there critical windows of life course across these pathways? “Perhaps all of our future for our brain health is written in our childhood, [so] gestational and early childhood effects could be profound, as we think about late life brain health,” said Kind. “Some of our newest work is focused on lead and heavy metal poisoning, because these metals accumulate in the tissue across the life course, and yet lead exposure is so common in our water supply, in the air that we breathe and in other places.” Kind and colleagues have worked closely with the Inner City Milwaukee Water Works Department in order to decrease the lead line pipe infrastructure to decrease lead in the water supply. Lead exposure has been linked to Alzheimer’s and cognitive decline, and a large study was released at the conference this week identifying the impact of leaded gasoline on the memory of older Americans. Reaching the Global South DAC founder George Vradenburg said one of the motives for collaboration is to link the global north and global South. “The majority of cases, by far, are already in the Global South, and by mid-century, it’s going to be 80% of cases of dementia are in the global South. So we have not fulfilled a patient mission if all we deal with is the top 20% of white people in the United States and Europe,” said Vradenburg. “DAC brings together researchers, healthcare systems, governments and funders to accelerate progress where it’s most needed,” DAC COO Drew Holzapfel told the meeting. It is based on three programmes – global cohort development, global clinical trials, and healthcare system preparedness – to address gaps in Alzheimer’s research and treatment. The cohort development programme aims to “increase the amount of research in diverse populations so that we can find better targets for drug development and associated biomarkers,” said Holzapfel. DAC’s global clinical trials programme aims to do clinical trials “better, faster, cheaper” around pharmacological and non-pharmacological interventions for brain health in parts of the globe that have never had those types of trials, he explained. The third component, healthcare system preparedness, aims to prime health systems to implement the innovations. “Our implementation scientists like to talk about how the time it takes for an innovation to go from availability to full clinical utilisation is about 17 years. We think that’s too long, so we’re trying to take the high-speed train and put it on high-speed tracks so that we can help patients,” said Holzapfel. By the end of this year, DAC will have worked in about 70 healthcare systems, implementing new tools for detection and diagnosis for about 60,000 patients. Image Credits: Cristina Gottardi/ Unsplash. Exposure to Leaded Fuel Affects Memory Loss of Older Americans 29/07/2025 Kerry Cullinan Exposure to leaded gasoline affects the memory loss of older Americans. Americans are about 20% more likely to experience memory problems if they lived in areas with high levels of atmospheric lead, according to a study of over 600,000 adults over the age of 65 released at the Alzheimer’s Association International Conference in Toronto on Tuesday. Researchers examined how exposure to airborne lead between 1960 and 1974, when leaded gasoline use was at its highest, may affect brain health later in life. They calculated exposure to historical atmospheric lead levels (HALL) by area and linked it to self-reported memory problems from two American Community Surveys (conducted between 2012 and 2021) involving over 500,000 people. Some 17-22% of people living in areas with moderate, high or extremely high atmospheric lead reported memory issues. “Our study may help us understand the pathways that contribute to some people developing dementia and Alzheimer’s disease,” said Dr Eric Brown, lead author and associate chief of geriatric psychiatry at the Centre for Addiction and Mental Health in Toronto. Lead was originally added to gasoline to increase performance until researchers determined it posed serious risks to health and the environment. The more than 20-year-long phase-out of leaded gas began in 1975. “When I was a child in 1976, our blood carried 15 times more lead than children’s blood today,” said Esme Fuller-Thomson, senior author of the study and a professor at the University of Toronto’s Faculty of Social Work. “An astonishing 88% of us had levels higher than 10 micrograms per deciliter, which are now considered dangerously high.” While the risk of atmospheric lead has decreased, other sources of exposure remain, such as old lead paint and pipes. Those who have been exposed to atmospheric lead should focus on reducing other risk factors for dementia, including high blood pressure, smoking and social isolation, said Brown. “Research suggests half the US population – more than 170 million people – were exposed to high lead levels in early childhood. This research sheds more light on the toxicity of lead related to brain health in older adults today,” said Dr Maria Carrillo, Alzheimer’s Association chief science officer and medical affairs lead. Another study reported at the conference found that older adults who live about three miles from a lead-releasing facility – such as glass, ready-mixed concrete or computer and electronics manufacturers – are more likely to have memory and thinking problems than those who live farther away. Lifestyle interventions help slow cognitive decline Alzheimer’s disease is the most common type of dementia found in elderly people. Social isolation, diet and lack of exercise affect the progression of the disease. Meanwhile, in better news, older adults at risk for cognitive decline and dementia who were actively encouraged to adopt healthy lifestyles were able to slow memory loss, the conference heard. A study of over 2,000 people compared the impact of a structured lifestyle intervention with a self-guided intervention and found that, while both interventions helped, those in the more intense intervention had better success at slowing cognitive decline. Both interventions focused on physical exercise, nutrition, cognitive challenge and social engagement, and heart health monitoring, but differed in intensity, structure, accountability and support provided. In the structured lifestyle group, participants attended 38 facilitated peer team meetings over two years. They were provided with an activity programme with measurable goals, encouraged to eat according to the MIND diet, given cognitive challenges and other intellectual and social activities. Their progress was reviewed regularly. In the self-guided lifestyle intervention, participants attended six peer team meetings to encourage self-selected lifestyle changes. Participants in the structured intervention showed greater improvement on global cognition, protecting cognition from normal age-related decline for up to two years. The results of the study, called US POINTER, were reported for the first time at the AAIC conference and published in the Journal of the American Medical Association (JAMA). “As the burden of dementia grows worldwide, US POINTER affirms a vital public health message: healthy behaviour has a powerful impact on brain health,” said Dr Joanne Pike, Alzheimer’s Association president and CEO. “This is a critical public health opportunity. The intervention was effective across a broad, representative group – regardless of sex, ethnicity, APOE [gene] genetic risk, or heart health status – demonstrating its applicability and scalability for communities across the country,” added Pike. “The positive results of US POINTER encourage us to look at the potential for a combination of a lifestyle program and drug treatment as the next frontier in our fight against cognitive decline and possibly dementia.” Image Credits: Dawn McDonal/ Unsplash, Photo by Steven HWG on Unsplash. Governments ‘Backslide’ on NCD Commitments After Pressure from Unhealthy Industries 28/07/2025 Kerry Cullinan Few countries are effectively taxing tobacco, alcohol, sugary drinks and ultraprocessed food, in part due to massive industry pushback. Governments have weakened their commitment to addressing non-communicable diseases (NCDs) after pressure from “big tobacco, alcohol, junk food, and fossil fuels”, according to civil society. Their claim centres on the draft political declaration due to be adopted at the UN High-Level Meeting (HLM) on NCDs in September, which no longer calls on countries to implement high taxes on these unhealthy products. Countries are due to wrap up negotiations on the declaration this week, with the final declaration due to be adopted at the HLM on 25 September. “It looks like health-harming industry fingerprints are all over this,” said Alison Cox, director of policy and advocacy at the NCD Alliance. “At a time of fiscal pressures, shrinking global health funding, and increased emphasis on domestic resource mobilisation, health taxes are a golden opportunity to both generate revenue and reduce the burden of NCDs and associated healthcare costs,” she added. “Yet as it stands, the declaration’s text contains weaker language around taxes and lets industry off the hook, prioritising profits over public health,” added Cox, describing the draft as “a backslide”. The language in the current draft has been watered down, and targets have been “flattened”, with active commitments to ‘implement’ and ‘enact’ replaced with the “far more passive language of ‘consider’ and ‘encourage’,” according to the NCD Alliance. ‘Reinstate commitment to taxes’ Vital Strategies, a global public health organisation, urged the negotiators to “reinstate explicit commitment to health taxes” on tobacco, alcohol and sugar-sweetened beverages. “These taxes should increase prices sufficiently to reduce affordability, prevent initiation and support reduction or cessation of use,” said Vital Strategies in a media release. “As outlined by the Task Force for Fiscal Policy on Health, a 50% price increase on tobacco, alcohol, and sugary beverages could raise $2.1 trillion in five years for low- and middle-income countries, revenue equal to 40% of their total health spending,” added the organisation. NCDs, including heart disease, cancer and diabetes, account for 43 million deaths annually, 75% of all deaths worldwide. The burden of NCDs is growing in low- and middle-income countries, driven primarily by smoking and poor diets. Taxes on alcohol, restricting marketing and regulating sales hours are proven interventions to reduce consumption. Vital Strategies also raised alarm about the removal of references to the World Health Organization’s (WHO) “Best Buy” policy recommendations for reducing alcohol consumption and related diseases, including raising taxes, restricting marketing and regulating availability. “The conspicuous deletion of these proven policies from the text strongly suggests undue alcohol industry influence aimed at weakening public health protections. We urge governments to immediately reverse these deletions and fully restore WHO’s recommendations in the final text,” said Vital Strategies. Harmful commercial practices It also wants the declaration to “explicitly tackle harmful commercial practices and strengthen conflict-of-interest protections to safeguard public health policymaking from industry interference”, strengthen commitments to “proven tobacco control measures” including effective taxation, and “recognise unhealthy diets as an urgent priority”. The WHO attributes some 2.8 million deaths a year to obesity and overweight, and Vital wants the declaration to “explicitly state that rising obesity rates are primarily driven by unhealthy diets, emphasising clear interventions like front-of-pack labelling and marketing restrictions targeting children”. The NCD Alliance is also unhappy about “significant backsliding” around social participation and the role of civil society, which is only referred to once. “History has taught us that ignoring the integral role of civil society, communities and people living with diseases weakens any meaningful public health response,” said Cox. With just a week of negotiations remaining, the NCD Alliance is calling on governments to “demonstrate true leadership and resist last-minute compromises that prioritise commercial interests over public health and reflect a genuine commitment to protecting lives”. Image Credits: Leo Zhuang/ Unsplash, Stanislav Ivanitskiy/ Unsplash. Smoke Signals from the Plastics Treaty: Why Geneva Negotiations Can’t Ignore Health Governance 25/07/2025 Deborah Sy Cigarette filters, made from a plastic called cellulose acetate, are world’s most littered plastic item. As negotiators prepare to meet in Geneva, 5-14 August in yet another attempt to finalize the United Nations Global Plastics Treaty addressing a pollution crisis affecting oceans and ecosystems worldwide – a critical linkage between health and environment governance seems to be largely missing from the draft text. After nearly three years of negotiations, the world may be on the verge of finalizing its first legally-binding global instrument to tackle plastic pollution – providing that treaty negotiators overcome massive pressures from the fossil fuel industry to further stall an agreement or weaken provisions aiming to limit plastics production. But as negotiators prepare for the resumed fifth session (INC-5.2), another fundamental flaw threatens the future treaty’s health objectives: the failure to integrate environmental and health governance. This is particularly apparent with regards to cigarette filters – the world’s most littered plastic item – although it extends to cross-sector cooperation on other issues regarding the health harms of other plastics as well. The current draft text makes with only one reference to ‘plastic’ cigarette filters (in draft Annex X) and makes no reference at all to the WHO Framework Convention on Tobacco Control – which could, in fact, be an important nexus for health-environment cooperation on the treaty – once it is approved. The treatment of cigarette filters – largely made of a plastic called cellulose acetate – sends smoke signals about more systematic problems with the treaty text in terms of its approach to environment and health. Health rhetoric vs reality gap Cigarette filters are the world’s most prevalent forms of plastic litter, marring beaches and from there, infiltrating to oceans and fresh water ways. The Chair’s text, the working document guiding final negotiations, acknowledges health extensively in its rhetoric, although much of it remains in brackets, indicating areas where countries have not yet reached agreement. The preamble recognizes plastic pollution as “a serious environmental and human health problem,” while the treaty’s stated objective is “to protect human health and the environment from plastic pollution.” But while the preamble recognizes mutual support with “other international agreements in the field of the environment,” it limits that framework to environmental treaties. Any reference to health instruments, including the WHO Framework Convention on Tobacco Control (FCTC), which has been ratified by 183 countries, are absent from this structure. Draft Plastics Treaty negotiating text – much of language on health remains in brackets. The Chair’s preambular text affirms that the plastics treaty will “not affect… existing treaty obligations,” but this is a non-binding statement that merely avoids direct legal contradictions without promoting substantive policy coherence. In practice, it enables siloed implementation, weakens the ability of health ministries to regulate tobacco product components, and gives the tobacco industry new opportunities to exploit regulatory gaps through the environment ministries. Most tellingly, a standalone health article remains uncertain, reduced to scattered references or a placeholder “pending informal drafting work.” Despite the draft’s stated health objectives, the institutional bridge to health governance is still missing. The ‘safe alternatives’ problem This gap matters because “safe substitutes,” “safe alternatives,” or “safe recycling” are at the heart of solutions throughout the draft treaty. But how can environmental authorities evaluate safety and health impacts without connecting to international or national health standards? The tobacco industry is already exploiting this governance gap by promoting “eco-filters” and “biodegradable” alternatives to plastic cigarette filters. While these products may appear to address plastic pollution, they remain harmful to both health and the environment. Worse, they risk misleading consumers and this kind of product feature substitution is typically assessed by health authorities, not environmental ministries, which may lack the mandate or expertise to evaluate such claims. The cigarette filter