Drug regulatory authorities of Switzerland, the Republic of Korea and Singapore have become the first three countries to be listed as WHO-Listed Authorities (WLA) and can be used as a point of reference for the approval of new drugs and vaccines.

The drug regulatory authorities of Switzerland, the Republic of Korea and Singapore have become the first three countries to be listed as WHO-Listed Authorities (WLA) that can be used as a point of reference for other countries’ deliberations on approval of new drugs and vaccines.

The WHO’s recently established WLA framework is intended to create an evidenced-based pathway for regulatory authorities operating at an advanced level of performance to be globally recognized.

The overall aim is to provide a point of reference for other national authorities in their consideration of new drugs for approval. This can help promote faster and more robust regulatory reviews in other countries of new, and potentially significant medical products that some national authorities may not have the resources to evaluate thoroughly on their own.

Traditionally, WHO as well as many low-and middle-income countries looked to the regulatory decisions of the US Food and Drug Administration (US FDA) or the European Medicines Agency (EMA) for guidance in their own national approval of new drugs and medicines.

However, the reference to the US FDA and EMA has always been informal and relatively ad-hoc.

WLA label creates a more systematic pathway for international recognition

The newly created WLA label aims to correct this by creating a more systematic pathway to international recognition for a national regulatory agency. That should signal to other countries that the agency meets WHO and other internationally recognized regulatory standards and practices.

A technical advisory group on WHO-Listed Authorities (TAG-WLA), which met for the first time in September at WHO headquarters in Geneva, made the designations based on a set of criteria established for the WLA framework. The group’s key task is to provide independent, strategic, and technical advice to the WHO as it decides who to add to the WLA. The group has 14 members from the six WHO regions with a broad range of expertise.

Asked by Health Policy Watch why the FDA and EMA hadn’t been granted certification yet, a WHO spokesperson said, “several stringent regulatory authorities (SRA) already initiated discussions with WHO on the process towards WLA.”

But the spokesperson added, “The decision to apply for evaluation and listing as a WLA is voluntary, and no selection is conducted by WHO; rather, it is initiated by or on behalf of the regulatory authority (RA) if satisfies one of the criteria.” They are:

  • The RA is on the list of transitional WLAs (tWLA).
  • The RA has attained at least overall Maturity Level (ML) 3 as determined through a formal benchmarking against the WHO Global Benchmarking Tool (GBT).

“Once eligibility is confirmed, the RA must undergo a performance evaluation process,” the spokesperson added, noting that the process is further described in a new Operational Guidance.

WLA designation applies to medicines, not medical devices

The WLA framework is currently only applicable to medicines [including multisource (generics), and new medicines (new chemical entities) and/or biotherapeutics and/or similar biotherapeutic products], and vaccines. Medical devices, including in vitro diagnostics, as well as blood and blood derivatives are not in the scope of the WLA, WHO said.

The newly WHO-certified authorities include the Health Sciences Authority (HSA), Singapore; the Ministry of Food and Drug Safety (MFDS), Republic of Korea; and the Swiss Agency for Therapeutic Products (Swissmedic), Switzerland. The listing indicated that the regulatory authority has complied with all the indicators and requirements specified by WHO.

“This achievement is the result of investment by the Governments of the Republic of Korea, Singapore and Switzerland in the strengthening of their regulatory systems and reaffirms the collaboration between WHO and the three Governments in promoting confidence, trust and further reliance on authorities that have attained this global recognition, through the transparent and evidence-based pathway for designating and listing of WLAs,” said Dr Yukiko Nakatani, assistant director-general for Access to Medicines and Health Products.

Although the WLA designation will provide a pathway for other countries in deliberating regulatory decisions, the WHO spokesperson  stressed that “the ultimate responsibility and decision for using or adopting the regulatory decisions taken by a WLA resides with the users (e.g., other regulatory authorities, procurement agencies) and will depend on the specific context and scope of its intended use.”

Image Credits: Unsplash.

 

People’s exposure to heat is increasing in Ethiopia due to climate change, which is also causing water shortage.

Heat is the deadliest of extreme weather events, and heat-related mortality could be 30 times higher than previously thought, killing 500,000 people annually between 2000 and 2019.

Yet only half the world’s governments have heat warning services, less than a quarter (23%) of health ministries use meteorological information to monitor climate-sensitive health risks, and only 26 countries have climate-informed, heat-health early warning systems.

These are some of the key findings of the 2023 State of Climate Services Report, prepared by the World Meteorological Organization (WMO) and partners, which was released on Thursday.

In assessing progress made in climate services for health globally, the report finds the health sector “ill-prepared to safeguard society”.

Addressing the report’s launch, WMO Secretary-General Prof Petteri Taalas said that, by the latter part of this century, “we are going to face very severe combined heat and humidity stress cases, especially at low latitudes”.

Prof Petteri Taalas, WMO Secretary General

Taalas added that, typically, during heatwaves, air quality was also poor: “When we had the 2003 heatwave Europe, there were 75,000 casualties and a large part of the deaths were related to poor air quality as we had a fairly high concentration of surface ozone.

“During these kinds of events, especially in urban areas, we also have challenges with ultrafine particles. That was the case in 2010, when Russia was facing a heat wave and 50,000 people died. There was also fairly poor air quality due to forest fires and peat fires, and we faced a similar situation in Canada this year,” said Taalas.

“And we know from the most recent IPCC [Intergovernmental Panel on Climate Change] report that practically the whole world has been experiencing an increase of heat waves. About half of the planet has been facing increased flooding events and a third has faced drought,” he added. 

Climate impacts on health

World Health Organization (WHO) Director-General Dr Tedros Adhanon Ghebreyesus said the report “highlights the need for tailored climate information to support the health sector on a wide range of functions from heat health warning systems to mapping the risk of infectious diseases”. 

“It also calls for more to be done to prepare the health community for future shocks and pressures due to climate variability. Going forward, we must work together to make high-quality climate services available to all communities and support the health and well-being of people facing the impacts of climate change,” added Tedros.

Maria Neira, WHO’s Director of the Environment, Climate Change and Health, said that the data generated by the WMO and partners was key in assisting the health sector.

“If we use this very powerful data, and we put it at the services of the health care system, we can be better prepared to respond and prevent events from heat waves to other extreme weather events to drought, to potential outbreaks of infectious diseases,” said Neira.

