Margaret Gyapong, director of the Institute for Health Research at the University of Health and Allied Sciences in Ghana, with her research team.
Margaret Gyapong, director of the Institute for Health Research at the University of Health and Allied Sciences in Ghana, with her research team.

Whether researchers provide good quality data or not, healthcare systems will continue to function. In this episode of the “Global Health Matters” podcast, Margaret Gyapong, director of the Institute for Health Research at the University of Health and Allied Sciences in Ghana, tells host Garry Aslanyan that this has been a hard lesson that has shaped her career.

Joining the podcast is also Lee Hampton, vaccine preventable disease surveillance and vaccine safety focal point at Gavi, the Vaccine Alliance based in Switzerland.

According to Gyapong, the drive to better serve healthcare providers has pushed her to ensure that she works on projects that are relevant and to consider them as true partners.

This approach has been crucial in the development and deployment of the new malaria vaccine.


“Just recently, the World Health Organization made their official recommendation to widely use the long-anticipated malaria vaccine,” Aslanyan notes. “This recommendation was based on research evidence from a pilot programme in Ghana, Kenya, and Malawi that reached more than 800 000 children since 2019. This is an excellent example of how evidence, based on implementation research, tells us whether the health interventions, such as vaccines, will be effective in real life beyond the laboratory.”

Focusing on health workers

Gyapong, who has been involved in the process, shares some of her experience.

“Many times when we are delivering a new intervention, we think that we should focus all our attention on community members because they have low levels of literacy,” she says. “But then one of the things I have realized from the introduction of the new malaria vaccine is that we need to have a better understanding of our health care providers and the way they think.”

“We found out that the health workers at the lower level who were going to be the frontline workers to deliver the vaccinations had a shorter period of training than those at the higher level, and the health workers complained bitterly,” Gyapong adds, pointing out that the need for better training is relevant also for COVID-19 vaccine’s deployment.

Asked about what researchers working in different settings and areas should do, the scientist encourages them to understand “the situation on the ground” and “the needs of your stakeholders.”

Different communities have different needs

One of the challenges in deploying new vaccines is the expectation that strategies that are developed and tested in a specific society, often a high-income one, can be applied to other places, Hampton tells Aslanyan.

“We have a strong tendency to try to apply the game plans and the experience that worked in those countries that had the resources to first do the development everywhere,” he points out. “But then we run into trouble.”

Understanding the needs and characteristics of each community is crucial for a successful vaccination campaign. Hampton offers the example of the newly developed typhoid conjugate vaccine, which they expect will help prevent tens of thousands of cases and potential deaths.

Image Credits: Courtesy of TDR.

Vaccines
A United States delivery of 655,200 COVID-19 vaccine doses through COVAX to Ethiopia on September 23, 2021.

Gavi, the Vaccine Alliance, has pushed back on media reports that its board has decided to end COVID vaccine support for 37 middle-income countries next year – and end altogether the dedicated COVAX vaccine facility, supplying free vaccines to some 92 low- and middle-income countries, in 2024.

A high-ranking official at Gavi told Health Policy Watch that its Board’s approval Thursday in principle of a plan to end the free provision of vaccines to the 37 countries – including Egypt, Indonesia and Argentina – is neither final nor definitive, and would not in any case affect vaccine deliveries in 2023. 

Other officials, meanwhile, said that if funding cuts for middle income countries are made in 2024, the money saved would be shifted to a pandemic pool to confront new, and more dangerous SARS-CoV2 surges or similar future threats. 

Even so, no changes to Gavi’s support of some 92 middle and low income countries for COVID vaccines through the COVAX facility’s Advance Market Commitment (AMC) will be made in 2023, said Dr Derrick Sim.  A final decision on the shape the COVAX facility takes in 2024 will not be voted on until June of 2023, he added, following consultations with countries themselves. 

“We are not changing the approach for 2023, all AMC countries including AMC-supported middle-income countries will be supported to get fully-funded doses and delivery support,” said Sim, who is the Acting Managing Director of the Gavi-led COVAX facility, which has rolled out some 1.8 billion COVID vaccines to 146 low and middle income countries over the past two years.  

“Looking forward to 2024, every scenario we are considering involves some support for middle-income countries, and no decision will be taken until at least next year after countries have been fully consulted – and it will be based on the state of the pandemic at that time,” he added. 

New pandemic pool aims to correct problems in COVID vaccine rollout 

A lack on on-hand funding at the onset of the COVID pandemic hamstrung Gavi’s ability to respond in the early stages of the outbreak.

Under the proposal approved by the board on Thursday, any money saved on procuring vaccines for the 37 middle-income AMC countries would instead go to funding a new pandemic finance pool, which could be rapidly and flexibly deployed to confront surges of new SARS-CoV2 variants, or similar threats, added Olly Cann, Gavi’s director of communications.

“The idea behind it is, can we learn the lessons from 2020?,” said Olly Cann, Gavi’s director of communications.

During the early stages of the COVID vaccine rollout, Gavi and COVAX were heavily criticized for over reliance on just one vaccine supplier, the Serum Institute of India, which then froze its shipments when India faced a major COVID surge. 

The problem, widely acknowledged later, was that Gavi had no cash in hand at that time  to seal deals with some of the other large vaccine manufacturers, like  Pfizer, Moderna and Johnson & Johnson, for advance vaccine purchases. So it was forced to the back of the vaccine procurement line. 

New strategy part of scenario planning 

The new strategy approved by the Gavi Board Thursday is anchored in alternative scenarios for COVID’s evolution, developed by the World Health Organization, which leads the policy side of COVAX. 

WHO has defined three scenarios for the evolution of the SARS-CoV2 virus and pandemic: a worst case surge of new or existing variants; a medium case; and a best case, in which mortality from SARCoV2 continues to decline as virus mutations become less deadly. 

Only in the ‘best-case’ scenario would the COVAX programme of free vaccines and vaccine distribution support to the 37 middle income countries be replaced with a more step-wise approach, officials said. 

Under the new approach, the countries would be able to receive a “catalytic grant” – a one-time payment covering 50-60% of the estimated cost of the jabs needed to immunize health workers, older people and other vulnerable groups. 

In a medium or worst-case scenario, assistance to these middle-income nations would be increased accordingly.

Integration of COVID vaccines into routine countries may be preferred  

COVAX deliveries arrive in Sudan, August 5, 2021.

In best-case scenarios, the COVAX facility might foreseeably dissolve its emergency operations and integrate COVID vaccine distribution – into routine national vaccination programmes, officials also admitted.  

However, regardless of whether COVAX is dissolved entirely, or not, the progressive main-streaming of Covid vaccinations into national vaccine delivery programmes is in line with good practice – and what countries want.  

“Countries are finding it administratively burdensome to administer COVID vaccines as an entirely separate emergency programme,” one Gavi official said, speaking on condition of anonymity. “They would rather see vaccine distribution integrated into ongoing routine vaccination programmes.”

