Electron microscope image of SARS-CoV-2, the virus that cause COVID-19

The World Health Organization announced on Wednesday a global “SOLIDARITY Trial” to generate a large, robust study comparing potential treatments for COVID-19. Currently there are 522 trials listed on WHO’s Clinical Trial registry under “COVID-19.”

Multiple small trials with different methodologies may not give us the clear, strong evidence we need about which treatments help to save lives,” WHO Director General Dr Tedros Adhanom Ghebreyesus told reporters Wednesday.

“WHO and its partners are therefore organizing a study in many countries in which some of these untested treatments are compared with each other.”

So far, Argentina, Bahrain, Canada, France, Iran, Norway, South Africa, Spain, Switzerland and Thailand have confirmed they will join the trial, and the Director-General expressed hope that others would soon join.

According to Ana Maria Henao Restrepo, medical officer in the Department of Immunization Vaccines and Biologicals at WHO, countries will be able to choose from 5 treatment arms:

  1. Standard of care available in the country, which will serve as a ‘control’ arm that the efficacy of other treatments will be compared with.
  2. Remdesivir, an antiviral drug with activity against Ebola, highlighted as one of the most promising potential treatments
  3. Lopinavir/ritonavir, a combination of two common HIV/AIDS antivirals
  4. Lopinavir/ritonavir and the anti-inflammatory drug interferon beta
  5. Chloroquine, an antimalarial drug, or its less toxic derivative, hydroxychloroquine

The large, international study will hopefully “generate the robust data we need to show which treatments are the most effective,” said Dr Tedros.

This story was updated 21 March 2020.

Image Credits: NIAID-RML.

Public health laboratory in Pennsylvania, USA extracts COVID-19 samples for testing

A worldwide shortage of chemical reagents needed for COVID-19 testing has emerged, World Health Organization officials admitted on Wednesday – even as the number of confirmed cases of the novel coronavirus worldwide surpassed the 200,000 mark.

Reports of shortages come days after WHO’s Director General Dr Tedros Adhanom Ghebreyesus issued an urgent appeal to countries worldwide to accelerate diagnostic testing in order to get the pandemic under control.

“There have been shortages of ancillary materials used in PCR (Polymerase Chain Reaction) reactions, which is the most common way to diagnose coronavirus,” said Mark Perkins, WHO lead for laboratory networks for infectious disease management, speaking at Wednesday’s press briefing.

Some important chemistries [reagents] you cannot find anywhere other than diagnostic manufacturers. And a lot of the diagnostic manufacturing has been done in China; with the outbreak in China, it decimated the workforce – and that has made them difficult to procure.”  

To make up for the gap, some 200 PCR tests have also been created and are being manufactured locally by different national, regional and local laboratories or private firms, he noted. “The vast number of diagnostic companies are scaling up their own capacity to produce reagents, so I think we are getting over that hump.”

However, having a “plethora” of choices is also creating new issues, he admitted.  “Sorting out which ones work and meet which needs is the next step.”

Additionally, tests on their own are not a panacea, stressed Maria Van Kerkhove, WHO’s Health Emergencies technical lead. What is required is a multi-pronged approach: increasing the number of tests; the number of labs that can run the tests; and the number of qualified technicians.

Testing alone is not enough either, stressed Mike Ryan, WHO Emergencies Head. To slow or interrupt transmission, not only do people found to be positive for the virus need to be isolated, but their close contacts as well: “The difficult part is contact tracing – countries need to mobilize a large public health mechanism needed behind to identify and isolate contacts of cases.”

Aggressive Testing Helps Reduce Germany’s Death Rates 

Even so, Germany’s aggressive early testing strategy may help explain why the country has so far managed to to keep disease death rates low, added Ryan. “They have had a very aggressive testing programme, and so far confirmed over 6000 cases with just 13 deaths.” The testing dragnet captures milder cases and also allows people to get treatment faster, reducing the overload on health systems. 

In contrast, Italy has experienced an 11% death rate from the virus.  However no one factor alone can explain the variations, the WHO officials stressed. Italy’s high death rate is likely also due to the older average age of its population; the fact that the epidemic cycle is more advanced; as well as the fact that health systems were caught by surprised and overwhelmed at the outset of the epidemic, also reducing the ability to treat serious cases.

“We see a pattern of long hospital admission,” Ryan observed.  “Italy, having experiencing the first wave, and a number of people reach a point when they can no longer be saved in the clinical system. We have to look at where each country is in the epidemic cycle.”

“We also have to look at demographics Italy has a much older profile. Italy has been a panacea for healthy people living to old age, but unfortunately in this case, the fatality rate may appear higher because of age distribution. 

“And there may be technical reasons as well in ability to provide care,” he added, noting that the country has seen over 1200 COVD-19 patients in intensive care simultaneously. “Anyone who has worked in the front lines of emergency, knows that when numbers begin to overwhelm, standards of care cannot be maintained.” 

At the same time, Van Kerkhove emphasized that it remains difficult to define and compare mortality rates, since in some countries many milder cases may be flying under the radar.

Also, the notion that the disease mainly affects older people, can be misleading, she added.

“Almost 20% of their [Republic of Korea] deaths have occurred in people under the age of 60,” Van Kerkhove said. “The idea that this kills only elderly is dangerous. This isn’t just a disease of the elderly – young people may have higher rates of mild disease. Otherwise healthy adults can develop a serious form of the disease.

“We haven’t seen how it will behave in vulnerable populations, HIV-positive and malnourished children, and that’s what we need to prepare for.”

Active cases of COVID-19 (middle) around the world as of 6:53 PM CET 18 March, Numbers change rapidly.

Europe Hits 80,000 Cases – Equal To China’s Cumulative Total  

Europe, now has over 80,000 confirmed cases and close to 3,500 deaths, Johns Hopkins University – making it the full-fledged epidemic epicentre.  In comparison, China has had over 81,000 confirmed cases but only 8,183 still remain active

Italy continued to be the hardest country hit, with a cumulative total of 31,506 confirmed infections and 2503 deaths, followed by Spain with 13,910 cases and 623 deaths; France with 7661 cases and 148 deaths; and Germany with 10,082 cases and only 27 deaths. Switzerland has reported 2772 cases while the UK has reported 1966 cases and 72 deaths. 

In a bid to contain transmission, the European Union (EU) has banned travellers from outside the bloc for 30 days – these measures also apply to Iceland, Liechtenstein, Norway and Switzerland, however travelers from the UK are unaffected. The travel ban will affect all non-EU nationals from visiting the bloc, except long-term residents, family members of EU nationals and diplomats, cross-border and healthcare workers, and people transporting goods. 

In Spain authorities were maintaining a partial lockdown on 47 million people, while in France people must carry a document detailing the reasons for leaving home, and face a €135 fine for non-essential travel. In the UK, in contrast, only voluntary measures are being used; the public has been told to avoid social contact, work from home and avoid all non-essential foreign travel. Germany has banned religious services and asked the public to cancel all domestic and international travel.

The Swiss government on Monday declared an “extraordinary situation” over the coronavirus, instituting a ban on all private and public events and closing restaurants and bars in a bid to harmonise policies nationwide; the new measures are in place until April 19. Some cantons have instituted even more stringent measures. Geneva, for instance, banned all gatherings of more than five people

In a World War II era move, US President Donald Trump on Wednesday announced he was invoking the “Defense Protection Act” in an effort to redirect American industries to produce more medical supplies amidst a growing shortage of protective equipment in healthcare facilities. Some 7769 cases have been reported in the US, with 118 deaths.

In WHO’s Eastern Mediterranean Region, Iran and other neighboring states continued to post the highest number of cases, with over 16,000 cases in Iran, 442 in Qatar and 100-200 cases each scattered across Bahrain, Egypt, Iraq, Kuwait, Lebanon, Saudi Arabia and the United Arab Emirates.

Health worker at Bole Chefe in Ethiopia wears protective gear to treat suspect cases of COVID-19

Latin America, South-East Asia and Africa Bracing For Next Wave  

Meanwhile, Latin America appeared to be poised to absorb the next wave of infections, with some 973 confirmed cases with 6 deaths; Brazil and Chile account for the most cases with 291 and 201 reported infections, respectively. In Venezuela, President Nicolás Maduro announced a nationwide quarantine amid deep concern about the havoc the coronavirus could cause in a nation where the health system’s collapsed and there’s a massive shortage of doctors, equipment and medicine. 

Colombia and Argentina have closed their borders to arriving foreigners; Chile followed suit Wednesday. Ecuador and Paraguay have established night time curfews.  And in Brazil, firemen using megaphones were patrolling beaches in Rio de Janeiro, asking people to go home. Rio’s famed Sugarloaf Mountain has been closed to the public.

WHO’s Africa Region, reporting 477 cases and South-East Asia with about 480 cases, were also trying to beef up their preparedness.

WHO’s Southeast Asia Regional Director Poonam Khetrapal Singh issued an urgent call Tuesday to all Member States in the region to “scale-up aggressive measures” for COVID-19 preparedness, as new cases trickled in and more clusters were confirmed. 

Looking at the numbers, some countries are clearly heading towards community transmission of COVID-19, said Singh in a press release“The situation is evolving rapidly. We need to immediately scale up all efforts to prevent the virus from infecting more people,” added Singh, calling on countries to ramp up testing and contact tracing, social distancing, as well as preparing networks of health facilities to triage a potential surge in patients.

In India, the total number of confirmed cases has risen to 151 with 3 deaths. The government on Tuesday banned the entry of passengers from Afghanistan, The Philippines and Malaysia.  Travelers arriving from the European Union, Turkey and the United Kingdom, including both foreign citizens and Indian nationals, are also barred from entering the country until March 31. 

As for Africa, WHO has equipped laboratories in countries across the continent with tens of thousands of tests, trained technicians, and distributed personal protective equipment to support COVID-19 surveillance, early detection and treatment. Some political leaders have also made personal appeals to their citizens to adopt preventive measures, such as social distancing and handwashing practices, including online challenges to promote good practices by Paul Kagame, President of Rwanda, and Abiy Ahmed Ali, Prime Minister of Ethiopia.  And many countries have also put into place unprecedented travel restrictions on visitors from Europea and the United States. 