Joy Shumake-Guillemot, Lead of the WHO/WMO Joint Climate and Health Office at WMO, summarising some of the report’s key findings.

Joy Shumake-Guillemot, WHO/WMO Joint Climate and Health office lead, detailed the “wide and varied” impact of climate on health, from the spread of infectious diseases such as dengue and malaria to impacts on food systems and air quality.

But she said one positive is that health has become a policy priority within the national climate policies in almost all countries and there is a “huge opportunity” to bring together climate adaptation and climate science to “help inform the decisions and policymakers to prepare communities that are vulnerable to climate change worldwide to adapt to the health risks”.

As usual, lack of finances is a problem. Currently, just 0.2% of total bilateral and multilateral adaptation finance supports health-focused projects. 

Fiji is vulnerable to sea levels rising and floods, exacerbating waterborne and vector-borne diseases.

The report includes case studies of successful partnerships between health and meteorological services. In Fiji, for example, the Ministry of Health and the meteorological services have data-sharing agreements to track waterborne and vector-borne diseases as the country battles with sea level rise and extreme weather events.

Argentina’s public institutions have been working with their research community to develop evidence-based public warnings for extreme heat for specific locations and populations. 

“In the first year of the launch of this heat-health early warning system, Argentina has launched 987 alerts across the country that have helped their public services and their communities to better prepare for the heat season,” said Shumake-Guillemot.

Meanwhile, in Europe an estimated 40 million people suffer from seasonal allergies and the region’s AutoPollen project predicts, detects and reports pollen concentrations in real time to doctors, patients and allergy patient associations via an online system and mobile app.

Way forward to COP28 and beyond

“Despite examples of success, data shows that the health sector is under-utilizing available climate knowledge and tools. At the same time, climate services need to be further enhanced to fully satisfy the health sector requirements,” the report notes.

Meanwhile, Neira told the launch that health is firmly on the agenda of the next global climate meeting, COP28.

“There will be a special ministerial high-level roundtable and the first-ever health day at COP28,” said Neira.

“This is not only to raise the voice of the health community to explain how bad [climate change] is impacting our health, but to ask for more action and to demonstrate that the health community is now very much into the political agenda and in pushing for the reduction of emissions and adaptation,” she added.

Wellcome Trust’s Madeleine Thomson, head of impacts and adaptation, predicts “a tsunami of demand coming to the climate community for climate information relevant to health”. 

“At the moment, we do not have a well-developed health community that is capacitated to ask the right questions, seek the right partnerships, and engage effectively,” said Thomson, but added that a lot more could be done to bring the health and climate communities together.

Image Credits: Oxfam East Africa.

Gaza Palestinian arrives in Egypt via the Rafah border, opened for the first time to the exit of critically wounded and ill since the start of the Israeli-Hamas conflict.

WHO’s Director General Dr Tedros Adhanom Ghebreyesus repeated calls for a “humanitarian pause” in the fierce fighting between Israel and Hamas-controlled Gaza to allow for the resupply of Palestinian hospitals in Gaza, and treatment of injured and ill, saying “we are running out of words to describe the horror.”

Speaking at a press briefing Thursday, Tedros welcomed Egypt’s agreement Tuesday to open two northern Sinai’s hospitals to critically ill or injured Palestinians, but noted that so far only 46 people have so far managed to cross over for treatment.  Three field hospitals to be set up in Gaza are also in the planning now to handle the humanitarian emergency. But implementation would depend on safe passage arrangements. And such facilities cannot replace regular services, Tedros stressed, noting that 14 out of 36 hospitals in the Gaza Strip are not functioning right now.  

Meanwhile, while the world’s attention is focused on Gaza and Israel, Sudan’s health system is also cracking under the strain of more than 7 million internally displaced people – one of the largest in the world, said WHO’s director general in his remarks.

“The already fragile health system is buckling under the load of injuries, outbreaks, malnutrition and untreated cases of diabetes, cancer and cardiovascular, kidney and respiratory disease,” Tedros said. “In addition to measles, rubella, malaria and dengue, outbreaks of cholera have been declared in three states.”   

Horror still unfolding

WHO Director General Dr Tedros Adhanom Ghebreyesus at 2 November press briefing.

“Since Hamas’s horrific attacks on Israel, on 7 October, more than 10,000 people have been killed. including more than 8500 in Gaza, and 1400 in Israel,” Tedros said. “In both Israel and Gaza,  Some 70% of those killed are women and children. More than 21,000 people are injured and more than 1.4 million people in Gaza have been displaced. 

Despite the rising calls for a “humanitarian pause” including from US President Joe Biden, the conflict showed no signs of letting up yet. Israeli ground troops appeared to be tightening their grip around Hamas strongholds in Gaza City, in the north of the enclave, backed by aerial bombardment.  Hamas missile attacks on Israeli cities continued for the 27th day, while in Lebanon, Hizbullah and Hamas stepped up pressure on Israel’s northern front, firing dozens of rockets into Israeli communities Thursday evening with a fiery direct hit in one city, Kiryat Shmona.  

“Everywhere…. death, destruction, loss. So far, WHO has verified 277 attacks on health care, including 218 in the occupied Palestinian territory, and 19 in Israel,” Tedros remarked. 

“The situation on the ground in Gaza is indescribable. Hospitals crammed with the injured lying in corridors…. Doctors performing surgery without anesthesia. Thousands of people seeking shelter from the bombardment. Families crammed into overcrowded rooms desperate for food and water.  Toilets overflowing and the risk of disease outbreak spreading and everywhere.

Flames and smoke billow during Israeli strikes in Gaza, which have caused an unprecedented level of destruction since the 7 October Hamas incursion into Israel.

“At the very least, we need a humanitarian pause in the fighting and ideally a ceasefire. We need unfettered access and safe passage agreed by both parties to ensure the security of access routes,”’” the WHO Director General warned. 

“Let me be clear, there can be no justification for Hamas’s horrific attacks on Israel,” he said referring to the 7 October surprise rampage by Hamas gunmen into 22 Israeli communities near Gaza that left over 1300 Israelis shot, burned or bludgeoned to death, while 242 men, women and children were taken hostage.

“I understand the grief, the anger and the fear of the Israeli people. I also understand the grief,  the anger and the fear of the Palestinian people,” Tedros said.

“WHO continues to call on Hamas to release the hostages, many of whom need urgent medical attention,” he added.  