“COVAX’s planning is driven by countries’ needs and what we are hearing,” Sim added.  “They want to find ways to integrate COVID-19 into existing programmes in a way that benefits both, and reduces the administrative burdens of running a separate emergency programme in a time of other competing priorities, from routine immunization to outbreak response.” 

The Pandemic Vaccine Pool is the long-term strategy 

Under one of the scenarios included in the proposal approved by the Board on Thursday, any savings in supplying free vaccines to the 37 middle-income AMC countries, that would be channelled into Gavi’s new Pandemic Vaccine Pool – so as to have cash in hand for any new SARS-2 surge, or other future pandemic threat. 

The Pandemic Vaccine Pool created by the Gavi Board in April is a critical, new part of Gavi’s long-term pandemic preparedness strategy, Sim said. The aim is to ensure ready funding that would allow the Alliance to be on proactive footing should another deadly variant or virus emerge. 

“The Pandemic Vaccine Pool helps us have funding on hand to act immediately if there is a need, for example, for new vaccines,” he explained. “Gavi put in place this contingency measure based on COVAX learnings from the beginning of the pandemic that the course of the pandemic can change suddenly and delays can occur due to lack of available financing.” 

Middle-income countries normally do not qualify for Gavi support

Arrival of the first COVAX package to Argentina, comprised of Oxford/AstraZeneca vaccines.

Gavi officials also stressed that prior to the COVID pandemic, Gavi’s remit was limited to assisting the world’s 54 lowest-income countries, as defined by World Bank economic data. Middle income countries were eligible only for targeted funding, upon request, and not free vaccines as such. 

But the historic nature of the Covid emergency led to an expansion of eligibility for countries that qualified for free vaccines and support. And thus for COVID vaccine rollout purposes, some 37 middle income countries, as well as India, were included to the Gavi “Advanced Market Commitment (AMC)” scheme – making for 92 countries eligible for free COVID vaccines as well as distribution support.  

“These middle-income countries normally run their own routine vaccination programs, without Gavi support except for one-off targeted interventions,” Sim said. “When COVAX was set up, it exceptionally included a larger group of countries given the unique challenges of equitable access in a supply-constrained pandemic environment.”

In effect, then, any policy change in 2024 would revert Gavi’s scope to what it was pre-pandemic: a system of free vaccines and distribution support for 54 of the world’s lowest-income countries – and targeted support to middle income countries in need, he said. 

Proposal not related to vaccine contracts

Gavi also pushed back on reports by the New York Times that the draft proposal, approved by the Board, is reflective of financial pressures resulting from Gavi being overcommitted to vaccine purchases for which there is now no demand. 

In fact, Gavi’s fixed purchase commitments for 2023 amount to only 150 million vaccine doses, one Gavi official told Health Policy Watch – while the rest are simply “options to buy”.

At the same time the existing list of AMC countries have already expressed interest in twice as many doses – 300 million in total for 2023 – and that is only after a polling of half of the eligible countries.    

 Global demand for vaccines has indeed fallen significantly as the world’s population already builds immunity, the Gavi official added.  For instance, some 52% of people in low income countries have at least had a primary vaccine dose – a far higher proportion than six months or a year ago. And countries have some 400 million doses in stock, as well. 

As a result of declining demand trends, Gavi had earlier renegotiated a number of fixed-order commitments in its portfolio to become options – orders they can fulfill if demand jumps.

But these negotiations had already happened before this week’s board meeting. 

And between a replenishment for the 2021-2025 period that exceeded Gavi’s request for $7.4 billion, reaching $10.5 billion, and the $4.8 billion committed by world leaders at the COVAX AMC summit in April, the alliance’s financials are in order.

“The focus is on increasing coverage rates, protecting high-risk groups including with boosters, and laying the foundation for integration into existing programs,” said Sim.

 “Budget isn’t a problem, and supply isn’t a problem,” Cann said. “The biggest problem is we have no idea what 2024 will look like.”

 

Image Credits: US State Department, Nana Kofi Acquah, Argentina Health Ministry.

As we observe Universal Health Coverage day, it’s time to look again at gender barriers to health care, and particularly health care for chronic diseases

Monowara lives in the Khulna Division of Bangladesh. A mother of four, she is from a rural community experiencing significant levels of poverty. Now in her sixties, she spent 13 years with cataracts and deteriorating vision, unable to fully participate in community life and see members of her family clearly. Eye disease has been found to be almost 35% higher among women than men in Bangladesh, yet the surgical coverage rate for cataracts is more than 12% lower in women .

Observations of Universal Health Coverage (UHC) Day on 12 December will surely focus on how far we remain from attainment of the SDG goal 3.8 of UHC for all by 2030

Coverage by essential UHC services, by country, according to the  WHO UHC Service Coverage Index.

In that context, it’s important to examine how gender inequality continues to pose a barrier to UHC for women and girls – particularly for prevention and treatment of non-communicable diseases which have not traditionally been part of the standard package of womens’ and girls’ health services. 

Many aspects of gender inequity are easy to see. Women and girls globally are more likely to be living in poverty, working low-skilled jobs for inferior rates of pay, providing unpaid care for their families, facing barriers to education and proper nutrition, or withdrawn from education should there need to be a choice between siblings of different genders. They are much more likely than men to face gender-based violence.

Beyond ‘bikini’ medicine

Other aspects of gender inequity are ‘invisible’. The term ‘bikini medicine’ describes the mistaken belief that women’s health only differs from men’s in the parts of the body that a bikini would cover. 

Our focus on reproductive health blinds us to broader gender differences – in risk factors, in access to care and health promotion, and in health outcomes. Around the world, girls and women living with NCDs experience specific challenges in accessing prevention, early diagnosis, treatment and care, particularly in low-resource contexts; for example, low prioritization of female health within families, women’s limited access to financial resources to cover the costs, their caring responsibilities, and restrictions on their ability to travel freely, to name a few.

India’s example: more insurance payouts to men than women

In Bangladesh, is it estimated that women are up to twice as likely to experience blindness as compared to men.

This can lead to stark gender differences. For example, an analysis of national data collected by India’s Insurance Information Bureau found that while more women were covered by government-funded health insurance schemes than are men, a staggering 70% of insurance pay-outs went to males. Barriers to accessing care are compounded by health systems that may fail to respond to the specific needs of girls and women with NCDs; either because they are not considered ‘women’s diseases’, or because gender differences in the way they are experienced are not understood.

For example, women are less likely than men to receive recommended medication after experiencing a heart attack. Women having a stroke are more likely than men to be wrongly diagnosed, and despite widely reported sex- and gender-based differences in asthma and asthma management, these issues frequently are not considered by health care professionals.

All this points to a need to address barriers to accessing health services for women in particular. We need to recognise gender as a determinant of health; for example, through the obstacles women face to adopting healthy lifestyles, such as unsafe environments that restrict their opportunities to be physically active. We need women-centred policies and programs focusing on prevention and care across the life course, prioritised to address the inadequacy of current systems. As the eyes of the global health sector turn to the High-Level Meeting on Universal Health Coverage in 2023, we must look anew at what’s needed to deliver effective, targeted services for both women and men.

