The working group on amending the IHR met in Geneva last week (20-24 Februar 2023).

Negotiations to tighten up the World Health Organization’s (WHO) International Health Regulations (IHR) to make them pandemic-ready made “excellent progress” – but it still faces enormous obstacles.

WHO member states spent four days last week addressing 100 of the 300 proposed amendments to the IHR, dealing particularly with compliance, implementation, and public health response. 

In describing the “excellent progress”, co-chair of the Working Group of the IHR (WGIHR), New Zealand’s Dr Ashley Bloomfield, said that discussions also “considered critical areas such as core capacities for surveillance and response, collaboration and assistance”. 

In addition, six newly proposed articles and one new annex were put on the table.

Fellow Co-Chair, Saudi Arabia’s Dr Abdullah Assiri described the tone of the meeting as positive and constructive.

“Countries are in the driving seat of this process as they need to implement the IHR, deliver on the obligations, and make the key decisions needed to respond to public health threats,” said Assiri.

Pandemic weaknesses

The IHR were originally adopted to set out agreed approaches and obligations for countries to prepare for, and respond to, disease outbreaks and other acute public health events with risk of international spread. 

However, they proved inadequate during the COVID-19 pandemic, as pointed out by WHO Director-General Dr Tedros Adhanom Ghebreyesus.

“During the COVID-19 pandemic, the international community has learned a great deal about how the IHR functions in a public health emergency of international concern. But the pandemic also revealed deep inequalities in the global health architecture at the national and global levels,” said Tedros.

“It’s important to note that currently, the IHR are the only universal instrument for global health security that the world has,” added Tedros.“That’s why bold but well-targeted amendments are so vital.” 

“The IHR rely on the worldwide application of obligations for international cooperation and assistance in respect of human rights and the underlying principles of solidarity,” said Tedros.

“The process of amending the IHR offers an opportunity to strengthen and extend these principles, but these adjustments to the IHR also have practical implications, as we have learned from many outbreaks in recent years, especially during the early stages of a potential public health emergency.”

Incentives for pathogen sharing

Tedros said that the IHR’s incentive structures are not well-aligned, as some states that quickly notified WHO were “sometimes penalised by travel and trade restrictions”. He added they should be amended to encourage rather than punish transparency and IHR compliance.

Huge challenges remain to be resolved, however, particularly around pathogen sharing. The Africa group wants the WHO to establish a repository for cell lines to accelerate the production and regulation of generic products and vaccines.

Meanwhile, Bangladesh also wants the WHO to set up a database of the ‘recipes’ of vaccines and medicines needed during public health emergencies of international concern, as well as know-how related to their manufacturing.

Image Credits: WHO.

Air pollution
Air pollution is the 10th leading cause of death in the European Union.

Air pollution causes over 1,200 premature deaths per year in people under the age of 18 in the Europe and significantly increases the risk of disease later in life, according to European Environment Agency (EEA) air quality assessment published on Monday. 

“Despite improvements over past years, the level of key air pollutants in many European countries remain stubbornly above World Health Organization (WHO) health-based guidelines, especially in central-eastern Europe and Italy,” according to the EEA. The agency’s report covers the 27 members of the European Union as well as some non-EU EEA members such as Switzerland, Norway, and Liechtenstein.

Some 97% of the urban population is exposed to annual concentrations of fine particulate matter (PM2.5) above the 2021 WHO annual guideline of 5 micrograms per cubic meter (µg/m3), the report stated.

Traffic, heating, and industry are the main sources of air pollution in Europe, and while emissions have declined, air pollution levels are still not safe – particularly for children.

Sector contributions to primary emissions of major hazardous air pollutants in the EU (2020).

Low birth weight, asthma, allergies and reduced lung function

Children are more vulnerable to air pollution than adults as they have higher and faster breathing rates, taking in more air per kilogram of body weight and breathe air closer to the ground where some pollutants, especially from vehicle exhaust, are emitted and become concentrated. 

“Moreover, children inhale a larger fraction of air through their mouths than adults. Due to this increased oral breathing, pollution penetrates deep into the lower respiratory tract, which is more permeable,” according to the EEA.

Their bodies and organs, including their lungs, are also still in development, which further increases risk and their immune systems are weaker than those of adults.

Children are more vulnerable to air pollution than adults (European Environmental Agency).

“Maternal exposure to air pollution during pregnancy is linked to low birth weight and risk of pre-term birth,” according to the agency.

“After birth, ambient air pollution increases the risk of several health problems, including asthma, reduced lung function, respiratory infections and allergies. It also can aggravate chronic conditions like asthma, which afflicts 9% of children and adolescents in Europe, as well as increasing the risk of some chronic diseases later in adulthood.”

There is also growing evidence that air pollution affects children’s brain development, contributes to cognitive impairment, and that it may play a role in the development of some types of autism.

The agency recommends that particular attention should be paid to improving air quality near schools and kindergartens, such as growing vegetation to screen pollution.

“Air pollution levels across Europe are still unsafe and European air quality policies should aim to protect all citizens, but especially our children, who are most vulnerable to the health impacts of air pollution,” said EEA Executive Director Hans Bruyninckx.

“It is urgent that we continue to step up measures at EU, national and local level to protect our children, who cannot protect themselves. The surest way to keep them safe is by making the air we all breathe cleaner.”

Image Credits: Mariordo, European Environment Agency (EEA).

 

In mid-2021, India was crumbling under the pressure of an intense COVID-19 wave, caused by the Delta variant of the SARS-CoV-2. But at the same time, misinformation was spreading exponentially – adding to the fear and anxiety of the time.

Thousands of people were scrambling to find oxygen cylinders and hospital beds for their loved ones infected with COVID-19, while others were struggling to recover completely from a previous COVID-19 infection and did not know what was happening to their bodies. Mis- and dis-information about the virus were rampant, creating widespread chaos in the country. 

Watching this situation unfold in front of his eyes pushed Sai Charan Chikkulla to take matters into his own hands. 

“A man lost his mother to COVID-19 after being shunted from one hospital to another due to lack of a bed with oxygen supply. He saw his mother die in an ambulance waiting for an oxygen-bed in a big government hospital because he didn’t know where else to take his mother,” Sai Charan told Health Policy Watch. 

A regular user of Twitter, the 29-year-old Hyderabad-based entrepreneur immediately decided to pick up the phone and start dialling. His idea was simple: to call hospitals in the region, enquire about the bed availability and the criteria for admitting patients and post the information on Twitter with the relevant hashtags. 