Still, in the WHO briefing on Wednesday, officials said that the measures taken have been insufficient. In particular, they urged countries with reports of cases to consider bans on mass gatherings where the virus could be easily transmitted.

“Certainly at this time, all countries with disease inside their borders should limit contact between individuals, particularly during large gatherings, particularly large, religious type gatherings that bring people from very far away into close contact.”

Dr Tedros, formerly Health Minister of Ethiopia, made a personal plea, saying: “Africa should wake up. My continent should wake up,” 

-Gauri Saxena contributed to this article 

Image Credits: Governor Tom Wolf, Johns Hopkins CSSE, WHO/ Otto B..

Triage tent for COVID-19 cases in a hospital in Visby, Sweden

A leading medicines access group in Europe has issued a protest against the high price of COVID-19 tests in France, amidst rising concerns that the cost of the diagnostic test may also be limiting the number of people who are being tested in Europe – the new global epicenter of the COVID-19 pandemic.

In France, the test costs 135 Euros, although production costs amount to only about  €12 according to the Observatoire Médicaments Transparences, a French civil society watchdog, that published an open message on the issue Tuesday.

Meanwhile, in a press conference on the COVID-19 pandemic in Europe, convened by WHO’s European Regional Office, Dorit Nitzan, WHO/European Coordinator of Health Emergencies, told reporters Tuesday that the cost of the test depends on the country, but ranges from €30 to €60 . 

“Some countries have to be economical and efficient in using it,” said Nitzan. “It’s not cheap, but it’s more costly to be sick.”

In an interview with Health Policy Watch, Paline Londeix, founder of the French Observatory for Medicines Transparency, said that it was unclear why the price was so high since the 48 labs in France performing the COVID-19 test are all public, and the tests are being performed on “open platforms” using molecular (PCR) tools whose patents have expired and are thus in the public domain.

“These 48 labs are public labs, so it might be a price set artificially by the public sector,” she said, adding that the group was asking the Ministry of Health to comment in greater detail on the costs of the tests.

“WHO is working very hard to make sure that people are rapidly tested and informed. This is a key element of the public health response. We are working with member states in Europe to advise them,” said Richard Pebody, WHO Europe’s Head of Emergencies.

But as more countries see intensive community transmission of the virus and the number of cases mounts, “there can be challenges in terms of accessing enough tests to meet the local demand,” acknowledged Pebody. “That has happened in some countries in Europe.”

“Some countries have made decisions to focus testing for more severe cases,”  Pebody admitted.

Whether by necessity or design, even some of Europe’s most affluent countries, such as Switzerland, are currently limiting testing to people who are either seriously ill or symptomatic people and at high risk due to their age or pre-existing conditions.  That contrasts sharply with experiences in other nations, which have aggressively pursued testing measures. Examples include Italy and Israel in WHO’s European Region, as well as the Republic of Korea and Singapore in WHO’s Western Pacific Regional bloc.  

While testing needs to be part of an integrated approach, countries should accelerate their efforts as much as possible to test not only seriously ill and symptomatic cases, but their contacts, said Hans Kluge, WHO’s Regional Director for Europe at the briefing.

“When a country has capacity, we need to increase testing. We need to test contacts of probable and confirmed cases. In healthcare settings, there may be reason to prioritize, particularly in closed settings. Addressing coronavirus in prisons is important,” he said. 

“Herd Immunity” Measures Not Recommended by WHO 

In the press conference, WHO officials also said that deliberate strategies that permit the virus to sweep through the population so as to generate “herd immunity”, lack sufficient scientific evidence, and are not recommended by WHO at this point.   

Such an approach is being taken by the United Kingdom, followed by The Netherlands, whose prime minister Mark Rutte delivered an extraordinary televised address to warn Dutch citizens that the country was facing an unprecedented peacetime threat. But Netherlands will not follow France, Spain, Switzerland and Italy in nationwide lockdowns,Rutte was quoted as saying, noting that along with the United Kingom, the Dutch would attempt to build “herd immunity” among healthy parts of the population, to protect the older and more vulnerable. 

Dutch PM Mark Rutte addresses the nation for the first time during the COVID-19 pandemic.

WHO has recommended against use of the herd immunity approach, saying it is untested in the case of this novel coronavirus. The virus leaves about 20% ill enough to require hospitalization, and about one-half of those hospitalized need advanced respiratory or ICU care. It has a fatality rate of about 3.4%, on average, rising sharply to about 20% among people over the age of 80.  

“We do not have enough evidence about the “herd immunity” approach. It’s not the right time to recommend this,” said Nitzan, of the WHO European Regional Office, in the press briefing about the COVID-19 pandemic in Europe, which was broadcast live on the European Region’s Facebook page.

Said Kluge, WHO continues to recommend the same strategies to Europe “that we know works to turn the tide against the epidemic.”

Number 1, contain the outbreak, do aggressive case finding which means then diagnosing/testing, putting in quarantine….. Number 2 strengthening the capacity of the healthcare system for the influx of patients. Number 3 – the whole community mobilization with social distancing.”

European Case Load Approaching Cumulative Count Of China  

The total number of COVID-19 cases in Europe now stood at more than 66,000 active cases and 2,740 deaths, according to the two leading sources tracking data, including Johns Hopkins University and China’s Health Ministry.   That is in comparison to China which saw a cumulative total of 81,058 cases, but was reporting no new cases at all on Tuesday. 

Italy, the epicentre of the European outbreak, now has the most active cases in the world, with a cumulative total of 27980 confirmed infections and 2158 deaths, followed by Spain with 11309 cases and 509 deaths; France with 6664 cases and 148 deaths; and Germany with 8082 cases and only 20 deaths. Switzerland has reported 2650 cases and 19 deaths, according to the Swiss Federal Office of Public Health

The Netherlands, which has 1413 confirmed cases and 24 deaths, is pursuing a strategy of “herd immunity.” 

The UK, with 1960 cases and 56 deaths, is doing the same – although Prime Minister Boris Johnson took a stronger approach to the country’s response on Monday, saying “we need to go further, it looks like we are approaching the fast-growth part of the upward curve.” 

Active cases of COVID-19 around the world as of 5:13 PM CET 17 March, Numbers change rapidly.

 

Gauri Saxena and Svet Lustig contributed to this story

Image Credits: Wikimedia Commons: Visbystar, Twitter: @Mehreen, Johns Hopkins CSSE.

Two workers screen people at a drive through COVID-19 testing center in New Rochelle, New York, USA

The World Health Organization issued an urgent call for countries worldwide to dramatically scale up COVID-19 testing, followed by stricter isolation of confirmed cases and contact tracing – saying that those steps are critical to getting the accelerating pandemic under control.

But there was far less clarity from WHO about the use of travel restrictions. This, despite Canada’s dramatic and unprecedented move to ban entry of all non-residents, with the exception of US citizens. Meanwhile, a host of low- and middle-income countries in Africa, eastern Europe and Latin America were also closing down their borders to travelers from the United States and western Europe, in order to contain the rapid virus spread – in a powerful reversal of patterns seen in previous epidemics such as SARS and Ebola.

“We cannot stop this COVID-19 pandemic if we do not know who is infected. So I have a simple message for all countries – Test, Test, Test,” said WHO Director General Dr Tedros Adhanom Ghebreyesus speaking at a press briefing on Monday.  

All countries should be able to test all suspected cases, they cannot fight this pandemic blindfolded, they should know where the cases are, and that is how they can take decisions,” said Dr Tedros

Dr Tedros said he had delivered that same message to European Ministers of Health, in a region which is now being overwhelmed by the surge in cases, and where large disparities have emerged in testing strategies. Some countries aggressively pursuing tests while others, such as the United Kingdom and Switzerland, have so far been more reserved. Switzerland is testing only people with serious symptoms or deemed to be at high-risk, a move which a group of leading scientists have protested is ill-advised.  The United Kingdom has undertaken an even more laissez-faire position, calling on older people to self-isolate while presuming that widespread infection of younger groups will occur and help build a “herd immunity” – a strategy opposed even more strenuously by other scientists and experts.

While refraining from calling out countries specifically, the WHO Director General said that testing needs to be prioritized more overall in order to combat COVID-19 more effectively.

“Social distancing measures can help reduce transmission…However, such measures are insufficient on their own,” said Dr Tedros, referring to the widespread closure of schools and commercial activities now being seen in Europe as well as in New York State and other US hotspots.

“The most effective way to reduce infection rates is to test, test test. Test every suspected case. If they test positive, isolate them and find out who they have been in contact with up to two days before they developed symptoms, and test those people too, and test these people too.”

“Test all cases – if you know all cases, you can follow up on all contacts. Going forward, my recommendation [to Europe] is that MoHs should be able to test ALL suspected cases.”

He also said that European countries should adopt more aggressive case quarantine and follow-up measures, including the potential hospitalization of mildly ill people in community centers, gyms or other public facilities – or carefully monitored home care with the observance of very strict isolation measures – in order to prevent further onward transmission.

“WHO advises that all confirmed cases, even mild cases, should be isolated in health facilities to prevent transmission and provide adequate care,” said Dr Tedros.

“But we recognize that many countries have already exceeded their capacity to care for mild cases in dedicated health facilities. In that situation, countries should prioritize older patients and those with underlying conditions. Some countries have expanded their capacity by using stadiums and gyms to care for mild cases, with severe and critical cases cared for in hospitals,” he said.  In that case, patients with mild disease should be isolated and cared for at home – with strict attention to WHO recommended protective gear for the caregivers, and separation of daily activities.

As for testing, so far WHO has distributed over 1.5 million tests to 120 countries worldwide, and now the Organization is looking at how to ramp up that capacity by expanding to multiple laboratories in countries that have the capacity to do testing at the molecular level, said Maria Van Kerkhove, WHO Emergencies Technical Lead.