test case Cigarette filters are the most littered plastic in the world. Used cigarette filters represent the world’s most littered plastic item, with trillions discarded annually. Each cigarette butt contains toxic lead, cadmium, phthalates, and polycyclic aromatic hydrocarbons that leach into waterways. A single cigarette butt can contaminate 1,000 liters of water, causing $26 billion in annual marine ecosystem damage. The FCTC provides clear guidance on these filters: Parties should prohibit ingredients in tobacco products that may create the impression that they have a health benefit. The WHO study group’s recommendations early this year included that filters should be banned to reduce the palatability and appeal of cigarettes. This would remove consumer misconceptions that filters reduce health harms, and it would also reduce a major source of toxic tobacco waste, including the microplastics deposited by cellulose acetate in filters. Annex X: plastics items recommended for limitations, but not ban or phaseout. Annex Y: proposed ban or phaseout list. Yet the draft plastics treaty only lists “cigarette filters made with plastic” in a priority list for mandatory or voluntary restriction or banning (Annex X), rather than on the ban or phaseout list (Annex Y). The “made with plastic” language for cigarette filters also creates a dangerous loophole that permits biofilters/ eco-filters, contradicting established health guidance. In contrast, Annex Y, the ban/ phase out list, itemizes toys and food containers containing lead, cadmium, and phthalates – the same toxicants found in cigarette filters. Broader governance architecture problem The cigarette filter case reveals systemic weaknesses in the treaty draft’s language around health. Article 2.2 of the FCTC requires Parties to ensure that subsequent international agreements should be compatible with FCTC obligations. However, the negotiating states have yet to provide a mechanism for ensuring this compatibility. When environmental ministries approve product redesigns without health authority input, both agendas suffer. When industries exploit policy gaps to rehabilitate their image while maintaining harmful products, both environmental integrity and health objectives are compromised. Extended Producer Responsibility schemes promoted throughout the draft treaty could also legitimize tobacco industry participation in environmental policy and its greenwashing, directly contradicting FCTC Article 5.3’s requirement to “protect tobacco-related environment policies” from industry interference. The problem extends far beyond tobacco. Plastic substitution decisions made in isolation from health expertise risk creating new health hazards while solving environmental concerns—essentially trading one set of risks for another. Environmental authorities may inadvertently approve alternatives that address plastic pollution while creating health risks. Infrastructure already exists Plastics health impacts in brief. The solution isn’t to build new health systems from scratch, as many countries already have relevant capacity, and global infrastructure exists, including for chemical safety, food standards, and medical devices. For tobacco, global networks like TobLabNet and TobReg provide evidence-based guidance. The real challenge is not global coordination, but national-level inter-agency cooperation. The future plastics treaty can help by explicitly obligating this, ensuring health and environment agencies work together. Without giving due regard to existing health treaties, such coordination will inevitably run up against the different standards these agencies follow on industry engagement. No credible health authority engages with the tobacco industry, which is prohibited globally under the WHO’s Framework of Engagement with Non-State Actors (FENSA) and nationally through Article 5.3 of the FCTC, which covers over 90% of the world’s population. The commitment to binding norms on conflict of interest in the FCTC is essential. It creates space for the broader safeguards called for by civil society, scientists, and the Office of the High Commissioner for Human Rights (OHCHR). Failing to respect existing obligations—especially in the clearest and extreme case of tobacco— effectively precludes any meaningful prevention of conflicts of interest. Integration not isolation The solution lies in strengthening the draft’s health foundation by explicitly recognizing existing health agreements, including the WHO’s FCTC, which was already referenced in previous drafts to promote “cooperation, coordination, and complementarity.” A global coalition focusing on this issue recommends a simple safeguard clause – “Measures taken under this instrument shall be without prejudice to, and aligned with, existing international public health treaties and obligations, (including the WHO FCTC)” – would help prevent regulatory conflicts while provide supportive infrastructures to bolster the authority of environmental ministries to implement the future treaty. For cigarette filters, the recommendation is to eliminate material qualifiers “made of plastic” and move filters to a list for immediate bans. More broadly, the future instrument needs formal mechanisms for health expertise integration—not transferring authority from the environment to health ministries, but creating coordination mechanisms ensuring both objectives are met. The Geneva opportunity The Global Plastics Treaty could model integrated governance for 21st-century planetary health challenges, or represent another missed opportunity for coherent global health governance. Tobacco control shows how weak coordination between health and environmental sectors can backfire. When environmental agencies promote so-called “eco-filters” without health input, they risk legitimizing harmful products. But the reverse is also true. During COVID-19, health-led responses drove a surge in plastic consumption, worsening pollution. Both cases expose the same flaw: without coordination, one sector’s solution can become another’s crisis. The Plastics Treaty offers a rare chance to correct this. The infrastructure exists. The evidence is clear. What’s missing is the political will to connect them through binding legal frameworks. Geneva may be the last, best opportunity, not only to curb plastic pollution, but to safeguard the future of global health governance. Integrating international health agreements into the treaty does more than align with existing obligations. It helps define the treaty’s direction and lays the foundation for a strong, legally binding instrument with robust regulatory measures and comprehensive protections for people and the planet. Deborah Sy is head of Strategy and Global Public Policy at the Global Center for Good Governance in Tobacco Control (GGTC) at Thammasat University in Thailand, the convener of Global Youth Voices and the Stop Tobacco Pollution Alliance (STPA). She is the founder and senior advisor of Health Justice Philippines, an observer to the UN Plastics Treaty negotiations. Image Credits: Dennis Skley, University of Bath , UNEP , Chairs Text, draft UN Plastics Treaty, December 2024, Chairs Text, UN Plastics Treaty, Draft 2024, Ciel.org. US Drafts Plan to Change PEPFAR’s Focus From HIV to Diseases that Could Threaten Americans 24/07/2025 Kerry Cullinan A woman with HIV takes her antiretrovial (ARV) medicine. Until earlier this year, over 20 million people with HIV received ARVs funded by PEPFAR. US State Department officials are developing a plan to transform the President’s Emergency Plan for AIDS Relief (PEPFAR) from an entity that tackles HIV to one that is broadly focused on protecting and promoting American interests. This is according to a report in the New York Times on Thursday, based on leaked planning documents that map out their vision for PEPFAR’s transition in in the next few years. “It would be replaced by ‘bilateral relationships’ with low-income countries focused on the detection of outbreaks that could threaten the United States and the creation of new markets for American drugs and technologies,” the newspaper reports. This is in keeping with the focus of the Trump administration’s first meeting with African health leaders after the US paused all foreign aid for 90 days in January. During the meeting between leaders of the US Centers for Disease Control and Prevention (CDC) and their counterparts in Africa CDC in March, the US officials indicated that they were interested in African business opportunities for American companies. Africa CDC official Dr Ngashi Ngongo told journalists after the meeting that the Trump administration “would like to see health more as a business, rather than something that functions on grants,” and is interested in “exploring how can we go into a partnership that translates into health as a business”. Aggressive transition planning Dr Jirair Ratevosian, a global health expert at Duke and previous PEPFAR chief of staff, said that the Trump administration has “made it very clear that they want to carry on with aggressive transition planning” for PEPFAR. “Transition planning is not a bad idea, but it must be done right, with timetables, developing indicators, matching government buy-in, getting community input etc,” Ratevosian said. While he has not seen the documents referred to by the New York Times, Ratevosian is concerned that the transition plan is being written in Washington rather than in and with the African countries most affected by PEPFAR’s transition. “There needs to be realistic timetables, careful planning and resources to successfully make the transition of HIV programming [from PEPFAR] to national control,” said Ratevosian. “Congress has made clear it rejects the administration’s rushed approach to PEPFAR’s transition, signalling bipartisan concern about protecting the program’s legacy and impact.” He added that the US State Department should also develop plans for US companies to sell their antiretroviral drugs to African countries, the largest market for these products. Brief defunding reprieve Luyengo Clinic in Eswatini. PEPFAR funded 80% of the clinic’s cost, and the HIV treatment of 3,000 people is in jeopardy. Last week, there was a brief moment of hope for PEPFAR recipients after the US Senate agreed to exempt the programme from a planned $400 million reduction, which had been included in a $9.4 billion rescission package put forward by President Donald Trump. The rescission package seeks to claw back federal funds from various programs, including approximately $900 million in global health allocations. Disruptions to US aid for global health including for PEPFAR programmes, have placed millions of lives at risk, particularly in countries heavily dependent on US-supported HIV infrastructure. Carolyn Amole, Clinton Health Access Initiative vice-president for HIV, hepatitis and TB, said PEPFAR’s funding cuts had disrupted commodities procurement, essential systems such as human resources, supply chains, and data infrastructure. Millions more AIDS deaths, infections projected An additional six million new HIV infections and four million AIDS-related deaths could occur between 2025 and 2029 if US-supported HIV treatment and prevention services collapse, according to UNAIDS. “This is not just a funding gap. It’s a ticking time bomb,” said UNAIDS Executive Director Winnie Byanyima at the launch of the organisation’s 2025 global AIDS update earlier this month. “We have seen services vanish overnight. Health workers have been sent home. And people – especially children and key populations – are being pushed out of care.” “Key populations” refer to people most vulnerable to HIV infection, including sex workers, men to have sex with men, people who inject drugs and young women. Some of the immediate effects of the US withdrawal of funds since Donald Trump assumed the presidency in January include the closure of health facilities, healthworker job losses, and disrupted treatment, testing and prevention services. Image Credits: The Global Fund/ Saiba Sehmi, UNAIDS. Posts navigation Older postsNewer posts This site uses cookies to help give you the best experience on our website. Cookies enable us to collect information that helps us personalise your experience and improve the functionality and performance of our site. By continuing to read our website, we assume you agree to this, otherwise you can adjust your browser settings. Please read our cookie and Privacy Policy. Our Cookies and Privacy Policy Loading Comments... You must be logged in to post a comment.
Addressing Alzheimer’s: Speech and Smell Tests May Help to Detect Cognitive Decline 30/07/2025 Kerry Cullinan New tests based on speech and smell may help to identify people at risk of dementia earlier Digital tests based on speech and smell are being developed to screen for cognitive decline, researchers told the Alzheimer’s Association International Conference in Toronto. Two speech apps are already some way down the road, testing several markers including speech speed, vocabulary and rhythm in different languages to establish a baseline for testing, a session convened by the Davos Alzheimer’s Collaboration (DAC) heard. A third initiative using smell is also in the mix, primarily testing people’s ability to smell certain scents via inhalers. DAC supports an innovation ecosystem to accelerate healthcare solutions to end Alzheimer’s disease globally, and DAC-supported projects in Kenya, India, Egypt and Chile have afforded the companies access to multicultural groups to refine their innovations. Better screening tests are essential as an estimated three-quarters of people with Alzheimer’s are never diagnosed and, as the burden grows in the global South, tests for low-resource settings as crucial. TELL’s Adolfo Garcia described his company’s product as “a digital speech biomarker app” that can run on multiple platforms, based on a collection of speech tasks ranging from spontaneous to non-spontaneous tasks. Several speech features “are very revealing about your mental health status”, said Garcia. Using speech timing metrics, for example, the app can measure “the rhythm with which people speak; the number of pauses that they make, how long those pauses are, how variable they are, how long the syllables that they produced are”, said Garcia. TELL has been tested in over 20 countries with over 40,000 hours of data from around 9000 participants. But Garcia describes the in-depth research with the DAC-supported researchers headed by Dr Karen Blackmon at Agha Khan University in Kenya, as “phenomenal, instructive and fulfilling.” Blackmon’s team has been testing Swahili-speaking Kenyans for cognitive decline based on simple speech timing metrics, while TELL has trained a machine learning regressor with various speech metrics. There has been a “moderate to strong correlation” between the results from TELL’s machine model and the real-time scores from people that Blackmon’s team has tested on “simple speech timing metrics, which are quite scalable across different languages”, Garcia noted. Nicklas Linz of Ki Elements said his speech app aims to find “something that works across languages, across cultural contexts, so that we have something that is culturally fair, neutral and usable in all of these contexts”. His group has worked with DAC teams in Egypt, India, Kenya and Chile who speak Arabic, Hindi, English, Swahili and Spanish. Loss of smell and neurodegeneration Subhanjan Mondal of Sensify said that the idea to use olfaction (smell) as a measure for neurodegeneration “came from COVID”, where many people who contracted the virus lost their sense of smell. People with the ApoE e4 allele, the gene variant that increases the risk of developing late-onset Alzheimer’s disease, also have an increased risk of olfactory decline. “There is an anatomical connection between olfaction and neurodegeneration for Alzheimer’s and Parkinson’s and many other neurodegenerative diseases,” said Mondal. “And there is also a genetic component, as ApoE carriers have a strong disposition to olfactory decline.” Sensify has developed a digital smell test, ScentAware, with smells contained in different inhalers that are QR-coded. Using an app connected to a mobile phone camera, people can conduct the smell test at home or in a clinical setting. “People found it easy to use, fun, and it can be done in a short time,” said Mondal. But there is some way to go. The field is so new that there are no common smell elements across cultures. “Can this be incorporated somewhere upstream in a screening mechanism in normal individuals with higher risk factors?” Mondal asks. Sensify is developing a smell test, ScentAware, to diagnose cognitive decline. Multicultural challenges “There are a lot of challenges in adapting speech tasks from multilingual contexts