Sai was not the only one leveraging the platform to do good during the pandemic in India. Several others across the country used their social media profiles for good during a wave that killed at least 240,000 persons in India. 

Twitter as a dashboard for hospital beds

“I used to collect data [of bed availability] from one hospital. I immediately posted on Twitter. Around 200 people reached out to me after that asking for more information on the availability of hospital beds. That’s when I realised the situation on the ground was horrible,” he recollected. 

Charan expanded his calls to cover more hospitals and eventually began focussing on government hospitals from across his state, Telangana, and posted the details on Twitter regularly. 

“The charges in government hospitals were lower and affordable to people. So I started collecting up to date information from these hospitals, the phone number of the person in charge there and posted on Twitter with their consent.”

 

Sai Charan getting an award from a state minister for his work during COVID-19.

His volunteering efforts also expanded to posting real-time, reliable and verified information about the availability and prices of treatments remdesivir and tocilizumab, which were in demand in India during the worst peak of COVID-19. 

Sai’s efforts led to at least 1,500 persons securing hospital beds during the time of need in Telangana. Acknowledging his work during this period, the Government of Telangana honoured him with a “COVID warrior” award in November 2021. 

For DVL Padma Priya, life has not been the same since April 2020 when she got her first COVID-19 infection. While getting tested for COVID-19 was challenging as she was not in one of the “high risk groups”, the period after recovery wasn’t a breeze either. 

“My sense of taste and smell did not return till July and in July, 2020, I fainted. I had gone grocery shopping and I completely blacked out,” she shared with Health Policy Watch. 

“My doctor put me on supplements and told me to drink more water, but I was having severe issues like with my heart rate since then and I had severe tachycardia and I would faint every time I would change positions.”

Long COVID unknown

At the time, long COVID was not as known and patients often faced gaslighting from the doctors or inconclusive diagnosis.

“Long story short, it took a lot of self-advocacy for myself because I was basically being told I am anxious. I had to advocate a lot for myself to finally find a good doctor in Hyderabad who ran a couple of tests and said, ‘It looks like you have some sort of autonomic dysfunction’,” she recollected. 

A media entrepreneur, Priya shared these experiences on Twitter and received solidarity from across the population who were also experiencing similar symptoms. 

This prompted her to start a group on the instant messaging platform Telegram, which became a forum for people to discuss their symptoms, doctor visit experiences and updated studies on long COVID. 

“We’ve had a lot of webinars with groups of experts like mental health experts, neurologists etc since they understand what the symptoms could be and what people need to be aware about long COVID.” 

At its peak, the group had around 500 members, who used the platform to share tips on how to advocate for oneself to the doctors and what to look out for after testing negative for COVID-19.

Padma also started a “Long COVID survivors India” handle on Twitter and Discord, mainly to disseminate information and create awareness among the people about the various effects of COVID-19 on the human body. 

Verified information as the right weapon

In April 2020, Vijay Anand, a Chennai-based techie was witnessing a barrage of fake news about COVID-19 being spread on WhatsApp and Twitter. The information being spread ranged from rumours around the spread of the virus in his city to “instant magic cures” against SARS-CoV-2. The urge to address these messages drove Vijay to use his Twitter account to do something meaningful. 

“I started looking into government data [on COVID-19 cases]. I could find a lot of people analysing similar data in the US and UK but couldn’t find anyone doing it in India at that time. I saw an information vacuum there and wanted to fill it,” he explained. 

In an interview to Health Policy Watch, he added that the idea was to study the pattern and interpret it into useful and actionable information. “I wanted to tell people what is really happening and if there is a need to panic or worry about the [COVID] wave.”

Vijay tweeted at least once a day with the data released by the government authorities and his analysis based on the numbers. His tweets often included details of the positivity rate and reproductive rate of the virus and the outlook for the next few days. 

“I used to follow a lot of epidemiologists from established organisations like the Indian Council for Medical Research (ICMR), the US CDC and the UK, to understand what they’re trying to do in the rest of the world,” he elaborated. “And I used to spend about two to three hours a day just reading white papers that were published on COVID-19 to arm myself with the knowledge.” 

Accepting that he is not a medical doctor and his messaging was inaccurate at times, Vijay was always open to correcting his tweets based on the feedback from experts. 

“So, because a lot of doctors and even senior experts follow me [on Twitter], they just give me some feedback and I just correct [the information I put out].”

His consistent analysis that focussed on cutting out misinformation and fake news earned him praise from several government officers. 

This article is part of a series to promote the UniteHealth Social Media Awards, which will showcase individuals and organisations who used social media to strengthen collective understanding of the pandemic and evidence-based responses. Learn more about the awards and vote until the end of the month.

Image Credits: Unsplash, Supplied.

Charles Gore(MPP), Petro Terblanche of Afrigen, Dr Tedros Ghebreysus, South African Health Minister Dr Joe Phaahla, and Anne Tvinnereim, Norwegian Minister of International Development, cut the ribbon to formally open Afrigen.

CAPE TOWN – South Africa’s Health Minister was somewhat embarrassed that his government’s decision to procure pneumococcal vaccines from an Indian company rather than local company Biovac became public during a high-level international meeting on the local production of mRNA vaccines in his country.

South Africa’s procurement decision coincided with a meeting in Cape Town this week of over 200 international delegates working with the mRNA technology transfer programme that was launched in June 2021 by the World Health Organization (WHO) and the Medicines Patent Pool (MPP).

The mRNA hub is based at South African company Afrigen, which has developed a COVID-19 vaccine based on Moderna’s recipe – albeit without Moderna’s help. Afrigen is passing this know-how to people from 15 other low- and middle-income countries (LMICs), and representatives of 14 of these countries participated in the five-day event.

Biovac, which is partly owned by the South African government, is Afrigen’s vaccine production partner, and it has been making Pfizer’s pneumococcal vaccine, Prevnar 13, since 2021.

Health Minister Dr Joe Phaahla explained on Thursday that the South African government is fully committed to building local vaccine development but that ministers were not involved in procurement decisions, which were governed by an Act of Parliament that civil servants were obliged to follow or face prosecution.

“But South Africa is in the process of reviewing its procurement policy to support local production,” Phaahla told the meeting.

Tensions between price and local production

While Biovac has expressed dismay at the decision, it is precisely this tension between price constraints and the drive to support more local production that countries, global vaccine procurement agencies and donors need to resolve if local vaccine and medicine manufacturing are to become a reality in regions like sub Saharan Africa, which are so lacking in this capacity today.