“We continue to call on Israel to restore supplies of electricity, water and fuel. We continue to call on both sides to abide by their obligations under international humanitarian law. And we call on who[ever] can, to de-escalate this conflict rather than inflame it.”

WHO supplies delivered – but not reaching all parts of the enclave 

WHO health supplies delivered to Al Nasser Medical complex in the southern Gaza city of Khan Younis on 23 October, after a humanitarian corridor from Egypt opened up. Resupply to hospitals in northern Gaza has become virtually impossible since Israeli ground troops entered Gaza, WHO says.

So far, WHO has been able to deliver some 54 metric tons of medical supplies to Gaza since an emergency corridor opened from Egypt, at the Rafah crossing, said Tedros.  But he described this as a “drip feed” of aid in comparison to the scale required. 

“Before the seventh of October, an average of 500 tracks a day were crossing in together with essential supplies. Since the seventh of October, only 217 tracks have entered in total.  To sustain the humanitarian response on the scale needed, we need hundreds of trucks to enter Gaza every day.” 

And with fierce fighting underway in northern Gaza between Israel and Hamas for the past several days, resupply of many health facilities has been impossible, said Mike Ryan, WHO’s Executive Director of Health Emergencies.  

“Getting trucks over the border is one thing, getting them to the places in which they’re needed is another and that has not been facilitated that has not been supported, in fact, if anything quite the opposite,” he said. 

Over the coming months,  WHO is developing a plan to set up three field hospitals in Gaza, including one in the northern part of the enclave and two in the south, said Dr Richard Peeperkorn, WHO’s Jerusalem-based representative for the Occupied Palestinian Territories.   

Dr Richard Peeperkorn, Jerusalem-based WHO representative to the Occupied Palestinian Territories.

The field hospitals would be part of a $50 million operational plan, also including recruitment of specialized emergency medical teams from abroad (EMTs). 

Even so, “the focus is first and foremost, on supporting existing health facilities, strengthening and maintaining services and instituting a trauma pathway,” Peeperkorn underlined. “We are now in an ultra-emergency phase. But in this humanitarian response, we have to focus on supporting, making sure that the existing health systems will be able to deliver. 

“It would be really a bit delusional if you think that when a few EMTs from outside, or setting up a few hospitals, that we can supply appropriate or even a minimum level of health services for 2.2 million Gazans.

“To have, of course, this plan – to make sure it’s operational, we need, ideally, a humanitarian ceasefire.  But we definitely need  humanitarian corridors and then a sustained access to the needed supplies.”

Presence of Hamas centers under hospitals – irrelevant to obligation to protect them 

Al Shifa Hospital – 15 October. Emergency Medical Teams (EMTs) deployed in a tent outside the hospital, the largest in Gaza, to handle the surge of patients.

As for Israel’s assertions that Hamas has sited key military command and control centers as well as supplies, underneath some of Gaza’s major hospitals, particularly Al Shifa and Al Quds in the northern part of the enclave, Ryan said that this didn’t absolve Israel from the responsibility to shield the facilities from attack.  Israel has told the hospitals that they need to evacuate patients and staff to the south, in order to stay clear of the conflict. 

“The reality on the ground at Al Shifa and other hospitals is that we have thousands of health workers, thousands of patients, and probably hundreds of thousands of civilians sheltering at these multiple facilities particularly, and all over but in the north now,” Ryan said. “The rules are clear on this. Health care must be protected. 

“We know what’s going on above the ground. We deal with the doctors, the nurses and the administrators of the hospitals, and they’re crammed full of patients, ongoing operations, intensive care, and much much else.

“We have no information on what may be happening elsewhere, or underneath these facilities. That’s not information we would have or could verify.”

Mike Ryan, WHO Health Emergencies ED: Use of hospitals for military purposes is illegal, but WHO has no independent verification of the reports.

While Ryan acknowledged that any “misuse of facilities for military purposes is equally outlawed under international law… we have no independent verification whatsoever of any of the information.

“And in this situation where such an eventuality occurs, again, it is the responsibility of the occupying power to, not only agree with the local health authorities on an evacuation, but then if that does happen, that has to be fully facilitated, fully supported logistically, and those patients those doctors need to have a place of safety where the patients can receive an adequate and similar amount of care. None of those, none of those criteria are met.” 

Mental health trauma on both sides 

Burnt-out remains of a home at Israel’s Kibbutz Kfar Aza, near the Gaza border where 52 of the community’s 400 members were killed by Hamas on 7 October, and another 20 are missing or held captive.

Israelis as well as Palestinians are suffering the snowballing mental health effects of the ongoing revelations around the Hamas massacre on 7 October and ensuing war, said Peeperkorn as well as WHO’s representative in Israel, Dr. Michel Thieren. 

In Gaza, there is the lack of day -to-day access to basic necessities, as well as the constant risk of death from aerial bombardments, Peeperkorn observed. 

While UN staff are often considered “a bit more privileged than the other Gazans…  in many of my staff, they are completely desperate, utterly, utterly desperate, and utterly depressed, and no vision about life anymore.  And this is a group that a lot of people would call privileged, so think about the rest of Gazans.    

On the Israeli side, still-unfolding evidence of the rape, mutilation, or burning of many civilian victims of the 7 October Hamas incursion, has become seared in the collective Isareli consciousness. Along with that, are the concerns about the fate of the 242 hostages reportedly held by Hamas, including about 50 infants, children and older people, as well as women and men. 

“It’s a whole shadow of trauma that is spreading across the country, the survivors, the families of hostages, the witnesses of atrocities,” said Thieren, who has been quoted saying that in Israel’s Kfar Aza, near the Gaza border, he saw scenes “that I never saw in  Syria, Iraq, Sudan or anywhere else.”   

“The displaced populations, the hosting communities of those displaced people and survivors. I would even say, the decision makers, the whole country is plunged into a night of trauma, and the trauma spreads like a virus.” 

He noted that WHO’s European Regional Director Hans Kluge had just visited Israel to see the site of the 7 October mass killings first-hand, and discuss strengthened collaborations on mental health and rehabilitation.

Image Credits: WHO/EMRO, Health Policy Watch.

A climate early warning system in Zambia.

Wealthy nations are falling tens of billions of dollars short of their pledge to help climate-vulnerable regions adapt to a warming planet, widening an already vast gap in funding and leaving millions at risk, according to a new report from the UN Environment Programme (UNEP).