Prioritize better data collection, service integration and women’s leadership

We suggest three key priorities:

  1. Disaggregated data and analyses – The gender inequities highlighted here are just the visible tip of a likely enormous iceberg, which remains hidden because we lack the data needed to identify these and other, intersecting inequities related to age, race, ethnicity, sexuality and so on. We urgently need data disaggregated and analysed by gender and other characteristics in order to effectively identify and break down barriers to health services access.
  2. Integration of services – Leveraging health infrastructure built for maternal and reproductive health can be an effective way to reach women with other services; for example, by incorporating screening and treatment for diabetes and high blood pressure into routine pregnancy checks.
  3. Women’s leadership in healthDespite making up close to 70% of the health workforce globally, women are underrepresented in health sector leadership, with only 25% of women in decision-making positions. Adequate representation of women at the top would ensure policies, programs and laws more fully consider the experiences and perspectives of half the population.

Monowara’s untreated cataracts were spotted when she accompanied her daughter Munni to a maternal and child health clinic which has integrated eye care into the services it offers, training MCH workers to detect basic eye conditions. Monowara’s eyes were checked while Munni was nursing her newborn baby, and her cloudy lenses were subsequently replaced with new ones in a relatively simple, 20-minute procedure, which was provided to her for free.

Both are simple examples of service integration that can be transformative for the individuals involved. 

The impact on Monowara’s life of being able to see clearly again after 13 years is immeasurable; not just for her, but for her entire family. Only by lifting our sights to the full picture of women’s health – including gender differences beyond the ‘bikini’ and across the life course – and by investing in women’s leadership and a whole-of-government approach to tackle deep-seated gender inequities across the board , can we hope to achieve the vision of universal health coverage for all.

About the authors

Jane Madden is the chair of The Fred Hollows Foundation.

Dr Monika Arora is the vice president of the Public Health Foundation of India and President-Elect of the NCD Alliance.

Emma Feeny is the global director of impact & engagement at Australia-based George Institute for Global Health.

UNITE
UNITAID Panel discussion at the UNITE Global Summit 2022.

The world can achieve the global health goals of the Sustainable Development Agenda 2030 only if it makes focussed investments into health innovation in the coming years. 

This was a key message from parliamentarians and representatives of the global health agency, UNITAID, at a panel on “Achieving the Global Health Targets Through Equitable Access to Health Innovation”, at the UNITE Global Summit 2022, which took place in Lisbon, Portugal this week. 

Dr Tenu Avafia, the deputy executive director of UNITAID, highlighted that the agency has an annual funding target of about $1.5 billion, which is funnelled into projects in low-income countries that help ensure equitable access to health tools – from prevention to diagnostics and treaments.  But the Geneva-based agency, which works in partnership with WHO and other global health partners, also has a strong innovation focus. It’s recent projects range from support for community trials testing shorter and less toxic formers of MDR-TB treatment in high-burden countries, to the testing and scale up of mass media campaigns for HIV self-testing amongst youth in Africa.  

UNITAID
Dr Tenu Avafia at the UNITE Global Summit 2022

“2023 is going to be a massive year for global health,” he said. Avafia added that Japan and India’s leadership at G-7 and G-20 respectfully will put universal health coverage and equitable access top priorities in the coming year. “We cannot keep the model where we concentrate, manufacture and distribute technologies in a handful of countries.”

Apart from Avafia, Maureen Murenga, a UNITAID board member, and Dr Ricardo Baptista Leite, UNITE head and a member of parliament from Portugal, were part of the panel discussion. 

Advancement in diagnostics, prevention and treatment has come a long way since HIV was discovered in the 1980s. Narrating the story of her own HIV diagnosis in those early years, Murenga related how she was initially tested five times, each test cycle returning the results after two weeks.  Now, health technology innovations has made possible immediate results, which opens up the door for more robust self-testing as well as other measures to prevent HIV infection from becoming full-blown AIDS.  

UNITAID
Maureen Murenga at the UNITE Global Summit 2022.

Murenga said that the invention of antiretroviral (ARVs) drugs was a game-changer for people living with HIV since it increased their lifespan and also decreased the chances of transmitting the virus to another person.

“So we are actually working towards the end of these epidemics…And if we don’t defeat them, they will come back and it’ll be too expensive for us to respond.” 

Attributing the progress in TB regimens and malaria vaccine to focussed efforts in innovation, Murenga stressed on the need to invest in solutions that will yield longer term benefits to the population. 

While investing in developing newer health solutions is important, it is equally important to ensure that the money goes into “innovation” and not “simple novelty”, Leite added. 

UNITE
Dr Ricardo B Leite, a Portuguese parliamentarian and head of UNITE, at the UNITE Global Summit 2022.

“I believe that the role of UNITAID is very important to also distinguish what is innovation from simple novelty. And there is a lot of industry interest, sometimes, trying to push certain technologies as being true innovation, but at the end of the day, are not adding value to health systems,” he said. 

Dr Leite added that investing wisely is the need of the hour and parliamentarians must do whatever it takes to ensure the well being of the people they represent. “We all know what it means to go against our own party, but that’s part of the job. Our first responsibility is not to our party, it’s to the people that we serve, and making sure that we use science to base all our positions and decisions so that it is very clear where we’re coming from.”  

Dr Avafia reiterated that collaboration is key in achieving goals of health equity and innovation. UNITAID’s goals over the next five years include accelerating the introduction and adoption to new health products and to address systemic conditions that affect equitable access and to encourage inclusive partnerships to set the health agenda, he explained. 

“A fully-funded global health response requires a fully funded Global Fund, a fully funded WHO, fully funded UNITAID and Gavi as well. Members of Parliament, as you know much better than I do, are key interlocutors in both programme and donor countries to make sure that resource allocation for unmet health needs is prioritised.” 

Ukrainian MP Galyna Mykhailiuk at the UNITE Global Summit
Ukrainian MP Galyna Mykhailiuk at the UNITE Global Summit

A four-year-old asthmatic girl from Ukraine was forced to relocate to a gas station earlier this week where she could connect her ventilator, after a Russian missile attack cut off her city’s electricity supply, leaving her without any other means of receiving life-saving oxygen.

Pictures of her frightened, frozen eyes made social media. But according to a Ukrainian MP, this story is not unique – “there are so many dramatic stories.”

The child, explained Ukrainian MP Galyna Mykhailiuk in an interview with Health Policy Watch, “requires a ventilator to breathe normally. She needed electricity to supply her with oxygen. The only possible option for her parents was to leave their home and take her to the gas station. At the gas station there is a generator.

“You might not think about how energy is connected to health, but there is a direct connection.”

‘Different being an official during war time’

Mykhailiuk spoke to Health Policy Watch during a visit to Lisbon for the UNITE Global Summit, a conference that brought together parliamentarians from around the world on December 5 to 7 to discuss issues of global health.