Unless governments and donor agencies are actually going to procure vaccines from regional manufacturers, the mRNA technology transfer will simply become lessons in science rather than a solution to structural manufacturing inequity.  But vaccines and medicines produced by new start-ups are also likely be more expensive than those produced by giant Indian or Chinese pharma firms that have been in the business for year and are already supplying large global markets. 

As Dr Blade Nzimande, South Africa’s Minister of Higher Education, Science and Technology, told the mRNA meeting, while, technology transfer is necessary, “this is not sufficient”. 

“We need government support, and this includes the willingness to invest in research and development, building of human capacity, and willingness to pay a premium for vaccines, at least until we achieve economies of scale,” he added.

But is it realistic to expect that countries economically battered by COVID-19 will be willing and able to pay this premium when generic companies such as India’s Cipla can deliver vaccines at a significantly cheaper rate?

South African health officials told Health Policy Watch that the decision to give a three-year contract to Indian generic company Cipla instead of buying Biovac’s vaccines would save the department so much money that it could introduce two new childhood vaccines.

Cipla – which has its vaccines made by the Serum Institute of India – publicly quantified the sums involved on Wednesday, saying that its contract with South Africa would save the government approximately $133 million (R2.4 billion) over its three-year lifespan.

Preferential procurement for African vaccines by global health agencies?  

WHO Director-General Dr Tedros Adhanom Ghebreyesus described the tension between the government and Biovac as a “heads up” that the same problem could arise for mRNA vaccines.

“It’s good that this happened now, so you can prevent it from happening, especially for this big and very strategic initiative,” said Tedros, who added that there had been a “very candid discussion” that morning with key mRNA hub partners.

Nzimande said that the Finance Ministry was busy amending its “preferential procurement” legislation in South Africa, including how to balance price and local production.

“This is a very complex issue. Sometimes you may find that an international company is cheaper than a local company because it is actually being subsidised by the government in its own country, and we are not doing the same thing. We might have to pay more sometimes because we want to build local capacity.”

While Tedros expressed support for preferential procurement to support local vaccine start-ups in their infancy, he added that this should be established at a “regional and continental level”, starting with Africa’s free trade zone.

At a global level, Tedros said that WHO, Gavi, UNICEF and other international organisations would also need to support Africa’s production. 

Indeed, after decades of chasing vaccines and medicines at the lowest price possible – no matter where they were produced, Gavi late last year committted to diversifying its procurement and purchasing more African health products. But that commitment remains only on paper, critics say. Actual implementation of plans to buy locally produced vaccines in Africa is being confined to a separate budget designated for funding pharma startups, and requiring more donor funds. 

Phaala conceded that “innovative funding mechanisms will be required, both in the short, medium and long term to assure sustainability”, and proposed that “appropriate trade incentives” could be used to build “more secure demand so that this industry can grow beyond our borders”. 

But he also said that South Africa was looking to the WHO, Gavi and the COVAX facilities for support.

Meanwhile, Nzimande said that approaching international partners to subsidise prices of products that are produced locally in South Africa is a good idea. This has been done on a time-bound basis of 10 years for the pneumococcal vaccine.

Significant investment required

South African Health Minister Dr Joe Phaahla, and Anne Tvinnereim, Norway’s Minister of International Development.

International donors have invested heavily in building the capacity of the African mRNA hub, mainly in reaction to the COVID-19 pandemic. Africa was isolated and vulnerable after the Indian government forbade the export of generic COVID-19 vaccines during the height of its pandemic, leaving the continent without access to COVID-19 vaccines as it imports 99% of its vaccines.

There was global recognition that building Africa’s vaccine manufacturing capacity is essential to prepare for the next pandemic, and idea of a hub to manufacture and train others germinated in the WHO and the Medicines Patent Pool (MPP).

The idea has been attractive to wealthier countries. The European Council alone has invested €40 million in the hub, and recently signed an additional €15.5 million grant with the European Investment Bank to facilitate the expansion of Biovac’s vaccines manufacturing capacity, said Martin Seycell, Deputy Director General of the European Council.

Canada has so far invested $45 million in the hub, and Caroline Delany, GlobalAffairs Canada’s Director General for Southern and Eastern Africa, announced a further commitment of $15 million on Thursday.

Norway and South Africa developed a special relationship during the pandemic as co-chairs of the Access to COVID Tools (ACT) Accelerator, and Norway’s Minister of International Relations, Anne Tvinnereim, stressed that the mRNA hub was part of a bigger ecosystem aimed at preparing for the next pandemic.

“Different parts of this system must be strengthened to facilitate increased local and regional production of vaccines, and the key will be to ensure that production capabilities will be commercially sustainable. This includes the production of other types of vaccines in non-pandemic times,” said Tvinnereim.

“South Africa and Norway follow the discussions on pandemic preparedness and a platform for medical countermeasures very closely,” she added, stressing that lessons learnt during the pandemic needed to be taken forward to the United Nations High Level Meeting on pandemic preparedness and response in September.”

Afrigen inauguration

Afrigen Executive Director Prof Petro Terblanche and scientists wait for the arrival of Dr Tedros.

Following the briefing of the mRNA hub meeting, Tedros and the international team headed to Afrigen to formally open the facility.

Waiting for the delegation was Afrigen Executive Director Prof Petro Terblanche, who said that the hub’s COVID-19 vaccine candidate, AfriVac 2121, “is currently in the scale-up phase”.

“Over the last 18 months, Afrigen has undergone an incredible transformation with the support of a network of partners and mentors enabled by this programme,” she added.

“We have grown our capability and capacity to meet the highest quality standards of mRNA vaccine development, serving the objective to build sustainable capacity in LMICs to produce mRNA vaccines.”

Afrigen is currently manufacturing vaccine batches to be used in Phase I/II clinical trials to good manufacturing practice standards, while also continuing with training and technology transfer to network partners.

Image Credits: WHO, Kerry Cullinan.

The World Health Organization (WHO) has launched the largest global collection of publicly available disaggregated data on health inequality, which aims to empower public health officials to conduct more targeted responses to health threats. 

Composed of over 11 million data points, the Health Inequality Data Repository (HIDR) is the first open-source tool to allow for the tracking of health inequalities between population groups over time. 

“Disaggregated data – which show how health or other aspects of life are experienced by people of different ages, economic status, education levels, place of residence, sex, and other characteristics – are a vital part of advancing equity,” WHO said. “To achieve equity, we first need to know where inequalities are.”

The lack of precise data on health indicators has long been a major challenge for global health officials. Despite constant calls by WHO for countries to improve their data collection and reporting systems, disaggregated data is still not available for many dimensions of health inequality. Only half of the qualifying Sustainable Development Goals, for example, are tracked with disaggregated data. 