The report, released on Thursday, found that international financial flows for climate adaptation in developing countries fell to just $21 billion in 2021, down 15% from a peak of $25.2 billion between 2017 and 2020.

This is a fraction of the estimated cost of helping low-income countries adapt to the worst effects of climate change, which UNEP estimates to be 10 to 18 times greater than current levels.

The annual gap in adaptation financing alone is now estimated at $194 billion to $366 billion, an increase of 50% from the UNEP’s estimate from last year.

The $21 billion provided by advanced economies in 2021 is equal to just $3 for each of the 6.82 billion people living in the 152 countries classified as developing by the International Monetary Fund. 

Adaptation costs in climate-vulnerable countries will soar as the planet warms, UNEP warned, exacerbating the adaptation gap unless countries step up to provide funding.

“The world is sleeping on adaptation even when the wake-up call that nature has been sending us is becoming ever more shrill,” Inger Andersen, Executive Director of UNEP, said at a press conference on Thursday. “This year we saw temperature records again being broken. We saw more floods, more heat waves, more droughts, and more wildfires [inflict] misery upon very vulnerable communities.”

The UNEP report comes as the world heads into the final quarter of what is set to be the hottest year on record. The average global temperature on a third of days in 2023 has already exceeded 1.5C over pre-industrial levels. 

“The international community should be throwing billions of dollars at helping developing nations to adapt to these impacts – but it isn’t,” said Andersen.

The UNEP report also sets the stage for COP29, the critical UN climate summit to be held in Dubai later this month. World leaders at the two-week summit will attempt to reverse the current trajectory of global fossil fuel emissions, which is on track to warm the planet by 2.4C to 2.8C by 2100 under a business-as-usual scenario.

A study published in Nature on Monday found that the planet will be locked into a future over 1.5C in just under three years, in early 2029.

“Storms, fires, floods, drought and extreme temperatures are becoming more frequent and more ferocious, and they’re on course to get far worse,” UN Secretary-General Antonio Guterres said in a statement accompanying the UNEP report. 

“Yet as needs rise, action is stalling,” said Guterres. “The world must take action to close the adaptation gap and deliver climate justice.” 

Why is the adaptation gap widening? 

The adaptation gap – the difference between the amount of money needed to allow developing countries to adapt to climate change and the financing that governments have made available – is widening as the risks posed by climate change in developing countries escalate. 

Three main reasons explain the widening gap.

First, climate change is happening faster and with more severe impacts than previously thought. This means countries on the frontlines of the climate crisis need to do more to adapt, which requires more money. Fifty-five of the world’s most vulnerable economies have already lost over $500 billion to the climate crisis in the past two decades, according to a recent study.

“On the basis of the IPCC’s (Intergovernmental Panel on Climate Change) sixth assessment report, we anticipate higher impacts from climate change, even in the short term,” said Paul Watkiss, lead author of the finance section of the UNEP report. “Higher [climate] impacts means we have to do more adaptation.”

Second, international funding for adaptation is not keeping pace with the increasingly urgent needs of developing countries. International public adaptation finance fell by 15% in 2021, despite the proven economic benefits of investing in adaptation.

Every $1 billion invested in infrastructure to protect people from coastal flooding could save $14 billion in economic damages, UNEP found. And for every $16 billion invested in agriculture each year, 78 million people could be spared climate crisis-related starvation or chronic hunger.

The authors of the UNEP report attribute the drop in adaptation funding in 2021 to the financial pressures caused by the COVID-19 pandemic and the war in Ukraine. However, they also noted that the $3 billion lost is a drop in the ocean compared to the $194 billion to $366 billion that developing countries need.

“Our estimates of the costs of adaptation of increasing, and at the same time, the financing is at least plateauing, or even decreasing,” said Watkiss. “And so the gap widens.” 

Third, developing countries are reporting more accurate data on their adaptation needs, helping UNEP to better forecast problems it may not have had sufficient data to include in previous reports. 

As more data comes in, UNEP is able to quantify more needs, suggesting that the current UN estimate of the adaptation gap likely remains too low.

Unkept promises underline the scale of the adaptation funding gap

Action zone at the COP26 venue in Glasgow, Scotland where this rotating globe hanging from the ceiling reminds delegates of what they are trying to save.

Unfulfilled climate funding pledges from advanced economies expose the vast gap between rhetoric and reality in adaptation funding.

In 2009, advanced economies pledged $100 billion per year by 2020 to help developing countries mitigate and adapt to climate change. This pledge was reaffirmed in the Paris Agreement in 2015, but eight years later, it has yet to be fully met.

“The numbers are not that big: if you compare the $100 billion to the money that the United States spends on its military, and that was spent on COVID or to save its banks, this is peanuts,” Pieter Pauw, a co-author of the UNEP report told Reuters. “It is time for developed countries to step up and provide more.” 

At the COP26 climate summit in Glasgow in 2021, rich countries made another pledge: to double adaptation funding to $40 billion annually by 2025. But with the shortfall in adaptation funding already at $366 billion, this pledge is no longer sufficient.  

“Even if the promise that we made together in Glasgow in 2021 to double adaptation finance support to 40 billion per year by 2025 were to be met – and that doesn’t look likely – the finance gap would fall by only five to 10%,” said Andersen.

Timeline of the emergence of loss and damage in the climate negotiations, culminating in the historic agreement at COP27 last year. The agreement to establish a loss and damage fund is now under threat.

The historic loss and damage fund agreed upon at COP27 in Egypt last year is also in jeopardy due to financing disputes between rich and developing countries, Politico reported this week. 

The question of who should pay for the damages caused by climate change, which is disproportionately impacting developing countries, has returned to the forefront of international climate negotiations.

The United States and Europe, two of the world’s largest historical emitters of greenhouse gases, are facing renewed calls to be held liable for their disproportionate contributions to the problem.

The United States, which resisted calls for a loss and damage fund for decades, is reportedly ready to exit negotiations on the fund if language holding them liable for their disproportionate contributions to global greenhouse gas emissions is not dropped. 

The agreement on the establishment of a loss and damage fund at last year’s COP27 summit in Egypt provided hope that this contentious issue could finally be resolved. However, the recent impasse over the fund has raised concerns that it could be derailed, threatening a critical step towards climate justice.

“We’re at a breaking point,” Avinash Persaud, the lead negotiator for Barbados and aide to Barbados Prime Minister Mia Mottley, told Politico.

