Africa’s population over the age of 60 will triple by 2050, bringing “a sharp rise in neurodegenerative diseases, including Alzheimer’s, with profound health and economic costs”, according to a paper published in Nature last week.

The paper highlights a five-year strategy, headed by a pan-African task force, to address this demographic shift on the continent, focusing on “early detection, timely care, data-driven systems, and equitable innovation”.

Some three-quarters of people living with Alzheimer’s globally are undiagnosed, denying them access to appropriate treatment and care. 

Given widespread systemic weaknesses in the health systems of several African countries, this may well be the fate of many of the estimated 226 million Africans over 60 projected to be living on the continent by 2050 (up from 69 million in 2017). 

Currently, only 12 African countries submit data to the Global Dementia Observatory.

Tunisia, Algeria and Egypt already have some of the highest dementia-related disease burdens in the world, and by 2050, 14 million Africans are expected to develop Alzheimer’s and related disorders. 

Health system transformation

The “6×5” plan developed by the Davos Alzheimer’s Collaborative (DAC) aims to assist African countries to address this growing problem using low-cost innovations.

It comprises six interventions over the next five years: strengthening advocacy and health literacy; positioning brain health as a socioeconomic driver; breaking down silos of people and data; repurposing local resources; investing in artificial intelligence and digital health, and boosting research funding. 

Advocacy and health literacy

“In many African cultural settings, dementia is often linked to madness, witchcraft and demonic possession, or it is dismissed as a natural part of ageing,” the report notes.

To address this stigmatising approach, it proposes health literacy campaigns aimed at establishing dementia as “a biological issue that requires immediate attention”. 

Brain health as a socio-economic driver

“Positioning brain health as a cornerstone of Africa’s societal well-being, economic growth and sustainable development is imperative,” according to the plan.

It calls for health policy makers to recognise brain health as a critical economic priority, and address individual and societal determinants of brain health across people’s entire lifespans.

This would start with the first 1,000 days of life, a critical phase for brain development, and include childhood education to build cognitive skills and lifelong learning opportunities.

It would also encompass women’s health initiatives to address gender disparities, initiatives to promote emotional resilience, and healthy ageing strategies that incorporate physical activity, nutrition and social engagement.

“The continent has a deeply rooted heritage of social connectedness, collective identity and intergenerational support – factors shown to promote cognitive well-being and mitigate cognitive decline,” the report notes.

Repurposing local resources

“The continent needs a comprehensive Pan-African Resource Repurposing Strategy for Brain Health – one that identifies underutilised resources and fosters sustainable, affordable and locally driven solutions,” the report notes.

Expertise in managing infectious diseases such as HIV can be harnessed to help with the early detection of dementia, for example.

Community health workers can be trained to identify early signs of the disease, primary healthcare facilities can serve as hubs for cognitive screening, education and management, and dementia care can be included in non-communicable disease (NCD) services.

Breaking down silos

“A well-integrated research and data ecosystem is essential for identifying high-risk populations and implementing targeted dementia prevention and early intervention strategies,” the report notes.

However, Africa’s research and information systems are fragmented, with “weak data-sharing platforms, limited connectivity between research hubs, and a lack of standardised mechanisms for harmonisation and reporting”. 

It proposes establishing “a Pan-African network of research centres” to drive a harmonised, transdisciplinary approach to data generation and utilisation. 

It also advocates for “strengthening cross-sector collaboration through partnerships between health systems, governments, researchers and nongovernmental organisations” and global partnerships.

Tech-enabled systems

“Digital health solutions offer accessible, scalable and cost-effective alternatives to traditional healthcare approaches,” and Africa’s mobile technology “revolution” means it is well placed to adopt these, the report notes.

New digital biomarkers enable early and accurate detection, monitoring and treatment of brain disorders – including data from speech patterns and typing.

This “allows for passive and remote monitoring of cognitive changes”, which facilitates the use of AI.

Digital technologies can also play a critical role in “identifying and mitigating modifiable risk factors associated with cognitive decline”, including “sleep patterns, physical activity, social engagement and mental health indicators (such as depression)”.

But AI-driven solutions are often developed on and for high-income populations, which means Africa needs “a pan-African strategy for AI and machine learning solutions in brain health”.

Strengthening research funding

“To attract investment from both public and private sectors, brain health leaders must present a compelling economic and social case,” the report notes. 

It proposes that brain health is integrated into existing healthcare priorities such as maternal and child health, NCDs and social determinants of health. 

Way forward

As Africa transitions to a society with smaller families, there is the prospect of greater economic wealth as the working-age population becomes proportionally larger than the non-working-age population – and this offers a chance to implement measures to prepare for an older population, the paper argues.

To effectively implement the priority areas outlined in the 6 × 5 Plan, DAC launched a pan-African task force on brain health in March 2025. 

The task force’s organising committee, which provides strategic oversight, is composed of DAC, the World Health Organization (WHO), the World Economic Forum (WEF), the World Bank, Alzheimer’s Disease International (ADI) and the African Union. 

DAC leads the secretariat, which coordinates operational support and communication. Six thematic chairs – covering research, nonprofit, industry, policy, economics and systems thinking – shape strategy and liaise with working group leads. 

Six working groups, led by operational leads from the five geopolitical zones, focus on executing the priorities of the 6 × 5 plan, ensuring regionally relevant and inclusive solutions across Africa.

“Unlike research efforts that focus on therapeutic interventions, DAC’s model emphasises health system transformation, from earlier detection and evidence-based care pathways to strengthening workforce training and improving global data sharing,” according to a media release from the Geneva-based collaboration.

Image Credits: Kizito Makoye Shigela/HPW, UCLA .