When data exists, it is most frequently broken down only by sex, and occasionally by age and place of residence, limiting the ability of health authorities to calibrate their policy responses to target those most in need of assistance. 

The HIDR data set contains statistics on over 2000 health indicators relating to the Sustainable Development Goals, COVID-19, immunization, reproductive, maternal and child health, infectious diseases like HIV, tuberculosis and malaria, and other health threats, broken down into 22 dimensions of inequality along demographic, socioeconomic and geographic lines. 

Armed with more precise information about which populations require the most help, global and national health officials can make more informed decisions, increasing the impact of often limited resources. 

“If we are truly committed to leaving no one behind, we must figure out who is being missed,” WHO Director-General Tedros Adhanom Ghebreyesus said. “The ability to direct services to those who need them the most is vital to advancing health equity and improving lives.”

Along with the launch of the database, WHO issued a call to governments to redouble their efforts to adopt routine health inequality monitoring and expand data collection capacities.

“Inequality analyses should be conducted regularly at the global, national and subnational levels,” the WHO said. “Inequality data can save lives by identifying who is left behind.”

Professor Kelly Chibale at the Holistic Drug Discovery and Development (H3D) Centre at the University of Cape Town in South Africa.

Access to universal healthcare remains a global challenge and even more pressing in the African region. While African-based researchers, scientists and innovators have the capability to make significant contributions towards building homegrown solutions, the continent lacks adequate financial investment in innovative pharmaceutical research and development (R&D).

To achieve the African Union’s Agenda 2063 for a bold transformation of the continent, we need to take action now.  

Coming off the heels of the recent  African Innovation for Inclusive Healthcare webinar hosted by the International Federation of Pharmaceutical Manufacturers and Associations (IFPMA) and the Holistic Drug Discovery and Development (H3D) Foundation, it is important to continue exploring how the African science and innovation community can be scaled up to capacitate the continent’s R&D to play a more effective role in responding to local health challenges. 

The webinar illustrated the successful drug development partnerships across the industry, government and academics in South Africa. 

Homegrown solutions should be at the heart of this ecosystem we want to build. We know that the continent’s public healthcare system and health innovation ecosystem face numerous challenges including limited access to medicines, competitive technologies, shortage of a critical mass of skilled personnel and inadequate funding. 

Underfunding

In 2006, African Union member states committed to spending 1% of their GDP on R&D. However, this is still not the case. African countries still vastly underfund their R&D efforts. According to a report from UNESCO, no country in Africa is spending 1% of its gross domestic product (GDP) on R&D, although spending on science has increased globally in the past five years. The report also highlights that while Africa has 16% of the world’s population, it only has 1.3% of the world’s researchers.

We’ve got our work cut out for us, but we have made some inroads. We’ve found that the best way to curb these problems is to build collaborations and strengthen existing capabilities. 

The Holistic Drug Discovery and Development (H3D) Centre, which I lead, provides avenues for research institutions to collaborate and work together to leverage our different capabilities and mobilise funding together. The past five years have taught us that we can transform and strengthen the capacity of historically disadvantaged institutions in South Africa and effectively expand the drug discovery community across the continent through partnerships and industry – and academic-led mentorship. 

At our webinar, I was pleased to hear Elizabeth V Mumbi Kigondu, Principal Research Scientist, Centre for Traditional Medicine and Drug Research at Kenya’s Medical Research Institute, say that this “will allow us to ensure that we have medicines and products coming from Africans and solve African health problems.”

Building on these partnership models, we recently partnered with the University of Limpopo and the University of Venda on tuberculosis (TB) research initiative to boost local TB research while also accelerating capacity development at these historically disadvantaged institutions.

Training scientists is one of the key tasks of H3D.

With these projects, H3D continues to address the challenges in capacity building by training local scientists – creating a steady stream of skilled scientists to generate African-led scientific knowledge while simultaneously closing the gaps in the local science and research sectors.  While building facilities is important, it is equally important to cultivate a skilled workforce to utilise these resources effectively.

The key to driving health innovation in Africa is in strengthening human resources through science mentorship. As a J&J Satellite Centre for Global Health Discovery, H3D has partnered with the company to harness the best scientific talent in Africa and to mentor them in boosting H3D’s antimicrobial resistance (AMR) drug discovery portfolio, which will eventually attract more projects and investments. These mentorship programmes foster a culture of innovation and entrepreneurship that encourages the development of new technologies, products and services.

Having highlighted the importance of partnerships and collaborations in African R&D innovation, it is equally crucial to discuss the role of financial investment in this sector as it provides access to resources that drive R&D, technology transfer and entrepreneurship. 

Manufacturing active pharmaceutical ingredients

H3D has recently been granted funding from the United States Agency for International Development (USAID) to boost medicines manufacturing in Sub-Saharan Africa. The fund through MATRIX will support a pilot project that will evaluate innovative technology for the cost-effective manufacturing of active pharmaceutical ingredients (APIs) in South Africa.

While the South African pharmaceutical formulation industry is well developed and produces more than half the final pharmaceutical product consumed locally, the country does not have the capacity to synthesise and manufacture APIs. 

To address this challenge, H3D has partnered with an international group of scientists and a local API manufacturing company, Chemical Process Technologies (CPT) Pharma, to develop a creative approach that, if successful, could revolutionise the manufacturing of medicines in South Africa, and the rest of the continent.

This collaboration will facilitate both technology transfer and on-the-job skills development and forms a crucial role in seeding new industrial development that is so critical for absorbing the abundant labour force available in South Africa.

While there is no silver bullet, these are perhaps valuable lessons for the types of health innovations that the continent can produce when vested interests are aligned towards the same goals, particularly considering Africa’s longstanding manufacturing scarcity and the urgent need to scale up R&D efforts.

With continued funding and support for African science, research, and development innovation, Africa’s capacity for R&D and innovation will increase and this will drive progress in achieving quality healthcare for all.

Professor Kelly Chibale is the founder and Director of the Holistic Drug Discovery and Development (H3D) Centre at the University of Cape Town, South Africa.

 

Image Credits: Kerry Cullinan.

Naomi Burke-Shyne, executive director of Harm Reduction International

Fifty years into the world “war on drugs”, the drugs are winning. Global levels of drug use and production, as well as drug-related deaths and incarcerations, are at all-time highs.

Leading proponents of drug-policy reform who have gathered at the International Harm Reduction Conference in Melbourne this week say the evidence is in that it is time for the world to adopt a new approach. 