like Kenya,” said Aga Khan’s Blackmon. “But these are challenges that we’re going to have to face across as, in the Global South, multilingualism is a norm in most post-colonial settings where… major languages like English are spoken in schools but not necessarily in homes.” “It’s been excellent to work with TELL, Ki Elements and Sensify Aware because, in each of these partnerships, we are identifying problems and we’re proactively solving them,” said Blackmon. For example, an app using automatic speech recognition did not do so well when people were switching languages, she explained. “Although our samples may seem small, the way that we’re approaching this is to solve problems [before the app is] scaled to larger populations.” The end goal is to integrate the apps into health systems to enable affordable and accurate early detection. “These tools are friendlier. Their interfaces have been really well designed. They’re user-friendly. Tools like the olfactory Sensify Aware are fun for patients,” said Blackmon. “It’s very different from a standard neuropsychological test setting that I’m used to, where people are sweating. “It’s an opportunity to do it well and do it differently with input from stakeholders across the global South. We may even discover new speech features that turn out to be diagnostically relevant, like the number of times someone switches language could tell us something about early signs of dementia.” Societal and genetic influences The exposome influencing Alzheimer’s disease. Professor Amy Kind of the University of Wisconsin (UW) addressed how cognitive decline is influenced by both genetic and societal elements, known as the “exposome”. “The term was first coined in 2005, and it means the integrated compilation of physical, chemical, biological and social influences across an entire life course that influence biology,” said Kind. “The environmental exposures are modifiable. These are things that we can intervene upon, over and above individual-level factors, to improve health. And this construct is thought of as precision health, not just precision medicine,” she said. “Individuals who live in adverse exposomes experience poor brain health, and hundreds of studies have shown this,” added Kind. She heads the largest study of the social exposome in the United States, The Neighborhoods Study, which works with large community-based surveys as well as with tissue from people who have donated their brains to the study to better understand the environmental risks influencing Alzheimer’s. “We work with brain tissue, and we link it back to the life-course social exposome,” said Kind. “Across 25 academic institutions, there are over 9,000 descendants’ brain donors in the cohort, and it allows us to link, with some certainty, the association between certain types of exposure – be that occupational, social, toxic, metabolic – to findings within the tissue. Kind and colleagues try to identify and mitigate the risks for people living in adverse exposomes. Factors influences Alzheimer’s, as identified by The Lancet “Are there critical windows of life course across these pathways? “Perhaps all of our future for our brain health is written in our childhood, [so] gestational and early childhood effects could be profound, as we think about late life brain health,” said Kind. “Some of our newest work is focused on lead and heavy metal poisoning, because these metals accumulate in the tissue across the life course, and yet lead exposure is so common in our water supply, in the air that we breathe and in other places.” Kind and colleagues have worked closely with the Inner City Milwaukee Water Works Department in order to decrease the lead line pipe infrastructure to decrease lead in the water supply. Lead exposure has been linked to Alzheimer’s and cognitive decline, and a large study was released at the conference this week identifying the impact of leaded gasoline on the memory of older Americans. Reaching the Global South DAC founder George Vradenburg said one of the motives for collaboration is to link the global north and global South. “The majority of cases, by far, are already in the Global South, and by mid-century, it’s going to be 80% of cases of dementia are in the global South. So we have not fulfilled a patient mission if all we deal with is the top 20% of white people in the United States and Europe,” said Vradenburg. “DAC brings together researchers, healthcare systems, governments and funders to accelerate progress where it’s most needed,” DAC COO Drew Holzapfel told the meeting. It is based on three programmes – global cohort development, global clinical trials, and healthcare system preparedness – to address gaps in Alzheimer’s research and treatment. The cohort development programme aims to “increase the amount of research in diverse populations so that we can find better targets for drug development and associated biomarkers,” said Holzapfel. DAC’s global clinical trials programme aims to do clinical trials “better, faster, cheaper” around pharmacological and non-pharmacological interventions for brain health in parts of the globe that have never had those types of trials, he explained. The third component, healthcare system preparedness, aims to prime health systems to implement the innovations. “Our implementation scientists like to talk about how the time it takes for an innovation to go from availability to full clinical utilisation is about 17 years. We think that’s too long, so we’re trying to take the high-speed train and put it on high-speed tracks so that we can help patients,” said Holzapfel. By the end of this year, DAC will have worked in about 70 healthcare systems, implementing new tools for detection and diagnosis for about 60,000 patients. Image Credits: Cristina Gottardi/ Unsplash. Exposure to Leaded Fuel Affects Memory Loss of Older Americans 29/07/2025 Kerry Cullinan Exposure to leaded gasoline affects the memory loss of older Americans. Americans are about 20% more likely to experience memory problems if they lived in areas with high levels of atmospheric lead, according to a study of over 600,000 adults over the age of 65 released at the Alzheimer’s Association International Conference in Toronto on Tuesday. Researchers examined how exposure to airborne lead between 1960 and 1974, when leaded gasoline use was at its highest, may affect brain health later in life. They calculated exposure to historical atmospheric lead levels (HALL) by area and linked it to self-reported memory problems from two American Community Surveys (conducted between 2012 and 2021) involving over 500,000 people. Some 17-22% of people living in areas with moderate, high or extremely high atmospheric lead reported memory issues. “Our study may help us understand the pathways that contribute to some people developing dementia and Alzheimer’s disease,” said Dr Eric Brown, lead author and associate chief of geriatric psychiatry at the Centre for Addiction and Mental Health in Toronto. Lead was originally added to gasoline to increase performance until researchers determined it posed serious risks to health and the environment. The more than 20-year-long phase-out of leaded gas began in 1975. “When I was a child in 1976, our blood carried 15 times more lead than children’s blood today,” said Esme Fuller-Thomson, senior author of the study and a professor at the University of Toronto’s Faculty of Social Work. “An astonishing 88% of us had levels higher than 10 micrograms per deciliter, which are now considered dangerously high.” While the risk of atmospheric lead has decreased, other sources of exposure remain, such as old lead paint and pipes. Those who have been exposed to atmospheric lead should focus on reducing other risk factors for dementia, including high blood pressure, smoking and social isolation, said Brown. “Research suggests half the US population – more than 170 million people – were exposed to high lead levels in early childhood. This research sheds more light on the toxicity of lead related to brain health in older adults today,” said Dr Maria Carrillo, Alzheimer’s Association chief science officer and medical affairs lead. Another study reported at the conference found that older adults who live about three miles from a lead-releasing facility – such as glass, ready-mixed concrete or computer and electronics manufacturers – are more likely to have memory and thinking problems than those who live farther away. Lifestyle interventions help slow cognitive decline Alzheimer’s disease is the most common type of dementia found in elderly people. Social isolation, diet and lack of exercise affect the progression of the disease. Meanwhile, in better news, older adults at risk for cognitive decline and dementia who were actively encouraged to adopt healthy lifestyles were able to slow memory loss, the conference heard. A study of over 2,000 people compared the impact of a structured lifestyle intervention with a self-guided intervention and found that, while both interventions helped, those in the more intense intervention had better success at slowing cognitive decline. Both interventions focused on physical exercise, nutrition, cognitive challenge and social engagement, and heart health monitoring, but differed in intensity, structure, accountability and support provided. In the structured lifestyle group, participants attended 38 facilitated peer team meetings over two years. They were provided with an activity programme with measurable goals, encouraged to eat according to the MIND diet, given cognitive challenges and other intellectual and social activities. Their progress was reviewed regularly. In the self-guided lifestyle intervention, participants attended six peer team meetings to encourage self-selected lifestyle changes. Participants in the structured intervention showed greater improvement on global cognition, protecting cognition from normal age-related decline for up to two years. The results of the study, called US POINTER, were reported for the first time at the AAIC conference and published in the Journal of the American Medical Association (JAMA). “As the burden of dementia grows worldwide, US POINTER affirms a vital public health message: healthy behaviour has a powerful impact on brain health,” said Dr Joanne Pike, Alzheimer’s Association president and CEO. “This is a critical public health opportunity. The intervention was effective across a broad, representative group – regardless of sex, ethnicity, APOE [gene] genetic risk, or heart health status – demonstrating its applicability and scalability for communities across the country,” added Pike. “The positive results of US POINTER encourage us to look at the potential for a combination of a lifestyle program and drug treatment as the next frontier in our fight against cognitive decline and possibly dementia.” Image Credits: Dawn McDonal/ Unsplash, Photo by Steven HWG on Unsplash. Governments ‘Backslide’ on NCD Commitments After Pressure from Unhealthy Industries 28/07/2025 Kerry Cullinan Few countries are effectively taxing tobacco, alcohol, sugary drinks and ultraprocessed food, in part due to massive industry pushback. Governments have weakened their commitment to addressing non-communicable diseases (NCDs) after pressure from “big tobacco, alcohol, junk food, and fossil fuels”, according to civil society. Their claim centres on the draft political declaration due to be adopted at the UN High-Level Meeting (HLM) on NCDs in September, which no longer calls on countries to implement high taxes on these unhealthy products. Countries are due to wrap up negotiations on the declaration this week, with the final declaration due to be adopted at the HLM on 25 September. “It looks like health-harming industry fingerprints are all over this,” said Alison Cox, director of policy and advocacy at the NCD Alliance. “At a time of fiscal pressures, shrinking global health funding, and increased emphasis on domestic resource mobilisation, health taxes are a golden opportunity to both generate revenue and reduce the burden of NCDs and associated healthcare costs,” she added. “Yet as it stands, the declaration’s text contains weaker language around taxes and lets industry off the hook, prioritising profits over public health,” added Cox, describing the draft as “a backslide”. The language in the current draft has been watered down, and targets have been “flattened”, with active commitments to ‘implement’ and ‘enact’ replaced with the “far more passive language of ‘consider’ and ‘encourage’,” according to the NCD Alliance. ‘Reinstate commitment to taxes’ Vital Strategies, a global public health organisation, urged the negotiators to “reinstate explicit commitment to health taxes” on tobacco, alcohol and sugar-sweetened beverages. “These taxes should increase prices sufficiently to reduce affordability, prevent initiation and support reduction or cessation of use,” said Vital Strategies in a media release. “As outlined by the Task Force for Fiscal Policy on Health, a 50% price increase on tobacco, alcohol, and sugary beverages could raise $2.1 trillion in five years for low- and middle-income countries, revenue equal to 40% of their total health spending,” added the organisation. NCDs, including heart disease, cancer and diabetes, account for 43 million deaths annually, 75% of all deaths worldwide. The burden of NCDs is growing in low- and middle-income countries, driven primarily by smoking and poor diets. Taxes on alcohol, restricting marketing and regulating sales hours are proven interventions to reduce consumption. Vital Strategies also raised alarm about the removal of references to the World Health Organization’s (WHO) “Best Buy” policy recommendations for reducing alcohol consumption and related diseases, including raising taxes, restricting marketing and regulating availability. “The conspicuous deletion of these proven policies from the text strongly suggests undue alcohol industry influence aimed at weakening public health protections. We urge governments to immediately reverse these deletions and fully restore WHO’s recommendations in the final text,” said Vital Strategies. Harmful commercial practices It also wants the declaration to “explicitly tackle harmful commercial practices and strengthen conflict-of-interest protections to safeguard public health policymaking from industry interference”, strengthen commitments to “proven tobacco control measures” including effective taxation, and “recognise unhealthy diets as an urgent priority”. The WHO attributes some 2.8 million deaths a year to obesity and overweight, and Vital wants the declaration to “explicitly state that rising obesity rates are primarily driven by unhealthy diets, emphasising clear interventions like front-of-pack labelling and marketing restrictions targeting children”. The NCD Alliance is also unhappy about “significant backsliding” around social participation and the role of civil society, which is only referred to once. “History has taught us that ignoring the integral role of civil society, communities and people living with diseases weakens any meaningful public health response,” said Cox. With just a week of negotiations remaining, the NCD Alliance is calling on governments to “demonstrate true leadership and resist last-minute compromises that prioritise commercial interests over public health and reflect a genuine commitment to protecting lives”. Image Credits: Leo Zhuang/ Unsplash, Stanislav Ivanitskiy/ Unsplash. Smoke Signals from the Plastics Treaty: Why Geneva Negotiations Can’t Ignore Health Governance 25/07/2025 Deborah Sy Cigarette filters, made from a plastic called cellulose acetate, are world’s most littered plastic item. As negotiators prepare to meet in Geneva, 5-14 August in yet another attempt to finalize the United Nations Global Plastics Treaty addressing a pollution crisis affecting oceans and ecosystems worldwide – a critical linkage between health and environment governance seems to be largely missing from the draft text. After nearly three years of negotiations, the world may be on the verge of finalizing its first legally-binding global instrument to tackle plastic pollution – providing that treaty negotiators overcome massive pressures from the fossil fuel industry to further stall an agreement or weaken provisions aiming to limit plastics production. But as negotiators prepare for the resumed fifth session (INC-5.2), another fundamental flaw threatens the future treaty’s health objectives: the failure to integrate environmental and health governance. This is particularly apparent with regards to cigarette filters – the world’s most littered plastic item – although it extends to cross-sector cooperation on other issues regarding the health harms of other plastics as well. The current draft text makes with only one reference