A breakdown in negotiations “will break COP,” Persaud added. “I feel that not enough people are sufficiently worried about that”.

Adaptation has limits

In Guinea, rural women form cooperatives where members learn how to plant a vitamin-rich tree called Moringa and how to clean, dry and sell its leaves. Used as medicine or a dietary supplement by societies around the world, Moringa also supports biodiversity and prevents soil erosion.

Adaptation measures such as early warning systems, sea walls, and mangrove restoration are essential for helping communities cope with the impacts of climate change.

Early warning systems help people evacuate ahead of extreme weather events, sea walls protect coastal communities from sea level rise and storm surges, and the restoration of natural ecosystems such as mangroves alleviates flooding and, in the case of Lagos, Nigeria, stops the city from going under water. 

But as the planet warms, warming seas and a rapidly changing climate are pushing these measures to their limits.

“The evidence is clear that climate impacts are rising and are increasingly translating into limits to adaptation,” said Henry Neufeldt, Chief Scientific Editor of the UNEP report. “Some of these may already have been reached.“

Hurricane Otis, which struck Acapulco, Mexico, in September 2023, is a prime example of these limits. The storm rapidly intensified from a tropical storm to a category 5 hurricane overnight, leaving residents off guard and meteorologists struggling to explain what happened.

Powerful hurricanes can normally be observed by meteorologists for weeks prior to landfall. But as the planet warms, sea levels are rising and storms are becoming more unpredictable, limiting the ability of early warning systems to reliably protect coastal communities from extreme weather.

In just 12 hours, Hurricane Otis’ strength more than doubled, reaching record wind speeds of 257 kilometres per hour at landfall. The residents of Acapulco had no time to evacuate, leaving 100 people dead or missing and wreaking vast destruction on the resort town.

“Every day, every week, every month and every year from now on within our lifetimes, things are going to get worse and not a single country in the world is prepared,” said Andersen. “We are inadequately investing and planning on climate adaptation, and that leaves the world exposed.” 

Adaptation: Essential for billions facing climate impacts, despite limits

Climate adaptation measures have limits, but they are essential for the lives and safety of billions of people around the world who are already facing the effects of climate change.

Every decimal increase in the planet’s temperature affects millions. Nowhere is the need for adaptation more acute than in Africa, where at least 15,700 people have been killed and 34 million affected by extreme weather disasters in 2023 so far, according to an investigation by Carbon Brief.

Meanwhile, more than 29 million people continue to face unrelenting drought conditions in Ethiopia, Somalia, Kenya, Djibouti, Mauritania, and Niger, and more than 3,000 people were killed in flash floods in the Democratic Republic of the Congo and Rwanda in May.

Debt-laden countries, suffocating under debt repayments that exceed healthcare spending, face a spiral of rebuilding, sacrificing basic needs, and losing lives if climate adaptation funding is not secured.

“Developing countries, poor countries that are really having difficulties having a balanced budget, will have to divest from education, from infrastructure, health, to simply feed some of their people and respond to major disasters and major catastrophes,” said Ibrahim Thiaw, Executive Secretary of the United Nations Convention to Combat Desertification (UNCCD). “This is the reality of the world today.” 

Projected annual deaths attributable to climate change in 2030 and 2050, according to the Intergovernmental Panel on Climate Change.

Without financial support to help regions adapt to climate change, front-line communities will face conflict and mass migration, Thiaw warned.

“What is left to a young Somali, Haitian, or Sahelian when there is nothing left? When there is no ecosystem to provide food, capital, or natural capital, what is left for them to do but flee?” Thiaw asked.

“People do not fight each other simply because they hate each other,” Thiaw said, on how climate change fuels conflict. “They fight because they are competing for survival.”

Even if global greenhouse gas emissions are halted tomorrow, the planet will continue to warm for decades. The International Energy Agency projected earlier this month that fossil fuel demand will peak by 2030 but remain constant through 2050, nowhere near enough to stop the planet from warming.

“That adaptation finance in the world is actually shrinking at a time when we are calling for a doubling of adaptation is actually quite remarkable,” Thiaw said. “Climate change is hitting more and more, and international climate finance is declining – so where are we going? What impact will it have on the poorest and most vulnerable communities?”

Image Credits: UNDEP, Joe Saade/ UN Women.

GARDP executive director Manica Balasegaram, whose partnership has led the trial.

The world may soon have a new antibiotic to treat gonorrhoea after a successful phase 3 trial of an oral pill, zoliflodacin, that was led and sponsored by a non-profit organisation.

The results were announced late Wednesday by the Global Antibiotic Research and Development Partnership (GARDP), which conducted the trial in collaboration with Innoviva Specialty Therapeutics.

The gonorrhoea bacteria – Neisseria gonorrhoeae – has slowly grown resistant to many classes of antibiotics, leaving injectable ceftriaxone in combination with oral azithromycin, as the last available recommended treatment for gonorrhoea globally.

In a 2017 World Health Organization (WHO) survey of 77 countries, 97% reported cases of drug resistance to common gonorrhoea antibiotics, while two-thirds reported resistance or decreased susceptibility to the last option for treatment with a single drug. Recent reports of emerging ceftriaxone-resistant gonorrhoea infections have heightened the urgency for new antibiotics.

Zoliflodacin showed “statistical non-inferiority” when compared to the standard regimen – and it is much easier to administer as it’s one pill rather than an injection and a pill.

Meanwhile, previous studies have shown that zoliflodacin is active against multi-drug resistant strains of Neisseria gonorrhoeae, including those resistant to ceftriaxone and azithromycin, with no cross-resistance with other antibiotics. 

“The outcome of this study is a potential game changer for sexual health,” said Professor Edward W Hook III, the study’s protocol chair and Emeritus Professor of Medicine at the University of Alabama in Birmingham, US.

“In addition to the potential benefits for patients with infections with resistant strains of Neisseria gonorrhoeae, the potential lack of cross-resistance with other antibiotics and the oral route of administration will simplify gonorrhoea therapy for clinicians worldwide.”

Gonorrhoea bacteria cells.

Non-profit ‘fix’

Gonorrhoea is one of the top three most common sexually transmitted infections with over 82 million new annual infections – mostly in Africa. If left untreated, it can also cause infertility in women, life-threatening ectopic pregnancies, pelvic inflammatory disease and sterility in men.