“The irony of the profound failure of the war on drugs is that it has actually driven the illicit production of more and more substances and has led to more toxic drug supply,” said Naomi Burke-Shyne, executive director of Harm Reduction International, the UK-based drug-policy justice NGO that convened the conference. 

“In order to save lives, we must offer overdose prevention and supervised space for people injecting drugs; together with pill testing to understand the potency, adulteration or toxicity of a substance,” she said. 

Helen Clark, chair of the Global Commission and Drug Policy and former prime minister of New Zealand, called the war on drugs “a complete failure”.

“The war on drugs is completely counterproductive. It has failed, and we need to try new approaches,” she told the conference. “Drug use continues to grow around the world, millions of people are imprisoned for drug possession and millions more are unnecessarily contracting HIV and hepatitis C because of lack of access to effective harm reduction measures.”

“Human beings have been using substances, for whatever reason, for thousands of years,” Clarke said. “We’re not dealing with new issues here. We’re dealing with totally inappropriate and wrong ways of tackling them.”

Drug overdose in the US continues to climb despite the ‘war on drugs’.

Supervised injection centers work

People who inject drugs in medically supervised settings are less likely to overdose, share needles, report emergency room visits, or develop abscesses when compared to people without access to such facilities, according to a new study presented to the conference on Tuesday by researchers from the French Institute of Health and Medical Research (INSERM). 

The 12-month study is the first-ever controlled trial on the efficacy and impacts of medically supervised injection rooms, which are hygienic facilities where people struggling with addiction can inject drugs under the watchful eye of medical staff. These facilities are government-operated, stocked with drug-testing kits and overdose-prevention medications like naloxone, and allow patients to access other health services like mental health support, blood tests and essential primary care.

“People can get tested for hepatitis and get started on treatment within two hours, there are sexual reproductive health services for women, lawyers dropping around, housing officers,” Burke-Shyne said.  “Yes, the space has drug consumption, but I think that really underplays how important the holistic approach to supporting vulnerable communities is.”

The study compared the behaviour of people who injected drugs in the supervised injection sites in Paris and Strasbourg to users in Bordeaux and Marseille, where no centers exist. In addition to the benefits to health and overdose reduction, the study found that people with access to supervised injection services were also far less likely to inject in public spaces or commit crimes.

Today, 16 countries around the world officially operate medically supervised injection rooms. These include the Netherlands, the United States, Canada, Australia and Switzerland – which pioneered the approach by legalizing prescription heroin in 1994.

 Results from a control study at New York City’s new supervised injection site are expected by the end of June.

 “Medically supervised injection rooms, the medicine naloxone to reverse overdoses, and drug checking technology work,” Burke-Shyne said. “They are public health no-brainers.”

Fentanyl fears multiply 

As the consequences of the push by Purdue Pharma to mainstream the prescription of high doses of the opiate pain-medication, Oxycontin, continues to ravage the United States, a new lethal drug has taken over: fentanyl.

The synthetic opiate, which is up to 50 times stronger than heroin and 100 times stronger than morphine, was identified in 66% of US drug overdose deaths in 2021. The growing inflitration of fentanyl in the country’s drug supply has resulted in many users unintentionally taking the drug – with deadly consequences.   

In New York City, where drug overdose deaths have nearly tripled since 2015, only 18% of people who inject drugs reported intentional fentanyl use, yet over 80% tested urine-positive for fentanyl, according to new toxicology data presented by researchers from the University of New York (NYU) on Tuesday.

Fentanyl is used by cartels and drug-smuggling networks to cheapen their up-front costs for heroin, which is more expensive to produce. Cutting heroin with fentanyl greatly increases their profit margins at the cost of heightened danger for users unaware their supply is mixed with a far more potent drug.

Drug-testing facilities, such as medically supervised injection rooms, can greatly reduce people’s risk of overdosing by providing clarity on the composition of the drugs they are injecting.  Intentional use of fentanyl was associated with more severe substance use disorders, high drug use frequency, and recent overdoses, the study found.  

“No one should die of an overdose,” Burke-Shyne said. “Drug consumption rooms should be accessible; they should be where people need them. It’s that simple.”

More than 1,500 people die from opiate overdoses every week in the United States. In the year leading up to March 2022, a staggering 110,366 people lost their lives to drug overdoses – nearly 20 times the per capita death rate of the European Union.

Needle-borne diseases are critically underfunded 

Medical advances in recent years have made hepatitis C highly treatable. While the medications are affordable in most low- and middle-income countries, chronic underinvestment in hepatitis C and harm prevention programmes have handicapped efforts to eradicate the disease. 

On Tuesday, UNITAID announced a $31 million commitment to prevent hepatitis C in high-risk populations like people who inject drugs and people in prisons. The investment represents a 20% increase in global harm prevention efforts, which UNITAID said will also assist health systems in curbing the transmission of other blood-borne diseases like HIV. 

While people who inject drugs make up just 10% of the world’s 58 million people infected with hepatitis-C, injecting drugs contribute to 43% of new infections. Eighty percent of people infected with hepatitis-C live in low- and middle-income countries. 

Criminalisation has long been a hallmark of the war on drugs, but advocates say the practice of confining high-risk populations to prisons actually multiplies the risk of infection. 

Criminalising drug use “only serves to overpopulate the prison services and the risks, therefore, multiply,” said Kgalema Motlanthe, former president of South Africa and a commissioner at the Global Commission on Drug Policy. “Those who are literally sleeping over each other in prisons that are overcrowded end up really being exposed to more risks.”

Jason Grebeley, head of the University of New South Wales’ Hepatitis C and Drug Use Group, added that the health benefits of decriminalisation are often overlooked. 

“It’s really critical that we think about the fact that decriminalisation could actually play a major role in reducing a range of harms for people who inject drugs,” he said. 

Image Credits: Conor Ashleigh/Harm Reduction International.

WHO
Dr Tedros Adhanom Ghebreyesus, director-general of the WHO.

Two weeks after a Texas judge stirred controversy by banning a popular US abortion pill, WHO’s Director General has explicitly re-affirmed the organization’s support for abortion rights, stating that “women should always have the right to choose when it comes to their bodies and their health”. 

Dr Tedros Adhanom Ghebreyesus’ comments came just a day before the US Supreme Court is set to decide whether to suspend the judge’s ruling and maintain full access to the abortion drug, mifepristone, while the case is appealed. The case will be the court’s most significant consideration of abortion rights since its landmark ruling last June overturning the 1973 decision of Roe v. Wade, guaranteeing abortion rights nationally.