to ‘plastic’ cigarette filters (in draft Annex X) and makes no reference at all to the WHO Framework Convention on Tobacco Control – which could, in fact, be an important nexus for health-environment cooperation on the treaty – once it is approved. The treatment of cigarette filters – largely made of a plastic called cellulose acetate – sends smoke signals about more systematic problems with the treaty text in terms of its approach to environment and health. Health rhetoric vs reality gap Cigarette filters are the world’s most prevalent forms of plastic litter, marring beaches and from there, infiltrating to oceans and fresh water ways. The Chair’s text, the working document guiding final negotiations, acknowledges health extensively in its rhetoric, although much of it remains in brackets, indicating areas where countries have not yet reached agreement. The preamble recognizes plastic pollution as “a serious environmental and human health problem,” while the treaty’s stated objective is “to protect human health and the environment from plastic pollution.” But while the preamble recognizes mutual support with “other international agreements in the field of the environment,” it limits that framework to environmental treaties. Any reference to health instruments, including the WHO Framework Convention on Tobacco Control (FCTC), which has been ratified by 183 countries, are absent from this structure. Draft Plastics Treaty negotiating text – much of language on health remains in brackets. The Chair’s preambular text affirms that the plastics treaty will “not affect… existing treaty obligations,” but this is a non-binding statement that merely avoids direct legal contradictions without promoting substantive policy coherence. In practice, it enables siloed implementation, weakens the ability of health ministries to regulate tobacco product components, and gives the tobacco industry new opportunities to exploit regulatory gaps through the environment ministries. Most tellingly, a standalone health article remains uncertain, reduced to scattered references or a placeholder “pending informal drafting work.” Despite the draft’s stated health objectives, the institutional bridge to health governance is still missing. The ‘safe alternatives’ problem This gap matters because “safe substitutes,” “safe alternatives,” or “safe recycling” are at the heart of solutions throughout the draft treaty. But how can environmental authorities evaluate safety and health impacts without connecting to international or national health standards? The tobacco industry is already exploiting this governance gap by promoting “eco-filters” and “biodegradable” alternatives to plastic cigarette filters. While these products may appear to address plastic pollution, they remain harmful to both health and the environment. Worse, they risk misleading consumers and this kind of product feature substitution is typically assessed by health authorities, not environmental ministries, which may lack the mandate or expertise to evaluate such claims. The cigarette filter test case Cigarette filters are the most littered plastic in the world. Used cigarette filters represent the world’s most littered plastic item, with trillions discarded annually. Each cigarette butt contains toxic lead, cadmium, phthalates, and polycyclic aromatic hydrocarbons that leach into waterways. A single cigarette butt can contaminate 1,000 liters of water, causing $26 billion in annual marine ecosystem damage. The FCTC provides clear guidance on these filters: Parties should prohibit ingredients in tobacco products that may create the impression that they have a health benefit. The WHO study group’s recommendations early this year included that filters should be banned to reduce the palatability and appeal of cigarettes. This would remove consumer misconceptions that filters reduce health harms, and it would also reduce a major source of toxic tobacco waste, including the microplastics deposited by cellulose acetate in filters. Annex X: plastics items recommended for limitations, but not ban or phaseout. Annex Y: proposed ban or phaseout list. Yet the draft plastics treaty only lists “cigarette filters made with plastic” in a priority list for mandatory or voluntary restriction or banning (Annex X), rather than on the ban or phaseout list (Annex Y). The “made with plastic” language for cigarette filters also creates a dangerous loophole that permits biofilters/ eco-filters, contradicting established health guidance. In contrast, Annex Y, the ban/ phase out list, itemizes toys and food containers containing lead, cadmium, and phthalates – the same toxicants found in cigarette filters. Broader governance architecture problem The cigarette filter case reveals systemic weaknesses in the treaty draft’s language around health. Article 2.2 of the FCTC requires Parties to ensure that subsequent international agreements should be compatible with FCTC obligations. However, the negotiating states have yet to provide a mechanism for ensuring this compatibility. When environmental ministries approve product redesigns without health authority input, both agendas suffer. When industries exploit policy gaps to rehabilitate their image while maintaining harmful products, both environmental integrity and health objectives are compromised. Extended Producer Responsibility schemes promoted throughout the draft treaty could also legitimize tobacco industry participation in environmental policy and its greenwashing, directly contradicting FCTC Article 5.3’s requirement to “protect tobacco-related environment policies” from industry interference. The problem extends far beyond tobacco. Plastic substitution decisions made in isolation from health expertise risk creating new health hazards while solving environmental concerns—essentially trading one set of risks for another. Environmental authorities may inadvertently approve alternatives that address plastic pollution while creating health risks. Infrastructure already exists Plastics health impacts in brief. The solution isn’t to build new health systems from scratch, as many countries already have relevant capacity, and global infrastructure exists, including for chemical safety, food standards, and medical devices. For tobacco, global networks like TobLabNet and TobReg provide evidence-based guidance. The real challenge is not global coordination, but national-level inter-agency cooperation. The future plastics treaty can help by explicitly obligating this, ensuring health and environment agencies work together. Without giving due regard to existing health treaties, such coordination will inevitably run up against the different standards these agencies follow on industry engagement. No credible health authority engages with the tobacco industry, which is prohibited globally under the WHO’s Framework of Engagement with Non-State Actors (FENSA) and nationally through Article 5.3 of the FCTC, which covers over 90% of the world’s population. The commitment to binding norms on conflict of interest in the FCTC is essential. It creates space for the broader safeguards called for by civil society, scientists, and the Office of the High Commissioner for Human Rights (OHCHR). Failing to respect existing obligations—especially in the clearest and extreme case of tobacco— effectively precludes any meaningful prevention of conflicts of interest. Integration not isolation The solution lies in strengthening the draft’s health foundation by explicitly recognizing existing health agreements, including the WHO’s FCTC, which was already referenced in previous drafts to promote “cooperation, coordination, and complementarity.” A global coalition focusing on this issue recommends a simple safeguard clause – “Measures taken under this instrument shall be without prejudice to, and aligned with, existing international public health treaties and obligations, (including the WHO FCTC)” – would help prevent regulatory conflicts while provide supportive infrastructures to bolster the authority of environmental ministries to implement the future treaty. For cigarette filters, the recommendation is to eliminate material qualifiers “made of plastic” and move filters to a list for immediate bans. More broadly, the future instrument needs formal mechanisms for health expertise integration—not transferring authority from the environment to health ministries, but creating coordination mechanisms ensuring both objectives are met. The Geneva opportunity The Global Plastics Treaty could model integrated governance for 21st-century planetary health challenges, or represent another missed opportunity for coherent global health governance. Tobacco control shows how weak coordination between health and environmental sectors can backfire. When environmental agencies promote so-called “eco-filters” without health input, they risk legitimizing harmful products. But the reverse is also true. During COVID-19, health-led responses drove a surge in plastic consumption, worsening pollution. Both cases expose the same flaw: without coordination, one sector’s solution can become another’s crisis. The Plastics Treaty offers a rare chance to correct this. The infrastructure exists. The evidence is clear. What’s missing is the political will to connect them through binding legal frameworks. Geneva may be the last, best opportunity, not only to curb plastic pollution, but to safeguard the future of global health governance. Integrating international health agreements into the treaty does more than align with existing obligations. It helps define the treaty’s direction and lays the foundation for a strong, legally binding instrument with robust regulatory measures and comprehensive protections for people and the planet. Deborah Sy is head of Strategy and Global Public Policy at the Global Center for Good Governance in Tobacco Control (GGTC) at Thammasat University in Thailand, the convener of Global Youth Voices and the Stop Tobacco Pollution Alliance (STPA). She is the founder and senior advisor of Health Justice Philippines, an observer to the UN Plastics Treaty negotiations. Image Credits: Dennis Skley, University of Bath , UNEP , Chairs Text, draft UN Plastics Treaty, December 2024, Chairs Text, UN Plastics Treaty, Draft 2024, Ciel.org. US Drafts Plan to Change PEPFAR’s Focus From HIV to Diseases that Could Threaten Americans 24/07/2025 Kerry Cullinan A woman with HIV takes her antiretrovial (ARV) medicine. Until earlier this year, over 20 million people with HIV received ARVs funded by PEPFAR. US State Department officials are developing a plan to transform the President’s Emergency Plan for AIDS Relief (PEPFAR) from an entity that tackles HIV to one that is broadly focused on protecting and promoting American interests. This is according to a report in the New York Times on Thursday, based on leaked planning documents that map out their vision for PEPFAR’s transition in in the next few years. “It would be replaced by ‘bilateral relationships’ with low-income countries focused on the detection of outbreaks that could threaten the United States and the creation of new markets for American drugs and technologies,” the newspaper reports. This is in keeping with the focus of the Trump administration’s first meeting with African health leaders after the US paused all foreign aid for 90 days in January. During the meeting between leaders of the US Centers for Disease Control and Prevention (CDC) and their counterparts in Africa CDC in March, the US officials indicated that they were interested in African business opportunities for American companies. Africa CDC official Dr Ngashi Ngongo told journalists after the meeting that the Trump administration “would like to see health more as a business, rather than something that functions on grants,” and is interested in “exploring how can we go into a partnership that translates into health as a business”. Aggressive transition planning Dr Jirair Ratevosian, a global health expert at Duke and previous PEPFAR chief of staff, said that the Trump administration has “made it very clear that they want to carry on with aggressive transition planning” for PEPFAR. “Transition planning is not a bad idea, but it must be done right, with timetables, developing indicators, matching government buy-in, getting community input etc,” Ratevosian said. While he has not seen the documents referred to by the New York Times, Ratevosian is concerned that the transition plan is being written in Washington rather than in and with the African countries most affected by PEPFAR’s transition. “There needs to be realistic timetables, careful planning and resources to successfully make the transition of HIV programming [from PEPFAR] to national control,” said Ratevosian. “Congress has made clear it rejects the administration’s rushed approach to PEPFAR’s transition, signalling bipartisan concern about protecting the program’s legacy and impact.” He added that the US State Department should also develop plans for US companies to sell their antiretroviral drugs to African countries, the largest market for these products. Brief defunding reprieve Luyengo Clinic in Eswatini. PEPFAR funded 80% of the clinic’s cost, and the HIV treatment of 3,000 people is in jeopardy. Last week, there was a brief moment of hope for PEPFAR recipients after the US Senate agreed to exempt the programme from a planned $400 million reduction, which had been included in a $9.4 billion rescission package put forward by President Donald Trump. The rescission package seeks to claw back federal funds from various programs, including approximately $900 million in global health allocations. Disruptions to US aid for global health including for PEPFAR programmes, have placed millions of lives at risk, particularly in countries heavily dependent on US-supported HIV infrastructure. Carolyn Amole, Clinton Health Access Initiative vice-president for HIV, hepatitis and TB, said PEPFAR’s funding cuts had disrupted commodities procurement, essential systems such as human resources, supply chains, and data infrastructure. Millions more AIDS deaths, infections projected An additional six million new HIV infections and four million AIDS-related deaths could occur between 2025 and 2029 if US-supported HIV treatment and prevention services collapse, according to UNAIDS. “This is not just a funding gap. It’s a ticking time bomb,” said UNAIDS Executive Director Winnie Byanyima at the launch of the organisation’s 2025 global AIDS update earlier this month. “We have seen services vanish overnight. Health workers have been sent home. And people – especially children and key populations – are being pushed out of care.” “Key populations” refer to people most vulnerable to HIV infection, including sex workers, men to have sex with men, people who inject drugs and young women. Some of the immediate effects of the US withdrawal of funds since Donald Trump assumed the presidency in January include the closure of health facilities, healthworker job losses, and disrupted treatment, testing and prevention services. 