A man with diabetes checking his blood sugar level with a glucometer

World Health Organization (WHO) member states should include personal-use glucose monitoring devices in their vitro diagnostics (IVD) lists to help people with diabetes, according to the global body’s 2023 Essential Diagnostics List (EDL) released this week.

Diabetes caused 1.5 million deaths in 2019, and including personal glucose testing devices “could lead to better disease management and reduced negative outcomes”, said the WHO.

Another first for the list is the inclusion of three tests for hepatitis E virus (HEV), including a rapid test to aid in the diagnosis and surveillance of HEV infection, an under-reported disease which causes acute liver failure in a small number of people.

The list offers guidance rather than being prescriptive, with the aim of increasing patients’  access to diagnostics and better outcomes.

“The WHO Essential Diagnostics List is a critical tool that gives countries evidence-based recommendations to guide local decisions to ensure the most important and reliable diagnostics are available to health workers and patients,” said Dr Tedros Adhanom Ghebreyesus, WHO Director-General. 

Other new tests added to the list include those for endocrine disorders, reproductive, maternal and new-born health and cardiovascular health:

The recent World Health Assembly  resolution on strengthening diagnostics capacity urges member states to consider the development of national essential diagnostics lists, adapting the WHO model list of essential in vitro diagnostics.  

Regulatory considerations for AI

The WHO also raised issues for consideration when regulating artificial intelligence (AI) for health this week.

With the increasing availability of health care data and the rapid progress in analytic techniques – whether machine learning, logic-based or statistical – AI tools could transform the health sector. 

WHO emphasizes the importance of establishing AI systems’ safety and effectiveness, rapidly making appropriate systems available to those who need them, and fostering dialogue among stakeholders, including developers, regulators, manufacturers, health workers, and patients.

“Artificial intelligence holds great promise for health, but also comes with serious challenges, including unethical data collection, cybersecurity threats and amplifying biases or misinformation,” said Dr Tedros.

“This new guidance will support countries to regulate AI effectively, to harness its potential, whether in treating cancer or detecting tuberculosis, while minimising the risks.” 

In response to growing country needs to responsibly manage the rapid rise of AI health technologies, the publication outlines six areas for regulation of AI for health:

  • transparency and documentation, such as through documenting the entire product lifecycle and tracking development processes.
  • risk management, including addressing issues including human interventions, training models and cybersecurity threats
  • externally validating data and being clear about the intended use of AI
  • commitment to data quality,
  • understanding the scope of jurisdiction and consent requirements, in service of privacy and data protection.
  • fostering collaboration between regulatory bodies, patients, healthcare professionals, industry representatives, and government partners.

 

Image Credits: Dischem.

WHO medical supplies shipped from Dubai and loaded onto trucks at Egypt’s Al Arish airport have been poised at Rafiah crossing awaiting a hoped-for Israel signal to enter Friday.

The World Health Organization (WHO) is poised to begin the transfers of medical supplies to the embattled Gaza Strip on Friday as part of a humanitarian convoy of 20 trucks, said WHO Director-General Dr Tedros Adhanom Ghebreyesus Thursday. 

But he and other senior WHO officials said the corridor needs to remain open permanently in order to respond to the gaping health and humanitarian needs that have emerged amongst Palestinians in Gaza where over 3,500 people – mostly women and children – have been killed and around 12,000 injured since  7 October.

Fighting broke out after Hamas broke through a border fence separating the enclave from pre-1967 Israel, killing over 1300 people in 22 rural communities.

Tensions were at fever-pitch Thursday evening in the region, as Hamas continued firing barrages of missiles into southern and central Israel, Lebanon aimed fire from the north, and Israeli officials hinted that a ground invasion of Gaza could be imminent, following 13 days of aerial bombings.   

“The situation is very dire and at a breaking point,” said Tedros. “We have been waiting with the supplies for a week. And with more attacks and less service, the levels of casualties will continue to rise. We hope there will be a crossing tomorrow.”

In line with a deal brokered by the United States, Israel on Wednesday agreed to allow an initial 20 trucks of medicines, food and water to enter Gaza through Egypt’s Rafiah border crossing.

“He [Israeli Prime Minister Binyamin Netanyahu] agreed that what he would do was to open the gate to let up to 20 trucks through, to begin with,” said US President Joe Biden, interviewed by reporters aboard Air Force One, following a one-day trip to Israel.  

Just a drop in the ocean of need  

Health workers in Gaza delivering emergency health care

But the 20 trucks Israel has agreed to let pass is only a “drop in the ocean” of what is needed right now in Gaza, WHO officials said. 

“It’s great to have a start. It’s fantastic that we’re beginning and I will pray this evening, and I don’t pray very often that that border will open tomorrow,” Ryan said.

“But we then need to take this beyond that beyond the gesture and then we need to make sure that a corridor is a corridor. Humanitarian assistance needs to move every day. 

“Two and a half million people need assistance,” Ryan added. “Twenty trucks is a drop in the ocean of need right now in Gaza…. We have the risk management processes in place. We have the means to monitor the delivery, but we need to be able to have access and we need to be able to have the deconfliction guarantees that will allow our staff to operate on the ground and do their jobs.”

Diesel fuel is for hospitals, desalination plant – and to bake bread

Palestinian families have taken refuge at a UNRWA schools in Gaza City to escape the ongoing Israeli airstrikes.

Fuel also is needed to power hospital generators and ambulances, Gaza’s desalination plant, and even to bake bread, the staple for survival in wartime, Tedros and Ryan stressed. 

“Fuel is also needed for hospital generators, ambulances, and desalination plants. And we urge Israel to add fuel to the life-saving supplies allowed into Gaza,” said Tedros at the presser. 

“The hospitals ran out of fuel days ago. What’s been happening is we’ve been finding fuel and others have been finding fuel within reserve stock. People on the ground in Gaza have been working together to try and re-prioritize whatever little fuel is left.

“The choice [right now] is between keeping a desalination plant going so you have some water or supplying the hospital, or supplying UNRWA, which are housing 600,000 internally displaced people,” Ryan added. 

But in the deal arranged Thursday, Israel refused to allow fuel to enter at all, contending that Hamas has been siphoning off supplies from UN agencies to fuel its weapons arsenal, being aimed at Israel.

No guarantees diversion of supplies can be avoided

Dr Mike Ryan, WHO head of Health Emergencies at Thursday’s press briefing.

Israel also has cautioned that it will only allow aid to flow so long as supplies are not diverted to Hamas fighters: “Israel will not prevent humanitarian assistance from Egypt as long as it is only food, water and medicine for the civilian population and not diverted to Hamas,” said Israel’s UN Mission in Geneva on Thursday.

Answered Ryan: “There are absolutely no guarantees in the humanitarian situation that you can completely avoid a diversion of resources. This is a fact that happens. 

“We do everything in our power to ensure that that doesn’t happen,” he said. “But what we need is a fully supported humanitarian operation, not a token. 

“Bringing supplies through a border crossing for humanitarian assistance requires security planning, logistics planning, it is best done with people on the ground. It is best done with independent monitoring of the delivery and we do that in countries all over the world and in very difficult humanitarian situations, and then zones of actual conflict. 

“But what we need are the guarantees and the joint planning on either side.  

Campaign of retaliation

Burned-out ruins of Kibbutz Beeri, Israel, where one in 10 residents died in the Hamas incursion on 7 October.

Since the mass killings of Israeli civilians on 7 October, Israel has launched an unprecedented campaign of retaliation – vowing to remove Hamas from power altogether in Gaza. It has dropped thousands of bombs in the tiny Gaza enclave, as well as demanding an evacuation of all civilians and hospitals in the northern part of the Gaza Strip, to the south.   