To get to the conference, the MP had to travel more than 36 hours, taking a 17-hour train ride from Kiev to Warsaw and then two flights. There is no safe airspace over Ukraine, so anyone trying to leave the country has to leave by car, train or foot. The cold weather – some days it is negative 5 Celsius and the ground is covered in ice and snow – can make it dangerous to drive or walk too far.

Mykhailiuk chose to attend the event both, because of her friendship with UNITE President Ricardo Baptista Leite, who volunteered at a Ukrainian hospital in the summer, and so that she could share what is going on in her country with the MPs directly and not through media interpretation, she said.

“It is very different being an official during war time than during peaceful time,” she explained to Health Policy Watch. “I cannot give you details of my day-to-day for security reasons, of course. But it is much more challenging. We work 24/7.”

‘We know diseases are spreading’

Although Mykhailiuk lives in Ukraine, her mother and the rest of her family live in Odessa, where she is originally from. During the UNITE event on Monday, December 5, Russian troops launched a missile attack on two infrastructure facilities in the Odessa region, leaving the region without power. She received a phone call from her older mother on Tuesday complaining that there is no electricity or warm water, and afraid for her life.

The extreme weather conditions for people without heat, proper clothing, blankets or access to supplies leaves them at risk of getting ill or even dying. Mykhailiuk said that flu and COVID-19 are a huge concern for the country.

Moreover, infectious diseases, cholera and dysentery are becoming widespread in the occupied territories, where Russian soldiers have slaughtered civilians and left them on the streets for the animals.

“Twenty percent of our territory is occupied,” Mykhailiuk told Health Policy Watch, “that is like the size of the whole of Bulgaria. We do not have access to these territories, but we know from witnesses the implications and we are recording the evidence.”

She said that in the city of Mariupol, located on the north coast of the Sea of Azov, the Russians were “killing people just for fun” and leaving them all lying all over the streets. “The animals started to eat them – the dead bodies in the streets. We were told the animals have gotten used to human meat.”

Mykhailiuk said many bodies remain decaying, their remains polluting the environment. Residents – the few that remain – have no access to drinking water, since the majority of the water infrastructure was destroyed. The sewage system is also not functioning.

“We know diseases are spreading, and there is no one to help them,” she said.

The MP called on the health community to help with desperately needed medical and other life-saving equipment. She said the country continues to have a shortage of medical supplies for chronic diseases, such as diabetes and for non-communicable diseases like cancer.

“These diseases are not put on hold because of war,” Mykhailiuk said. “So, people are dying. The death rate in Ukraine is now seven times higher than during the COVID-19 pandemic, and it is just because of natural diseases and because of stress.”

She said “any kind of medicine would be helpful … we have a desperate need for any kind of help.”

‘A black period of Ukrainian history’

A recent health needs assessment conducted by the WHO Country Office in Ukraine found that “spiraling costs, logistical hurdles and damaged infrastructure are making access to essential services all the more challenging for growing numbers of civilians.”

The survey found that one in three people living in temporarily occupied territories and active combat areas – in comparison to one in five people nationwide – had reduced access to services and medicines.

Specifically, around 50% of respondents said it was difficult to obtain medication for high blood pressure and for heart conditions. Another 41% of respondents said it was hard to access pain medication, 33% said it was hard to obtain sedatives and 32% said it was difficult to get antibiotics.

Mykhailiuk noted that local hospitals are looking for partner hospitals abroad to provide them with supplies. She highlighted a recent incident where an individual died during surgery because the power went out and there were no generators. The doctors could not complete their work with solely their surgical headlights.

Additionally, analyses by the World Bank and the United Nations Development Programme (UNDP) showed that the war could push 60% or more of the Ukrainian population below the poverty line.

“This is a black period of Ukrainian history,” Mykhailiuk said. “Only with international partners can we survive.”

She added that “time is of the essence” as winter races across the country and the cold weather threatens to take more lives.

“We will continue our resistance until we are victorious,” Mykhailiuk stressed. “We will not stop until we win.

“In these dreadful times, just having our bravery will not be enough,” she continued. “We see ourselves as defending the whole democratic community… The Russians should be held accountable, and international justice should prevail.”

Image Credits: Maayan Hoffman.

Spending on Health
A new WHO report shows rising health expenditure in 2020, the first year of the COVID-19 pandemic.

Spending on health increased worldwide by 6% on average in real terms in the year 2020, according to the World Health Organization’s latest global review of health finance.

The analysis found that global spending on health reached US$ 9 trillion in 2020, or 10.8% of global gross domestic product (GDP), but remains highly unequal across income groups.

But the 6% global increase is skewered by huge outlays in the United States, which is by far the biggest global health spender, said WHO’s Joe Kutzin, the head of WHO’s health finance team that authored the report.

In real terms, average country growth was more like 4% he noted in a series of Tweets following the reports publication.

And in contrast to previous WHO studies on health spending trends, this latest report only captures more detailed and granular spending patterns for 4 low-income countries and 11 middle-income countries. The remaining 29 countries analyzed are all high-income nations.

This means that global spending trends for health care remain difficult to analyse more granularly, WHO officials speaking at Thursday’s report launch event cautioned. With just 4 low-income countries reporting data, spending patterns in this income group in particular cannot be generalized.

“While we can put this together globally, to look at these patterns and trends, it’s not a substitute for the country-level work and analysis that’s needed,” said Kutzin. “We need to be careful in drawing conclusions about “the average country” given this limitation.

In contrast, a WHO study of data from 2018 found global health expenditures rose by 6% annually but noted that government spending on health in some poor countries was stagnant or even declining, with some pulling back funding due to greater reliance on donors.   A study of data from 2019 also found that high-income countries accounted for approximately 80% of global spending on health. 

Those report had more representative sample of rich, middle income and poor countries. But for the report released on Thursday, the interruptions in routine health system operations caused by the COVID pandemic made it difficult for low-income countries to report their data this year, leading to a heavy bias in findings in favour or rich countries, Kutzin and other panelists at the WHO launch event said.

“What we have for only 50 countries in 2020 is a detailed decomposition of spending by “health care function” (inpatient, outpatient, medicines, etc), and indeed it is skewed towards higher income countries,” said Kutzin in a follow up tweet. This underlines the need to improve data availability as the pandemic’s impacts wane.

More public spending possibly driven by the COVID response

Spending on Health
Government spending was the main driver of the increase in total health spending from 2019 to 2020. Per capita government spending on health increased in all income groups and rose faster than in previous years, according to the report.

In the countries where data was available, the growth in spending was largely driven by increased public expenditure, the report found.

​​”The whole growth of health spending is really driven by government spending,” said Dr Ke Xu, the report’s lead author. “This year it has grown much faster than previous years.”

While vaccines were not yet widely available in 2020, it is likely some of the increase in government spending was driven by the early stages of the COVID response. Early waves led to sharp increases in hospitalizations, a competitive dash for procurement of items from oxygen to PPE, and bidding wars over vaccine contracts.