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Exposure to Leaded Fuel Affects Memory Loss of Older Americans 29/07/2025 Kerry Cullinan Exposure to leaded gasoline affects the memory loss of older Americans. Americans are about 20% more likely to experience memory problems if they lived in areas with high levels of atmospheric lead, according to a study of over 600,000 adults over the age of 65 released at the Alzheimer’s Association International Conference in Toronto on Tuesday. Researchers examined how exposure to airborne lead between 1960 and 1974, when leaded gasoline use was at its highest, may affect brain health later in life. They calculated exposure to historical atmospheric lead levels (HALL) by area and linked it to self-reported memory problems from two American Community Surveys (conducted between 2012 and 2021) involving over 500,000 people. Some 17-22% of people living in areas with moderate, high or extremely high atmospheric lead reported memory issues. “Our study may help us understand the pathways that contribute to some people developing dementia and Alzheimer’s disease,” said Dr Eric Brown, lead author and associate chief of geriatric psychiatry at the Centre for Addiction and Mental Health in Toronto. Lead was originally added to gasoline to increase performance until researchers determined it posed serious risks to health and the environment. The more than 20-year-long phase-out of leaded gas began in 1975. “When I was a child in 1976, our blood carried 15 times more lead than children’s blood today,” said Esme Fuller-Thomson, senior author of the study and a professor at the University of Toronto’s Faculty of Social Work. “An astonishing 88% of us had levels higher than 10 micrograms per deciliter, which are now considered dangerously high.” While the risk of atmospheric lead has decreased, other sources of exposure remain, such as old lead paint and pipes. Those who have been exposed to atmospheric lead should focus on reducing other risk factors for dementia, including high blood pressure, smoking and social isolation, said Brown. “Research suggests half the US population – more than 170 million people – were exposed to high lead levels in early childhood. This research sheds more light on the toxicity of lead related to brain health in older adults today,” said Dr Maria Carrillo, Alzheimer’s Association chief science officer and medical affairs lead. Another study reported at the conference found that older adults who live about three miles from a lead-releasing facility – such as glass, ready-mixed concrete or computer and electronics manufacturers – are more likely to have memory and thinking problems than those who live farther away. Lifestyle interventions help slow cognitive decline Alzheimer’s disease is the most common type of dementia found in elderly people. Social isolation, diet and lack of exercise affect the progression of the disease. Meanwhile, in better news, older adults at risk for cognitive decline and dementia who were actively encouraged to adopt healthy lifestyles were able to slow memory loss, the conference heard. A study of over 2,000 people compared the impact of a structured lifestyle intervention with a self-guided intervention and found that, while both interventions helped, those in the more intense intervention had better success at slowing cognitive decline. Both interventions focused on physical exercise, nutrition, cognitive challenge and social engagement, and heart health monitoring, but differed in intensity, structure, accountability and support provided. In the structured lifestyle group, participants attended 38 facilitated peer team meetings over two years. They were provided with an activity programme with measurable goals, encouraged to eat according to the MIND diet, given cognitive challenges and other intellectual and social activities. Their progress was reviewed regularly. In the self-guided lifestyle intervention, participants attended six peer team meetings to encourage self-selected lifestyle changes. Participants in the structured intervention showed greater improvement on global cognition, protecting cognition from normal age-related decline for up to two years. The results of the study, called US POINTER, were reported for the first time at the AAIC conference and published in the Journal of the American Medical Association (JAMA). “As the burden of dementia grows worldwide, US POINTER affirms a vital public health message: healthy behaviour has a powerful impact on brain health,” said Dr Joanne Pike, Alzheimer’s Association president and CEO. “This is a critical public health opportunity. The intervention was effective across a broad, representative group – regardless of sex, ethnicity, APOE [gene] genetic risk, or heart health status – demonstrating its applicability and scalability for communities across the country,” added Pike. “The positive results of US POINTER encourage us to look at the potential for a combination of a lifestyle program and drug treatment as the next frontier in our fight against cognitive decline and possibly dementia.” Image Credits: Dawn McDonal/ Unsplash, Photo by Steven HWG on Unsplash. Governments ‘Backslide’ on NCD Commitments After Pressure from Unhealthy Industries 28/07/2025 Kerry Cullinan Few countries are effectively taxing tobacco, alcohol, sugary drinks and ultraprocessed food, in part due to massive industry pushback. Governments have weakened their commitment to addressing non-communicable diseases (NCDs) after pressure from “big tobacco, alcohol, junk food, and fossil fuels”, according to civil society. Their claim centres on the draft political declaration due to be adopted at the UN High-Level Meeting (HLM) on NCDs in September, which no longer calls on countries to implement high taxes on these unhealthy products. Countries are due to wrap up negotiations on the declaration this week, with the final declaration due to be adopted at the HLM on 25 September. “It looks like health-harming industry fingerprints are all over this,” said Alison Cox, director of policy and advocacy at the NCD Alliance. “At a time of fiscal pressures, shrinking global health funding, and increased emphasis on domestic resource mobilisation, health taxes are a golden opportunity to both generate revenue and reduce the burden of NCDs and associated healthcare costs,” she added. “Yet as it stands, the declaration’s text contains weaker language around taxes and lets industry off the hook, prioritising profits over public health,” added Cox, describing the draft as “a backslide”. The language in the current draft has been watered down, and targets have been “flattened”, with active commitments to ‘implement’ and ‘enact’ replaced with the “far more passive language of ‘consider’ and ‘encourage’,” according to the NCD Alliance. ‘Reinstate commitment to taxes’ Vital Strategies, a global public health organisation, urged the negotiators to “reinstate explicit commitment to health taxes” on tobacco, alcohol and sugar-sweetened beverages. “These taxes should increase prices sufficiently to reduce affordability, prevent initiation and support reduction or cessation of use,” said Vital Strategies in a media release. “As outlined by the Task Force for Fiscal Policy on Health, a 50% price increase on tobacco, alcohol, and sugary beverages could raise $2.1 trillion in five years for low- and middle-income countries, revenue equal to 40% of their total health spending,” added the organisation. NCDs, including heart disease, cancer and diabetes, account for 43 million deaths annually, 75% of all deaths worldwide. The burden of NCDs is growing in low- and middle-income countries, driven primarily by smoking and poor diets. Taxes on alcohol, restricting marketing and regulating sales hours are proven interventions to reduce consumption. Vital Strategies also raised alarm about the removal of references to the World Health Organization’s (WHO) “Best Buy” policy recommendations for reducing alcohol consumption and related diseases, including raising taxes, restricting marketing and regulating availability. “The conspicuous deletion of these proven policies from the text strongly suggests undue alcohol industry influence aimed at weakening public health protections. We urge governments to immediately reverse these deletions and fully restore WHO’s recommendations in the final text,” said Vital Strategies. Harmful commercial practices It also wants the declaration to “explicitly tackle harmful commercial practices and strengthen conflict-of-interest protections to safeguard public health policymaking from industry interference”, strengthen commitments to “proven tobacco control measures” including effective taxation, and “recognise unhealthy diets as an urgent priority”. The WHO attributes some 2.8 million deaths a year to obesity and overweight, and Vital wants the declaration to “explicitly state that rising obesity rates are primarily driven by unhealthy diets, emphasising clear interventions like front-of-pack labelling and marketing restrictions targeting children”. The NCD Alliance is also unhappy about “significant backsliding” around social participation and the role of civil society, which is only referred to once. “History has taught us that ignoring the integral role of civil society, communities and people living with diseases weakens any meaningful public health response,” said Cox. With just a week of negotiations remaining, the NCD Alliance is calling on governments to “demonstrate true leadership and resist last-minute compromises that prioritise commercial interests over public health and reflect a genuine commitment to protecting lives”. Image Credits: Leo Zhuang/ Unsplash, Stanislav Ivanitskiy/ Unsplash. Smoke Signals from the Plastics Treaty: Why Geneva Negotiations Can’t Ignore Health Governance 25/07/2025 Deborah Sy Cigarette filters, made from a plastic called cellulose acetate, are world’s most littered plastic item. As negotiators prepare to meet in Geneva, 5-14 August in yet another attempt to finalize the United Nations Global Plastics Treaty addressing a pollution crisis affecting oceans and ecosystems worldwide – a critical linkage between health and environment governance seems to be largely missing from the draft text. After nearly three years of negotiations, the world may be on the verge of finalizing its first legally-binding global instrument to tackle plastic pollution – providing that treaty negotiators overcome massive pressures from the fossil fuel industry to further stall an agreement or weaken provisions aiming to limit plastics production. But as negotiators prepare for the resumed fifth session (INC-5.2), another fundamental flaw threatens the future treaty’s health objectives: the failure to integrate environmental and health governance. This is particularly apparent with regards to cigarette filters – the world’s most littered plastic item – although it extends to cross-sector cooperation on other issues regarding the health harms of other plastics as well. The current draft text makes with only one reference to ‘plastic’ cigarette filters (in draft Annex X) and makes no reference at all to the WHO Framework Convention on Tobacco Control – which could, in fact, be an important nexus for health-environment cooperation on the treaty – once it is approved. The treatment of cigarette filters – largely made of a plastic called cellulose acetate – sends smoke signals about more systematic problems with the treaty text in terms of its approach to environment and health. Health rhetoric vs reality gap Cigarette filters are the world’s most prevalent forms of plastic litter, marring beaches and from there, infiltrating to oceans and fresh water ways. The Chair’s text, the working document guiding final negotiations, acknowledges health extensively in its rhetoric, although much of it remains in brackets, indicating areas where countries have not yet reached agreement. The preamble recognizes plastic pollution as “a serious environmental and human health problem,” while the treaty’s stated objective is “to protect human health and the environment from plastic pollution.” But while the preamble recognizes mutual support with “other international agreements in the field of the environment,” it limits that framework to environmental treaties. Any reference to health instruments, including the WHO Framework Convention on Tobacco Control (FCTC), which has been ratified by 183 countries, are absent from this structure. Draft Plastics Treaty negotiating text – much of language on health remains in brackets. The Chair’s preambular text affirms that the plastics treaty will “not affect… existing treaty obligations,” but this is a non-binding statement that merely avoids direct legal contradictions without promoting substantive policy coherence. In practice, it enables siloed implementation, weakens the ability of health ministries to regulate tobacco product components, and gives the tobacco industry new opportunities to exploit regulatory gaps through the environment ministries. Most tellingly, a standalone health article remains uncertain, reduced to scattered references or a placeholder “pending informal drafting work.” Despite the draft’s stated health objectives, the institutional bridge to health governance is still missing. The ‘safe alternatives’ problem This gap matters because “safe substitutes,” “safe alternatives,” or “safe recycling” are at the heart of solutions throughout the draft treaty. But how can environmental authorities evaluate safety and health impacts without connecting to international or national health standards? The tobacco industry is already exploiting this governance gap by promoting “eco-filters” and “biodegradable” alternatives to plastic cigarette filters. While these products may appear to address plastic pollution, they remain harmful to both health and the environment. Worse, they risk misleading consumers and this kind of product feature substitution is typically assessed by health authorities, not environmental ministries, which may lack the mandate or expertise to evaluate such claims. The cigarette filter test case Cigarette filters are the most littered plastic in the world. Used cigarette filters represent the world’s most littered plastic item, with trillions discarded annually. Each cigarette butt contains toxic lead, cadmium, phthalates, and polycyclic aromatic hydrocarbons that leach into waterways. A single cigarette butt can contaminate 1,000 liters of water, causing $26 billion in annual marine ecosystem damage. The FCTC provides clear guidance on these filters: Parties should prohibit ingredients in tobacco products that may create the impression that they have a health benefit. The WHO study group’s recommendations early this year included that filters should be banned to reduce the palatability and appeal of cigarettes. This would remove consumer misconceptions that filters reduce health harms, and it would also reduce a major source of toxic tobacco waste, including the microplastics deposited by cellulose acetate in filters. Annex X: plastics items recommended for limitations, but not ban or phaseout. Annex Y: proposed ban or phaseout list. Yet the draft plastics treaty only lists “cigarette filters made with plastic” in a priority list for mandatory or voluntary restriction or banning (Annex X), rather than on the ban or phaseout list (Annex Y). The “made with plastic” language for cigarette filters also creates a dangerous loophole that permits biofilters/ eco-filters, contradicting established health guidance. In contrast, Annex Y, the ban/ phase out list, itemizes toys and food containers containing lead, cadmium, and phthalates – the same toxicants found in cigarette filters. Broader governance architecture problem The cigarette filter case reveals systemic weaknesses in the treaty draft’s language around health. Article 2.2 of the FCTC requires Parties to ensure that subsequent international agreements should be compatible with FCTC obligations. However, the negotiating states have yet to provide a mechanism for ensuring this compatibility. When environmental ministries approve product redesigns without health authority input, both agendas suffer. When industries exploit policy gaps to rehabilitate their image while maintaining harmful products, both environmental integrity and health objectives are compromised. Extended Producer Responsibility schemes promoted throughout the draft treaty could also legitimize tobacco industry participation in environmental policy and its greenwashing, directly contradicting FCTC Article 5.3’s requirement to “protect tobacco-related environment policies” from industry interference. The problem extends far beyond tobacco. Plastic substitution decisions made in isolation from health expertise risk creating new health hazards while solving environmental concerns—essentially trading one set of risks for another. Environmental authorities may inadvertently approve alternatives that address plastic pollution while creating health risks. Infrastructure already exists Plastics health impacts in brief. The solution isn’t to build new health systems from scratch, as many countries already have relevant capacity, and global infrastructure exists, including for chemical safety, food standards, and medical devices. For tobacco, global networks like TobLabNet and TobReg provide evidence-based guidance. The real challenge is not global coordination, but national-level inter-agency cooperation. The future plastics treaty can help by explicitly obligating this, ensuring health and environment agencies work together. Without giving due regard to existing health treaties, such coordination will inevitably run up against the different standards these agencies follow on industry engagement. No credible health authority engages with the tobacco industry, which is prohibited globally under the WHO’s Framework of Engagement with Non-State Actors (FENSA) and nationally through Article 5.3 of the FCTC, which covers over 90% of the world’s population. The commitment to binding norms on conflict of interest in the FCTC is essential. It creates space for the broader safeguards called for by civil society, scientists, and the Office of the High Commissioner for Human Rights (OHCHR). Failing to respect existing obligations—especially in the clearest and extreme case of tobacco— effectively precludes any meaningful prevention of conflicts of interest. Integration not isolation The solution lies in strengthening the draft’s health foundation by explicitly