“We are building on existing systems, on national influenza centres that exist across the globe,” she said, “and we trying to increase the number of labs that can test in individual countries, whether it is national, subnational or private labs.  We are also working on getting the physical tests out there.” she said. As new automated systems go online capacity can be ramped up further, WHO officials also noted, with reference to Friday’s announcement by Roche Pharmaceuticals of a US Food and Drug Administration Emergency Authorization for an automated COVID-19 test.

Dr Tedros at WHO’s Monday press briefing on COVID-19

WHO Officials Sidestep Issue of Travel Restrictions – Even as More Countries Shut Or Limit Border Crossings 

Unlike the call to testing, Dr Tedros and other top emergency team leaders avoided comment on the travel restrictions now being seen across the globe as a pandemic response.

Asked by one journalist, whether along with the lack of aggressive testing, European free movement policies, have now boomeranged, Mike Ryan, who had in the past staunchly opposed travel bans at all, said:

“The epidemics of different countries are in different stages of development. Europe is a multi-country partnership.

“Many countries are attempting lockdown, but relying on travel measures is not enough,” he added. “It may have an impact, but it is not sufficient. Let’s talk about solidarity and how countries can work together instead of comparing them – although lessons learned in China, in Singapore, in Japan are now being transferred in Europe. And hoping we can accelerate that in the coming days.”

Said Dr. Tedros.  “The rule now is how to live with globalization.”

Still, African countries — whose citizens often have to provide an update on their health status just to get a visa to travel to Europe — were now moving to stop or limit arrivals from both Europe as well as the United States, noted The Intercept.

Among those, Uganda and the Democratic Republic of Congo have now imposed quarantine measures on travelers from Italy, France, China and Germany and in the case of Uganda, from the United States as well.  Ghana and Kenya became the first two African nations to set down forceful travel restrictions, in the case of Ghana on arrivals from countries with more than 200 coronavirus cases.  Rwanda, Uganda, Mali, and others have imposed similar quarantine measure for European travelers, while across the continent, passengers are screened for their temperature at international airports.  After restricting travelers from high-risk countries to quarantine, Mauritania deported 15 Italian tourists and Tunisia deported 30 other Italians for violating theirs. A Cameroonian news outlet reported higher arrivals from Italy due to people trying escape their coronavirus-infected country.

Active cases of COVID-19 around the world as of 6:13 PM CET 16 March, Numbers change rapidly.

In Europe, meanwhile, European Union Commission President Ursula von der Leyen announced on Monday a temporary restriction on non-essential travel into the European Union’s Schengen passport-free zone for 30 days in order to slow the spread of the virus. The ban on entry would cover all non-essential visits from third countries, with exemptions for Schengen area long-term residents, family of EU nationals and diplomats.

The announcement follows a span of individual European countries shutting down borders to nationals from other European countries deemed to be hotspots, as COVID-19 cases accelerated across the continent, to a total of 51,771 cases and 2,316 deaths on Monday afternoon.

Germany, with the third highest case-load in Europe at 7174 cases, became the latest country to restrict border crossings by visitors from neighboring France, Austria and Switzerland, along with closing eateries, entertainment venues and places of worship. That followed similar moves by Austria, the Czech Republic, Denmark, Hungary, Poland, and Switzerland to partly or completely close borders as well. Italy, with 14,991 confirmed cases and Spain, with 9428 cases, had already restricted travel into and out of the country as the two countries with the highest number of cases in the European epidemic.  After declaring a state of emergency on Saturday, Spain announces also announced it a series of other sweeping measures including requisitioning the private healthcare sector and shutting all but essential services on Monday.

Switzerland also announced that it would close down all schools, commercial centres, leisure establishments as of Monday and until April 19, leaving only essential services such as banks, health care facilities, pharmacies, food stores and take-away. Hotels and transport facilities would also remain open. French President Emmanuel Macron followed soon after with even more extreme measures, asking French citizens to remain at home except for essential errands.

Meanwhile, Prime Minister Boris Johnson of The United Kingdom, which has been an outlier in approaches to fighting the virus, called on Britons to adopt a series of voluntary measures, including the voluntary seclusion for 12 weeks of people over the age of 70, and other at-risk groups.

“It looks as though we are now approaching the fast growth part of the upward curve and without drastic action, cases could double every five or six days,” said Johnson in a televised address on BBC.

He also called for a shift to teleworking, and said people should also avoid crowded pubs, clubs and theatres – although no closures of any establishments were announced. Johnson also said that schools would remain open for the moment. Rather than aggressively testing, the UK has said that anyone with a persistent cough or fever should stay home for 14 days, along with other members of their household. The moves, which treat spread of the virus as inevitable and attempt to create a herd immunity effect first among healthier parts of the population, have left him open to criticism from some health experts.

In Latin America, Colombia and El Salvador have also banned all foreigners from entering the country. Guatemala has banned the entry of citizens of the United States, Canada, South Korea, Italy, France, the United Kingdom, China and Iran.

In the US, meanwhile, the governors of New York State, New Jersey and Connecticut, on Monday announced a “regional approach to combating COVID-19” – pointedly noting that it was “amid a lack of federal direction and nationwide standards.”

The Tri-State strategy, which is the basin of commuter traffic in and out of New York City, calls for a limit on social and recreational gatherings to 50 people effective at 8 p.m. Monday evening. The move, the governors stated, followed upon updated guidance from the Centres for Disease Control and Prevention, calling for the postponement or cancellation of in-person events of 50 people or more.  As the total number of COVID-19 cases in New York State climbed to nearly 1000 cases, New York City’s Mayor Bill de Blasio on Saturday announced that public schools would be moving to remote learning, and on Sunday ordered the closure of all leisure and entertainment venues, as well as restaurants, with the exception of take-away food services, followed by a similar move in Los Angeles.

“These places are part of the heart and soul of our city. They are part of what it means to be a New Yorker. But our city is facing an unprecedented threat, and we must respond with a wartime mentality,” de Blasio was quoted as saying.

More than US$19 Million Secured For WHO COVID-19 Response  

In one bright spot, Dr Tedros said that he was confident of meeting the WHO goal of raising some $US 675 million for the organization to fight the epidemic, noting that in just the last few days over $US 19 million had been secured from private and public donors for a COVID-19 response fund co-launched with the UN Foundation on Friday.

He also praised the United States for coming forward with more funds to fight the pandemic; this was despite pre-pandemic proposals for sweeping cuts in allocations to WHO from the US Federal Budget for 2020.  The United States had pledged in early February up to US$100 million for COVID-19 response. On March 2, the U.S. Agency for International Development (USAID) made its first concrete commitment of $37 million in financing from the Emergency Reserve Fund for Contagious Infectious Diseases – monies destined to 25 of the countries most affected by the novel coronavirus or at high risk of its spread.

“It’s not just the funding, it is the human spirit that we see fighting this virus.  When there is unity and solidarity of spirit, the resources can come. I am really encouraged over the spirit of solidarity that I see,” said Dr. Tedros.

That spirit of solidarity was less evident in unconfirmed reports that the administration of US President Donald Trump had attempted to gain exclusive rights to an experimental COVID-19 vaccine under development by the pharmaceutical firm CureVac in Germany.

The allegation, first reported on Sunday in German media, and then widely circulated in The New York Times, Washington Post and elsewhere, centered on the suggestion that the Trump administration sought to strike a deal with CureVac, a drug maker that is based in the city of Tübingen but that also has operations in the United States.

CureVac issued a statement on Sunday rejecting the “rumors”, while key shareholders, including the Bill and Melinda Gates Foundation and private investor Dietmar Hopp said the rights would not be sold to any single country. Hopp said he wanted the vaccine to “help people not just regionally but in solidarity across the world. I would be glad if this could be achieved through my long-term investments out of Germany,” Reuters reported.

However the report, which followed upon other moves by the German government to restrict the export of personal protective equipment for health workers, has sparked debate around the dangers of nationalizing and stockpiling of essential drugs and supplies that could hinder global cooperation and solidarity in the face of the pandemic, STAT News reported.

While avoiding reference to the controversy in his briefing, Dr. Tedros observed that “Crises like this tend to bring out the best and worst in humanity.

“Like me, I’m sure you have been touched by the videos of people applauding health workers from their balconies, or the stories of people offering to do grocery shopping for older people in their community,” he said referring to the nightly scenes that began in Italy of urban dwellers signing, clapping and playing instruments from their balconies at 6 p.m. every evening to boost morale and voice appreciation.

“This amazing spirit of human solidarity must become even more infectious than the virus itself. Although we may have to be physically apart from each other for a while, we can come together in ways we never have before.”

 

 

 

Image Credits: U.S. Army National Guard/Sgt. Amouris Coss), Johns Hopkins CSSE.

Active cases of COVID-19 around the world as of 5:00PM CET 13 March, vividly display Europe as new epicentre. Numbers change rapidly.

Europe has now become the epicenter of the COVID-19 pandemic, with more cases and deaths than the rest of the world combined, apart from China, said WHO Director General Dr Tedros Adhanom Ghebreyesus.

Even more worrisome, there are now more new cases being reported everyday in Europe, which has a population of about 741 million people, than were reported among China’s 1.4 billion people at the height of its epidemic, Dr Tedros Adhanom Ghebreyesus said Friday at a press briefing.

Around the world, 8,527 new cases of COVID-19 were reported in the last 24 hours, for a total of 137,385 cumulative cases. In the United States, another evolving epicentre, some 1,268 cases were being reported, and US President Donald Trump was set to appear on national television today to declare a State of Emergency, major media was reporting.

New Roche Test Offers Possibility of Testing “Millions” – Opening Way to More Rapid Treatment or Quarantine 

But as cases skyrocketed around the world, there was one new bright light on the emerging drugs, diagnostics and vaccines scene.

A new test by the Swiss-based Roche pharmaceuticals, approved for emergency use on Friday by the US Food and Drug Administration, could be a game-changer on the diagnostics – the first step to combatting the disease. The newly-approved test could lead to a rapid scale up of COVID-19 testing by millions of new tests a month, based on an automated technology.