Spending on COVID accounted for an average of 8% of public spending on health in 2020, but the type of COVID spending varies vastly among country income groups. 

“In high-income and some upper-middle-income countries, you have significant spending on treatment,” Xu said. “In low-income countries spending is mostly on other preventative measures.” 

These discrepancies are related to the capacity of countries of differing income levels to set up testing, contact tracing, and provide access to facilities and equipment capable of treating COVID patients. The data may also be influenced by the different approaches taken by countries to control the outbreak at the early stages of the pandemic when the nature of the virus was still unclear. 

Conversely, out-of-pocket spending per capita fell during the first year of the pandemic, which may reflect reduced health service utilization of out-patient services. Fear of the virus may have encouraged many patients to stay away from hospitals or seek care for basic illnesses, while many health systems were overwhelmed by the weight of the pandemic, leading to reduced capacity to treat other patients.

There was also increased government support for items like free PCR diagnostics for people with suspected COVID, potentially lifting financial weight from individuals. The team in charge of the report stressed that further research is needed to understand the whats, whys and hows behind the datasets provided. 

“We raise issues, and there are clearly hypotheses or questions that might arise from the data,” Kutzin said. “It’s our job to help sharpen those questions, but not really answer policy questions. It is more to provide a foundation so that those questions can be answered.”

Low income countries increased health spending 

While the sample size of low-income countries’ spending was limited to just 4 nations, the report tracks other finance indicators across a larger share of developing countries. Among them, health spending as a share of total government expenditure increased from 2019 to 2020 in all income groups except high income countries. 

This presumably reflects the greater resources countries had to allocate to COVID response. The spending increase is a welcome development, but panelists warned it is not guaranteed to be a sustained one.  “In times of crisis, governments find the money,” Kutzin said. “The challenge is to sustain that over time.” 

And among the poorest countries, private, out-of-pocket spending increases comprised the largest share of the pie. 

Low income countries continue to rely heavily on external aid to finance health spending.

Little change was observed in external aid funding levels, but it continued to play a critical role in funding health systems in low-income countries. The report found external aid accounted for 29% of health spending on average in the low-income countries that provided data, the same as in 2020. 

Per capita health spending derived from external aid increased by US$0.70 to $10.80 on average, slightly higher than government spending in these low-income countries, which sits at $9.20 per capita. 

Health priority rose sharply in low, lower-middle and upper-middle income countries in 2020

The report also noted the continued gap in spending on primary health care versus outpatient care between country income groups. WHO’s 2021 report found primary health care spending for low-income countries sits around 70% of total health spending, while in middle and high income countries, this is reduced to around 50% and 40% respectively. 

“In low-income countries, most of the spending goes to prevention, while in upper-middle income countries outpatient services take a large share of total government and donor spending” Xu said.

Prevention services include population-based services such as information campaigns like brochures or public messaging campaigns, epidemiological surveillance and individual services like immunization, and condition monitoring. 

Study first to include social spending as part of health spending 

Health priority rose sharply in low, lower-
middle and upper-middle income countries in 2020, the report found.

What the WHO finance report lacks in representative data-sets it makes up for in innovation. The 2022 report is the first to consider government spending on social programmes as a factor contributing to overall health outcomes. 

“Government spending on health does not exist in a vacuum,” the report said. “Health outcomes are also shaped by other social spending, particularly on education and social protection.”

The panel defined social protections as in-kind benefits provided to in-need individuals and households. These include standard benefits such as disability, sickness, and child support payments, and transfers and services provided on a collective basis in the form of pension schemes, unemployment assistance or public housing. 

“We saw in previous years that even if the share of health and overall government spending fell, it didn’t necessarily mean that health was losing its priority because social spending is also good for health,” Kutzin said. “For WHO it’s a big challenge, and not typical for us to stop beyond our sectoral silo, but I think this is important.” 

While Kutzin stressed the WHO is not planning to become experts in social protections, the added scope of the report aims to acknowledge that medicines and hospitals are not the only contributing factors to health outcomes in a given country. 

“Health outcomes are also determined by other social and economic sectors,” Xu said. Sometimes, a roof over someone’s head or an accessible education in health literacy can be just as impactful to improving a life as providing disease screening services. 

Updated 9 December 2022 with further clarifications from WHO about the features of the global dataset. 

Digital health
Panelists at a digital health session at this week’s UNITE Global Summit in Lisbon.

Digitalization of health services and systems needs to be approached holistically, and take a rights-based approach to services that makes access more equitable, not less so. These were two themes that emerged at a session on ditigal health as an enabler of universal health coverage at the UNITE Global Summit 2022, In Lisbon, Portugal this week. The Summit, from 5-7 December brought health-focused parliamentarians from countries around the world together to see how they might use their legislative clout more effectively to advance global health goals.   

Achieving universal health coverage by 2030 is part of the global SDG agenda and digitalisation could play a key role that goal, Dr Christoph Benn, the director for global health diplomacy at the Joep Lange Institute, Amsterdam, said at the panel session. 

But digital health trends could also increase inequalities, he warned. And that is something legislators need to be mindful of when initiating and reviewing digital health investments in their own countries. “There is a fast paced digital transformation that can increase the digital divide and leave more people behind. And I think our discussion is about how we turn that around to make sure that this really serves all people in need.”

Digital health
Dr Christoph Benn

Benn added that a global framework on data privacy, ownership and security is another issue that would be important for parliamentarians to tackle at national level and multilaterally.  Such frameworks are critical to build confidence in digital health systems that politicians support and people will actively use. 

“If you are asking me one issue where I feel, you know, parliamentarians can really make a difference, I think it is about legislating data governance principles in your various countries,” he said. 

In countries with federal systems of government, ensuring consistency in digital health platforms can be particularly complex because health systems, as well as related digital systems and regulations, may not be harmonized across different states or provinces, added Gisela Scaglia, a former member of parliament from Argentina.  This is yet another issue for parliamentarians to address. 

Political will is a main component in transformation of health systems in any country. However, it is equally crucial that civil servants and politicians approach and overcome technical challenges, step by step, said Luis Goes Pinheiro, a senior Portuguese Health Ministry official.  

He described, for instance, how Portugal has used European Union funding to strengthen telecom infrastructure that would be critical for digital health interactions with the nation’s health centres via peoples’ smart-phones and computers.  Infrastructure in about half of the 3,000 health services targeted have been improved over the past few years, he said, but many barriers have had to be overcome.  

Digital health
Luis Goes Pinheiro

“This is very challenging even for someone who’s been involved in the government,” he said, of the nuts-and-bolts issues that came up around strengthening health systems’ digital capacities. 

“In Portugal, we have 300 million Euros that we need to use by 2024,” he said. “So this is a major thrust there, but there are also headwinds all over the world. These are trying times when it comes to access to human resources, not just in the field of digital work. We need qualified people which are lacking and we need material resources. There’s been a breakdown in supply chains by the pandemic and made worse by the war in Ukraine.”