Speaking at a Tuesday press briefing, Dr Tedros Adhanom Ghebreyesus also called on Afghanistan’s Taliban regime to reconsider their ban on Afghan women working with UN agencies to deliver vital health services.

Echoing a recent statement by UN Secretary General Antonio Guterres that the ban is a “violation of the fundamental human rights of women”, Tedros said: “Female staff members and health workers are essential for delivering lifesaving and services to those in need. I call on the Taliban to rethink a decision that will massively reduce access to health services and only harm the Afghan people”.  

On 4 April, 2023, Taliban banned women from working in UN offices in Afghanistan. UN officials have initiated a period of operational review in Afghanistan till 5 May, 2023 and have reportedly warned that the organization may choose to halt all operations in the country if the ban is not rescinded. The Taliban move follows on a December 2022 decision banning women from working in NGOs across Afghanistan.

DG articulates longstanding WHO abortion rights policy

In commenting on the US abortion controversy, now before the US Supreme Court, Tedros protested attempts by politicians and courts to curtail women’s right to access safe abortions.  

“WHO is concerned that the right of women to access safe abortion services, including through use of medical abortion medicines, are being limited by legislators and or courts. To be clear on WHO’s position, women should always have the right to choose when it comes to their bodies and their health,” Tedros said. 

“Restricting access to abortion does not reduce the number of procedures and only drives women and girls towards unsafe ones and also death. Ultimately, access to safe abortion is healthcare that saves lives.” 

Tedros was, in fact, repeating a longstanding WHO position on abortion rights, which is articulated on its Health Topics page, which states:

“Ensuring that women and girls have access to abortion care that is evidence-based – which includes being safe, respectful and non-discriminatory – is fundamental to meeting the Sustainable Development Goals (SDGs) relating to good health and well-being (SDG3) and gender equality (SDG5).”

Even so, it was the first time in several years that the WHO DG had taken such an explicitly public position on the charged issue. Far milder language supporting women’s right to access sexual and reproductive health services was often hotly opposed by the previous US administration of President Donald Trump in a number of UN fora, including the World Health Assembly, because it was presumed to include abortion services.

Response to controversy sweeping the United States

WHO’s statement came in response to a ruling by the Texas US Northern District Judge Matthew Kacsmaryk on 7 April that the Food and Drug Administration (FDA) had erred by approving the abortion pill, mifepristone, suspending the initial FDA approval of the drug more than two decades ago, as well as a number of regulatory amendments made since that eased access.  

Kacsmaryk‘s  ruling not only threw into question the legal status of the pill used for 54% of US abortions, but also the longstanding authority of the FDA to determine what drugs are safe and authorized to use – or not – nationwide.  Only hours later, Judge Thomas Rice of the U.S. Eastern District in the state of Washington, issued an opposing ruling, ordered the Food and Drug Administration to preserve access to mifepristone in the 17 states and the District of Columbia which had sued to protect access to the drug.

Then on 12 April, 2023, a partial stay was granted on Kacsmaryk‘s ruling by the Fifth Circuit Court of Apeals after the drug’s manufacturer Danco Laboratories, the FDA and the US Department of Health and Human Services (HHS) appealed. The partial stay allowed mifepristone to be available to women pregnant for seven weeks or less, but only with a doctor’s prescription delivered in person. That was in contrast to more recent FDA rulings that women can safely use the drug in pregnancies up to ten weeks, and may also access the drug via the post.   

On 14 April, 2023, the Supreme Court issued a temporary hold on the original decision until 19 April, 2023; the Court is preparing to  reconsider the Texas court’s ruling, at the request of the US HHS for an emergency intervention. 

16 confirmed, 23 probable Marburg cases

Meanwhile, the number of cases of Marburg virus disease in Equatorial Guinea has increased to 16 confirmed and 23 more probable cases with 11 deaths, WHO officials also reported at the briefing. 

That’s more triple the number of confirmed and probable cases that were last reported on 30 March,when Equatorial Guinea announced a total of 13 people had been infected.  Two more people have also succumbed to the disease, bringing the death count to 11 since the outbreak began in February. 

Bata, a port city in Equatorial Guinea’s Litoral district, is the most affected area with nine cases, WHO officials said at the briefing. 

But they pushed back on reporters’ suggestions that travel restrictions might be necessary to contain disease spread.

“It’s not the time for travel restrictions. It has not helped the world. It just harms those countries who are doing the right thing, struggling [against] these macroeconomic challenges the whole world is facing,” said Dr Abdi Rahman Mahamud, director of WHO’s Alert and Response Coordination Department. 

“A few countries have screening, which has some rationale, and we received the update on that, but it’s not the time for travel restrictions,” he added, saying that “WHO is very clear” in its opposition.  

Mahamud added that Equatorial Guinea has also learnt a lot from its COVID-19 experience and has established a “good, robust” response to the Marburg outbreak. 

–Updated on 20.4.2023 to correct the name of the Texas judge who on 7 April issued the original ruling suspending use of mifepristone to US Northern District Judge Matthew Kacsmaryk; On the same day. US District Court Judge Thomas Rice, of the US Eastern District Court in the State of Washington, issued the contradictory ruling to preserve access in 17 other states and Washington DC. 

Medical technologist Candice Snyders preparing samples for analysis at the BMRI facility in South Africa

CAPE TOWN – The most advanced biomedical research centre on the African continent has opened in South Africa, boasting state-of-the-art research and training facilities.

Stellenbosch University’s Biomedical Research Institute (BMRI) houses over 500 researchers who are examining the genetic and biomolecular basis for diseases afflicting Africans – including Professor Tuilo De Oliveira, renowned for decoding the COVID-19 variant, Omicron.

De Oliveira’s Centre for Epidemic Response and Innovation (CERI) is one of only two specialised genomic facilities on the African continent, the other being Christian Happi’s African Centre of Excellence for Genomics of Infectious Diseases at Redeemer’s University in Nigeria. 

“Our mandate on the continent from the Africa CDC is to support other African countries with identifying and characterising pathogens, and we do that – dozens and dozens of pathogens, many of them that you may not have ever heard,” De Oliveira told the media launch.

“For example, we sent a team to Malawi last week to help characterise their explosive cholera outbreak. We have a team going to Mozambique to do a similar thing. We also  receive samples from other countries in Africa and produce genomes that can better characterise the pathogens because if you can characterise the pathogen, you can develop the diagnostics, you can develop the therapeutics and you can develop a vaccine.”