According to a press release from Roche, the widely-available Roche’s Cobas 6800/8800 automated diagnostic systems, will be used to perform the  test for the SARS-CoV-2 virus that causes COVID-19. It can provide a total of 1,440 test results with the 6800 System and 4,128 results for the Cobas 8800 System over a period of 24 hours. The can be run simultaneously with other assays provided by Roche for use on the high-throughput Cobas 6800/8800 Systems.

About 96 tests can be run in a batch, with results delivered in 3.5 hours.

Roche Cobas 6800 Diagnostic system

A Roche spokesperson told Health Policy Watch that the company would now begin ramping up a plan to deploy the tests in eligible sites, in line with the emergency FDA authorization.

“We are prioritizing those customers and laboratories with the highest ability to implement routine testing (for example, those with the necessary instruments in place for successful testing and consumable products needed to run the tests) combined with the highest market need. We will be working with customers, nonprofit and government organizations and regulatory bodies to ensure that tests make the greatest patient and community impact,” said Karsten Kleine.

“At our current rate, we can supply approximately millions tests/month on the Cobas 6800/8800 instruments globally. We are working around the clock to increase that quantity as we recognize the importance that patients need access to these critical tests,” she said.

The breakthrough is  significant because the more rapidly and easily testing can be performed, the more easily health systems can either hospitalize or quarantine people who test positive for COVID-19, avoiding further spread of the virus, as well as serious disease progression and acute respiratory distress syndrome, which requires intensive care.

The severe shortages of test capacity in the United States has received widespread attention there. However, test shortages are also plaguing European countries from Switzerland to Norway – creating a playground where the virus can replicate. Whether due to necessity or choice, some European countries are thus deliberately choosing to test only cases among high risk and highly symptomatic groups. Now it remains to be seen if policies in such countries will change – if mass testings olutions become more widely available.

WHO experts have warned that limited testing is not the right approach. Speaking at today’s press briefing, WHO’s technical Emergency lead Maria Van Kerkhove issued a plea to governments.

“Please look for cases so we can turn the tide,” she said. “If case numbers increase because countries are aggressively testing, we should support that.

Testing must, however be part of an integrated strategy, nontheless, said Dr. Tedros. “Our message to countries continues to be you must take a comprehensive approach. Not testing alone, not contact tracing along, not quarantine alone. Not social distancing alone. Do it all,” he urged.

Attendee of the 43rd Session of the UN Human Rights Council in Geneva, wears a face mask. The Human Rights Council is ongoing, but in reduced format with additional precautionary measures.

United Kingdom and Europe See Tremendous Virus Acceleration

In less than two weeks cases in the European Union and the United Kingdom have shot up to at least 29,404 infections in 32 countries.

Italy remains the epicenter of Europe’s epidemic, with a total of 15,113 confirmed cases and 1,016 deaths. But the outbreak is spreading amongst Italy’s neighbors – Spain has the second largest outbreak in Europe with 4,334 cases and 122 deaths, Germany the third largest with 3,156 cases and 7 deaths, France has reported 2882 cases and 61 deaths, and Switzerland has confirmed 1125 test-positive cases and 7 deaths as of Friday afternoon.

Meanwhile in China, only 8 new cases were reported on Friday – the country’s lowest daily figure on record since January. South Korea reported a further decline in new cases (110) after a brief spike with an outbreak in Seoul yesterday. The country has reported a total of 7979 cumulative cases and 66 deaths.

With the outbreak accelerating and decelerating in different countries around the world, WHO scientist Maria Van Kerkhove told journalists, “We will not be able to predict what will happen. We need to prepare for every scenario… the trajectory is dependent on the country.”

Another hotspot of the pandemic is Iran; the Islamic State is also taking drastic new measures to contain the virus, ordering most people to stay home and announcing a plan to test every one of its 80 million citizens for the virus.

“Iran’s strategies and priorities to control COVID-19 are evolving in the right direction… but more needs to be done,” Richard Brennan, regional director of Emergencies for WHO’s Eastern Mediterranean Region in a press release Thursday, following the conclusion of a WHO mission to Iran, and shortly before the new measures were announced.

“We are all still students of this new virus, so we need to track its spread closely and quickly apply proven public health measures… More work also needs to be done to protect health workers,” said

Switzerland Closes Border with Italy  – First Time Since Schengen Zone Creation in 1985

Meanwhile in Berne, the Swiss Federal Council announced a series of unprecedented measures, including limits on any kind of mass gathering to 100 people; a shift of education to virtual school platforms; and the closure of its border with Italy – for the first time since the European Union’s Schengen zone of free area movement was created in 1985.

According to the Federal Council announcement, the measures restrict the entry into Switzerland of people from “high-risk” countries and regions, which also share a border with Switzerland.

“At present Italy is designated a high-risk country,” the announcement stated. “People from Italy will be refused entry to Switzerland. Exceptions are possible, for example for people who live or work in Switzerland. Anyone wishing to enter Switzerland despite the entry ban must prove that one of the exceptional conditions is met. These measures are intended to assure the provision of adequate care and therapeutic products to members of the public,” said the statement.

Speaking at a press conference, Confederation President Simonetta Sommaruga said, “The situation is difficult, but we have the means and we are ready to confront this, both in terms of our health system and financially.”

Alain Berset, head of the Federal Department of Health, said: “We now have positive tests for 1,125 people.  The situation changes all of the days, but the strategy lines that we are pursuing remains the same. The principle objective is to protect the population, with measured, considered steps.

Berset said, “The measures that have been taken include to reinforce protections for the most vulnerable and to also prevent a surcharge of hospital cases.

“We are running this with calm and determination. There will never be one measure taken for all times, that will solve the problem. We are going to have to continuously adapt. So there is no particular reason to be afraid. It’s serious, but we need to be led by calm and determination,” Berset added.

He said that not only sites such as museums, but also ski stations and swimming pools would be restricted to accommodating 100 people at a time.  Education will be shifted to virtual platforms, firstly for university and high schools. Primary and secondary schools will also be asked to develop distance or individualized education solutions for high schools and elementary schools that avoid bringing large groups together. The press conference also included Swiss Vice President Guy Parmelin, Department of Justice and Peace head, Karin Keller-Sutter, in a display of unity across Swiss agencies as well as political ranks.

WHO Headquarters in the Epicentre – Staff Fears & Frustrations Growing With No Clear Move to Teleworking

Despite the nationwide Swiss shift to an emergency footing, WHO’s Administration seem to be hesitant about making its own sweeping internal shift to teleworking at the Geneva Headquarters, despite mounting staff fears and a trend to teleworking across the rest of Geneva’s global health hub agencies and NGOs.

Concerns peaked after a WHO staff member collapsed and was rushed to the hospital on Thursday by ambulance. The staff member’s partner had reportedly already been under quarantine due to his contact with a COVID-19 case at his workplace in neighbouring France, staff members, who requested anonymity, told Health Policy Watch.

So far WHO’s Aministration has told staff that there are no “confirmed” cases among staff at the Geneva headquarters, and it has made no internal or public comment on suspected cases either.

Frustration and anger was growing among the grim and worried WHO staff  over the fact that teleworking for most staff remains limited to just four days a month, even in light of the expanding pace of infection in Switzerland and the Geneva area.

“The new rules say that ‘If you are over 65 or someone with pre-existing medical conditions, which you have to have a certificate, or if you are pregnant, you can go to Staff Health and Welfare and ask for a consultation, and then Staff Health and Welfare might give you a recommendation for teleworking,” observed one staff member.

“Well, WHO doesn’t have any people over 65, that is the mandatory age of retirement…They did say they are working a system for getting teleworking approved by emails. It still is the same old, same old. The message is that teleworking is not the norm.”

A mass teleworking drill was initiated on Friday for purposes of “continuity planning”. But as of Friday afternoon staff were still being told to return to their office workstations, as usual, on Monday.

Overall, the Organization’s top leadership seemed unclear about how to respond to the unique situation of a pandemic literally at its doorsteps, rather than in a remote Asian or African country, noted the staff members who requested anonymity.

“Teleworking will be adopted either when the Swiss government forces them to, or staff revolts,” said one staff. “Until then, staff are risking getting infected while commuting, potentially exposing themselves, colleagues and others in their social circle if infected, added the source.

“We are still operating in the dark ages, we haven’t adapted,” said another at-risk staff member, echoing complaints that paperwork for expanded teleworking permissions remains onerous even for those with a pre-existing condition.

For the first time since the crisis began, however, WHO’s media briefing was conducted on Friday only by virtual format.  Over the past 6 weeks, since daily briefings began, some 20-30 journalists and staff had been crowding together every afternoon in a tiny, airless “SHOC” emergency nerve center at WHO headquarters for the events, while hundreds also watched online.

“WHO has shifted to an online format – we are only having journalists online today to pilot a teleworking format,” said Tarik Jaresevic, a WHO spokesman.

Zixuan Yang contributed to this story.

 

Image Credits: Johns Hopkins CSSE, Roche Pharmaceuticals , UN Photo / Jean Marc Ferré.

UN Headquarters in Geneva: Participant in 43rd Session of the UN Human Rights Council dons mask to protect herself from COVID-19. All parallel sessions and side events have been cancelled.

With escalating COVID-19 outbreaks in Europe, the Middle East, and the United States, some countries are heeding the World Health Organization’s advice and ramping up containment measures, while others, including Switzerland, home to WHO’s Geneva Headquarters, appeared more resigned to the uncontrolled spread of the disease in the wake of yesterday’s declaration of a COVID-19 pandemic.

Denmark and Austria joined Italy, France, Germany and Spain in far-reaching measures to contain the virus, such as: tightening travel restrictions; closing education facilities in affected areas; cancelling large events; and closing some public institutions such as museums, libraries and concert halls. US President Donald Trump announced a temporary 30 day travel ban on all people entering the US from 29 European countries, as the outbreak escalated within US borders to 1,323 cases, and US Centres for Disease Control officials accelerated nationwide COVID-19 testing.  

But in Switzerland, Federal Health authorities  have said that only people with serious symptoms or at “high-risk” and displaying respiratory symptoms were to be tested. A communique circulated to parents of children at one of Geneva’s leading international schools warned that the Swiss testing protocols meant that “cases of COVID-19 which may occur among the healthy population will not be confirmed by testing.”