Hamas has meanwhile fired an estimated 5,500- 6,700 rockets at Israeli towns and cities in the country’s southern and central region. Hostilities have slowly been heating up along Israel’s northern border with Lebanon. And Thursday, the Iran-aligned Hizbullah launched a barrage of rockets at Israeli cities across the border after days of more sporadic clashes. 

The human damage on the Gazan side exceeds all previous Israeli-Gaza wars  – due to the unprecedented intensity of Israeli bombings over Gaza’s densely populated cities and refugee camps, where few civilians have access to bomb shelters.

Gaza Palestinian child looks over the destruction of a recent Israeli air raid.

Some 3,500 Palestinians have so far perished, more than half are women and children, said Richard Peeperkorn, WHO Representative at WHO’s Jerusalem-based office for the West Bank and Gaza at Thursday’s briefing. Another 12,000 have been injured.

Most Israeli casualties happened during the 7 October attacks, while fewer numbers have died in missile fire, against which Israel has built an extensive system of civilian shelters. Another 203 Israelis are being held by Hamas as hostages. 

There are over one million internally displaced Gazans, including people whose homes were reduced to rubble as well as Palestinians moving southwards in line with the Israeli evacuation order – which WHO and other UN agencies have repeatedly called Israel to rescind.

Some 100,000 Israelis have been forced to evacuate homes near the Lebanese border and in rural communities around the Gaza border, some of which are now little more than burnt fields of rubble. Thursday evening, Israel’s government approved a partial evacuation of the coastal city of Ashkelon, a city of 132,000 people just 13 kilometres from Gaza.  

“Like the rest of the world, all of us who have been shocked, appalled and saddened by the conflict in Israel and Gaza,” said Tedros.

“The attacks by Hamas and other armed groups on 7  October that targeted Israeli civilians were horrific and unjustifiable.  At the same time, WHO is gravely concerned about the health and well-being of civilians in Gaza, who are suffering from bombardment and siege.” 

Attacks on health workers and health facilities 

Dr Tedros Adhanom Ghebreyesus: WHO supports the UN Secretary General’s call fo an immediate ceasefire and safe return of hostages held in Gaza.

In Gaza, there have also been 59 attacks on health workers or health facilities, while in the occupied West Bank, there have been another 77 attacks on Palestinian ambulances and responders since 7 October.  

In Gaza, the worst attack came Tuesday night when some 470 people were killed in a huge explosion at Gaza’s Al Ahli hospital, where many displaced civilians had been seeking shelter, WHO said. 

Regardless of who was responsible, health workers and facilities need to be left out of the circle of hostilities, said Tedros. 

“I deplore the attacks on health care in both Gaza and Israel, which have led to deaths and injuries of health workers and patients on both sides. Under international humanitarian law, all armed actors are obliged to actively protect health care. The bomb that striked Al Ahli Hospital in Gaza City on Tuesday night, and the loss of life it caused, regardless of who was responsible cannot be tolerated.” 

Opportunity to prevent further escalation? 

Added Tedros, “There is still time and opportunity to prevent the situation from escalating further. 

“WHO supports the United Nations Secretary General’s call for an immediate humanitarian ceasefire. We call for the immediate and safe release of hostages seized and taken into Gaza by Hamas and other armed groups, among them children, older people and those who need urgent medical care. 

“We continue to appeal to Israel and Hamas to abide by their obligations under international law to protect civilians and healthcare. We appeal to Israel to restore supplies of electricity and water [to Gaza].”

Image Credits: WHO , WHO/Ministry of Health/Occupied Palestinian Territory , WHO/Eastern Mediterranean Region .

Pollution levels are rising in India’s capital, Delhi.

There have been some gains in the past decade, but peak pollution is still 30 times WHO’s safe limit. Top Delhi government advisor Reena Gupta speaks with Health Policy Watch about progress and obstacles.

Come October and millions of people in and around Delhi brace for a sharp rise in pollution in the last quarter of the year and on cue, the level of PM 2.5, a critical microscopic air pollutant that is usually the best measure of air quality, has already tripled from a month earlier. 

It’s been 10 years since the World Health Organization (WHO) deemed the city to be the most polluted in the world – even worse than Beijing whose air was notorious at the time. 

Although there has been progress, Delhi is still often labelled as the most polluted capital in the world. Back then, the annual average of PM 2.5 was 149 micrograms per cubic metre. Now it’s about 100, an improvement of a third. But between October and December 2022, the average was almost 160, which is over 30 times the WHO’s safe limit. This year could be worse, experts warn.

Reena Gupta, the national spokesperson of Delhi’s governing party, Aam Aadmi Party.

To understand why pollution is still so bad, Health Policy Watch spoke with Reena Gupta, the national spokesperson of Delhi’s governing party, Aam Aadmi Party (‘common person’s party’). She represented the state government at the United Nations (UN) Climate Week in mid-September in New York and has previously worked at the World Bank as a Natural Resource Management Specialist. As a top advisor to the government on environmental and air pollution matters, she recently held a meeting with experts and civil society representatives. 

Dirty industries shift out of Delhi’s jurisdiction

Delhi is doing its bit, according to Gupta – even at the cost of losing revenue to reduce pollution. She cites a recent study which shows only about a third of the pollution sources are within the megacity’s boundary. 

“In Delhi, we have converted all the industry to clean (sic) and natural gas. Why has that not happened in Gurgaon and Ghaziabad [which border Delhi]?

“Also what has happened is, because we are so strict in the industrial areas of Delhi, the industries actually move to Gurgaon and Ghaziabad. They move just outside Delhi because they want to be outside the control of Delhi Pollution Control Board and they set it up on the outskirts of Delhi and continue to pollute the air shed of Delhi. So we lost the revenue but our airshed didn’t get cleaned.”

The responsibility for cleaning the air in Delhi and its neighbouring areas rests with a statutory body called the Commission for Air Quality Management (CAQM). It is headed by a retired bureaucrat and has the authority to direct over a hundred officials, including police across this vast region with a population of over 70 million.

“It’s a bureaucratic body,” says Gupta, who describes it as “very ineffective”.

“You don’t have any politicians there. The people in CAQM will continue to draw their salaries whether the air pollution improves or doesn’t improve. However, if you had a body where you had ministers who were accountable to the people, then you would see more action.” 

Gupta advocates for an air quality centre that is parallel to India’s Goods and Services Tax (GST) Council, where the centre can play the leading political role. 

Led by India’s finance minister, the GST Council includes finance ministers from the states and meets frequently to jointly administer the landmark regime which helped unify India as a single market for most goods and services. 

The council’s work may have its critics but its continued existence is seen as an example of how India’s federal structure can work in an otherwise very divisive political landscape. 

“In the GST Council, at least you have all the finance ministers and everybody comes and gives their opinion because they know that they have to go back and be accountable to the people. CAQM is not accountable to anybody,” AAP’s national spokesperson says. The AAP and the Bharatiya Janata Party (BJP) , Prime Minister Modi’s party, are bitter political rivals. 

Another alternative for the centre, she says, is to do what China did – incentivise city authorities. 

“In China you had these regional bodies which set targets for cities and for so, for example, the Central government was to tell Delhi, Gurgaon, Noida, Ghaziabad, any cities that it thinks of, to reduce your PM2.5 by 10% in the next two to three years and an additional 1,000 crore rupees (10 billion rupees) can be given from an environment fund.”

‘Can’t shut schools, can’t cut Metro fares’

There are questions over the Delhi government’s own strategy to speedily reduce air pollution in its jurisdiction. 