In addition, political will is not always as strong as it should be, he pointed out, and this is something that legislators can be mindful about: “Creating projects whose results will come in the long term is always very unsettling for the government. Sometimes politicians think short term, but these projects need to have short, medium, and long term perspectives. 

Legislation is needed to institutionalize digital practices established during pandemic   

Dr Marisa Aizenberg, a lawyer and researcher in public health at the University of Buenos Aires also flagged the need for new legislation to drive digital transformation in health in the post COVID era, to make improvised telemedicine systems established during the pandemic more permanent. “We have had many emergency laws to validate digital tools like distance care or remote care and others. So I think this is a true challenge, digital transformation. It does not have just to do with public policies, but it’s legal. Legal instruments are necessary for this transformation to take place.” 

Digital health
Dr Mariza Aizenberg

And while formulating rules and norms around digitalisation is important, it must all be based on a human rights perspective, she added. 

“Otherwise, legislation may even be widening the inequalities, widening the gap. And when I talk about reasonable costs, I’m thinking about what happens to people with disabilities that won’t have access to these health technologies. I’m also talking about gender perspectives and vulnerabilities (like children and senior citizens) and how these adjustments are so important to include all these groups.” 

Stressing the need to have proper legislation in place for data protection and citizens’ privacy, Dr Aizenberg said. “Any new legislation must be able to be adapted quickly to the changes that take place and create a single digital health system.”

Digitalization often in the Communications Ministry – not Health

Digital health is, however, a multisectoral issue, Neema Lugangira, a member of parliament from Tanzania said. And she underlined that many countries place this portfolio under the Information and Communication Technology ministry and not in the health ministry. That can, however, create barriers for fit-for-purpose digital health systems to flourish. 

“When we’re talking about digital health, there needs to be some sort of alignment between the ICT ministry and the Health Ministry. So one of the first things that can enhance our role as parliamentarians is to have this multi-sector approach.”

Digital health
Neema Lugangira

Along with a multi-sectoral approach from the government, Lugangira stressed the importance of viewing digitalisation of health on a continuum. In low- and middle-income countries in particular, this must begin with digital literacy, access to electricity and mobile connectivity. 

“We need to also look at their entire digital infrastructure. There’s access to electricity, access to just simple mobile connectivity and access to the knowledge and the skills (needed to use devices)…So if it’s digital health, how will that work? So we need to look at all of those things.”

Multilateralism on the agenda

To bridge the digital divide in developing countries like Mexico, developed countries must come forward to invest resources, said Sarai Nuñez Ceron, a member of parliament from Mexico, stressing the importance of multilateralism in digitalization of health systems. 

“Digital health should be a priority for the development of health systems everywhere in the world. This requires up to date dynamic regulations that can be a solid basis for the protection of people and also investment in innovation,” Ceron said. 

Matthew Kavanagh, Deputy Executive Director of UNAIDS called on Parliamentarians to close the global HIV funding gap.

This year, “Equalise” was chosen as the slogan for World AIDS day, observed 1 December. The theme is a call to action around the need to address the injustices that are fuelling the AIDS epidemic as pre-existing inequalities are exacerbated by the serious disruptions to health systems caused by the Ukraine war, COVID-19 pandemic and global economic crisis.

New infections have increased in Eastern Europe, Latin America, the Middle East, and Asia, a continent where cases had long been falling. Across the board, Global South countries have been disproportionately impacted.

Young African women are at particularly high risk. In the Sub-Saharan region, 6 of every 7 new infections are among adolescents girls aged 15 to 19. Vulnerable populations such as gay men, people who inject drugs, sex workers, and prisoners remain the key at risk demographics.

“We are deeply worried about where we are in the AIDS response right now,” Matthew Kavanagh, Deputy Executive Director of UNAIDS said. “We still see the vast majority of new infections are happening in the Global South. This is the legacy of years of insufficient progress on North-South inequalities we know are actually growing.”

Cutting-edge treatments remain out of reach for LMICs

A new drug designed to prevent HIV infection is now available in the comfort of London, Paris, or New York, but has yet to arrive in the Global South. These long-acting injections can help prevent HIV infection if taken every two months.

But the cost of the drug precludes it from being an option in areas with fewer resources. Without this medication gaining traction in the Global South, many will still be at risk of contracting the virus.

The lack of access to this new breakthrough is not the first example of HIV treatments being out of reach for Global South countries. Until a few years ago, more people in North America were receiving pre-exposure prophylaxis (PrEP) than in the entire African continent, where the majority of new infections occur.

“We need to ensure that we actually make these medicines available,” Kavanagh said. “That means making them generically. It means producing them in Africa, Asia, Latin America and around the world to ensure access and affordable prices.”

Kavanagh also stressed the importance of decriminalization, stressing that countries that avoided highly criminalized approaches have fared far better over the last decade than those that maintained legal penalties.

Closing the funding gap is critical

Underfunding for HIV programmes in low and middle-income countries has left a gap of $8 billion for 2021 in HIV support. A steep figure at first glance, it is a drop in the bucket in comparison to global economic budgets.

“That $8 billion is very achievable,” Kavanagh said. “We need a push from parliamentarians in the north and in the south to ensure that this funding actually becomes available. In a moment of economic crisis, this matters the most.

“Only with access to this life-saving medication can a real effort be made to tackle HIV/AIDS-related inequalities,” he concluded. “If a larger population can access this HIV prevention injection, then a real change can be made and help save lives around the world.”

Hassana Sa-adu with her children, holds a free mosquito delivered to her household during a door-to-door mosquito distribution in Gabasawa in Kano State, Nigeria.

A massive campaign is underway to distribute at least 8.8 million nets to 16 million residents of Kano State in Nigeria to prevent malaria

Morning sunlight, bright as a dazzling diamond, sets Mazangudu village in Kano, northern Nigeria, awake. Motorcycle rumbles mix with the boom of microphones calling Muslims to salat prayer. A gentle breeze tickles the green leaves of nearby neem trees, easing the rising warmth with its chill.

Behind the curtain of a one-room bungalow, a whisper, a cup of tea, and a smile pass between Yau Mustapha and his wife. Fourty-five-year-old Mustapha gulps the dregs of the tea in his ceramic cup before heading out with his motorcycle. As he rides through Mazangudu, a small farm settlement, mud huts and fumes unfurl behind his stretched shadows.

Thousands of volunteers

The settlement is a blend of mud huts and cement-walled houses. The mud huts are roundly shaped and made of colored clay. Its thatched roof, spread out like a beach hat, is made of dried millet stalks, stringed into a firm shape. 

Once settled, Mustapha consults with the rickshaw puller, the educator, and security, all members of his team. Now, they move from house to house, waking residents with an echo of their greetings and a hard tap at the door. “Peace be unto you,” he shouts routinely. “We are to deliver nets to you and your family, so you are fully protected from malaria.”