Although Swiss authorities have now banned events of more than 100 people, the policy to limit COVID-19 testing seemed to run counter to WHO advice that aggressive testing was key to early identification and quarantine or treatment, so as to prevent a surge of serious cases that overwhelm hospitals and health workers.  In a press briefing Wednesday, WHO Emergencies Head, Mike Ryan said that he recommended against a “diagnostic algorithm that only allows testing on only a small number of people.”

In the wake of the confusion, some are calling on WHO to provide more clear guidance on which containment strategies countries should be using.

“Where is the conductor?” Antoine Flahault, co-director of the Swiss School of Public Health in Zurich and director of Global Health at the University of Switzerland Medical School, tweeted Thursday. “There is a set of 4 major non-pharmaceutical interventions: school close, gathering ban, population transport restrictions, cordons sanitaires.

“We expect from WHO to provide clear recommendations on when, how and for how long to implement them.”

Critics are also calling for better guidance on reporting and managing COVID-19 cases in the workplace. In Geneva, home of many global health agencies and NGO headquarters, organizations were rapidly shifting their staff to teleworking as cases began to be confirmed inside their institutions, or nearby.

Those included Medicines for Malaria Venture, Gavi the Vaccines Alliance, The Global Fund, and the International Committee of the Red Cross (ICRC). WHO has not yet begun any mass transition to remote working, although staff were nervously anticipating that such a move might soon be on the horizon following reports that ambulances had been dispatched to WHO headquarters on Thursday to respond to emergency calls on behalf of two sick staff members, one of whom had collapsed at work due to unknown causes. WHO did not reply to queries from Health Policy Watch about the incident, or its own workplace protocols on reporting COVID-19 cases to staff.   

Meanwhile, universities around the world were also taking matters into their own hands. The Graduate Institute in Geneva announced that all courses will be moved to an online format starting on 23 March. Across the Atlantic, Harvard University, Yale University, Columbia University, and Cornell University have all begun plans to shift classes online. However in the United Kingdom, while five Oxford University community members have tested positive for COVID-19, the university continued activities as normal while monitoring the situation with the aid of public health authorities.

Switzerland’s initial cases were largely imported from northern Italy to the Italian-speaking Swiss canton of Ticino, but the Federal Health authorities now say that the virus spread is country-wide, and even with restricted testing, there were 858 cases reported as of Thursday afternoon. Italy, meanwhile, saw another increase in some 1,872 cases in the last 24 hours, and now had 12,462 cases and 827 deaths as of Thursday afternoon. France saw 497 new cases for 2,281 in total, although Germany, which had  had closed schools in affected regions, reported no new cases on Thursday.

Pandemic Spread; Active Cases Worldwide

Time is of Essence for Containment of COVID-19

WHO has frequently stressed that time is of the essence, in enacting containment measures.

A new study by researchers at the University of Southampton underlined that.  It found that in the case of China’s outbreak, enacting strong “non-pharmaceutical interventions” even one week earlier could have prevented almost two-thirds of COVID-19 cases in the epicentre of, Wuhan, a city of 11 million people.

The problem now is that worldwide, the same measures, including: monitoring and tracing contacts; restricting travel; closing schools and public institutions; as well as fencing off and limiting movement in areas with sustained community transmission – are now being adopted at different times and to differing degrees in other countries, as the outbreak hotspots shift to Europe, the Middle East, and North America.

Alarmed by some countries’ delays, experts are urging their governments to act fast.

Former US Commissioner for the US Food & Drug Administration Scott Gottlieb warned Thursday that the US faces “two alternative but hard outlooks with COVID-19.” 

“The virus is firmly rooted in our cities. We’re losing time,” Gottlieb tweeted. “We [can] follow a path similar to South Korea or one closer to Italy. We probably lost the chance to have an outcome like South Korea. We must do everything to avert the tragic suffering being borne by Italy,”

Every day we delay hard decisions, every day leaders don’t demand collective action, the depth of epidemic will be larger. We must act now. We have narrow window to avert a worse outcome.”

Travelers donned in protective plastic jackets at Hong Kong airport; Hong Kong has ‘bent the curve’ of the outbreak with large-scale protective measures.

Action One Week Earlier Could Have Prevented 71% of Cases in Hubei and 78% in Rest Of China 

Chinese authorities enacted a cordon sanitaire of Wuhan on January 23 along with strict restrictions on inner-city travel, strategies that were quickly expanded to the rest of Hubei Province, and then the rest of China.

The Southamptom study, published in pre-print on MedRxiv estimated that enacting such “non-pharmaceutical interventions” even one week earlier could have prevented up to 71% of cases in Hubei Province, and 78% of cases in the rest of China, as well as 61% of cases in Wuhan – by preventing a large migration of people right before Lunar New Year on 25 January. Taking action two weeks earlier could have prevented 84% of the cases in Wuhan, 90% of the cases in Hubei Province, and 91% of cases in other provinces.

On the flip side, the researchers also estimated that if Chinese authorities had moved even one week slower, the case load of COVID-19 may have doubled in the country. Two weeks slower, and the case load could have increased by 5.8 times.

Given the modeled scenarios,  the authors recommended that “countries facing potential spread of COVID-19 should consider proactively planning NPIs and relevant resources for containment, given how the earlier implementation of NPIs could have lead to significant reductions in size of the outbreak in China.”

Th authors used population movement data from Baidu, China’s Google search engine equivalent, and modeled the effects of three buckets of containment strategies on the spread of COVID-19 in China:

1. Inter-city travel bans and restrictions, including the unprecedented cordon sanitaire of Wuhan – the Wuhan lockdown effectively fenced off the epicenter of the outbreak to the rest of the world.

2. Screening, contact tracing, identification, diagnosis, isolation and reporting of suspected ill persons and confirmed cases – in wuhan, citizens were required to report their temperature daily via an online app, and mild and symptomatic cases were quarantined away from crowded apartment complexes at makeshift hospitals in stadiums and conference centers

3. Restricting contact and inner-city travel even for healthy people – As part of “social distancing” policies, the Chinese government encouraged people to stay at home as much as possible; cancelled or postponed large public events and mass gatherings; shuttered public institutions, schools, and workplaces; and extended the Lunar New Year holiday for anywhere from 2 weeks to over a month in different provinces depending on COVID-19 caseload.

Image Credits: UN Photo / Jean Marc Ferré, Johns Hopkins CSSE.

Nurses preparing a diagnostic test for COVID-19 at a “drive-through” testing center at University of Washington Northwest Hospital & Medical Center

As the COVID-19 crisis seeps into financial markets, corporate board rooms, and global health systems, there may be one silver lining in an otherwise dark cloud.

The 21st century era of digital health, virtual meetings and teleworking is upon us.

Countries as far-flung as the Republic of Korea, Israel and even some forward-looking US health care providers are rushing to adopt tele-health, mobile health and AI solutions to protect their front-line health workers from COVID-19 infection.

Meanwhile in Geneva’s global health policy hub, institutions large and small, including Gavi, The Vaccine Alliance; The Global Fund; The International Committee of the Red Cross; and Medicines for Malaria Venture (MMV), are rapidly shifting into the virtual world of teleworking and video conferencing to keep operations going smoothly.

For others, however, change is at a slower pace, and more painfully reached.

Although the World Health Organization has long been outspoken about the benefits of telemedicine, in the case of virtual meetings and teleworking the Organization has been slower to adopt new practices, its critics say.

It’s also starting from a very low baseline. In 2018, WHO’s carbon footprint, mostly due to travel, was the second highest in the UN system, exceeded only by the World Meteorological Organization.  Its staff teleworking policies, limited to 4 days a month and subject to a paper chain of bureaucratic approvals, are among the most restrictive in the UN system.

But as COVID-19 cases explode across Europe, including in Switzerland, where the first infection of a staff member in a UN-affiliate, The World Trade Organization, was announced on Tuesday, the events on the ground are driving ever more rapid change.

After MMV reported to staff about a “probable COVID-19 case” over the weekend, all staff immediately shifted to teleworking on Monday.

In an internal message to staff on Tuesday, WHO said that to protect its headquarters operations, all external meetings would be cancelled, visitor access restricted, and a transition to virtual meetings accelerated. But the agency has so far held back on any dramatic expansion of  teleworking – saying only that current policies would now be relaxed for staff with confirmed “pre-existing medical conditions”.

Despite such hiccups, some global health influencers have dared to say that a faster shift to virtual channels could be a faint silver lining in the COVID-19 clouds.

“This *could* be the moment when we collectively finally crack videoconferencing on a mass scale, for good,” Wellcome Trust’s Director of Strategy, Ed Whiting, tweeted after the World Bank announced it would shift its annual Spring Meetings to virtual channels.

Can health policy institutions and the systems that they guide and manage use this crisis to make some leapfrog improvements in the use of digital technologies to better protect health workers and patients, slow infection transmission, and also make operations more efficient?

Here’s a rundown of scenes from a fast-changing landscape in hospitals, health clinics and head offices.

A nurse deposits a COVID-19 swab taken from a patient at a “drive-through” COVID-19 testing center at the University of Washington Northwest Hospital & Medical Center

Boosting PPE With Virtual Technologies  

Equipping health workers in countries worldwide with personal protective equipment (PPE) to protect them from the highly infectious virus has been a key priority for WHO since the new coronavirus first became a threat at ground zero, in Wuhan, China. Hundreds of thousands of PPE kits were distributed across China and rushed by WHO to countries around the world – although working in cramped, crowded conditions, health workers still often became exposed.

With just a few weeks of experience behind them, some countries, from Korea to Israel and forward-looking hospitals in the United States are experimenting with creative ways to test, triage and treat coronavirus patients while reducing those exposure risks.

Korea has received acclaim for its “drive-in” testing centers where patients can be tested with a nose swab in their cars – making the vehicle a kind of “isolation chamber” and protecting health workers as well as others waiting for similar tests.

The testing model is proving to be contagious in the United States, which invented the drive-in burger bar, after all.