Why, for instance, aren’t schools closed when air pollution turns hazardous? Children can be seen walking into school when PM 2.5 levels are well over 100-200 micrograms. This toxic pollutant is linked to inhibiting the development of young lungs and cognition apart from causing respiratory diseases. 

Why aren’t fares to the metro train service slashed specially during high pollution times? This could incentivise many to move away from private vehicles as vehicular pollution is significant – contributing around 41% of air pol;ution, according to one study.

But Gupta says her government doesn’t have the authority to cut fares even though they wanted to. 

“The Metro right now is very, very expensive for people, for 70% of the population of Delhi. So we wanted to decrease the metro fares. That was rejected by the Central government. Because of Delhi’s complicated structure, some of these reforms are very difficult for us to implement.” 

Delhi is a union territory not a state and, as such, the Central government, led by the rival BJP, has overriding powers over Delhi despite the city having its own elected legislature and government.

If cutting metro fares is out, so is closing schools. Gupta explains this doesn’t make sense because most of the kids – 70-80% she reckons – live in “one-room” houses. 

“Those parents want the kids to come to school because their argument is that it’s not as if at home they have air purifiers, it’s not as if at home they have any better air quality. So they would rather have their children in school. Whereas the rich of the city probably feel that their kids are more protected at home and sitting with air purifiers. And as a government we found that there is not that much of a difference in terms of the air quality at homes or in schools.”

Private vehicles priority over public transit?

There are, however, deeper questions about AAP’s focus on public transit. For decades better public transit has been linked to air quality. AAP has been continuously in power in Delhi since 2015 and boasts of constructing 27 new flyovers and widening roads. The city now has the most road space in its land use plan amongst Indian cities. 

Yet it has been slow in adding buses despite a Supreme Court order, made in 1998, for 10,000 more buses to purchased to improve air quality. Twenty-five years later,  the population has grown and some estimate over 20,000 buses are now needed. 

 Currently, although there’s a plan to rapidly add more electric buses, there are still fewer than 8,000 buses for the entire city of almost 33 million residents. 

Gupta, however, denies that her government’s priorities are misplaced. 

“I disagree. The focus is on public transport. The focus is on increasing the metro connectivity, the focus is on increasing the last mile connectivity because unless we improve that, we will not be able to get the rich people to leave their cars.” 

She blames the opposition for complaining about the procurement which delayed the process. 

Too many plans, too many cooks?

The capital’s air crisis invariably makes the headlines this time of year, and often draws the attention of India’s top court and recently even the Prime Minister’s Office

Delhi Chief Minister Arvind Kejriwal, announced a 15-point programme to reduce air pollution in the capital. Some involve direct action against pollution sources, such as monitoring over a dozen “hotspots” and deploying 600 teams to stop the burning of garbage. 

There is also an app where the public can post complaints and a “war room” set up by the government. However, experts point out, enough isn’t being done to actually stop sources of pollution. 

Some of the other measures raise questions of implementation and impact. The plan includes planting ten million saplings, although the ideal time do so was a few months ago mid-monsoon; a ban on fireworks, which has repeatedly failed in the past couple of years; hundreds of ‘smog guns’ and sprinklers to spray water in a bid to suppress pollutants, the efficacy of which has been questioned; almost 400 teams to check pollution-under-control certificates (PUCs) for vehicles, but this doesn’t check for PM 2.5 even though vehicles can contribute to about a third or more of Delhi’s PM 2.5 pollution. 

Apart from the state government, there is also central government’s Graded Response Action Plan (GRAP) overseen by the CAQM. Each time the Indian air quality index deteriorates and crosses certain benchmarks, the CAQM orders tighter controls. For example, ‘GRAP 1’ is implemented when the air quality index (AQI) crosses 201. 

GRAP has been a dynamic programme although further studies are needed to show whether this is conclusively reducing pollution. 

For the last two years it’s been implemented since 1 October, perhaps to have protocols in place for quicker reaction as pollution spikes from mid-October. This is when multiple factors – including cooler temperatures and low wind speed which trap pollutants, crop stubble being burnt and festive firecrackers – make the air extremely hazardous to breathe. 

Several studies have linked even short term exposures to PM 2.5 pollutants to strokes, heart attacks and respiratory problems. Incidentally most of the stubble fires that affect Delhi are in Punjab, where Gupta’s party is in power. The state promised to halve the number of fires compared to last year but at the time of writing this the number had already exceeded last year’s count.

Significant changes

A significant change has been to base action on Air Quality Index (AQI) forecasts in Delhi rather than waiting for pollution to worsen and then take action. 

Other changes this year included a complete ban on diesel generators – only for this to be eased two days before imposition; a ban on burning coal and firewood in all restaurants, at the very first stage of GRAP unlike earlier; “strict restrictions” for the first time on certain types of vehicles operating on old fuel standards (which largely follow the Euro standards.) 

For all the political tension between the AAP and the BJP,  there is commonality in their pollution-control plans. Both back the ban on firecrackers, both press for planting more trees and drivers turning off vehicles at a stop light. Neither explicitly links the closure of schools to rising pollution but tacitly permits this when the pollution hits the “Severe” or “Severe +” benchmarks, levels that are extremely high even by Delhi’s poor record. 

Fireworks ban a mega-fail

The firecracker ban, specially during Diwali but also in other festive occasions, has failed repeatedly, despite having the official concurrence of the central and state governments, the Supreme Court and even the city police. 

“The regional issue comes into play, right? You have a firecracker ban in Delhi but you don’t have a ban in (next-door) Noida, how is it going to be effective?” asks Gupta.

“If the crackers are sold, people will buy and they will burst it. So I think in this also, we as citizens need to take ownership. How many policemen can you actually have on the ground that day to say that crackers should not be burnt?”

Banning firecrackers on Diwali also tends to be politically contentious. The BJP protested that this can hurt “religious sentiments” but their protest was overruled by the Supreme Court. 

No help for poor migrants burning biomass to cook

AAP’s Gupta points out another source of pollution: impoverished migrants coming to Delhi for better prospects, and burning biomass to cook food. 

“Some of the surveys that we did showed us that, because of poverty rates going up, a lot of migration is happening to Delhi right now,” said Gupta.

“So we looked into this whole idea that is it possible for the Delhi government at least to give subsidised (cooking gas) cylinders to some of our people who are living in the slums. We went very deep into it, but it would have been very difficult to implement because it would have been almost impossible to figure out who is a resident of Delhi and operationally it would have been very difficult. So we gave up that idea.”

 

Lifesaving WHO humanitarian aid to Gaza arrives in Egypt from Abu Dhabi. It is now poised at the Rafiah crossing into Gaza.

Israel on Wednesday confirmed that it would agree to allow humanitarian aid into Gaza via its Rafiah crossing from Egypt, where truckloads of  food, water and medicines have already been positioned in the hopes that a humanitarian corridor could soon be opened to reach some 2.3 million Gazans in a deepening humanitarian crisis.  

The Israeli agreement came after days of high stakes diplomacy involving Israel, Egypt and the United States, and was announced by US President Joe Biden during his whirlwind visit to the country – an unprecedented gesture by an American president in wartime. 

“In light of President Biden’s request, Israel will not prevent humanitarian assistance from Egypt as long as it is only food, water and medicine for the civilian population locating in the southern Gaza Strip, or which is evacuating to there, and as long as these supplies do not reach Hamas,” said the Israeli statement confirming the arrangements, and released shortly after Biden’s departure.

“Israel will not allow any humanitarian aid from its territory to the Gaza Strip as long as our hostages are not returned,” the statement  added. 