While the WHO designated gonorrhoea as a “priority pathogen”, no new treatments have been trialled in the past 40 years.

This is the first trial of a priority pathogen led by a non-profit organisation.

“Despite the extremely high public health value, there has been a lack of investment to develop new drugs for gonorrhoea,” said Dr Manica Balasegaram, GARDP’s executive director.

“The zoliflodacin programme demonstrates that it is possible to develop antibiotic treatments targeting multidrug-resistant bacteria that pose the greatest public health threat, and which may not otherwise get developed.”

Meanwhile, Professor Glenda Gray, GARDP board member and President of the South African Medical Research Council (SAMRC), said that “GARDP’s model can play a crucial role in helping to fix the public health failure at the heart of the global AMR crisis and is a significant step forward in the treatment of gonorrhoea”.

The trial involved 930 patients with uncomplicated gonorrhoea and included men, women, adolescents and people living with HIV. Around half the trial participants came from South Africa, with other trial sites in Belgium, the Netherlands, Thailand, and the US.

First-line treatment?

Sinead Delany-Moretlwe, principal investigator for the trial in South Africa

Prof Sinead Delany-Moretlwe, principal investigator for the trial in South Africa, said that the trial had been conducted under difficult circumstances during the height of the COVID-19 pandemic.

“The huge investment in HIV trial infrastructure has really given South African scientists the capacity to do trials in infectious diseases and to yield results that can be submitted to a range of regulatory authorities,” Delany-Moretlwe told Health Policy Watch.

While countries’ medicine regulators still need to grant approval for the drug, parties involved in the trial have discussed an implementation strategy – including whether zoliflodacin should be given as a first-line drug.

“Because it’s an easier drug to administer, if the cost is affordable, it makes sense to implement it [as a first-line treatment],” Delany-Moretlwe, research director of Wits RHI at the University of Witwatersrand in Johannesburg, South Africa.

“And ceftriaxone is not just used to treat gonorrhoea, so it is important to protect a class of drug that is used for more than gonorrhoea in terms of good antibiotic stewardship.”

Another factor in favour of using zoliflodacin for first-line treatment is that it has a unique mechanism that inhibits a crucial bacterial enzyme, which can also help to avoid the emergence of resistance.

Applying for approvals

“GARDP has the right to register and commercialise the product in more than three-quarters of the world’s countries, including all low-income countries, most middle-income countries, and several high-income countries,” according to a GARDP spokesperson. 

However, Innoviva affiliate Entasis Therapeutics has commercial rights for zoliflodacin in the lucrative markets of North America, Europe, Asia-Pacific and Latin America.

“Our aim is to provide sustainable access to an affordable product but we are unable to give further details at this time, as we move into negotiations with commercial partners,” a GARDP spokesperson told Health Policy Watch.

GARDP and Innoviva ST will apply for approval with the US Food and Drug Administration (FDA), and initiate registration activities in South Africa and Thailand shortly after FDA submission. 

“Once approval is obtained in these two countries, we will expand access to zoliflodacin through a process of collaborative approvals within a number of countries,” said GARDP, depending on “the public health need and on the epidemiological situation in each country”.  

Meanwhile, Innoviva CEO Pavel Raifeld said that treatment “could have a profound effect on how physicians approach gonorrhoea infections, as an oral alternative to an injection could improve patient access and compliance, as well as help reduce the increasing spread of antibiotic-resistant strains of the disease”.

The GARDP trial was funded with support from the governments of Germany, UK, Japan, the Netherlands, Switzerland and Luxembourg, as well as the Canton of Geneva, the South African MRC, and the Leo Model Foundation. It builds on a phase 2 clinical trial sponsored by the US National Institute of Allergy and Infectious Diseases (NIAID).

WHO-SEARO 76th Regional Committee Session in New Delhi
WHO-SEARO Regional Director Poonam Khetrapal Singh at the 76th Regional Committee Session in New Delhi, meeting this week in Delhi, where she announced that Bangladesh has become the world’s first country to eliminate visceral leishmaniasis or kala azar.

Bangladesh has become the first country globally to be validated by the World Health Organization for the elimination of visceral leishmaniasis or kala azar, as a public health problem.

VL, a life-threatening neglected tropical disease (NTD) caused by a parasite transmitted by sandflies,  affects some one million people worldwide every year, mostly in Southeast Asia and North Africa.

Bangladesh, India, and Nepal accounted for 70% of the global cases between 2004 and 2008. By 2016, Bangladesh and Nepal brought down the number of cases drastically while the burden in India remains relatively high. While death rates are relatively low, disfigurement of limbs, sexual organs, etc. create huge levels of disability among those untreated.

However, new diagnostics and tools have helped make big inroads in morbidity.

The country achieved the elimination target of less than one case per 10,000 population at the sub-district level in 2017. It has managed to sustain that progress despite the COVID-19 pandemic, leading to the WHO elimination milestone, said WHO Regional Director Poonam Khetrapal Singh speaking at the SEARO Regional Committee meeting ongoing in Delhi this week, where the achievement was announced. .

At the meeting the global health agency also noted that the DPR Korea has eliminated rubella and Maldives has interrupted transmission of leprosy – another NTD.

Maldives has not reported a leprosy case for more than five years now, WHO said, making it the first country in the world to officially verify interruption of transmission, through a concerted effort to reduce stigma and discrimination so that people infected could be diagnosed, treated and cured.

NTDs are a diverse group of 20 tropical infections that are common in low-income regions of Africa, Asia, and the Americas. They are also often under-researched and ignored by the research community and pharmaceutical companies. WHO’s NTD Roadmap aims to reduce by 90% the number of people requiring treatment for NTDs by 2030.

“Neglected tropical diseases like lymphatic filariasis, visceral leishmaniasis and leprosy, along with the threat to children and young people posed by rubella, require continued national leadership, commitment and collaborative action by countries and health partners worldwide,” said WHO Director-General Dr Tedros Adhanom Ghebreyesus, in a WHO statement. “These achievements will positively impact the lives of the most vulnerable populations now and in the future,” he added.

Image Credits: WHO.

Climate change: A firefighter fighting against a veld-fire at  Jeffreys Bay, Eastern Cape Province, Republic of South Africa

A group of international health organisations representing 46 million healthcare workers, has published an open letter to the COP28 president Dr Ahmed Al Jaber demanding an “end to the fossil fuel era” at the upcoming UN Climate Conference in Dubai (29 November-12 December). Al Jaber, is the United Arab Emirates Minister of Industry and Advanced Technology as well as Special Envoy for Climate Change.