The first American drive-in testing clinic was piloted at the University of Washington’s Northwest Hospital and Medical Center, a state where a large cluster of cases has emerged. Colorado, another outbreak area, soon followed suit. It opened a drive-through testing center on Wednesday. And Connecticut is now experimenting with the same approach too, reports the Science journal, The Verge.

It remains to be seen how fast the trends will be picked up by other US states, where test shortages and rigid protocols have triggered horror stories about the hurdles some people had to face, just to get tested, while also spending time emergency rooms or health clinics where others could easily be infected.

In Israel, meanwhile, people who suspect that they have the virus don’t go leave their home at all. They call a special emergency number, and a mobile unit visits to administer a swab. That has helped give Israel one of the highest testing rates in the world (401 tests/million), outside of Korea (3,692 tests/million), and Italy (826 tests/million), and Guangdong, China (2,820). It has also kept the number of infections down to about one-eighth of those in Switzerland, a country that has roughly the same number of people spread over twice the land area and is limiting its testing to severely ill patients or those with pre-existing conditions.

Health care staff interact with patients via a robot at Sheba Medical Centre.

At Sheba Medical Centre, in the city of Ramat Gan, doctors and nurses are performing basic checks on hospitalized COVID-19 patients via a robot, to reduce the threat of contagion.  One of the first patients to be hospitalized there after returning from a trip to Italy described it as a “Back to the Future” experience.

The robot can monitor lung function with a stethoscope, said Dr. Galia Barkai, head of Sheba’s Telemed Services. Added Eyal Leshem, director of Sheba’s Travel Medicine and Tropical Diseases unit, and a former scientist at the US Centres for Disease Control: “The robot moves has the capability to reduce the most fearful thing about this disease in health care facilities, which is nosocomial transmission,” Leshem said in an interview with Health Policy Watch.

Patients who are not sick enough to be hospitalized, are given a tiny handheld medical device called a Tyto to take home. It allows a medical professional to remotely check the patient’s lung function, throat, heart rate, temperature, and other vital signs, notes al Leshem, head of the hospital’s Travel and Tropical Medicine Centre.

Checking a child’s temperature at home with a remote Tyto monitor.

“We can monitor vital signs, such as temperature, and then talk with them on a secure telemedicine application,” Leshem said. “We can also save a lot of the unnecessary travel as well as contact with health care workers, which is also a source of a lot of nosocomial infections.”

On the other side of the ocean, meanwhile, the crisis may also be providing a boost to virtual delivery of more routine health care services – to keep uninfected patients away from crowded hospitals or clinics where they could catch COVID-19.

In a landmark measure approved last week by the US Congress, Medicare, the universal federal health insurance system for older Americans, will be allowed to reimburse clients living in COVID-19 outbreak areas for telehealth consultations with their regular care providers.

The decision, part of a US$8.3 billion emergency funding bill, was hailed by telehealth advocates as an important breakthrough in a country where growth in telehealth services has been constrained by Medicare rules that, until now, strictly limited telehealth service reimbursements to people in remote rural areas.

“During these types of outbreaks, you really don’t want to go where people are sick,” Rusty Hofmann, medical director of digital health care integration at Stanford University School of Medicine, told the The Verge. Although, he warned that the new provisions should be expanded further so such reimbursement is not only limited to a patient’s pre-existing health care providers.

The US administration is also said to be looking at ways to develop home-based COVID-19 testing solutions. “When we think of telemedicine and home testing, it reduces the risks, and makes it easier,” particularly for older Americans, who are among those most at risk, said Seema Verma, head of the US Medicare programme, at a televised meeting Tuesday between US President Donald Trump and major health insurance providers.

Virtual Meetings – Reducing the Footprint of COVID-19 & Carbon Emissions  

When the World Bank announced on March 4 that it would put its annual Spring Meetings, which draw tens of thousands of people to Washington DC every year, on a virtual footing, Whiting in a Tweet filled with emojis of airplanes and trees, said “Bring it. Interested how tech steps up.”

On it came. Just two days later, Friday 6 March, the Secretariat of the United Nations Framework Convention on Climate Change (UNFCC) cancelled its planned March-April rounds of negotiations in Bonn. In Geneva, parallel sessions and side events around the annual UN Human Rights Council meeting, which would normally draw hundreds of people to the city, were also cancelled. And Swiss authorities announced that they would also forbid any mass gatherings of more than 1000 people throughout the country.

Despite the ominous signs, in a WHO press briefing on the same Friday, WHO Director General Dr Tedros Adhanom Ghebreyesus refused to speculate about whether the world’s signature global health event, The World Health Assembly might have to shift to a virtual footing if it convenes at the scheduled dates in late May.

He said that virtual meetings should be encouraged to reduce costs and climate emissions, but decisions “should be made not because of COVID now, but when there is no COVID as well.”

Against the mounting tide of Swiss COVID-19 cases, which on Thursday stood at 868 cases and four deaths, a new order by Swiss authorities limiting meetings to under 100 participants seems likely to dramatically change the shape of how the WHO does business in the coming months.

In the internal memo sent out to WHO staff Tuesday evening, a rapid scale-up of virtual meetings was promised to offset the cancellation of all meetings at Headquarters with external experts and partners.

“To support these changes in our ways of working, steps have been taken to increase our bandwidth to accommodate the expected increase in virtual meetings,” said the note to all WHO Headquarters staff.  “In order for the Organization to fully implement virtual solutions, additional support in setting up virtual meetings and relevant training will be provided.”

Some WHO insiders, who have been pressing for years for such changes, see it as none too soon.

With 13.7 tons of CO2-equivalent emissions (tCO2-eq) per capita, WHO’s carbon footprint is the second largest across some 50 UN agencies and affiliates, exceeded only by the WMO footprint (16.4 tCO2-eq) per capita, according to the 2019 report of the UN Greening the Blue initiative.

Some 90% of WHO’s carbon emissions  or 12.64 (tCO2-eq) was attributable to air travel in 2018 – a more than 50% increase over emissions from the year before, of just 8 (tCO2-eq), WHO’s own emissions inventory available on the Greening The Blue website.

There are strong arguments that periodic face-to-face meetings are critical to build trust and facilitate collaboration between professionals from vastly different countries and institutional cultures. But critics say WHO has lagged for years on investments in stronger videoconference facilities that would save costs and carbon – and this will jump start the process.

“It’s true that you can’t have hallway discussions, that is correct,” said one WHO scientist, who asked to remain anonymous. “But how much do hallway discussions contribute in comparison to the damage that you are doing to the climate?

“In the 1960s, when telephones were first installed in homes, they were put high up on the wall. You could only talk standing up, and that meant passing on a short message. Today,  we have a completely different attitude towards the phone. So, I think it is for the most part it’s an attitude problem.”

Teleworking   

Teleworking is another area in which attitudes are now changing rapidly.

Staff at The Global Fund to Fight AIDS, Tuberculosis and Malaria and Gavi-the Vaccine Alliance, the two giant public-private partnerships founded two decades ago by the Bill and Melinda Gates Foundation, have been teleworking one or two days a week for some years already.

As the COVID-19 outbreak began to amplify, The Global Fund administration asked its IT consultants to build a scenario in which all staff would be teleworking. Today, after weeks of trial runs at team level, an organization-wide drill of teleworking procedures will be conducted, said Melanie Brooks, Editorial Team Manager.

“Technology is increasingly playing a part in our ability to work effectively in the building. We are providing regular guidance to staff for teleworking, including Q&As, tips for effective working from home, and training on our remote-working teleconferencing system,” said Brooks.

To ensure our organizational readiness to be able to react to the developing COVID-19 coronavirus situation, this Thursday morning, 12 March, we are undertaking an organization-wide trial of our home-working capabilities. All staff, consultants and interns are required to work normally, but from home, before coming back to the office for the afternoon, from 13.00. Following the successful testing of our offsite working… last week, this Thursday’s exercise will enable us to more fully assess both our system and individual capacity to work effectively from home.”

Gavi, The Vaccine Alliance, which shares The Global Fund campus, right down the street from WHO, has a less formalized teleworking policy, said spokeswoman Frederique Tissandier. But the overall result is almost the same. Already for the past several weeks, employees have been instructed to back up, and take home their laptop computers…. Just in case.

“The approach is to be mindful of our colleagues and the campus. If someone suspects that they are ill, he is free to stay home, to go home, to work from home and quarantine himself automatically and there will be no questions asked,” she said.

Regular teleworking options have been “standard policy,” at MMV for some time, added Dr David Reddy, MMV’s CEO, whose offices are located in a busy hotel complex near Geneva Airport. On Monday, following a report of a “probable case” among a staff member, MMV shifted to a mandatory teleworking protocol for everyone.

“As part of our COVID-19 preparedness plans that we put into place two weeks ago, we then determined two probable scenarios that would lead to flex in that policy,” he said. “First, in a bid to reduce possible transmission, those employees who wished to do so, could work from home full-time for the immediate future.  Second, as the situation evolved with a probable case among our team over the weekend, we implemented mandatory working from home as of Monday.”

Back at WHO, however, teleworking remains limited to 4 days a month. In order to have a request approved, a staff member has to print out a hard copy form, fill it out and have it signed by a supervisor, then scan it, and then send it to half a dozen other emails – in advance of the planned teleworking days.

WHO’s Staff Association has long complained that WHO’s practice is out of line with broader UN policies on Flexible Working Arrangements, which allows teleworking for up to two days a week, in line with two  UN General Assembly member state resolutions supporting a more  “flexible workforce.”

When Dr. Tedros took the helm of the organization in 2017, WHO’s Staff Association attempted to gain his support for a more flexible policy, arguing among others things, it would “help business continuity in case of a pandemic or natural disaster and enable the workforce to work from outside the premises,” according a message shared by multiple WHO staff, who requested confidentiality.  

A 2019 WHO Staff Association message to the WHO Executive Board publicly called for the standard UN policies to replace the existing WHO provisions. But it was never adopted.

On Tuesday, WHO announced more flexibility for with “pre-existing medical conditions” to request broader teleworking privileges for a time-limited period, through the Staff Health and Wellness Services.