Aside from providing genomic sequencing for 26 African countries in the past year, CERI has had is running an African genomics Africa fellowship, and has trained 320 fellows so far to take the technology back to their own countries. 

Prof Tulio De Oliveira, who decoded Omicron, has a research unit at BMRI.

De Oliveira is one of only 20 scientists represented on the World Health Organisation’s virus evolution committee that helps to guide the global response to new virus threats as they evolve. 

“Unfortunately, that’s what viruses do – evolve. We saw that with COVID evolving a lot. We see how HIV evolved to generate drug resistance. We are now very worried about the evolution of the the avian pathogenic strain of H5N1 that’s decimating the bird populations around the world,” says De Oliveira. “Pathogens don’t respect borders.”

The BMRI cost around $66-million, was financed primarily by the university itself, and took four years to build as the pandemic slowed construction, said vice-dean Professor Nico Gey van Pittius.

“Fifty percent of the African continent is under the age of 25. We want to capacitate the future scientists. This is where the future Nobel Laureates will come from,” said van Pittius.

Fingerprick TB test

Prof Novel Chegou

For Professor Novel Chegou, who has spent 18 years at the university from when he was an honours student to his current position as a professor in molecular biology and human genetics, the beauty of the facility is that it enables conversations between scientists in different disciplines.

“This building was designed with collaboration in mind. It’s easy to collaborate. I can go and talk to the microbiology people. I can track down Tulio and bounce some ideas off him. There are all these top scientists. If you’re a younger person, you’re not really limited to work with with your supervisor,” says Chegou.

In contrast, in the past scientists were crammed four people to an office, even if you were a full professor, Chegou remembers.

One of the most exciting prospects for BMRI is the fingerprick blood test for tuberculosis that Chegou and his team are testing in clinical trials – something that has developed as a result of a “huge collaborative effort”, he adds.

Tuberculosis is the most common – and deadliest – infectious disease in South Africa, but testing for it isn’t that easy, particularly if it is outside the lungs.

Another exciting initiative is a project examining how an active ingredient in turmeric called curcumin might play a role in mitigating Parkinson’s Disease.

Prof Soraya Bardien

“Around one percent of the global population over the age of 60 suffers from Parkinson’s Disease,” says Professor Soraya Bardien, who heads the only research project on the disease in the country.

“Unfortunately, the prevalence in South Africa is not known because studies have been done on that. What is known is that Parkinson’s is the fastest growing neurological disorder worldwide,” adds Bardien.

“Our research focus is twofold. One, we work on the genetic causes of the disease and we use genetic and genomic approaches to identify cases in South African individuals with Parkinson’s disease. And then secondly, we use therapeutic approaches on curcumin.” While results are “years away”, curcumin has proven to be a “powerful antioxidant” acting against cell death in the laboratory.

Another pressing problem is the rise of cardiovascular and metabolic diseases in South Africa, which are projected to rise exponentially over the next few decades.

Prof Faadiel Essop

“There’s a paucity of work that we’ve studied our own populations,” says Professor Faadiel Essop heads the Centre for Cardio-metabolic Research in Africa (CARMA). 

But one of his concerns is how cardio-metabolic diseases are interacting with HIV. Souh Africa has the largest HIV burden globally, and people with the virus are living longer but also developing cardio-metabolic diseases related to a host of factors including diet and the side effects of antiretroviral drugs. 

CARMA is conducting a longitudinal study of people living with HIV in a community called Worcester examining contributing factors to cardio-metabolic diseases, such as changes in the bad cholesterol (LDL), obesity, smoking, and the side effects of ARVs.

Virtual reality

The Biomedical Research Institute was launched this week in Cape Tpwn.

During a tour of BMRI, teams of neurosurgeon registrars are doing simulated laparoscopic neck surgeries on cadavers while supervised by Professor Ian Vlok in the SunSkill facility, a specialist facility for training surgeons.

In the psychiatry laboratory, students hope that they will be able to treat post-traumatic stress disorder, using virtual reality to understand how stress hormone cortisol is released and whether they can find a way to stop this.

The largest biosafety level three laboratory enables research on a wide variety of pathogens, while a biorepository can store 3.5 million samples in temperatures of -80 degrees C.

Bioinformatics students are coding, a staff member is packing away bones.

“The investment in the BMRI will allow significant human capacity development through training some of the best students from the continent and exposing them to extensive national and international research networks,” says Medical Dean Professor Elmi Muller.

“The BMRI will be a game changer for healthcare in Africa and is true evidence of using breakthrough science to improve lives.”

 

Image Credits: Kerry Cullinan, Stellenbosch University.

WHO's New Leadership Team

Nearly a year after his appointment to a second term as WHO’s Director General, Tedros Adhanom Ghebreyesus has finished a revamp of his senior leadership team –  keeping key loyalists in place, while adding new faces that are a clear nod to powerful member states such as China, France and Japan. 

But the new team members come with a mixed bag of experience – and some have hardly any experience at all in the areas to which they have been appointed, WHO insiders were quick to say in reaction to the new appointments.  

The new appointees include Dr Ailan Li, a Chinese national and head of WHO’s Cambodia office, as Assistant Director-General for WHO’s ‘Healthier Populations’ cluster which covers the increasingly critical areas of climate change, pollution, healthy lifestyles and nutrition. 

Dr Yukiko Nakatani, currently deputy director in Japan’s Ministry of Health, will become Assistant Director-General for Access to Medicines and Health Products, a politically charged area of work marked by oft-highly charged battles between pharma companies and medicines access groups over drugs costs and IP rights. 

Another new appointment is Dr Jérôme Salomon, a French national, as Assistant Director-General for Universal Health Coverage, Communicable and Non-communicable Diseases.  Of the three, Salomon has the most extensive global public health experience, including stints on the WHO Emergencies Committee; as a director at Institut Pasteur in Paris, and as a  full professor at the Simone Veil Medical School, Paris.  

Significant to the success of the pandemic treaty negotiations is the appointment of Catherina Boehme, formerly chef de cabinet, as ADG of External Relations and Governance. In that role, Boehme will represent WHO in critical negotiations between WHO member states over the proposed treaty, as well as other processes, such as reform of the existing International Health Regulations.  As a German national who also previously served as chief medical officer at the Geneva-based Foundation for Innovative New Diagnostics (FIND), before becoming its CEO, she brings with her both deep speciality expertise as well as an understanding of member state pressures and needs – both in high income and developing countries.

Trusted advisor Aylward gets new role

Dr Bruce Aylward has been a key member of Tedros’s inner circle throughout his tenure as Director General.