Over 70 cubic tons of medicines and health equipment have been waiting at Rafiah for over 72 hours, WHO said in a press conference on Tuesday, as the US and neighboring Arab states sought to broker a deal amidst heavy Israeli bombardment of Gaza and constant Hamas  missile fire into Israel.

Gaza man walks across a pile of rubble in a week that has seen the heaviest bombing attacks of the area ever by Israel.

Still held by Hamas forces 

Some 200 Israelis, as well as an uncounted number of foreign students and workers are meanwhile still being held by Hamas forces in Gaza – after they were taken captive in raids on 22 Israeli communities near the Gaza border on 7 October.  More than 1300 other Israelis were killed in the surprise Hamas attack, in which gunmen broke through a separation fence and went door to door, shooting and burning victims in their homes and on the streets in the early morning hours of a holiday weekend. 

While Israel has vowed to remove Hamas from power altogether now in the wake of the attacks, pressure has also been mounting on Israel’s government to advance moves that could gain the release of the hostages, which include mothers and young children, older people, many of whom are also dual nationals from some 22 countries, ranging from Nepal to Canada.  On Wednesday, Israel’s Prime Minister Binyamin Netanyahu said that he had asked Biden to intervene so as to arrange Red Cross visits to the captives.

Hamas militants arrive at Kibbutz Beeri. at 7 a.m. Saturday 7 October. A total of 100 people, one in 10 members of the kibbutz, were short or burned by the gunmen.

For 11 days now, Israel has been pounding Gaza constantly from the air, wreaking unprecedented damage on the enclave’s densely populated urban areas. The Palestinian Hamas authorities have reported some 2750 Palestinian casualties so far. 

Hamas has meanwhile continued firing thousands of missiles on wide swathes of southern and central Israel. Israel, which has anti-missile defenses and civilian shelters, has reported about another 100 casualties since the initial incursions by thousands of Hamas gunmen who broke through a fortified fence dividing Gaza from pre-1967 Israel on 7 October. 

A ground invasion on the horizon?

There were some flickering hopes Wednesday that the agreement over a humanitarian  corridor could create the foundation for a de-escalation of the crisis, advancing negotiations over the hostages and staving off an Israeli ground incursion into northern Gaza.  

Several days ago, Israel ordered the million or so Palestinians living in the northern part of the Gaza to relocate, as expectations rose of a Israeli military ground campaign to put an end to Hamas rule in Gaza – as Israel has now vowed.

The World Health Organization and other humanitarian organization have condemned the Israeli evacuation order, saying that forced relocation would be tantamount to a “dense sentence” for patients in 22 hospitals in the northern part of the enclave.  

“We have reiterated calls for Israel to reverse its evacuation orders for 1.1 million people in northern Gaza, including more than 2000 patients in 23,” said Dr Ahmed Al-Mandhari Director for WHO’s  Eastern Mediterranean Region, Tuesday morning. 

“We have highlighted both the impossibility of moving critical patients without risking their death and the already dire situation in southern Gaza’s hospitals, which are entirely unable to handle additional caseloads of patients.”

WHO Condemns Destruction of Al Ahli Hospital 

In a second late night press conference Tuesday, WHO officials condemned the attack on Al Ahli, which occurred just before 7 p.m. 

But WHO’s Director of Health Emergencies, Mike Ryan, refrained from assigning blame for the explosion, which killed some 500 people, saying only that attacks on a hospital are illegal in international law and “this violence on all sides has to stop.”  

The explosion, which Gaza’s Health Ministry blamed on an Israeli aerial bombing,, touched off spontaneous, angry protests in Beirut, Amman, and elsewhere in the Arab world, which continued Wednesday for a second night. 

Israeli officials  flatly denied that it had bombed the hospital, and shared TV footage filmed live at the time of the incident from both Al Jazeera and Israel’s Channel 12 station, suggesting that a missile shot from Gaza had misfired, with shrapnel falling on the hospital, triggering an explosion. 

The time-stamped  Al Jazeera footage captures the launch of a missile from arching in the darkened sky and then flaring as it suddenly descends – followed by a dome-like orange explosion seen on the ground at 18:59.  

Israel’s N12 TV channel also shared live footage of the same moments, showing a similar missle trajectory and explosion at 18:59, which it captured from a border watch post.   

The fact that no large crater was evident at the hospital site also tends to indicate that the explosion was not the result of a bombing, one international official involved in the Gaza relief effort told Health Policy Watch, on condition of confidentiality. 

On his visit to Israel, Biden said that US intelligence corroborated the Israeli reports that the blast had been caused by “the other team.”  

Image Credits: Care International , @uasupport999.jpg.

A lab technician in South Africa’s mRNA vaccine hub, Afrigen.

BERLIN – German mRNA vaccine maker BioNTech’s partnerships with vaccine manufacturing facilities in Rwanda, Senegal and South Africa will support the African Union’s ambition to produce 60% of the continent’s vaccine needs by 2040, the company told the World Health Summit.

But Ayaode Alakija, former Chief Humanitarian Coordinator for Nigeria and World Health Summit Ambassador, cautioned that Africa needs “end-to-end manufacturing” not a “cut-and-paste model”.

“It’s really about partnerships. Nobody can do this alone,” stressed BioNTech’s Sierk Potting. “What we are trying to establish right now, with the partners at the table and in Rwanda in Africa, is a first step into real manufacturing in Africa.”

Despite pandemic lockdown constraints, BioNTech took little over a year from conceptualizing a modular facility for the production of mRNA vaccines in Rwanda in March 2020 to breaking ground in that country in June 2021, Potting told a session hosted by the Partnership for African Vaccine Manufacturing (PAVM).

Ayaode Alakija

PAVM was launched in April 2021 and is a key component of the AU’s ambition to expand local production of vaccines. Currently, less than 1% of vaccines administered in the continent are locally manufactured, which contributed to the continent being last in line to receive COVID-19 vaccines during the pandemic.

“We have to start building this because otherwise we will be in the next pandemic and during the next pandemic, nothing would be happening,” said Potting, adding that local manufacturing in Africa is both necessary and feasible through partnerships with organizations like the AU and the African Centre for Disease Control and Prevention (Africa CDC). 

Emile Bienvenu, Director-General of Rwanda’s Food and Drug Administration, highlighted his country’s strategic approach towards achieving this goal as part of PAVM. 

“Building a vaccine industry in Africa relies on developing a conducive environment and the two main targets for Rwanda were attracting investors and becoming a regional hub for vaccine production,” he said. 

Bienvenu said that Rwanda’s collaboration with BioNTech has been successful thanks to five key factors: research and development, regulatory framework, supply chain, manufacturing, and human capital. 

He also emphasized the significance of the African Medicines Agency, which is in the process of being set up in Rwanda, in boosting pharmaceutical manufacturing across the continent.

Not tech transfer

But Alakija, who also served as the World Health Organization’s (WHO) Special Envoy for the Access to COVID-19 Tools Accelerator (ACT-Accelerator) during the pandemic, cautioned against tokenism.

“What we need in Africa is end-to-end manufacturing,” she said. “We don’t need a cut-and-paste model to give a sort of appeasement to keep Africa acquiescent,” referring to BioNTech’s self-contained modular approach, which it has shipped to the African countries to launch a production facility, and promoted as an efficient way to jump-start manufacturing in the region. 

“This is not how tech-transfer works,” Alakija told Health Policy Watch, in an interview after the panel. “Let us not sugarcoat: the discussion should not be infantalizing Africa, rather about decolonizing it.”

Historically the continent had been manufacturing vaccines, but inefficiency, corruption and under-investment had made the continent dependent on the global north for disease surveillance and response tools, critiqued Alakija during the panel.