Mustapha is not alone. Across Kano, for a period of two weeks, thousands of trained volunteers would distribute insecticide-treated mosquito nets to millions of Kano residents. 

“These nets will help my people; they will protect them,” says Mustapha. Residents in Mazangudu believe the chances of a pregnant woman and her children surviving sudden malaria fever attack at midnight are slim. “Many have died as a result of malaria situations,” says Ibrahim Salie, an herbalist in nearby Gwaza.

Salie says the community sometimes relies on herbs to manage malaria infections, but the outcome is always a gamble. Unfortunately, the nemeses of Gwaza and Mazangudu are not one-offs. Nigeria, with over 200,000 malaria deaths annually, accounts for more than a quarter of all cases in Africa. The highest burden occurs in northern states like Kano, where poverty, combined with widespread apathy and poor sanitation, increases the risk of infection.

Problematic pregnant women?


Mustapha Yau, a mosquito net mobilizer and distributor giving a beneficiary mosquito nets in Gabasawa, Kano.

One sunset in late September, Mustapha’s wife, a health worker in a nearby village, narrated her experiences with malaria infecting pregnant mothers. 

“My wife told me that malaria in pregnant women can be more violent and problematic,” says Mustapha. Many nights later, the burden of that single story remained with Mustapha. After a radio jingle announced the upcoming net campaign a few weeks ago, his wife pursued him to enrol as a volunteer.

This morning, as he sets out to distribute the nets from house to house, a warm goodbye and smile pass between him and his wife, who wore a long yellow veil. Mustapha is expected to distribute at least 2,800 insecticide-treated mosquito nets to hundreds of households within a period of two weeks. In all, more than 8 million nets will be distributed in Kano to at least 16 million residents.

Only two days of the two weeks have passed. However, Mustapha can attest to the dramatic shift in his fame as well as the immediate use of the nets after only two days on duty. “My wife is very happy. She is happy to see her husband greatly involved in an important campaign.”

Better than traditional remedies

Mazangudu’s residents say the nets are twice as helpful to them as they might have been to any other community because there is no single health facility to cater to the many malaria cases. And when these malaria attacks come by midnight, the only option is to offer traditional remedies and pray. In some cases, the infected person dies before dawn.

With financial backing from The Global Fund, this year’s campaign, arguably the largest in Africa, aims to distribute at least 8.8 million nets to 16 million residents of Kano, one of the largest cities in Africa. 

“Kano is crucial because of the size. Kano, because of its population, looks like a country. If you are fighting malaria and Kano is not in the plan, it is a waste of time,” says Ernest Nwaokolo, the project director for the Global Fund Malaria Project of the Society for Family Health (SFH). 

SFH’s John Ocholi, who is the manager of the 2022 nets campaign in Kano, says that the state has 44 local governments and 484 wards. 

“We are working with over 20,000 personnel, which is the most for any Nigerian campaign. It is a large team, drawn from various partners and parts of the country. It takes a lot of experience to pull together to achieve this. We had advocacy visits to the government of Kano State, traditional rulers, and religious bodies in an effort to pull them into the campaign.”

Delivery: from camels to canoes

Ismail Yusuf and Awalu Iliasu inspect the offloading of mosquito nets bales.

Educators trained in behavioral change communication work closely with the house-to-house distributor team. Before the nets are distributed to the households, each family has a brief discussion about net apathy, proper use, trading, and maintenance. More so, community and religious leaders, often revered and obeyed, have been engaged as partners in spreading and reinforcing the net-use messages.

Kano has proven to be a bigger puzzle from a logistics point of view. In the absence of precise figures, Chemonics, a global consulting firm that manages logistics for the campaign, says thousands of vehicles and personnel were involved. It is like a pyramid. Nets are moved to local government areas on larger trucks and trailers. Next, the nets are then transported from local government areas in smaller vans and mini trucks. Roads to communities are often narrower and, in some cases, untarred, making smaller vans more suited for moving nets.

As the nets move from house to house, the options for transporting them become more diverse and adaptable. In some desert communities, where the risk of sandstorms is higher, and cars sink in sand, camels, donkeys, and cow-carts have been deployed to move the nets to households and between settlements and communities. In a few riverine areas, canoes and paddlers are used. In areas pockmarked by mountains and hills, engage porters. 

Each distributor is trained and handed a mobile device with an app that allows them to enter records of the number of nets issued per household, the coordinates of the area, and the names of the recipients, often the household head.

Digital tracking

The data is then uploaded to a central database, which is monitored and analyzed every evening to ascertain the number of nets distributed for the day, absentees, and locations covered. Organizers receive real-time updates from all over Kano. 

“There is real-time tracking and monitoring of all data in the field.” It is easier to dictate areas where there are issues that deserve urgent attention. It is also faster than using papers and tally sheets. “It makes it easier to provide evidence and verify the work done,” says Asuni.

The technology is also designed to flag areas where there is unusually dense or sparse net distribution. When such issues are flagged, monitors are sent to the flagged locations to verify the situation on the ground.

On paper, the process sounds smooth, but Asuni says that the Kano campaign presented a couple of familiar issues. Many volunteers are not computer literate and frequently struggle with basic device setup. Secondly, limited network coverage, especially in rural communities, means that data uploads to the central server are delayed and backlogged. Volunteers undergo intense training on device use.

Aisha Aliyi Danyar, a mobilisation and distribution team member, is receiving training in Gabasaw LGA, Kano, Nigeria, on how to engage beneficiaries in mosquito net distribution.

However, not every ambition can be squeezed into the short timeframe of the net campaign. There are still minimal concerns that net collection is rarely equivalent to use. Some residents say the nets restrict their breathing and have limited ventilation. Myths that link white nets to corpses also build stereotypes that hinder net use.

“Fixing these issues can be gradual and long,” says Nwaokolo.

Back in Mazangudu, the fruits of Mustapha’s work are instant. Families, who received the nets a few days ago are already putting them to use. They say these nets, more than ever, will ease their burden. The fame of Mustapha grows with every new inch he covers. “My people see me as a hero,” he says. But it’s not the heroism that makes him happy; it’s the lives that will be saved and the medical bills that will be avoided. “This net distribution has brought excitement. “The people are grateful,” says Mustapha. “And no amount invested in mosquito nets is too big. To save a single life is worth more than millions, for we really do not know what the children we are saving today might turn out to be in the future.”

Better than a wedding

When Aisha Lawal, 35, had to choose between attending a friend’s wedding and staying behind to pick her nets, it was an easy choice. “I didn’t want to miss [the nets],” she says. “If I choose weddings over nets, how would my household sleep peacefully? I have been expecting the new net since two days ago.”

Aisha and her family of eight live at Sabon-Gari, Gabasawa, on the outskirts of Kano metropolis, where malaria is rampant. Long lines form at health centers from time to time, she claims. Her own family is also exposed. The last set of nets that came to them three years ago are discolored, torn, and pockmarked. 