recognizing existing health agreements, including the WHO’s FCTC, which was already referenced in previous drafts to promote “cooperation, coordination, and complementarity.” A global coalition focusing on this issue recommends a simple safeguard clause – “Measures taken under this instrument shall be without prejudice to, and aligned with, existing international public health treaties and obligations, (including the WHO FCTC)” – would help prevent regulatory conflicts while provide supportive infrastructures to bolster the authority of environmental ministries to implement the future treaty. For cigarette filters, the recommendation is to eliminate material qualifiers “made of plastic” and move filters to a list for immediate bans. More broadly, the future instrument needs formal mechanisms for health expertise integration—not transferring authority from the environment to health ministries, but creating coordination mechanisms ensuring both objectives are met. The Geneva opportunity The Global Plastics Treaty could model integrated governance for 21st-century planetary health challenges, or represent another missed opportunity for coherent global health governance. Tobacco control shows how weak coordination between health and environmental sectors can backfire. When environmental agencies promote so-called “eco-filters” without health input, they risk legitimizing harmful products. But the reverse is also true. During COVID-19, health-led responses drove a surge in plastic consumption, worsening pollution. Both cases expose the same flaw: without coordination, one sector’s solution can become another’s crisis. The Plastics Treaty offers a rare chance to correct this. The infrastructure exists. The evidence is clear. What’s missing is the political will to connect them through binding legal frameworks. Geneva may be the last, best opportunity, not only to curb plastic pollution, but to safeguard the future of global health governance. Integrating international health agreements into the treaty does more than align with existing obligations. It helps define the treaty’s direction and lays the foundation for a strong, legally binding instrument with robust regulatory measures and comprehensive protections for people and the planet. Deborah Sy is head of Strategy and Global Public Policy at the Global Center for Good Governance in Tobacco Control (GGTC) at Thammasat University in Thailand, the convener of Global Youth Voices and the Stop Tobacco Pollution Alliance (STPA). She is the founder and senior advisor of Health Justice Philippines, an observer to the UN Plastics Treaty negotiations. Image Credits: Dennis Skley, University of Bath , UNEP , Chairs Text, draft UN Plastics Treaty, December 2024, Chairs Text, UN Plastics Treaty, Draft 2024, Ciel.org. US Drafts Plan to Change PEPFAR’s Focus From HIV to Diseases that Could Threaten Americans 24/07/2025 Kerry Cullinan A woman with HIV takes her antiretrovial (ARV) medicine. Until earlier this year, over 20 million people with HIV received ARVs funded by PEPFAR. US State Department officials are developing a plan to transform the President’s Emergency Plan for AIDS Relief (PEPFAR) from an entity that tackles HIV to one that is broadly focused on protecting and promoting American interests. This is according to a report in the New York Times on Thursday, based on leaked planning documents that map out their vision for PEPFAR’s transition in in the next few years. “It would be replaced by ‘bilateral relationships’ with low-income countries focused on the detection of outbreaks that could threaten the United States and the creation of new markets for American drugs and technologies,” the newspaper reports. This is in keeping with the focus of the Trump administration’s first meeting with African health leaders after the US paused all foreign aid for 90 days in January. During the meeting between leaders of the US Centers for Disease Control and Prevention (CDC) and their counterparts in Africa CDC in March, the US officials indicated that they were interested in African business opportunities for American companies. Africa CDC official Dr Ngashi Ngongo told journalists after the meeting that the Trump administration “would like to see health more as a business, rather than something that functions on grants,” and is interested in “exploring how can we go into a partnership that translates into health as a business”. Aggressive transition planning Dr Jirair Ratevosian, a global health expert at Duke and previous PEPFAR chief of staff, said that the Trump administration has “made it very clear that they want to carry on with aggressive transition planning” for PEPFAR. “Transition planning is not a bad idea, but it must be done right, with timetables, developing indicators, matching government buy-in, getting community input etc,” Ratevosian said. While he has not seen the documents referred to by the New York Times, Ratevosian is concerned that the transition plan is being written in Washington rather than in and with the African countries most affected by PEPFAR’s transition. “There needs to be realistic timetables, careful planning and resources to successfully make the transition of HIV programming [from PEPFAR] to national control,” said Ratevosian. “Congress has made clear it rejects the administration’s rushed approach to PEPFAR’s transition, signalling bipartisan concern about protecting the program’s legacy and impact.” He added that the US State Department should also develop plans for US companies to sell their antiretroviral drugs to African countries, the largest market for these products. Brief defunding reprieve Luyengo Clinic in Eswatini. PEPFAR funded 80% of the clinic’s cost, and the HIV treatment of 3,000 people is in jeopardy. Last week, there was a brief moment of hope for PEPFAR recipients after the US Senate agreed to exempt the programme from a planned $400 million reduction, which had been included in a $9.4 billion rescission package put forward by President Donald Trump. The rescission package seeks to claw back federal funds from various programs, including approximately $900 million in global health allocations. Disruptions to US aid for global health including for PEPFAR programmes, have placed millions of lives at risk, particularly in countries heavily dependent on US-supported HIV infrastructure. Carolyn Amole, Clinton Health Access Initiative vice-president for HIV, hepatitis and TB, said PEPFAR’s funding cuts had disrupted commodities procurement, essential systems such as human resources, supply chains, and data infrastructure. Millions more AIDS deaths, infections projected An additional six million new HIV infections and four million AIDS-related deaths could occur between 2025 and 2029 if US-supported HIV treatment and prevention services collapse, according to UNAIDS. “This is not just a funding gap. It’s a ticking time bomb,” said UNAIDS Executive Director Winnie Byanyima at the launch of the organisation’s 2025 global AIDS update earlier this month. “We have seen services vanish overnight. Health workers have been sent home. And people – especially children and key populations – are being pushed out of care.” “Key populations” refer to people most vulnerable to HIV infection, including sex workers, men to have sex with men, people who inject drugs and young women. Some of the immediate effects of the US withdrawal of funds since Donald Trump assumed the presidency in January include the closure of health facilities, healthworker job losses, and disrupted treatment, testing and prevention services. 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Governments ‘Backslide’ on NCD Commitments After Pressure from Unhealthy Industries 28/07/2025 Kerry Cullinan Few countries are effectively taxing tobacco, alcohol, sugary drinks and ultraprocessed food, in part due to massive industry pushback. Governments have weakened their commitment to addressing non-communicable diseases (NCDs) after pressure from “big tobacco, alcohol, junk food, and fossil fuels”, according to civil society. Their claim centres on the draft political declaration due to be adopted at the UN High-Level Meeting (HLM) on NCDs in September, which no longer calls on countries to implement high taxes on these unhealthy products. Countries are due to wrap up negotiations on the declaration this week, with the final declaration due to be adopted at the HLM on 25 September. “It looks like health-harming industry fingerprints are all over this,” said Alison Cox, director of policy and advocacy at the NCD Alliance. “At a time of fiscal pressures, shrinking global health funding, and increased emphasis on domestic resource mobilisation, health taxes are a golden opportunity to both generate revenue and reduce the burden of NCDs and associated healthcare costs,” she added. “Yet as it stands, the declaration’s text contains weaker language around taxes and lets industry off the hook, prioritising profits over public health,” added Cox, describing the draft as “a backslide”. The language in the current draft has been watered down, and targets have been “flattened”, with active commitments to ‘implement’ and ‘enact’ replaced with the “far more passive language of ‘consider’ and ‘encourage’,” according to the NCD Alliance. ‘Reinstate commitment to taxes’ Vital Strategies, a global public health organisation, urged the negotiators to “reinstate explicit commitment to health taxes” on tobacco, alcohol and sugar-sweetened beverages. “These taxes should increase prices sufficiently to reduce affordability, prevent initiation and support reduction or cessation of use,” said Vital Strategies in a media release. “As outlined by the Task Force for Fiscal Policy on Health, a 50% price increase on tobacco, alcohol, and sugary beverages could raise $2.1 trillion in five years for low- and middle-income countries, revenue equal to 40% of their total health spending,” added the organisation. NCDs, including heart disease, cancer and diabetes, account for 43 million deaths annually, 75% of all deaths worldwide. The burden of NCDs is growing in low- and middle-income countries, driven primarily by smoking and poor diets. Taxes on alcohol, restricting marketing and regulating sales hours are proven interventions to reduce consumption. Vital Strategies also raised alarm about the removal of references to the World Health Organization’s (WHO) “Best Buy” policy recommendations for reducing alcohol consumption and related diseases, including raising taxes, restricting marketing and regulating availability. “The conspicuous deletion of these proven policies from the text strongly suggests undue alcohol industry influence aimed at weakening public health protections. We urge governments to immediately reverse these deletions and fully restore WHO’s recommendations in the final text,” said Vital Strategies. Harmful commercial practices It also wants the declaration to “explicitly tackle harmful commercial practices and strengthen conflict-of-interest protections to safeguard public health policymaking from industry interference”, strengthen commitments to “proven tobacco control measures” including effective taxation, and “recognise unhealthy diets as an urgent priority”. The WHO attributes some 2.8 million deaths a year to obesity and overweight, and Vital wants the declaration to “explicitly state that rising obesity rates are primarily driven by unhealthy diets, emphasising clear interventions like front-of-pack labelling and marketing restrictions targeting children”. The NCD Alliance is also unhappy about “significant backsliding” around social participation and the role of civil society, which is only referred to once. “History has taught us that ignoring the integral role of civil society, communities and people living with diseases weakens any meaningful public health response,” said Cox. With just a week of negotiations remaining, the NCD Alliance is calling on governments to “demonstrate true leadership and resist last-minute compromises that prioritise commercial interests over public health and reflect a genuine commitment to protecting lives”. Image Credits: Leo Zhuang/ Unsplash, Stanislav Ivanitskiy/ Unsplash. Smoke Signals from the Plastics Treaty: Why Geneva Negotiations Can’t Ignore Health Governance 25/07/2025 Deborah Sy Cigarette filters, made from a plastic called cellulose acetate, are world’s most littered plastic item. As negotiators prepare to meet in Geneva, 5-14 August in yet another attempt to finalize the United Nations Global Plastics Treaty addressing a pollution crisis affecting oceans and ecosystems worldwide – a critical linkage between health and environment governance seems to be largely missing from the draft text. After nearly three years of negotiations, the world may be on the verge of finalizing its first legally-binding global instrument to tackle plastic pollution – providing that treaty negotiators overcome massive pressures from the fossil fuel industry to further stall an agreement or weaken provisions aiming to limit plastics production. But as negotiators prepare for the resumed fifth session (INC-5.2), another fundamental flaw threatens the future treaty’s health objectives: the failure to integrate environmental and health governance. This is particularly apparent with regards to cigarette filters – the world’s most littered plastic item – although it extends to cross-sector cooperation on other issues regarding the health harms of other plastics as well. The current draft text makes with only one reference to ‘plastic’ cigarette filters (in draft Annex X) and makes no reference at all to the WHO Framework Convention on Tobacco Control – which could, in fact, be an important nexus for health-environment cooperation on the treaty – once it is approved. The treatment of cigarette filters – largely made of a plastic called cellulose acetate – sends smoke signals about more systematic problems with the treaty text in terms of its approach to environment and health. Health rhetoric vs reality gap Cigarette filters are the world’s most prevalent forms of plastic litter, marring beaches and from there, infiltrating to oceans and fresh water ways. The Chair’s text, the working document guiding final negotiations, acknowledges health extensively in its rhetoric, although much of it remains in brackets, indicating areas where countries have not yet reached agreement. The preamble recognizes plastic pollution as “a serious environmental and human health problem,” while the treaty’s stated objective is “to protect human health and the environment from plastic pollution.” But while the preamble recognizes mutual support with “other international agreements in the field of the environment,” it limits that framework to environmental treaties. Any reference to health instruments, including the WHO Framework Convention on Tobacco Control (FCTC), which has been ratified by 183 countries, are absent from this structure. Draft Plastics Treaty negotiating text – much of language on health remains in brackets. The Chair’s preambular text affirms that the plastics treaty will “not affect… existing treaty obligations,” but this is a non-binding statement that merely avoids direct legal contradictions without promoting substantive policy coherence. In practice, it enables siloed implementation, weakens the ability of health ministries to regulate tobacco product components, and gives the tobacco industry new opportunities to exploit regulatory gaps through the environment ministries. Most tellingly, a standalone health article remains uncertain, reduced to scattered references or a placeholder “pending informal drafting work.” Despite the draft’s stated health objectives, the institutional bridge to health governance is still missing. The ‘safe alternatives’ problem This gap matters because “safe substitutes,” “safe alternatives,” or “safe recycling” are at the heart of solutions throughout the draft treaty. But how can environmental authorities evaluate safety and health impacts without connecting to international or national health standards? The tobacco industry is already exploiting this governance gap by promoting “eco-filters” and “biodegradable” alternatives to plastic cigarette filters. While these products may appear to address plastic pollution, they remain harmful to both health and the environment. Worse, they risk misleading consumers and this kind of product feature substitution is typically assessed by health authorities, not environmental ministries, which may lack the mandate or expertise to evaluate such claims. The cigarette filter test case Cigarette filters are the most littered plastic in the world. Used cigarette filters represent the world’s most littered plastic item, with trillions discarded annually. Each cigarette butt contains toxic