Meanwhile, an official declaration set to be signed by the world’s  Ministers of Health at the first-ever  UNC climate conference “Health Day” makes no reference to the fossil fuel phase out at all. On the plus, side, the final version, seen by Health Policy Watch, makes reference to a “just transition” in energy consumption as well as the important of reducing air pollution – much of which is emitted from climate-polluting sources.

The letter organized by two civil society organizations, Health Care Without Harm and the Global Climate and Health Alliance, uses stronger language than the official declaration:

“Fossil fuel interests have no place at climate negotiations,” states the letter, signed by some two dozen heads of global and regional associations and federations of health workers.

It demands that “countries commit to an accelerated, just and equitable phase-out of fossil fuels as the decisive path to health for all” at the annual UN climate conference.

“Ending our dangerous dependency on fossil fuels will improve the health prospects of future generations and will save lives. Keeping the global temperature increase within the 1.5°C target of the Paris Agreeement.”

“A full and rapid phase-out of fossil fuels is the most significant way to provide the clean air, water, and environment that are foundational to good health,” the open letter further states. “We cannot rely on unreliable and inadequate solutions, like Carbon Capture and Storage (CCS), that extend the use of fossil fuels but do not generate the real and immediate health improvements which a renewable energy transition provides. False solutions like CCS risk making harmful emissions worse, straining the health of overburdened communities and delaying our progress toward meaningful climate progress.”

Exclude fossil fuel industry representatives from COP

Can fossil fuels give way to solar power? COP28 UAE’s host is a petrostate – where fossil fuel pressures are keen to slow or stop the clean energy transition.

Another key demand of the appeal is that fossil fuel industry representatives be excluded from climate negotiations.

“Fossil fuel interests have no place at climate negotiations…. Just as the tobacco industry is not allowed to participate in the WHO Framework Convention on Tobacco Control, it is imperative to safeguard global collaboration on climate progress from the lobbying, disinformation, and delays in favour of industry interests,” states the letter.

Last year’s COP27 saw a record number of representatives for the oil and gas industry in attendance, and this year the number is expected to be higher.

The letter, supported by organisations that represent 46.3 million health professionals such as the World Medical Association, World Federation of Public Health Association and International Council of Nurses, outlines the critical need to protect  human health by reducing dependence on fossil fuels, rapidly investing in clean energy technology and reducing air pollution – all from the perspective that public health will benefit from this rapid transition. This letter is also endorsed by leading medical journals such as the British Medical Journal.

“As representatives of the global medical community, … we are already seeing the impacts of the climate crisis on our health – heat stress, malnutrition, anxiety, vector-borne diseases, respiratory illnesses due to dirty air to name a few. Extreme weather events have another far reaching impact- hospitals and healthcare centres that are meant to provide cure and relief are often first in the line of fire, with access and infrastructure getting hit. Our dangerous addiction to fossil fuels will only aggravate this further. This is why we think that a rapid transition to clean and equitable forms of energy is a win-win on all fronts,” stated Dr. Lujain Alqodmani, President, World Medical Association.

“For the first time in the history of climate talks, there will be an entire day dedicated to health, providing an opportunity to address the direct health impacts of climate change on individual wellbeing and health care systems,” said Josh Karliner of Healthcare Without Harm.

“Health Day is a fantastic achievement to be celebrated. But unless the UAE COP Presidency and the world’s governments, including the health ministers attending health day, can address fossil fuels as the root cause of the climate crisis, it will call the credibility of health day and the COP process itself into question.”

When disaster strikes, healthcare at the forefront

Climate change: when disaster strikes, the health sector is at the forefront.

“When disaster strikes, hospitals and health care centres are often at the forefront,” added Dr. Pam Cipriano, President, International Council of Nurses. “They are also the epicenter of addressing the escalating and noxious effects of climate change that are robbing people of their health. We are seeing more people come into our health care centres, hospitals and clinics complaining of heat exhaustion, respiratory issues and allergies, second hand smoke exposure among other things.

“We firmly believe that COP28 is an opportunity to adopt unified solutions and take action to implement mitigation and adaptation policies that also protect our health. This means phasing out “dirty energy” like coal, oil and gas that have negative impacts on health and the environment and prioritising clean energy sources. We must invest in a healthy and climate-safe future–the time to act on this is now.”

“The Elders”, a group of senior leaders founded in 2007 by Nelson Mandela working for peace, justice and sustainability,  also added their support, “calling on the COP28 Presidency and all countries to commit to an accelerated, just and equitable phase-out of all fossil fuels.

“To safeguard the well-being of future generations, we must sever our dangerous reliance on fossil fuels and move quickly to support a transition into renewable energy so we can stay within the 1.5°C limit pledged in Paris. Without a resolute commitment to phasing out fossil fuels, we risk undoing our hard-won progress in safeguarding human health,” they stated.

Health Day Declaration makes no mention of fossil fuels

COP27
Global Young Greens protestors demanding the end of fossil fuels at last year’s UN Climate Conference in Sharm el Sheikh (COP27).

In terms of the absence of any reference to fossil fuels in the official Health Day declaration, the United States – not the UAE – pressured for more indirect language, sources told Health Policy Watch.

Since the main COP negotiations are anyway going to focus on the framing of the fossil fuel issue – US negotiators preferred not to draw that central controversy into the Health Day declaration, the sources said.

“We did manage to get in just transition and a reference to air pollution.  But no strong language on fossil fuels; countries did not want to pre-empt the wider discussions at COP,” said one diplomatic source.

The letter, organized by civil society groups, pulls no punches. It affirms that, “a rapid and full and rapid phase-out of fossil fuels is the most significant way to address health impacts of climate change.”

However it also does stress that unlocking more finance for low and middle income countries is the essential path to deliver an energy transition that is “just and equitable to all.”

Image Credits: Pixabay, Commons Wikimedia, Gellscom/CC BY-ND 2.0., Commons Wikimedia, Twitter/Global Young Greens.

Image Credits: AfricaNews.

A healthcare provider screens people for African sleeping sickness.

The global health landscape is marked by paradoxes. The last several decades have been shaped by progress and setbacks – new medicines and emerging diseases, technological advancements and entrenched inequities. 