“We in Africa have had governance problems and we need to first discuss these within home before publicizing bold plans as were shared in the panel today,” she told the session.

Stop gaslighting Africa 

Alakija also challenged the illusion of a seamless path to vaccine equity in Africa, pointing to the glaring realities of vaccine procurement challenges seen during the COVID pandemic, which have not yet been systematically addressed.

“Africa had pooled procurement, but BioNTech and Pfizer wouldn’t sell to us,” she pointed out, recalling the failed African Vaccine Acquisition Trust efforts to buy COVID vaccines in bulk shortly after they were put on the market in developed countries. 

“I’m sitting here (in this panel) mildly frustrated because some of what I’m hearing almost feels like gaslighting.”

“Money is power and would the global north, with vaccine hoarding history during COVID, really be ready to lose their contentious stronghold in the $5 billion vaccine market?” Alakija asked. 

“This is why I say we must all learn geopolitics, because until we have the right governance, poor governance in Africa will benefit high-income countries of the world.”

Alakija also challenged the emphasis on manufacturing vaccines, suggesting that focusing on health infrastructure may be a more important priority: “It is a money sink when we should be investing in our health systems.”

BioNTech CMO Özlem Türeci and CEO Ugur Sahin with African heads of state, Nana Akufo-Addo (Ghana); Macky Sall (Senegal) and Paul Kagame (Rwanda) and WHO’s Director-General Tedros Adhanom Ghebreyesus; and kNUP’s Holm Keller at BioNtech briefing on new BioNTainer plug-and-play facility.

Long-term commitment 

Reflecting on PAVM and Rwanda’s example, Marie-Ange Saraka-Yao of the global vaccine platform, Gavi, stressed the importance of a sustained, long-term effort to bolster vaccine manufacturing in Africa. 

Saraka-Yao also underlined the necessity of matching supply with actual needs, pointing to the slump in demand for COVID vaccines. 

“We need to find an equilibrium in both product quality and pricing,” she added, referring to the recent controversy in South Africa when the government opted to procure its pneumococcal vaccine from the Indian manufacturer Serum Institute of India, rather than locally, because tendering to India was more affordable. 

She also introduced the new financial instrument that Gavi is in the process of designing – the African Vaccine Manufacturing Accelerator (AVMA), which aims to provide support for sustainable procurement and long-term vaccine manufacturing on the continent, in recognition of the larger initial costs faced by new African vaccine manufacturers.

“It’s really about supporting manufacturers to come into this market, to be able to produce at least 700 million doses a year over time,” she said. 

Image Credits: Kerry Cullinan.

An estimated 99% of the world’s population is exposed to air pollution.

The world’s biggest greenhouse gas emitters are doing very little to address air pollution, with Saudi Arabia scoring worst of the group, according to a new global air pollution evaluation released on Wednesday.

The 2023 Clean Air Scorecard analyses how governments’ climate commitments – called nationally determined contributions (NDCs) – recognise and contribute to ensuring healthy air.

Countries are scored on how they integrate air quality considerations into their national climate plans to deliver the Paris Agreement to contain global warming to 1.5ºC, and whether they recognise the health impacts of air pollution and prioritise action to improve air quality. 

But the world’s top 10 air polluters – China, United States, India, European Union (EU), Russia, Brazil, Indonesia, Japan, Iran, and Saudi Arabia – scored a miserable average of 2.7 points out of a possible 15.

Saudi Arabia was bottom of the group, scoring zero out of 15, according to the scorecard, which was produced by the Global Climate and Health Alliance. Saudi Arabia’s NDC climate commitments align with global warming of an additional 4°C and it does not even mention air quality considerations. 

Bahrain and North Korea also scored zero, as do three Pacific island countries – Nauru, Palau and Solomon Islands. 

“North Korea and Solomon Islands carry the highest air pollution mortality rate of all countries analysed,” according to the scorecard. “In Solomon Islands, this is driven by household air pollution, as most households do not have access to electricity and use solid fuels for cooking.”

Among the G20 countries, Canada and China lead the way in integrating air quality in their national climate plans. The lowest scorers are Australia, Brazil, the EU and India.

The United Arab Emirates, host of the next Conference of the Parties (COP) meeting to assess countries’ progress in implementing the Paris Agreement, scored merely one point.

Highest scores for Colombia and Mali 

In contrast, Colombia and Mali lead on the integration of air pollution considerations into their NDCs, achieving 12 out of 15 possible points. They are followed by Chile, Côte d’Ivoire, Togo and Nigeria with 10 points. 

Pakistan, Togo, Ghana, Albania, Bangladesh, Cambodia, El Salvador, Honduras, Moldova and Sierra Leone also score highly.

“Fourteen of the 15 top-scoring countries are low- or middle-income countries,” according to the report. Chile is the only high-income country to score highly.

“Air pollution already causes 6.7 to 7 million deaths annually, including due to cardiovascular disease, stroke, respiratory conditions, and some cancers,” according to the scorecard.

“Fossil fuel dependence is a major cause of both climate change and air pollution. Fossil fuel phase-out is a public health and planetary health imperative.”

“Of the 170 NDCs analysed, almost all (164) mention air pollution to some extent,” according to the scorecard.

“As major global polluters, it is crucial for G20 countries to embed air quality considerations into their NDC, yet no G20 government even scores half marks – indicative of lack of recognition of the links between climate and air quality, or ambition to take action”, said said Jess Beagley, Policy Lead at the Global Climate and Health Alliance. 

“It is also telling that the countries seeking to take the greatest action on air pollution are often those bearing the brunt of the impacts.

“In several countries with higher scores, including Mali, Cambodia, Pakistan and China, high levels of air pollution mortality exist. Increased finance could enable these countries to accelerate implementation of actions they have identified.”

“Air pollution sits at the nexus of public health and climate change, yet too many countries are still failing to reap the health benefits of clean air and climate action”, said Nina Renshaw, Head of Health at the Clean Air Fund, which funded the report. 

“This means they are missing out on better air quality, which would dramatically reduce the number of people suffering from heart disease, stroke, lung cancer and asthma, which are all caused or worsened by air pollution. 

Renshaw added that while several African countries are recognising the health impacts of air pollution, this consciousness was “conspicuously absent from many G20 countries’ climate plans”.

“Ahead of COP28 and the first ever Health Day, we remind the host country, the United Arab Emirates, and all delegates, that the health benefits are at the heart of the case for climate action – and these can only be unlocked by taking action for clean air”, added Renshaw. 

“A full stop to burning fossil fuels is essential to unlock the enormous co-benefits of clean air” said Beagley. “Protecting people’s health cannot be achieved by carbon capture technologies, which do not address toxic pollutants and particulates, such as black carbon which also accelerates warming.The vested interests of fossil fuel companies and their influence over national and international policy processes are costing lives, and must be ended”, continued Beagley. 

Air quality groups – including the Global Climate and Health Alliance – have written to COP28 President Dr Al Jaber, calling on him to focus on air pollution during the climate summit. However, the scorecard reveals that the UAE is not yet adequately considering air quality alongside its national climate commitments.

Image Credits: Mariordo, Photologic.

Can oil, gas and coal give way to renewables? A draft COP 28 declaration on climate and health omits any reference to fossil fuels or their phase-out, something scientists say is critical to human and planetary health.

BERLIN –  A draft  “health and climate ministerial declaration” set to be released at the upcoming UN Climate Conference in Dubai (COP28) 30 November-12 December, omits any reference to fossil fuels and their health harms, Health Policy Watch has learned. 