lead, cadmium, phthalates, and polycyclic aromatic hydrocarbons that leach into waterways. A single cigarette butt can contaminate 1,000 liters of water, causing $26 billion in annual marine ecosystem damage. The FCTC provides clear guidance on these filters: Parties should prohibit ingredients in tobacco products that may create the impression that they have a health benefit. The WHO study group’s recommendations early this year included that filters should be banned to reduce the palatability and appeal of cigarettes. This would remove consumer misconceptions that filters reduce health harms, and it would also reduce a major source of toxic tobacco waste, including the microplastics deposited by cellulose acetate in filters. Annex X: plastics items recommended for limitations, but not ban or phaseout. Annex Y: proposed ban or phaseout list. Yet the draft plastics treaty only lists “cigarette filters made with plastic” in a priority list for mandatory or voluntary restriction or banning (Annex X), rather than on the ban or phaseout list (Annex Y). The “made with plastic” language for cigarette filters also creates a dangerous loophole that permits biofilters/ eco-filters, contradicting established health guidance. In contrast, Annex Y, the ban/ phase out list, itemizes toys and food containers containing lead, cadmium, and phthalates – the same toxicants found in cigarette filters. Broader governance architecture problem The cigarette filter case reveals systemic weaknesses in the treaty draft’s language around health. Article 2.2 of the FCTC requires Parties to ensure that subsequent international agreements should be compatible with FCTC obligations. However, the negotiating states have yet to provide a mechanism for ensuring this compatibility. When environmental ministries approve product redesigns without health authority input, both agendas suffer. When industries exploit policy gaps to rehabilitate their image while maintaining harmful products, both environmental integrity and health objectives are compromised. Extended Producer Responsibility schemes promoted throughout the draft treaty could also legitimize tobacco industry participation in environmental policy and its greenwashing, directly contradicting FCTC Article 5.3’s requirement to “protect tobacco-related environment policies” from industry interference. The problem extends far beyond tobacco. Plastic substitution decisions made in isolation from health expertise risk creating new health hazards while solving environmental concerns—essentially trading one set of risks for another. Environmental authorities may inadvertently approve alternatives that address plastic pollution while creating health risks. Infrastructure already exists Plastics health impacts in brief. The solution isn’t to build new health systems from scratch, as many countries already have relevant capacity, and global infrastructure exists, including for chemical safety, food standards, and medical devices. For tobacco, global networks like TobLabNet and TobReg provide evidence-based guidance. The real challenge is not global coordination, but national-level inter-agency cooperation. The future plastics treaty can help by explicitly obligating this, ensuring health and environment agencies work together. Without giving due regard to existing health treaties, such coordination will inevitably run up against the different standards these agencies follow on industry engagement. No credible health authority engages with the tobacco industry, which is prohibited globally under the WHO’s Framework of Engagement with Non-State Actors (FENSA) and nationally through Article 5.3 of the FCTC, which covers over 90% of the world’s population. The commitment to binding norms on conflict of interest in the FCTC is essential. It creates space for the broader safeguards called for by civil society, scientists, and the Office of the High Commissioner for Human Rights (OHCHR). Failing to respect existing obligations—especially in the clearest and extreme case of tobacco— effectively precludes any meaningful prevention of conflicts of interest. Integration not isolation The solution lies in strengthening the draft’s health foundation by explicitly recognizing existing health agreements, including the WHO’s FCTC, which was already referenced in previous drafts to promote “cooperation, coordination, and complementarity.” A global coalition focusing on this issue recommends a simple safeguard clause – “Measures taken under this instrument shall be without prejudice to, and aligned with, existing international public health treaties and obligations, (including the WHO FCTC)” – would help prevent regulatory conflicts while provide supportive infrastructures to bolster the authority of environmental ministries to implement the future treaty. For cigarette filters, the recommendation is to eliminate material qualifiers “made of plastic” and move filters to a list for immediate bans. More broadly, the future instrument needs formal mechanisms for health expertise integration—not transferring authority from the environment to health ministries, but creating coordination mechanisms ensuring both objectives are met. The Geneva opportunity The Global Plastics Treaty could model integrated governance for 21st-century planetary health challenges, or represent another missed opportunity for coherent global health governance. Tobacco control shows how weak coordination between health and environmental sectors can backfire. When environmental agencies promote so-called “eco-filters” without health input, they risk legitimizing harmful products. But the reverse is also true. During COVID-19, health-led responses drove a surge in plastic consumption, worsening pollution. Both cases expose the same flaw: without coordination, one sector’s solution can become another’s crisis. The Plastics Treaty offers a rare chance to correct this. The infrastructure exists. The evidence is clear. What’s missing is the political will to connect them through binding legal frameworks. Geneva may be the last, best opportunity, not only to curb plastic pollution, but to safeguard the future of global health governance. Integrating international health agreements into the treaty does more than align with existing obligations. It helps define the treaty’s direction and lays the foundation for a strong, legally binding instrument with robust regulatory measures and comprehensive protections for people and the planet. Deborah Sy is head of Strategy and Global Public Policy at the Global Center for Good Governance in Tobacco Control (GGTC) at Thammasat University in Thailand, the convener of Global Youth Voices and the Stop Tobacco Pollution Alliance (STPA). She is the founder and senior advisor of Health Justice Philippines, an observer to the UN Plastics Treaty negotiations. Image Credits: Dennis Skley, University of Bath , UNEP , Chairs Text, draft UN Plastics Treaty, December 2024, Chairs Text, UN Plastics Treaty, Draft 2024, Ciel.org. US Drafts Plan to Change PEPFAR’s Focus From HIV to Diseases that Could Threaten Americans 24/07/2025 Kerry Cullinan A woman with HIV takes her antiretrovial (ARV) medicine. Until earlier this year, over 20 million people with HIV received ARVs funded by PEPFAR. US State Department officials are developing a plan to transform the President’s Emergency Plan for AIDS Relief (PEPFAR) from an entity that tackles HIV to one that is broadly focused on protecting and promoting American interests. This is according to a report in the New York Times on Thursday, based on leaked planning documents that map out their vision for PEPFAR’s transition in in the next few years. “It would be replaced by ‘bilateral relationships’ with low-income countries focused on the detection of outbreaks that could threaten the United States and the creation of new markets for American drugs and technologies,” the newspaper reports. This is in keeping with the focus of the Trump administration’s first meeting with African health leaders after the US paused all foreign aid for 90 days in January. During the meeting between leaders of the US Centers for Disease Control and Prevention (CDC) and their counterparts in Africa CDC in March, the US officials indicated that they were interested in African business opportunities for American companies. Africa CDC official Dr Ngashi Ngongo told journalists after the meeting that the Trump administration “would like to see health more as a business, rather than something that functions on grants,” and is interested in “exploring how can we go into a partnership that translates into health as a business”. Aggressive transition planning Dr Jirair Ratevosian, a global health expert at Duke and previous PEPFAR chief of staff, said that the Trump administration has “made it very clear that they want to carry on with aggressive transition planning” for PEPFAR. “Transition planning is not a bad idea, but it must be done right, with timetables, developing indicators, matching government buy-in, getting community input etc,” Ratevosian said. While he has not seen the documents referred to by the New York Times, Ratevosian is concerned that the transition plan is being written in Washington rather than in and with the African countries most affected by PEPFAR’s transition. “There needs to be realistic timetables, careful planning and resources to successfully make the transition of HIV programming [from PEPFAR] to national control,” said Ratevosian. “Congress has made clear it rejects the administration’s rushed approach to PEPFAR’s transition, signalling bipartisan concern about protecting the program’s legacy and impact.” He added that the US State Department should also develop plans for US companies to sell their antiretroviral drugs to African countries, the largest market for these products. Brief defunding reprieve Luyengo Clinic in Eswatini. PEPFAR funded 80% of the clinic’s cost, and the HIV treatment of 3,000 people is in jeopardy. Last week, there was a brief moment of hope for PEPFAR recipients after the US Senate agreed to exempt the programme from a planned $400 million reduction, which had been included in a $9.4 billion rescission package put forward by President Donald Trump. The rescission package seeks to claw back federal funds from various programs, including approximately $900 million in global health allocations. Disruptions to US aid for global health including for PEPFAR programmes, have placed millions of lives at risk, particularly in countries heavily dependent on US-supported HIV infrastructure. Carolyn Amole, Clinton Health Access Initiative vice-president for HIV, hepatitis and TB, said PEPFAR’s funding cuts had disrupted commodities procurement, essential systems such as human resources, supply chains, and data infrastructure. Millions more AIDS deaths, infections projected An additional six million new HIV infections and four million AIDS-related deaths could occur between 2025 and 2029 if US-supported HIV treatment and prevention services collapse, according to UNAIDS. “This is not just a funding gap. It’s a ticking time bomb,” said UNAIDS Executive Director Winnie Byanyima at the launch of the organisation’s 2025 global AIDS update earlier this month. “We have seen services vanish overnight. Health workers have been sent home. And people – especially children and key populations – are being pushed out of care.” “Key populations” refer to people most vulnerable to HIV infection, including sex workers, men to have sex with men, people who inject drugs and young women. Some of the immediate effects of the US withdrawal of funds since Donald Trump assumed the presidency in January include the closure of health facilities, healthworker job losses, and disrupted treatment, testing and prevention services. 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Smoke Signals from the Plastics Treaty: Why Geneva Negotiations Can’t Ignore Health Governance 25/07/2025 Deborah Sy Cigarette filters, made from a plastic called cellulose acetate, are world’s most littered plastic item. As negotiators prepare to meet in Geneva, 5-14 August in yet another attempt to finalize the United Nations Global Plastics Treaty addressing a pollution crisis affecting oceans and ecosystems worldwide – a critical linkage between health and environment governance seems to be largely missing from the draft text. After nearly three years of negotiations, the world may be on the verge of finalizing its first legally-binding global instrument to tackle plastic pollution – providing that treaty negotiators overcome massive pressures from the fossil fuel industry to further stall an agreement or weaken provisions aiming to limit plastics production. But as negotiators prepare for the resumed fifth session (INC-5.2), another fundamental flaw threatens the future treaty’s health objectives: the failure to integrate environmental and health governance. This is particularly apparent with regards to cigarette filters – the world’s most littered plastic item – although it extends to cross-sector cooperation on other issues regarding the health harms of other plastics as well. The current draft text makes with only one reference to ‘plastic’ cigarette filters (in draft Annex X) and makes no reference at all to the WHO Framework Convention on Tobacco Control – which could, in fact, be an important nexus for health-environment cooperation on the treaty – once it is approved. The treatment of cigarette filters – largely made of a plastic called cellulose acetate – sends smoke signals about more systematic problems with the treaty text in terms of its approach to environment and health. Health rhetoric vs reality gap Cigarette filters are the world’s most prevalent forms of plastic litter, marring beaches and from there, infiltrating to oceans and fresh water ways. The Chair’s text, the working document guiding final negotiations, acknowledges health extensively in its rhetoric, although much of it remains in brackets, indicating areas where countries have not yet reached agreement. The preamble recognizes plastic pollution as “a serious environmental and human health problem,” while the treaty’s stated objective is “to protect human health and the environment from plastic pollution.” But while the preamble recognizes mutual support with “other international agreements in the field of the environment,” it limits that framework to environmental treaties. Any reference to health instruments, including the WHO Framework Convention on Tobacco Control (FCTC), which has been ratified by 183 countries, are absent from this structure. Draft Plastics Treaty negotiating text – much of language on health remains in brackets. The Chair’s preambular text affirms that the plastics treaty will “not affect… existing treaty obligations,” but this is a non-binding statement that merely avoids direct legal contradictions without promoting substantive policy coherence. In practice, it enables siloed implementation, weakens the ability of health ministries to regulate tobacco product components, and gives the tobacco industry new opportunities to exploit regulatory gaps through the environment ministries. Most tellingly, a standalone health article remains uncertain, reduced to scattered references or a placeholder “pending informal drafting work.” Despite the draft’s stated health objectives, the institutional bridge to health governance is still missing. The ‘safe alternatives’ problem This gap matters because “safe substitutes,” “safe alternatives,” or “safe recycling” are at the heart of solutions throughout the draft treaty. But how can environmental authorities evaluate safety and health impacts without connecting to international or national health standards? The tobacco industry is already exploiting this governance gap by promoting “eco-filters” and “biodegradable” alternatives to plastic cigarette filters. While these products may appear to address plastic pollution, they remain harmful to both health and the environment. Worse, they risk misleading consumers and this kind of product feature substitution is typically assessed by health authorities, not environmental ministries, which may lack the mandate or expertise to evaluate such claims. The cigarette filter test case Cigarette filters are the most littered plastic in the world. Used cigarette filters represent the world’s most littered plastic item, with trillions discarded annually. Each cigarette butt contains toxic lead, cadmium, phthalates, and polycyclic aromatic hydrocarbons that leach into waterways. A single cigarette butt can contaminate 1,000 liters of water, causing $26 billion in annual marine ecosystem damage. The FCTC provides clear guidance on these filters: Parties should prohibit ingredients in tobacco products that may create the impression that