“Medical evidence, which will remain fully confidential, will need to be subsequently provided in support of these measures. The recommended duration of teleworking will be determined on the basis of the evolving epidemiological situation and risk in the community,” stated the message. The announcement hinted that more changes might be on the horizon, but didn’t say what:  “Additional general guidance on teleworking arrangements will be issued in the next update.”

Current policies, staff complain, are contradictory with WHO’s Global Influenza’s Programme Guidelines on pandemic and epidemic influenza measures that company’s can take. Those guidelines recommend the adoption of telecommuting and staggered hours saying that it was associated with a median 23% percent reduction in infection incidence – although the recommendation is framed as “conditional” due to the dearth of controlled bio-medical studies

Now that theory has become reality, staff are worried that the current policy makes it almost impossible for them to use teleworking measures to work from home preemptively, in case they feel just a bit ill, or have returned recently from travel. And that forces them to face a hard choice – take a sick day or go to work and risk infecting others. Older staff, who may be healthy but still at risk, due to their age, are also exposed.

Said one senior staff member, who asked not to be named: “We still have a teleworking policy that requires a physical signature. So  if I do decide I have a cold or want to stay home, I still have to go to the office, print out the form, fill out the form, get it signed, and send it to 7 people, and spread the virus in the meanwhile. Or I stay home, and then I waste a vacation day, or I waste public health resources going to a doctor, saying I need a sick certificate.

“I know there are efforts ongoing in WHO to make us technically fit for teleworking. My guess is that they will start an up-to-date and public health appropriate teleworking policy, when either the Swiss government requires it, or when we have proof of WHO inter-office transmission – and then the baby will have already fallen out of the bath.”

Updated 12 March 2020

Image Credits: University of Washington Northwest Hospital & Medical Center, TytoCare , https://www.greeningtheblue.org/.

Iranian healthcare workers in personal protective equipment

As cases of COVID-19 surpassed 120,000 around the world, the World Health Organization on Wednesday declared a pandemic – a move the organization stressed was intended to “trigger” even more aggressive action from governments against the virus rather than surrender to its rapid spread.

In line with current trends, numbers of COVID-19 cases, deaths and number of affected countries will “climb even higher,” Dr Tedros Adhanom Ghebreyesus warned on Wednesday, before they decline.

However, WHO sees this as a “call to action” to spur countries to scale up efforts to contain the virus and slow the spread, and prepare their health systems for an influx of patients, said WHO’s Head of Emergencies Mike Ryan.

“Declaration of a pandemic is not an “escape clause” to mitigation – a strategy focused only on saving lives when uncontrollable spread of a disease is inevitable, Ryan said. “There is a strong element of controllability in this disease.…We have a real chance to bend the curve – and give the health system a chance to save more lives.”

Dr Tedros added that the dramatic decline in new cases in certain countries, and the low numbers of cases in others means that governments still have the chance to stop the virus from spreading further.

“Eighty-one countries have no cases – they should not give any ground for this virus to set foot in their country. Fifty-seven countries have less than 10 cases – they can cut it from the bud,” he said.

‘Bending the Curve’ of Rising COVID-19 Cases

The Republic of Korea has already ‘bent the curve’  of the epidemic with an aggressive testing and containment strategy. In what was two weeks ago the largest outbreak outside of China, the daily new case count has fallen to approximately 30 – 40 per day compared to a peak of over 500 a day just last week.

Increasingly governments across the WHO European region are taking an iron fist to the virus as well, replicating tracts that have succeeded in China, Singapore and the Korea. Italy has locked down the entire country; school classes and mass gatherings across France and Germany are suspended. In Spain – now the country in Europe most affected outside of Italy – daycare centers and schools in key affected areas are closed, flights between Italy and Spain are suspended, and large sporting events have been cancelled.

In the most assertive preemptive moves so far outside of China and the Republic of Korea, Israel announced this week that it will place all Israeli citizens re-entering the country under 14 days of self-quarantine regardless of where they are coming from, and bar the entry of foreign tourists altogether.  So far Israel has reported just 76 cases, mostly among Israelis or tourists arriving from abroad, while there are 26 cases in the Israeli-occupied Palestinian territories; In contrast, Switzerland, a country of approximately the same size, now has 645 people who have tested positive.

Meanwhile, WHO was recommending that countries around the world take a ‘blended’ approach to the battle against the virus – bolstering the capacity of hospitals and health care facilities to prepare for a surge in patients while at the same time, continuing to make containment “the major pillar” of the response, said Tedros.

The trade-offs are challenging. Tracking down contacts of cases and enforcing quarantine measures to slow down transmission of the virus could slow the surge of patients that require hospital care. At the same time, they can be complex and costly to carry out.

“The difficulty is that if you do not try to suppress this, it could be very straining to your health system,” said Ryan. In Italy, for example, some 900 patients were have been hospitalized within intensive care units, who also need to be continuously monitored by health workers wearing full protective gear.

“We’ve had lots of people talking about containment vs mitigation – countries should focus on containing where there is opportunity, and preparing the health system to reduce the impact,” said Ryan.

“There’s a shortage of ventilators, a shortage of oxygen… ” he added, noting that “the caseload, the demand on the healthcare workers, and the risks that come with the fatigue and the shortage of personal protective equipment,” are overwhelming for health systems,  said Ryan. “We need to focus on getting them equipment, supplies, and the training that they need to do the job.

Pandemic Spread; Active Cases Worldwide

European Countries Declaring Emergencies – But Responses Still Lagging Behind Outbreak Curve

European governments are enacting emergency executive powers as the outbreak explodes across the continent – just days after the Prime Minister of Italy locked down the country, applying travel restrictions on its citizens that were unprecedented since the end of World War II.

Along with Italy, Switzerland, Spain, and Israel have activated national emergency rules, which allow federal powers to control aspects of daily life in order to slow the spread of COVID-19.

Spain, which is now the country with the fifth highest number of cases, has taken a “whole of society approach” to the virus – all schools, daycares and university classes are suspended in La Rioja, Basque, and Madrid, while the national government shut down all flights to Italy and canceled sporting events.

Even so, those measures may not be sufficient, Ryan warned, saying: “Countries in the EU and Western Europe should assess whether efforts are good enough to suppress the virus.”

As of noon Wednesday, 645 people in Switzerland have tested positive for the disease, and events of more than 100 people were banned by Swiss Government authorities – striking at the core of Geneva’s economy, host to dozens of UN agencies, the world’s largest global health hub, and among the world’s most popular venues for related international events..

As the case count crept higher, Geneva’s UN agencies and affiliates, as well as other global health and development organizations and non-profits, rolled out aggressive screening measures, policies on telecommuting, and new protocols for potentially sick employees.

Shortage of Hospital Equipment In Iran

Meanwhile in Iran, local and central governments have improved coordination of COVID-19 efforts, said Ryan.

Schools and universities across the country are closed until after Nowruz, the Iranian New Year that falls this year on 20 March. Opening hours of large tourist attractions have been limited, and checkpoints have been established in major cities such as Tehran according to the official state news agency IRNA.

Right now, “the concern is a shortage of ventilators and oxygen” for treating severe cases, said Ryan.

“We’ve seen this in Italy. What happens at this stage is that it generates a lot of cases, that requires a huge effort by health workers,” he added.

Data from The WHO-China Joint Commission report on COVID-19 showed that approximately 14-20% of critical or severe cases will require hospitalization. Patients can require ventilator support for more than two weeks, and must be attended by at least two healthcare workers wearing full personal protective gear at all times.

WHO and China are still supplying the country with diagnostic supplies and protective equipment. WHO shipped 140,000 diagnostic tests to Iran today, following a shipment of 7 tons of personal protective equipment along with other outbreak response supplies sent last week.

Iranian officials are now aggressively tracing contacts and testing suspect cases, as the outbreak escalated to 9000 total cases and reached the highest echelons of government. Some 24 Iranian government officials and Members of Parliament have died from the disease, and many are reportedly ill.

According to Al Jazeera more than 70,000 prisoners were released following reports of a COVID-19 cases in overcrowded prisons with inadequate isolation facilities. Those sentenced for less than five years for non-violent crimes are subject to release.

Image Credits: Twitter: @WHOEMRO.

Electron microscope image of SARS-CoV-2— the virus that causes COVID-19—isolated from a patient in the U.S. Virus particles shown in red with their signature “crown-like” spikes in green.

The Bill and Melinda Gates Foundation, Wellcome Trust, and Mastercard on Tuesday announced a US $125 million commitment of seed funding to a new COVID-19 Treatment Accelerator – whose aim as its name implies, will be to speed up the development of urgently needed drugs to treat people infected with COVID-19.

Just hours later, the Coalition for Epidemic Preparedness Innovations (CEPI), which is engaged in a similar race for new vaccines, announced a $4.4 million investment to advance preclinical and Phase 1 trials of two of the most promising vaccine candidates that it has identified.

As cases shot up in Italy to over 10,000, spurring a nation-wide lockdown; and US Centres for Disease Control officials warned the US public to prepare to move into the “mitigation phase,” of reducing the worst consequences of the disease – rather than containing it, these ‘sister’ initiatives reflect how the global R&D community is racing against time to find game-changing drugs and vaccines. 

The downside, however is this. Neither initiative has enough funding right now to fully finance a drug or vaccine to from end-to-end.

CEPI issued a statement warning that it lacks financial resources needed to continue the next steps in the development process and “deliver the vaccines the world needs.”

Trevor Mundel, president of the Gates Foundation, told STAT News that there is not enough funding for the COVID-19 Treatment Accelerator to take a one all the way from discovery to disbursement into providers’ hands.

Even if new treatments and vaccines are successfully developed, some infectious disease experts worry that the biggest barrier may be scaling up manufacturing capacity of an approved product.

Normally, drugs get stuck in a regulatory bottleneck waiting for approval from agencies like the US Food and Drug Administration (US FDA), Stephen Morse, professor of Infectious Disease Epidemiology at Columbia’s Mailman School of Public Health, told Health Policy Watch.