While the declaration mentions the need for climate mitigation, as well as the related health harms of air pollution in passing, the language and commitments focus mostly on the “adaptation” of health systems to climate change.

The omission of any reference to what is widely recognized as the leading driver of climate change in the draft declaration was confirmed to Health Policy Watch by a negotiator who had seen the text, which began circulating Tuesday among UN member states. 

“Mitigation language from Intergovernmental Panel on Climate Change (IPCC) is in there, so is air pollution,” said the source, who requested anonymity. “Just nothing on fossil fuels.”

Assistant Foreign Minister, Maha Barakat unveils key messages in the COP28 declaration on climate and health

Speaking about the still-unpublished declaration at a session on “The Road to COP28” on the closing day of the World Health Summit, a senior official from the United Arab Emirates (UAE), which is hosting COP28, discussed the urgency of integrating health into climate debates.

But the comments by Dr Maha Barakat, an assistant foreign minister, also made no reference to fossil fuels – and to what scientists say is the urgent need for a fossil fuel phase-out in energy, transport systems and cities to prevent snowballing health impacts.  

COP 28 declaration: focus on health sector adaptation

The UAE is organizing a first-ever day dedicated to Health, Relief, Recovery and Peace” on 3 December. during COP28. It is also sponsoring the first-ever Health Ministerial meeting at the meeting – a much-trumpeted event in global health circles. 

Key health-related climate messages at COP28 would rather focus on more health sector adaptation to climate change;  increasing the health sector’s access to climate adaptation finance; and “mainstreaming” of health into climate policies, said Barakat, at the “Road to COP28” session, the keynote climate event at the Berlin conference.

Three actions to be highlighted in the declaration 

Drought, flooding and extreme heat are among the growing health impacts of climate change in WHO’s Eastern Mediterranean region – and at current trajectories, temperature rise could double within a century.

“I would like to highlight three key action areas of climate and health to be captured in the declaration,” stated Barakat

“First, the declaration relates to the need for stronger climate adaptation in the health sector itself. Health care makes up around 4.4% of global (climate) emissions and takes up around 10% of global GDP. Health systems will need a transformational shift in order to become climate resilient, low carbon sustainable and equitable,” Barakat said.

“Secondly, the declaration requires significant concentration on finance and at COP28, we want to increase not only the overall amount of climate financing but also the proportion devoted to public health. Today, just 2% of adaptation funding and 0.5% of multilateral climate funding, go to health. 

“And thirdly, there is the need to break down silos between health and other sectors in the climate response. We know that in order to keep people healthy, we rely on actions far beyond the health sector. Building climate resistant societies with healthy populations therefore needs better cross-sectoral collaboration and the mainstreaming of health into climate policies.”

The pre-release of the draft declaration seems to confirm mounting fears that the UAE, a major fossil fuel producing nation, will sidestep the main issue at stake in the climate debate: unsustainble oil, gas and coal production.

Urgent need for reduction in fossil fuels  

Solar panels provide electricity to Mulalika health clinic in Zambia. ‘Greening’ health facilities is important – but its not a solution on its own, advocates say.

‘The proposed commitments to fund adaptation in the health sector are certainly welcome, but if fossil fuels aren’t addressed, then the declaration is incomplete, ‘said Jeni Miller, head of the Global Climate and Health Alliance (GCHA), who said she hasn’t seen the text but knows what the science says.

“We do need greater investments in our health systems to adapt to the impacts we are feeling across the world. But we are currently feeling large health impacts at 1.1 C [of warming] in terms of extreme weather, heat and disease, while we are on track to hit 2.8 C.

“So we just don’t have the capacity to adapt to the level of warming that we are currently projected to hit based on the policies being implemented,” said Miller, speaking to Health Policy Watch

“Mitigation is critically important and fossil fuels are the major driver of climate change.  We have to phase out fossil fuels.  

Levels of population access to electricity, by country, 2021

“And even if some of the strategies to reduce emissions from fossil fuels were feasible, they’re not currently feasible at scale, and this wouldn’t address the other many harms of fossil fuels,” she pointed out.

Those include seven million premature deaths a year from air pollution and over 750 million people lacking household energy access – whose needs can be served more efficiently and cost-effectively by community electrification and mini-grid systems, based on renewables, as compared to conventional power plants.   

“A rapid transition to clean and renewable energy is essential to meet the energy needs of the world, while keeping our climate and environment healthy and habitable,” added Miller. “And while mitigation in the energy sector is vital, we need strong mitigation across all sectors, food systems, transportation and industry.” 

Merits to health adaptation plans 

That’s not to say that the declaration, as it stands, would lack any merit.  As health facilities are major carbon emitters, more carbon-efficient and climate-resilient facilities with greater reliance on renewable energy sources such as solar power, would set an example for other sectors to follow. 

Similarly, climate “adaptation” in the housing sector can converge with climate mitigation if strategies promote, for instance, green  building codes and ventilation standards, as well as greater use of solar and thermal power.  Housing is another target of the UAE’s COP28 climate and health declaration, said Barakat. 

“We plan to launch a set of financing initiatives on climate and housing, and to do a pipeline of climate and health investments that  have strong country ownership, and can be scaled up to save lives and safeguard health – while materially reducing carbon emissions and other forms of pollution,” Barakat declared.

The Intergovernmental Panel on Climate Change (IPCC) has long identified buildings as a major carbon emitter, highlighting the huge climate mitigation potential offered by more climate-friendly and carbon-efficient housing and domestic energy systems  – that reduce reliance on fossil fuels. 

Health benefits from climate mitigation

(L-R) (left-right) Viktor Dzau, National Academy of Medicine; Alan Dangour, Wellcome Trust; and Nísia Trindade, Minister of Health, Brazil and Dr Maria Neira, WHO discuss climate mitigation and health synergies and the need for a broader evidence base to persuade policymakers to act.

In the Berlin climate and health events, leading figures from the US National Academy of Medicine, the World Health Organization (WHO),  governments and civil society, restated these themes over and again at different sessions. They stressed the need to remake transport, energy and urban design – along with health systems- so as to reap the full range of health “co-benefits” from climate action.

“When you think about of the sectors that are impacting climate change: agriculture, transportation, energy, you name it, every one of these sectors …is where we need to mitigate, but rarely does anyone say, what does that mean for health?” said Dr Victor Dzau, president of the US National Academy of Medicine, at a Tuesday afternoon session on “Sustainable Health for People and Planet.”

UK school children protest against climate change in February 2022.

“And, in fact, very few policymaking decisions are [framed] by the sectors in terms of health.”  That, despite the fact that meat-heavy diets rich in saturated fats, for instance, typically lead to more animal and agricultural waste, which also means more emissions of methane, a powerful short-lived climate pollutant more powerful than CO2, in the near-term.

“There are many issues, but in fact, if you get it right, you get better health as well as much lower carbon emissions.”

Said Dr Maria Neira, WHO’s Director of Climate, Environment and Health, at one session: “Instead of communicating about ‘co-benefits’, I prefer to talk about health outcomes and health benefits,” underlining that the health gains from cleaner transport, energy production and cities are arguably so great that they should be able to drive a change in policy direction.

Declaration endorsed by over a dozen member states 

A press release circulated by the UAE COP presidency at the end of the Berlin summit, states that the health and climate declaration had been developed “in close collaboration” with the WHO and a dozen “country champions – including Brazil, Malawi, UK, US, Netherlands, Kenya, Fiji, India, Egypt, Sierra Leone and Germany, as well as the UAE.

“Kenya, Fiji, Liberia, Sierra Leone and Malawi also expressed their support as ‘early endorsers’ of the Declaration,” the press release states. 