they have a health benefit. The WHO study group’s recommendations early this year included that filters should be banned to reduce the palatability and appeal of cigarettes. This would remove consumer misconceptions that filters reduce health harms, and it would also reduce a major source of toxic tobacco waste, including the microplastics deposited by cellulose acetate in filters. Annex X: plastics items recommended for limitations, but not ban or phaseout. Annex Y: proposed ban or phaseout list. Yet the draft plastics treaty only lists “cigarette filters made with plastic” in a priority list for mandatory or voluntary restriction or banning (Annex X), rather than on the ban or phaseout list (Annex Y). The “made with plastic” language for cigarette filters also creates a dangerous loophole that permits biofilters/ eco-filters, contradicting established health guidance. In contrast, Annex Y, the ban/ phase out list, itemizes toys and food containers containing lead, cadmium, and phthalates – the same toxicants found in cigarette filters. Broader governance architecture problem The cigarette filter case reveals systemic weaknesses in the treaty draft’s language around health. Article 2.2 of the FCTC requires Parties to ensure that subsequent international agreements should be compatible with FCTC obligations. However, the negotiating states have yet to provide a mechanism for ensuring this compatibility. When environmental ministries approve product redesigns without health authority input, both agendas suffer. When industries exploit policy gaps to rehabilitate their image while maintaining harmful products, both environmental integrity and health objectives are compromised. Extended Producer Responsibility schemes promoted throughout the draft treaty could also legitimize tobacco industry participation in environmental policy and its greenwashing, directly contradicting FCTC Article 5.3’s requirement to “protect tobacco-related environment policies” from industry interference. The problem extends far beyond tobacco. Plastic substitution decisions made in isolation from health expertise risk creating new health hazards while solving environmental concerns—essentially trading one set of risks for another. Environmental authorities may inadvertently approve alternatives that address plastic pollution while creating health risks. Infrastructure already exists Plastics health impacts in brief. The solution isn’t to build new health systems from scratch, as many countries already have relevant capacity, and global infrastructure exists, including for chemical safety, food standards, and medical devices. For tobacco, global networks like TobLabNet and TobReg provide evidence-based guidance. The real challenge is not global coordination, but national-level inter-agency cooperation. The future plastics treaty can help by explicitly obligating this, ensuring health and environment agencies work together. Without giving due regard to existing health treaties, such coordination will inevitably run up against the different standards these agencies follow on industry engagement. No credible health authority engages with the tobacco industry, which is prohibited globally under the WHO’s Framework of Engagement with Non-State Actors (FENSA) and nationally through Article 5.3 of the FCTC, which covers over 90% of the world’s population. The commitment to binding norms on conflict of interest in the FCTC is essential. It creates space for the broader safeguards called for by civil society, scientists, and the Office of the High Commissioner for Human Rights (OHCHR). Failing to respect existing obligations—especially in the clearest and extreme case of tobacco— effectively precludes any meaningful prevention of conflicts of interest. Integration not isolation The solution lies in strengthening the draft’s health foundation by explicitly recognizing existing health agreements, including the WHO’s FCTC, which was already referenced in previous drafts to promote “cooperation, coordination, and complementarity.” A global coalition focusing on this issue recommends a simple safeguard clause – “Measures taken under this instrument shall be without prejudice to, and aligned with, existing international public health treaties and obligations, (including the WHO FCTC)” – would help prevent regulatory conflicts while provide supportive infrastructures to bolster the authority of environmental ministries to implement the future treaty. For cigarette filters, the recommendation is to eliminate material qualifiers “made of plastic” and move filters to a list for immediate bans. More broadly, the future instrument needs formal mechanisms for health expertise integration—not transferring authority from the environment to health ministries, but creating coordination mechanisms ensuring both objectives are met. The Geneva opportunity The Global Plastics Treaty could model integrated governance for 21st-century planetary health challenges, or represent another missed opportunity for coherent global health governance. Tobacco control shows how weak coordination between health and environmental sectors can backfire. When environmental agencies promote so-called “eco-filters” without health input, they risk legitimizing harmful products. But the reverse is also true. During COVID-19, health-led responses drove a surge in plastic consumption, worsening pollution. Both cases expose the same flaw: without coordination, one sector’s solution can become another’s crisis. The Plastics Treaty offers a rare chance to correct this. The infrastructure exists. The evidence is clear. What’s missing is the political will to connect them through binding legal frameworks. Geneva may be the last, best opportunity, not only to curb plastic pollution, but to safeguard the future of global health governance. Integrating international health agreements into the treaty does more than align with existing obligations. It helps define the treaty’s direction and lays the foundation for a strong, legally binding instrument with robust regulatory measures and comprehensive protections for people and the planet. Deborah Sy is head of Strategy and Global Public Policy at the Global Center for Good Governance in Tobacco Control (GGTC) at Thammasat University in Thailand, the convener of Global Youth Voices and the Stop Tobacco Pollution Alliance (STPA). She is the founder and senior advisor of Health Justice Philippines, an observer to the UN Plastics Treaty negotiations. Image Credits: Dennis Skley, University of Bath , UNEP , Chairs Text, draft UN Plastics Treaty, December 2024, Chairs Text, UN Plastics Treaty, Draft 2024, Ciel.org. US Drafts Plan to Change PEPFAR’s Focus From HIV to Diseases that Could Threaten Americans 24/07/2025 Kerry Cullinan A woman with HIV takes her antiretrovial (ARV) medicine. Until earlier this year, over 20 million people with HIV received ARVs funded by PEPFAR. US State Department officials are developing a plan to transform the President’s Emergency Plan for AIDS Relief (PEPFAR) from an entity that tackles HIV to one that is broadly focused on protecting and promoting American interests. This is according to a report in the New York Times on Thursday, based on leaked planning documents that map out their vision for PEPFAR’s transition in in the next few years. “It would be replaced by ‘bilateral relationships’ with low-income countries focused on the detection of outbreaks that could threaten the United States and the creation of new markets for American drugs and technologies,” the newspaper reports. This is in keeping with the focus of the Trump administration’s first meeting with African health leaders after the US paused all foreign aid for 90 days in January. During the meeting between leaders of the US Centers for Disease Control and Prevention (CDC) and their counterparts in Africa CDC in March, the US officials indicated that they were interested in African business opportunities for American companies. Africa CDC official Dr Ngashi Ngongo told journalists after the meeting that the Trump administration “would like to see health more as a business, rather than something that functions on grants,” and is interested in “exploring how can we go into a partnership that translates into health as a business”. Aggressive transition planning Dr Jirair Ratevosian, a global health expert at Duke and previous PEPFAR chief of staff, said that the Trump administration has “made it very clear that they want to carry on with aggressive transition planning” for PEPFAR. “Transition planning is not a bad idea, but it must be done right, with timetables, developing indicators, matching government buy-in, getting community input etc,” Ratevosian said. While he has not seen the documents referred to by the New York Times, Ratevosian is concerned that the transition plan is being written in Washington rather than in and with the African countries most affected by PEPFAR’s transition. “There needs to be realistic timetables, careful planning and resources to successfully make the transition of HIV programming [from PEPFAR] to national control,” said Ratevosian. “Congress has made clear it rejects the administration’s rushed approach to PEPFAR’s transition, signalling bipartisan concern about protecting the program’s legacy and impact.” He added that the US State Department should also develop plans for US companies to sell their antiretroviral drugs to African countries, the largest market for these products. Brief defunding reprieve Luyengo Clinic in Eswatini. PEPFAR funded 80% of the clinic’s cost, and the HIV treatment of 3,000 people is in jeopardy. Last week, there was a brief moment of hope for PEPFAR recipients after the US Senate agreed to exempt the programme from a planned $400 million reduction, which had been included in a $9.4 billion rescission package put forward by President Donald Trump. The rescission package seeks to claw back federal funds from various programs, including approximately $900 million in global health allocations. Disruptions to US aid for global health including for PEPFAR programmes, have placed millions of lives at risk, particularly in countries heavily dependent on US-supported HIV infrastructure. Carolyn Amole, Clinton Health Access Initiative vice-president for HIV, hepatitis and TB, said PEPFAR’s funding cuts had disrupted commodities procurement, essential systems such as human resources, supply chains, and data infrastructure. Millions more AIDS deaths, infections projected An additional six million new HIV infections and four million AIDS-related deaths could occur between 2025 and 2029 if US-supported HIV treatment and prevention services collapse, according to UNAIDS. “This is not just a funding gap. It’s a ticking time bomb,” said UNAIDS Executive Director Winnie Byanyima at the launch of the organisation’s 2025 global AIDS update earlier this month. “We have seen services vanish overnight. Health workers have been sent home. And people – especially children and key populations – are being pushed out of care.” “Key populations” refer to people most vulnerable to HIV infection, including sex workers, men to have sex with men, people who inject drugs and young women. Some of the immediate effects of the US withdrawal of funds since Donald Trump assumed the presidency in January include the closure of health facilities, healthworker job losses, and disrupted treatment, testing and prevention services. Image Credits: The Global Fund/ Saiba Sehmi, UNAIDS. Posts navigation Older postsNewer posts This site uses cookies to help give you the best experience on our website. Cookies enable us to collect information that helps us personalise your experience and improve the functionality and performance of our site. By continuing to read our website, we assume you agree to this, otherwise you can adjust your browser settings. Please read our cookie and Privacy Policy. Our Cookies and Privacy Policy
US Drafts Plan to Change PEPFAR’s Focus From HIV to Diseases that Could Threaten Americans 24/07/2025 Kerry Cullinan A woman with HIV takes her antiretrovial (ARV) medicine. Until earlier this year, over 20 million people with HIV received ARVs funded by PEPFAR. US State Department officials are developing a plan to transform the President’s Emergency Plan for AIDS Relief (PEPFAR) from an entity that tackles HIV to one that is broadly focused on protecting and promoting American interests. This is according to a report in the New York Times on Thursday, based on leaked planning documents that map out their vision for PEPFAR’s transition in in the next few years. “It would be replaced by ‘bilateral relationships’ with low-income countries focused on the detection of outbreaks that could threaten the United States and the creation of new markets for American drugs and technologies,” the newspaper reports. This is in keeping with the focus of the Trump administration’s first meeting with African health leaders after the US paused all foreign aid for 90 days in January. During the meeting between leaders of the US Centers for Disease Control and Prevention (CDC) and their counterparts in Africa CDC in March, the US officials indicated that they were interested in African business opportunities for American companies. Africa CDC official Dr Ngashi Ngongo told journalists after the meeting that the Trump administration “would like to see health more as a business, rather than something that functions on grants,” and is interested in “exploring how can we go into a partnership that translates into health as a business”. Aggressive transition planning Dr Jirair Ratevosian, a global health expert at Duke and previous PEPFAR chief of staff, said that the Trump administration has “made it very clear that they want to carry on with aggressive transition planning” for PEPFAR. “Transition planning is not a bad idea, but it must be done right, with timetables, developing indicators, matching government buy-in, getting community input etc,” Ratevosian said. While he has not seen the documents referred to by the New York Times, Ratevosian is concerned that the transition plan is being written in Washington rather than in and with the African countries most affected by PEPFAR’s transition. “There needs to be realistic timetables, careful planning and resources to successfully make the transition of HIV programming [from PEPFAR] to national control,” said Ratevosian. “Congress has made clear it rejects the administration’s rushed approach to PEPFAR’s transition, signalling bipartisan concern about protecting the program’s legacy and impact.” He added that the US State Department should also develop plans for US companies to sell their antiretroviral drugs to African countries, the largest market for these products. Brief defunding reprieve Luyengo Clinic in Eswatini. PEPFAR funded 80% of the clinic’s cost, and the HIV treatment of 3,000 people is in jeopardy. Last week, there was a brief moment of hope for PEPFAR recipients after the US Senate agreed to exempt the programme from a planned $400 million reduction, which had been included in a $9.4 billion rescission package put forward by President Donald Trump. The rescission package seeks to claw back federal funds from various programs, including approximately $900 million in global health allocations. Disruptions to US aid for global health including for PEPFAR programmes, have placed millions of lives at risk, particularly in countries heavily dependent on US-supported HIV infrastructure. Carolyn Amole, Clinton Health Access Initiative vice-president for HIV, hepatitis and TB, said PEPFAR’s funding cuts had disrupted commodities procurement, essential systems such as human resources, supply chains, and data infrastructure. Millions more AIDS deaths, infections projected An additional six million new HIV infections and four million AIDS-related deaths could occur between 2025 and 2029 if US-supported HIV treatment and prevention services collapse, according to UNAIDS. “This is not just a funding gap. It’s a ticking time bomb,” said UNAIDS Executive Director Winnie Byanyima at the launch of the organisation’s 2025 global AIDS update earlier this month. “We have seen services vanish overnight. Health workers have been sent home. And people – especially children and key populations – are being pushed out of care.” “Key populations” refer to people most vulnerable to HIV infection, including sex workers, men to have sex with men, people who inject drugs and young women. Some of the immediate effects of the US withdrawal of funds since Donald Trump assumed the presidency in January include the closure of health facilities, healthworker job losses, and disrupted treatment, testing and prevention services. Image Credits: The Global Fund/ Saiba Sehmi, UNAIDS. Posts navigation Older postsNewer posts