Meanwhile, Bruce Aylward, a longtime Tedros senior advisor, was appointed Assistant Director-General of the Universal Health Coverage, Life Course Division – where he will “drive the organization’s agenda to transform primary health care as central to universal health coverage, as well as overseeing WHO’s work on health systems, immunization and reproductive, maternal and child health,” according to a WHO press release Monday announcing the new team.

Aylward had previously led the DG’s “Transformation” initiative which sought to revamp the organization’s internal structure until the COVID pandemic shifted his attention to health emergencies, where he participated in the first visit by senior WHO leaders to China at the outset of the pandemic in February 2020, and later led WHO’s work on the multi-agency Access to COVID-19 Tools Accelerator (ACT-A) Hub, including the creation of the COVAX vaccine facility. 

“In his new role, Dr Aylward will drive the Organization’s agenda to transform primary health care as central to universal health coverage, as well as overseeing WHO’s work on health systems, immunization and reproductive, maternal and child health,” said Tedros’ announcement. Aylward holds a medical degree and a master’s degree in public health.

Previously announced additions to the senior management team include Jeremy Farrar, former head of Wellcome Trust, as new Chief Scientist. Farrar, a noted epidemiologist who also played a key leadership role in the global public health response to COVID, is probably the most high-profile public health personality to join the WHO senior team. He replaces Indian national Soumya Swaminathan.  

Disappointment in healthier population cluster 

Dr Ailan Li has been head of WHO’s Cambodian office since July 2019.

There was, meanwhile, disappointment in WHO’s internal ranks over the appointment of Li to the Healthier Populations cluster.  With a background primarily in emergencies and emerging infectious diseases, it is an area of work that will be entirely new to her professionally.  

“Clearly she has no experience in this area of work at all,” said one WHO staff member. Another insider who previously worked with her in the Western Pacific region described Li as a “micro-manager” who had performed a primarily political role until now as head of the Cambodia WHO office.

While it is common for the DG to give influential WHO member states a seat around the leadership table, previous Chinese appointees, such as Ren Minghui, also had significant public health careers alongside their political assignments and gained wide respect during their time in Geneva.  Minghui, a former ADG of WHO’s Universal Health Coverage cluster until recently, is now a director general at the Chinese Ministry of Health. 

Dr Yukiko Nakatani (middle) will become Assistant Director-General for Access to Medicines and Health Products in May.

Meanwhile, Nakatani, appointed ADG in the Access to Medicines cluster, is regarded as a largely unknown quantity by Geneva observers of the complex set of issues circling around that topic – which range from the high cost of cancer drugs to issues around the transparency of clinical trial data and prices paid by countries for bulk medicines purchases. 

A paediatrician by training, Nakatani has worked on topics such as medical device reimbursement and price-setting regimes during her time at Japan’s Ministry of Health – sometimes defending policies that raised the ire of industry.  

During her two years as a WHO technical officer, she also co-authored a number of papers on assistive technologies.  But she appears to lack the rich policy background of her predecessor, the Brazilian Dr Mariângela Simão, in the area of medicines access. Prior to arriving at WHO, Simão was a senior official at UNAIDS and in Brazil’s Ministry of Health, where she led successful negotiations with pharma companies to lower the price of HIV medicines.   

Appointments of trusted associates a Tedros hallmark  

Dr Mike Ryan alongside Tedros on a visit to areas of northwestern Syria affected by the February earthquakes.

Only a handful of senior officials who served in the first five years of Tedros tenure, remain in the new leadership team. Those include  Dr Hanan Balkhy, a Saudi Arabian national, as Assistant Director-General for Antimicrobial Resistance (AMR), where she is leading a multi-sectoral collaboration with the Food and Agriculture Organization, the World Organization for Animal Health, and the United Nations Environment Programme, to enhance prevention of AMR through better management of animal and environmental drivers.

Prior to joining WHO, Dr Balkhy, a paediatrician, was Executive Director for Infection Prevention and Control at Saudi Arabia’s Ministry of National Guard. 

Other long-serving staff include Mike Ryan, Executive Director of Health Emergencies, and Samira Asma, head of Data, Analytics and Delivery for Impact (DDI).   

Ryan, a respected emergencies specialist, was the public WHO face of the global COVID response. But he also demonstrated intense loyalty to Tedros echoing his statements on controversial WHO positions, such as opposition to public masking in the early days of the pandemic.  

Asma is considered a close Tedros confidante. Her management of DDI has been controversial internally insofar as she lacks the health statistics, measurement and monitoring of her predecessor, Ties Boerma, now a professor at the University of Manitoba. As the head of WHO’s former department covering health metrics and monitoring, he wielded huge influence and authority in both the strategic direction and implementation of WHO’s work.  

Triple Billion targets – a movable goalpost 

Dr Samira Asma is considered one of Tedros’s closest confidantes by WHO insiders.

Asma is also tasked with showing progress on WHO’s ‘Triple Billion’ targets for achieving access to universal health coverage, improved health emergencies’ response, and healthier lifestyles and environments for three billion people worldwide by 2023. 

The Triple Billion targets were the centerpiece of Tedros’ strategic direction in his first five years of office.

In Monday’s announcement, the DG recalled them once more, saying that the reformed senior leadership team aims to: “accelerate progress on implementation of WHO’s 13th General Programme of Work (GPW13), and achievement of its “triple billion” targets and the health-related Sustainable Development Goals.”

But critics say that the targets are a moveable goalpost – a useful public relations tool but targets for which it is virtually impossible to demonstrate concrete, measurable progress, in the ways outlined by WHO’s 13th Programme of Work (2019-2023).   

Disappointment among senior civil servants 

There was also some disappointment that none of the senior WHO staff that had been serving as interim Assistant Director Generals received final appointments to Tedros management team, with the exception of Aylward. 

Influential member states like the United States had earlier expressed some hopes that the promotion of more senior WHO staff through the ranks to senior leadership positions could help convey a stronger sense of professionalism and accountability within the organization’s ranks. 

Instead, four senior staff who had briefly served as interim ADG’s were summarily dismissed by Tedros with little more than a ‘thank you’ conveyed via an internal note sent out to WHO staff simultaneously to Monday’s announcements.

Observed one WHO scientist, “I think our organization needs a very clear and honest agenda first of all. We need strong technical competency, less political mumbo jumbo, and honesty and accountability; this is what we have lost over time.” 

-Updated on Tuesday, 18 April 2023

Image Credits: Guilhem Vellut, DFID, WHO, Japan MoH, WHO.