“Receiving these nets feels like I have been given at least 1 million naira (local currency). Everyone craves rest after toiling all day. Without the net here, one can rarely get that desired rest. Mosquitoes are an enemy of good sleep. And without a good sleep, I wake up feeling sick.”

As the interview unwinds, Aisha cuddles her baby, Nasiru Yusuf, closer to her ribs, allowing him to wriggle his feet around her waist. He thumped her blouse, trying to get into her nipple. Seeing his attempts ignored, Nasiru Yusuf, began to sniffle and kick. He is prone to malaria, as are the rest of the kids. She hopes that the new nets will reverse the trend and save on medical bills.

Aisha Lawal with her child, holds free mosquito delivered to her household during a door-to-door mosquito distribution in Gabasawa, Kano, Nigeria.

Aisha is impressed by the format adopted in this campaign. She thinks the house-to-house approach is more efficient than the past model of depositing the nets in a pickup center. More than eight million nets are expected to reach at least 16 million residents in this year’s campaign, making it arguably the largest ever in the world.

But she has one bright idea, which might create a bigger impact. Women, she says, are the health managers of their families. In northern Nigeria, where most rural women are uneducated, Aisha says households’ handling of malaria, despite the nets, can be compromised. 

“More mothers need to be educated. The more education mothers have, the more they can play a role in their family’s health. Mothers are the protectors of the family. Once women are empowered, the communities will remain healthy,” she says.

Deadly malaria

Each night, as Yusuf Basira closes her eyes to sleep, she dreams of Maila Baila, her two-year-old child laid to rest a few weeks ago.

“I always remember him,” says Basira, her face lowered to conceal her dark eyeballs, which have grown red and teary. 

In the morning of 25 October, Maila Baila experienced a severe malaria fever, which marked the beginning of his death. Basira took her child to Khalifa Sheikh Isyaku Rabiu Paediatric Hospital after two failed attempts at nearby primary health centers to stabilize him. The pediatrician diagnosed severe malaria, which resulted in multiple convulsions. A few hours after their arrival at the hospital, Maila’s body grew cold, and his eyes lost light. The doctors confirmed his death.

Basira is among the 16 million residents of Kano who will benefit from the 2022 net campaign, which aims to provide more than eight million nets for households in the state. As she receives the nets, nostalgia returns, bringing with it regrets but also lessons.

Prior to Biala’s death, she believed that malaria, though common and costly, was not deadly. Her attitude towards net use was carefree.  She now has a new perspective, both from her past mistakes and the brief pep talk that is offered by the net distribution team.

“I didn’t have much knowledge about malaria prior to the death of my baby. I never expected it to cause the death of a child. I now know that malaria can cause severe fever, even to the extent of killing a child. I take each sleeping child to the net once it’s past 6 pm.

Reporting for this story was supported by the Global Fund.

Image Credits: Global Fund.

Fight the Fakes held an event in Geneva to highlight the dangers of falsified medicine.

There should be much harsher penalties, including homicide charges, for those who intentionally falsify medicine and include harmful ingredients, according to Kawaldip Sehmi, CEO of the International Alliance of Patients’ Organisations (IAPO).

Sehmi was speaking at an event hosted by Fight the Fakes Alliance in Geneva on Wednesday to highlight the global proliferation of fake medicine and the threat it poses to patients.

In October, 99 children died in Indonesia from cough syrup contaminated with anti-freeze chemicals.

The previous month, 66 children died in The Gambia – also from contaminated cough syrup. These tragedies echo the deaths of 12 Indian children in 2020 – from cough syrup that had been rendered poisonous after one of the ingredients was replaced by a toxic one.

Yet, said Sehmi, most countries treated falsified medicines as a commercial crime such as “product liability or negligence” when they should be treating it “in the same way as narcotics”.

“Trust is at the heart of everything. Patients have to trust that the product they’re getting is of the appropriate quality and safety,” said Pernette Esteve, who heads the World Health Organization’s (WHO) team on substandard and falsified medical products.

“Gaining the confidence of the public once you’ve lost it is very difficult. Think back to the COVID pandemic. Making sure that people trusted the vaccines, vaccine acceptability, was a key point.”

For 10 years, the WHO has been building a database of substandard (unintentionally defective) and falsified (deliberately altered) medicine to understand the scope, scale and harm.

From this database, the WHO has identified the three driving forces: lack of access to medicine, poor governance including corruption, and weak technical capacity, said Esteve.

The WHO’s response was based on “prevention, detection and response”, she added.

The extent of the problem

Stanislav Barro, Novartis’s global head of anti-falsified medicines, says that his company has confronted fake medicine in every region of the world.

The timely authentication of medicines was both the biggest challenge and the biggest opportunity to stamp out fakes, he said – but warned that it is “a very complicated process”. 

All the suspect samples have to be brought to a place where they can be actually properly authenticated using forensic means,” said Barro.

However, almost 50 pharmaceutical companies were now sharing data via the Pharmaceutical Security Institute, and there had been a 38% increase in the incidence of falsified medicines between 2016 and 2020 in 142 countries, and incidence had surged in 2021 during the early days of the COVID pandemic.

“Basically, this is whatever the criminal organisations can make money with. It doesn’t really matter whether it’s falsified, tampered, stolen, illegally diverted. It’s a bit of everything, quite frankly,” added Barro, noting that it usually meant “terrible news for patients”.

“We need to find solutions to leverage digital technologies to localise authentication, identify falsified medicines and make that timely. Cut down these timelines from weeks to basically days, hours if possible, and accelerate the reporting to local authorities and to the WHO.”

Policing raw materials 

Sireesha Yadlapalli, vice president for international government and regulatory affairs for United States Pharmacopeia (USP), called for more policing of raw materials.

Medicines are made of two components, the active pharmaceutical ingredients (API) and the inactive ingredients or excipients, including reagents, solvents and items related to the taste or look of the product.

There was less stringent policing of the excipients, and these were often where problems arose, Yadlapalli said.

“There might be an issue with an ingredient but the manufacturer may not know about that particular issue because he just took the supplier’s word and certificate of analysis at face value, and that’s because raw materials are not being tested when they’re accepted from suppliers,” she added.

“Manufacturers need to test the raw materials. Regulations should be put in place requiring testing of these raw materials.”

Improving regulatory systems

Members of the International Generic and Biosimilar Medicines Association made up to 80% of quality-assured medicines around the world, according to its general secretary, Suzette Kox.

“We think that the biggest challenge is weak healthcare systems which includes, of course, the insufficiently resourced regulatory system and quality control. Most countries around the world do not have proper regulatory systems in place, and also no proper competition policies.”

Oksana Pyzik, who lectures at the UCL School Pharmacy, said that one of the biggest challenges is a lack of public awareness. 

Pointing to the proliferation of online medical supply outlets during COVID-19, Pyzik said that many patients didn’t know how to verify legal online pharmacies.

“Pharmacists are the last line of defence before patients received those medications and take them home with them. And there’s a real opportunity there for patient education as part of wider public awareness,” she said, adding that this was why educating pharmacists about falsified medicines was essential.