But this time, he said, “the problem isn’t going to be FDA approval… they’re going to put this on a fast track, they want to have this quickly.

“In this case… the rate-limiting step is producing enough of [a vaccine] in time,” he said. Only “a handful” of large pharma companies have the capacity to produce the quantities of vaccines that would be needed to protect entire populations against the disease – which has infected more than 118,000 worldwide as of Tuesday night.

Out of some 50 different COVID-19 vaccine development programs, only two vaccine candidates are housed by large, multinational pharma companies according to a round-up by Biocentury. The others are being developed by small biopharma companies or academic institutions – the types of organizations which Morse says do not have the manufacturing capacity to scale production by themselves.

New Funding for COVID-19 Treatment Accelerator 

The US $125 million infusion into COVID-19 treatment research will still be able to help push forward treatment candidates stuck at certain stages of development.

“Viruses like COVID-19 spread rapidly, but the development of vaccines and treatments to stop them moves slowly,” said Mark Suzman, chief executive officer of the Bill & Melinda Gates Foundation in a press release.

“If we want to make the world safe from outbreaks like COVID-19, particularly for those most vulnerable, then we need to find a way to make research and development move faster.”

Modeled after CEPI’s vaccine development platform, the new COVID-19 Treatment Accelerator offers funding at all stages of development – including identification of drug candidates, clinical trials, and working with regulators and manufacturers to bring a treatment to patients.

More than 300 trials on COVID-19 are currently registered with WHO’s International Clinical Trial Registry with at least 15 trials testing antiviral treatments, and no treatments have so far been approved. With the abundance of treatment candidates, WHO officials have said they are nailing down a system for prioritizing clinical trials for the most promising treatments.

Many collaborations across borders have been forged. Sixthtone reported that some 60% of academic papers on potential treatments were rapidly disseminated through open-access pre-print servers such as MedRxiv, which allowed researchers to share key findings and exchange knowledge before going through long peer review processes.

“Science is moving at a phenomenal pace against COVID-19, but to get ahead of this epidemic we need greater investment and to ensure research coordination,” said Jeremy Farrar, director of Wellcome.

“The Therapeutics Accelerator will allow us to do this for potential treatments with support for research, development, assessment, and manufacturing. COVID-19 is an extremely challenging virus, but we’ve proved that through collaborating across borders we can tackle emerging infectious diseases.”

The Gates Foundation and Wellcome are each contributing up to $50 million, and the Mastercard Impact Fund has committed up to $25 million to catalyze the initial work of the accelerator.

CEPI Announces US $4.4 Million Investment In Two New Vaccine Candidates, Asks For Additional Funding

CEPI’s additional US $4.4 million investment announced today would fund Phase 1 trials for a COVID-19 vaccine candidate currently in the pipeline of the pharma company, Novavax, along with the preclinical and Phase 1 safety trials of a potential vaccine developed by the University of Oxford. The two new commitments bring the total number of candidates in CEPI’s portfolio to six.

Novavax, a company that has previously conducted vaccines research into MERS and SARS coronaviruses, is using a proprietary technology to create a vaccine that targets the signature (S) spike protein on the surface of SARS-CoV-2 – the coronavirus that causes COVID-19.

The University of Oxford is working on a COVID-19 vaccine using a simian adenoviral vaccine vector, which has been used as a delivery vehicle in vaccines for other viruses like MERS, Nipah, and Influenza.

However, the organization says that donors need to step up funding to help finance the COVID-19 vaccine projects to completion.

Without “immediate additional financial contributions,” the vaccine programs CEPI has begun will “not be able to progress and ultimately will not deliver the vaccines that the world needs,” the organization warned in the press release announcing the new investments.

“Vaccine development is complex and difficult and will require concerted global effort,”  said CEO of CEPI Richard Hatchett. He clarified CEPI was investing in a variety of different options in order to maintain a “balanced portfolio” and “ensure multiple shots on goal.”

“There are no guarantees of success, but we are working as fast and as hard as we can,”  he added, but the organization hopes to deliver a safe and efficacious vaccine for broader use within the next 12-18 months.

The commitments resulted from submissions made to a global call for proposals that CEPI issued in early February, which invited funding applications for proven vaccine technology that could be used to rapidly develop a vaccine against the new coronavirus. Most importantly, the new vaccine must be able to be manufactured at scale and with the necessary equitable access provisions.

The two new investments join the CEPI-funded COVID-19 vaccine development initiatives by Inovio Pharmaceuticals, Moderna and the US National Institutes of Health, Curevac Inc., and the University of Queensland.

Image Credits: NIAID-RML.

The World Trade Organization’s director general Roberto Azevêdo announced on Tuesday that he was suspending all WTO meetings at its Geneva offices, following the confirmation of a COVID-19 case among staff. It was the first publicly-announced case of the novel coronavirus infection at a Geneva-based United Nations or UN-affiliated organization since the epidemic began, which has seen a the recent acceleration of reported cases in Switzerland.

Meanwhile, in a late-night internal circular, the World Health Organization told its Geneva staff that meetings with external participants would also be cancelled until 15 April, Health Policy Watch learned. WHO also announced a series of dramatic new measures to protect staff and the headquarters’ work premises from infection, including:

  • Self-monitoring by staff of their health status (e.g. temperature, cough) before coming to work;
  • Installation of thermoscanners in WHO’s two main entrances (i.e. Main entrance and D-Building);
  • Establishment of isolation areas;
  • Restriction of visitor access to the premises, and access to other doors to emergency staff;
  • Ramping up of virtual meetings, with technologies and support.

The circular said that while there had not been any confirmed COVID-19 cases in the building, the measures were being taken to proactively “to protect Staff as well as the working environment here at headquarters.”

In a press release posted on the WTO website this evening, Director-General Roberto Azevêdo said that he had informed WTO members that, as of 11 March, all meetings at the WTO will be suspended until 20 March. “The decision follows confirmation that one WTO staff member has contracted the COVID-19 virus,” the press release stated.

“We take the health of Secretariat staff and our members very seriously which is why we have taken this unprecedented step,” Azevêdo was quoted as saying. “We are monitoring the situation very closely and will take whatever measures are necessary to protect health and safety. We will monitor the situation constantly and review this decision before the end of next week.”

The WTO has a coronavirus Task Force in place.  In addition, WTO has been coordinating with other UN organizations in Geneva around the COVID-19 crisis, spokesman Daniel Pruzin told Health Policy Watch.

“I can tell you that we have an interagency network in place to monitor and respond to the coronavirus outbreak and that we are in very good contact with the network,” he said.

While not a United Nations or UN specialized agency, as such, the WTO sits on the United Nations Chief Executive Board (CEB), and is therefore part of the constellation of UN agencies, and global health and development NGOs that make up the hub of so-called “International Geneva.”

WHO did not respond last night to Health Policy Watch queries about new protocols for staff safety at its building, or about measures being taken elsewhere in Geneva’s UN system.

A WHO spokesman said only that: “The UN activated a Crisis Management Team (CMT) on the COVID-19 outbreak, led by Dr Mike Ryan, Executive Director of WHO Health Emergencies Programme as the Crisis Manager. The CMT brings together WHO, OCHA, IMO (International Maritime Organization), UNICEF, ICAO, WFP, FAO, the World Bank and others UN entities.”

As of noon Tuesday, some 476 COVID-19 cases had been reported in Switzerland by the Federal Office of Public Health.

New Infections in Italy, Switzerland and Europe Surging – But Republic of Korea Sees Dramatic Reductions 

COVID-19 cases began to spill over into Switzerland over the past week, largely as a result of the traffic between Italy and southern Switzerland’s Italian speaking Ticino region, where many people have work, study and family ties. Infections have gradually spread out throughout the country, including potential clusters of community transmission in Geneva as well as other expanding disease clusters in the Zurich area.

Over the past 24 hours nearly 100 new infections were reported in Switzerland – an increase of about 25%.  France also saw cases rising by about 30% in the last 24 hours to a total of 1,606 reported cases on Tuesday evening.

On Saturday, an employee of the European Organization for Nuclear Research, CERN, which is based just over the Geneva border in nearby France, was also reported to be infected.

“The infected person was in close contact with a small number of colleagues. In accordance with procedures put in place in collaboration with its Host State expert authorities, CERN has implemented measures to quickly identify potential cases and limit the risk of infection on the CERN site,” a press release stated. The agency has suspended all work-related travel for employees, although it continues to host meetings onsite, however, of less than 100 people.

As cases in the UK rose to 382 total, British Health Minister Nadine Dorries announced she tested positive for the coronavirus Tuesday night. Dorries tweeted she was self-quarantining at home with her 84-year old mother – who had just began to cough and is getting tested tomorrow.

In Germany, the increase was more moderate with only about 130 new cases, for a total of 1,281.  Inconsistencies in testing protocols across Europe leave considerable uncertainty about what proportion of cases are actually being identified and reported, although it appears clear that patterns of community-wide transmission are now occurring in all three countries.

Latest COVID-19 data according to Johns Hopkins CSSE as of 6:53PM CET 10 March (1:53PM EST)- Note numbers are changing rapidly, this map has not been updated with the latest Switzerland cases.

In Italy on Tuesday, there were now 10,149 COVID-19 cases, an increase of nearly 3,000 infections over the day before, when the entire country went under lockdown by order of Prime Minister Giuseppe Conte. However in the Republic of Korea, only 35 new cases were recorded overnight, a striking indication that with tough measures, the epidemic could be brought under control.

In Iran, while reported infections still increased by nearly 1,000, that was a slower pace than in days before, offering some hope that the Islamic Republic might soon turn the corner on the epidemic as well.  Globally, there were now over 118,000 cases in 113 countries and self-administered territories.

Some 45 countries have enacted some form of travel restriction on entering and leaving the country. As virus transmission shifts to other global hotspots, more restrictions are being enacted on people transiting from outside of China such as Italy, Iran, S. Korea, Japan, and the United States.

In China, the number of new cases has slowed dramatically to only 20 in the past 24 hours. However, 17 new deaths were reported, indicating that some patients had died even after a long period of hospitalization.

Image Credits: Johns Hopkins CSSE.