But with the UAE in the driver’s seat, it’s unclear how much practical influence the global health institutions and health experts can really have on the text references to the politically charged fossil fuel debate, insiders observed.

Meanwhile, a closed-door meeting with WHO member state representatives in Berlin kicked off the arduous process of circulating and collecting country signatures to the draft Climate and Health declaration in its current form.  

“Country endorsements of the COP28 Declaration on Climate and Health will be announced at COP28, and cover a range of areas, including cross-sector collaboration on climate and health, reducing emissions within the health sector, and increasing the amount and proportion of financing devoted to climate and health,” the UAE press release said. 

The link between climate change and health is becoming increasingly evident every day, with diseases like malaria surging as temperatures rise, and extreme weather events impacting people around the globe,” says COP28 President, Dr. Sultan Al Jaber, in the press release.

“Through the Declaration on Climate and Health, we aim to help deliver public health systems that are climate-resilient, sustainable and equitable, and we urge all nations to endorse it.”

Al Jaber also avoided any reference to fossil fuels. 

Image Credits: Mazen Malkawi/WHO, Gellscom/CC BY-ND 2.0., E. Fletcher/Health Policy Watch, UNDP/Karin Schermbrucker for Slingshot , Callum Shaw/ Unsplash.

South Sudanese Minster of Health Elizabeth Chuei receiving a COVID-19 vaccine at Juba Hospital.

Time-bound waivers of intellectual property (IP) rights and benefits for countries that share information about threatening pathogens are some of the key components of the draft pandemic accord  sent to World Health Organization (WHO) member states by the Intergovernmental Negotiating Body (INB) on Monday.

These two issues have been major bones of contention in negotiations and may well be watered down during the horse trading that will commence on the first official negotiating draft. (So far, there has been a “zero-draft” drawn up by the INB Bureau and a “zero draft +”.)

The International Federation of Pharmaceutical Manufacturers and Associations (IFPMA), swiftly condemned the draft, describing it as “damaging” and “bad”, warning that it would have “a chilling effect on the innovation pipeline for medical countermeasures”.

Earlier in the week, German Health Minister Karl Lauterbach stated unequivocally that his country would not countenance an IP waiver in the pandemic accord.

“For countries like Germany and most European countries, it is clear that such an agreement will not fly if there is a major limitation on intellectual property rights,” Lauterbach told the World Health Summit

“That is a part of our DNA … we need intellectual property security in order to invest into vaccines, invest into therapeutics, diagnostics, and so forth.” 

However, Helen Clark, co-chair of the The Independent Panel for Pandemic Preparedness and Response, countered on social media that “maintaining pure adherence to intellectual property protection in a pandemic costs lives”.

Double-whammy for pharma

Article 11 contains a double-whammy for big pharma. First, it calls on parties to commit to “time-bound waivers of intellectual property rights to accelerate or scale up the manufacturing of pandemic-related products during a pandemic, to the extent necessary to increase the availability and adequacy of affordable pandemic-related products”.

Then it “encourages” patent-holders that are producing pandemic-related products “to waive or manage” royalties payment by developing country manufacturers during pandemics.

Patent holders that have received “significant public financing” to develop their products shall be “required” to waive their royalties.

“It is reassuring that, despite ferocious lobbying by pharmaceutical companies, the provision on the waiver of intellectual property is still in the text, but the current wording does not provide a significant change in the status quo,” said Mohga Kamal-Yanni, Policy Co-Lead for the People’s Vaccine Alliance.

“Making the adoption of the waiver discretionary by using qualifiers such as ‘to extent necessary’ would make it difficult to apply this provision in practice.”

R&D and transparency

The draft tries to promote transparency by calling on member states to “encourage” manufacturers in their countries to “share undisclosed information” with qualified third-party manufacturers if withholding it “prevents or hinders urgent manufacture”.

During the pandemic, for example, Moderna steadfastly refused to share its know-how with the WHO mRNA vaccine production hub in South Africa, which had found Moderna’s mRNA vaccine “recipe” online but was stymied by certain aspects of its production.

In addition, countries “shall” publish the terms of government-funded research and development (R&D) agreements for pandemic-related products, including “pricing of end-products”.

In the past, many countries have not imposed any conditions on pharma companies that have received government grants to develop medicines, leaving them to determine prices and access on their own.

But the Drugs for Neglected Diseases initiative (DNDi), which develops treatments for neglected diseases, said it was “extremely disappointed” that a provision “to attach conditions to public R&D funding” that had been in the zero draft, had been excluded.

“An obligation to publish contract terms, which we support as a separate obligation, does not ensure that public R&D funders use their leverage to attach pro-access conditions to their funding in the first place, nor ensure that recipients of funding enact pro-access activities,” explained Rachael Crockett, DNDi’s Senior Policy Advocacy Manager.

“Both are needed – transparency and conditions – to not only ensure the fast and efficient development of health tools but also to ensure equitable access,” added Crockett.

The draft also proposes “technology co-creation and joint venture initiatives” using an “open science”  approach that encourages collaboration, particularly with scientists and research centres from developing countries. 

WHO Director-General Dr Tedros Adhanom Ghebreyesus and Professor Petro Terblanche, head of the WHO mRNA vaccine development hub in South Africa.

Access and benefit-sharing

One of the trickiest sections up for negotiation is Article 12, which deals with access to pandemic products and benefit-sharing arising from sharing information about pathogens.

To address this, the draft proposes the establishment of the WHO Pathogen Access and Benefit-Sharing System (WHO PABS System) to “ensure rapid and timely risk assessment” and “facilitate rapid and timely development of, and equitable access to, pandemic-related products”.

National laboratories and health authorities will be required to upload the genetic sequences of pathogen material to “one or more publicly accessible database(s)” of their choice in “a rapid, systematic and timely manner”. 

They will need to be part of a WHO-coordinated laboratory network to receive material from other bodies and won’t be able to seek IP rights on any of the material they receive. A standard material transfer agreement (a PABS SMTA) will govern the material transfer

“Benefits, both monetary and non-monetary, arising from access to WHO PABS materials, shall be shared fairly and equitably,” the draft notes.

WHO should get “a minimum of 20%” pandemic-related products” for distribution, with 10% being donated and 10% sold “at affordable prices”.

Each country with manufacturing facilities to produce pandemic-related products “shall take all necessary steps to facilitate the export of such pandemic-related products,” the draft adds – no doubt, to circumvent a repeat of India’s refusal to allow the Serum Institute of India to export COVID vaccines during the pandemic. 

Manufacturers from developed countries should be “encouraged” to collaborate with manufacturers from developing countries “through WHO initiatives to transfer technology and know-how and strengthen capacities for the timely scale-up of production of pandemic-related products”.

The draft also proposes options such as tiered pricing and “no loss/ no profit” arrangements for pandemic products that take into account the income level of countries.

Even if a manufacturer does not opt for a PABS SMTA, if it produces pandemic-related products out of WHO PABS materials, it will be required “to ensure their fair and equitable allocation”.

Civil society groups, with UNAIDS Executive Director Winnie Byanyima, for an IP waiver for COVID vaccines

But Kamal-Yanni of People’s Vaccine Alliance said that while the language on PABS is improved, “we strongly disagree with the logic that allocating a percentage of production to WHO can ensure equitable access”.

“Sharing technology, knowledge and intellectual property by manufacturers accessing pathogens and data should be mandatory to ensure equitable access to all medical countermeasures during a pandemic,” she added.

Country obligations,

The draft also sets out countries’ obligations to prevent, prepare and respond to pandemics – finally giving weight to the pandemic cliché that “no one is safe until everyone is safe”.