The Ebola outbreaks and COVID-19 pandemic exposed many of the already existing inequities in our global health ecosystem, from unequal access to vaccines to restrictive intellectual property laws that prevent low- and middle-income countries from developing their own medical products.

 As we witness both remarkable progress and glaring disparities in global health, it is abundantly clear that we have to redefine our approach as health funding, research and decision-making for African countries cannot be managed in the Global North. 

Advancing health equity and ownership in Africa is not merely a moral imperative; it is an essential pathway to harnessing the vast potential of the continent. In pursuit of this imperative, we must dismantle the barriers within global health institutions that have hindered Africa’s progress, and foster partnerships that empower African nations to lead the charge in shaping their own health destinies, being mindful of the new mantra: decolonising global health.

Disproportionate impact of infectious diseases

Africa has historically been disproportionately affected by infectious diseases such as HIV/AIDS, malaria, tuberculosis, and several other neglected tropical diseases with some conditions like yaws and guinea worm resurfacing in areas where they had previously been eradicated. 

At the height of the HIV/AIDS epidemic, access to life-saving antiretroviral therapy (ART) was severely limited in Africa as high drug prices, patent protections, and trade barriers made it challenging for African countries to procure and provide ART to their populations. 

In contrast, high-income countries in the Global North had widespread access to ART, which significantly improved the prognosis and quality of life for people living with HIV.

A woman prepares for an HIV test in Uganda.

Many African countries also have amongst the highest maternal and child mortality rates in the world, reflecting disparities in access to quality health care, including skilled birth attendants and emergency obstetric care. In some cases, very basic interventions such as clean water and clean hospitals can make a very significant difference in mortality. 

 Africa also faces significant health inequities in terms of access to sexual and reproductive health and rights (SRHR), such as limited or insufficient access to contraception and comprehensive sexual health education, which is sometimes hindered by religious practices in some African countries.

These barriers and inequities have hampered Africa’s health progress. Addressing and dismantling them demands a comprehensive approach.

Funding mechanisms must advance equity

 First, global health funding mechanisms must have a stronger focus on advancing health equity. This means directing more resources to countries and regions with the greatest health disparities and challenges, as well as prioritizing investments in health system strengthening, including infrastructure and workforce development. 

African governments should also explore innovative financing mechanisms that drive up domestic financing for health – such as social health insurance, community-based health financing, and public-private partnerships – to diversify funding sources for health.

 Simultaneously, all stakeholders must work to dismantle the systemic biases within global health, including empowering more women to hold leadership roles and prioritizing the health needs of vulnerable and marginalized communities. 

Moreover, while international partners and donors play a vital role in supporting health interventions across the continent, Africa’s health priorities, policies and research must be locally led. Empowering African leaders and experts is key to addressing these biases and ensuring that the unique challenges faced by African nations receive the attention and resources they deserve.

Collaboration is important for impact

 Collaboration across sectors and geographies is also indispensable in the pursuit of global health equity. International organizations, governments, academia, civil society, and the private sector all have a role to play in sharing best practices and directing resources where the need is greatest.

South-South cooperation, in particular, can facilitate knowledge-sharing and foster greater collaboration among countries facing similar resource constraints and health challenges.

The year 2030 is just around the corner and questions still remain about our ability to reach the sustainable development goals which, while not legally binding, require African governments, researchers and scientists to take responsibility.

African-led and supported research initiatives, conferences and platforms are crucial for understanding health disparities and designing effective interventions. 

The upcoming Third International Conference on Public Health in Africa (CPHIA 2023) will provide a platform for African leaders to reflect on lessons learnt in health and science, spotlight African research and innovation, and align on a way forward for creating more resilient health systems. 

Platforms like CPHIA exemplify the potential of home-grown initiatives to tackle health challenges through regional collaboration, with a focus on equity and inclusivity.

In our increasingly interconnected world, the urgency of advancing health equity in Africa cannot be overstated. 

The pursuit of health equity is an immediate and collective responsibility and requires a multifaceted approach that encompasses equitable and sustainable funding, empowered leadership, successful homegrown initiatives, and inclusive collaboration. 

By harnessing the collective will of all stakeholders, we can dismantle the barriers that have hindered Africa’s health progress and usher in a healthier, more equitable Africa.

Prof Margaret Gyapong is the Director of the Institute of Health Research, University of Health and Allied Sciences (UHAS) in Ghana, and co-chair of the upcoming Conference on Public Health in Africa (CPHIA).

Shingai Machingaidze is Acting Chief Science Officer at the Africa Centre for Disease Control and Prevention (Africa CDC) and the CPHIA secretariat lead.

Image Credits: Xavier Vahed/DNDi, 2011, Sokomoto Photography for International AIDS Vaccine Initiative (IAVI).

Dr Tlaleng Mofokeng (right), the United Nations Special Rapporteur on the Right to Health

Tackling inequities in food, nutrition and health outcomes needs a rights-based approach to food and nutrition, based on equality and centred on historically marginalised individuals and communities, according to Dr Tlaleng Mofokeng, the United Nations (UN) Special Rapporteur on the Right to Health.

“The intersection of the right to health and right to food is central to achieving substantive equality and realising sustainable development, human rights, lasting peace and security,” Mofokeng told a New York audience at the launch of her report on food, nutrition and the right to health.

“Ultra-processed products, with marketing strategies that disproportionately target children, racial and ethnic minorities, and people from socially disadvantaged backgrounds, have replicated colonial power structures and dynamics, with traditional diets and food cultures being replaced by diets largely shaped by corporations headquartered in historically powerful and wealthy countries,” said Mofokeng at the launch, which was hosted by Vital Strategies.

She called for mandatory front-of-package nutrition labelling, and fiscal and food policies consistent with the obligation of member states to protect the right to health and health-related rights.

“Within the context of food and nutrition, the obligation to respect human rights requires that states not engage in any conduct that is likely to result in preventable, diet-related morbidity or mortality, such as incentivizing the consumption of unhealthy foods and beverages,” according to the report.

Mofokeng also raised the issue of land expropriation, occupation and destruction, noting that this “eliminates the ability of Indigenous Peoples and other local communities to produce their own food for a healthy diet and turns food into a commodity controlled by those in power, thus violating their right to adequate food and health.’.

“Food is more than nutrition. Besides being one of the most common sources of pleasure, food is a social glue,” she said.