All countries “shall”, for example, “detect, identify and characterise pathogens presenting significant risks” and “conduct risk assessment of such pathogens and vector-borne diseases to prevent spill-over in human and animal populations and cause serious diseases leading to pandemic situations”.

Countries are also required to strengthen animal disease preventive measures to prevent zoonotic spillover, strengthen laboratory biosafety to curtail lab accidents and address antimicrobial resistance.

To achieve this, developing countries will get “financial and technical support, assistance and cooperation” to strengthen and sustain a skilled and competent public health workforce.

Tighter language – or belonging in the bin?

Mohga Kamal-Yanni, Policy Co-Lead for the People’s Vaccine Alliance.

 

“While it is positive that many equity provisions are included, their language is inadequate and unnecessarily vague to achieve their goals,” warns Kamal-Yanni.  “The ability to apply transparency, technology transfer or intellectual property measures could be undermined by qualifiers and limiting language.”

“Provisions calling only for the promotion and encouragement of measures necessary to ensure equitable access to medical countermeasures must be transformed into obligations and commitments,” she added.

The Independent Panel’s Helen Clark welcomed the progress towards a pandemic agreement “which, together with reformed International Health Regulations, remains a unique opportunity to secure a world better protected from pandemic threats”.

“A core principle and approach in the agreement should frame pandemic preparedness and response as a global common good. This would contribute to building the regional capacity, resilience and stated commitment to equitable access that is fundamental to a transformed international system,” Clark told Health Policy Watch.

“I encourage member states to aim high on this aspect of the negotiations and on all others,” added Clark, the former Prime Minister of New Zealand.

“We urgently need transparency on how the barriers to equity that were so evident in the global response to the COVID-19 pandemic will be addressed,” said Aggrey Aluso, the Pandemic Action Network’s Africa Director.

“Key aspects to focus on right now are the inclusivity and transparency of the negotiating process, countries’ political engagement, as well as transparency on the pathway of transformation to address the barriers to equity,” added Aluso, who described the draft as “a good starting point for thinking about the key elements of a new pandemic accord”.

He called for all countries, regardless of their size or wealth, to have an equal voice in the negotiations, and for the drafting group negotiations to be open to civil society, organisations and other stakeholders.

But IFPMA Director General Thomas Cueni would prefer to bin the draft: “It would be better to have no pandemic treaty than a bad pandemic treaty, which the draft circulated to member states clearly represents,” said Cueni in a media statement on Tuesday.

“The ability of the private sector to develop new vaccines and treatments in response to COVID-19 was driven by decades of R&D investment and the ability of scientists to rapidly access data on pathogens. If adopted, the draft treaty would undermine both and leave us weaker ahead of the next pandemic than we were in December 2019, and we urge governments to make significant revisions to the current text.” 

* Story updated to include comment on the draft from Helen Clark, co-chair of the Independent Panel.

Image Credits: ULISES RUIZ / Getty Imageses Contributor, UNICEF, WHO, @FilesGeneva .

A Palestinian boy with his cat in the ruins of an apartment bombed by Israel.

Health workers in Gaza face “agonising choices” in the face of Israel’s order that all people evacuate the north of the territory: “abandon ill patients amid a bombing campaign, put their lives at risk while remaining on-site to treat patients or endanger patients’ lives while attempting to transport them to facilities that have no capacity to receive them”.

This is according to the World Health Organization’s (WHO) Eastern Mediterranean Region, which “strongly condemned” Israel’s “repeated” evacuation orders – including more than 2,000 patients in 22 health facilities.

“The lives of many critically ill and fragile patients hang in the balance: those in intensive care or who rely on life support; patients undergoing hemodialysis; newborns in incubators; women with complications of pregnancy, and others all face imminent deterioration of their condition or death if they are forced to move and are cut off from life-saving medical attention while being evacuated,” said WHO EMRO.

Although Israel’s evacuation deadline expired on Saturday, Israel has not yet deployed ground troops into the areas of Gaza that it ordered evacuated.  Meanwhile, some Palestinian health workers in the hospitals affected have chosen to stay with their patients, who cannot be moved in any event.

Dr Christos Christou, president of Medecins sans Frontieres (MSF), described the situation in health facilities in Gaza as “horrific and catastrophic”, with surgeons at Al-Shifa Hospital currently “operating without painkillers”.

“People are trapped, unable to escape, with absolutely nowhere safe to go. They’re deprived of essential needs – water, food, protected shelter, medicines,” added Christou. “This is unimaginable. This is inhumane. As doctors, humanitarians, human beings, we cannot tolerate this. While we are frightened of what is coming, our only hope is for humanity to prevail.”

Huge death toll

At least 2,750 Palestinians have been killed and 9,700 have been wounded in Israeli air strikes on Gaza since 7 October, the Palestinian health ministry said on Monday. This is the highest Palestinian death toll since Hamas took control of Gaza in 2007, wresting power from the Fatah-aligned Palestinian Authority in a violent takeover, after both sides failed to win a clear majority in elections, the last ever to be held. 

Israel launched unprecedently intense airstrikes on Gaza after Hamas attacked  towns, villages and collective farms inside Israel on 7 October, killing around 1,300 people and abducting 199 others, including babies, children and elderly, whom it is currently holding hostage in Gaza.

Around half the population of Gaza is under the age of 18, and the UN Children’s Agency, UNICEF, called for an immediate ceasefire last week, saying that “hundreds and hundreds of children have been killed and injured”.

UNICEF has also called for Israeli children held captive by Hamas to “be safely and immediately reunited with their families and loved ones”.

 

Palestinians killed on designated safe route to the south

Meanwhile, some 70 Palestinians were killed on Friday while trying to leave northern Gaza along one of the routes designated as safe by the Israeli Defense Force (IDF) when their convoy was bombed, according to media reports.

Amnesty International said on Sunday that it had verified six videos of the Israeli attack on a civilian convoy on Salah al-Din Road, and a follow-up bombing of ambulances that arrived to assist. IDF has denied responsibility for the attacks.

The Israeli strikes on Gaza have been unprecedented in their intensity.  Hamas has also continued to fire missiles into southern and central Israel, leading to the evacuation of Israeli communities in proximity to the Gaza border. Although most Israeli civilians have access to shelters, the total Israeli death toll so far in the hostilities has now risen to over 1400, according to Israel, including several dozen foreign workers, students and Palestinian-Israeli citizens.

White phosphorus use?

Last week, Human Rights Watch (HRW) said it had verified videos that showed Israel had fired white phosphorous “over Gaza City’s port and in two rural locations along the Israel-Lebanon border.”

“Upon contact, white phosphorus can burn people, thermally and chemically, down to the bone as it is highly soluble in fat and therefore in human flesh. White phosphorus fragments can exacerbate wounds even after treatment and can enter the bloodstream and cause multiple organ failure,” according to HRW.

“Its use in densely populated areas of Gaza violates the requirement under international humanitarian law that parties to the conflict take all feasible precautions to avoid civilian injury and loss of life,” HRW added.

However, Israeli military spokesperson Lieutenant Colonel Peter Lerner denied that the army had used the substance, saying “categorically no” in an interview with CNN. 

Gaza is without power, low on water and food 

Meanwhile, Israel has implemented a total blockade of Gaza alongside its aerial bombing and is not allowing aid trucks carrying food, water, fuel and medical supplies to enter Gaza from Egypt via the Rafah crossing.

“There is not one drop of water, not one grain of wheat, not a litre of fuel that has been allowed into the Gaza Strip for the last eight days,” said Philippe Lazzarini, Commissioner-General of the United Nations Agency for Palestine Refugees (UNRWA), at a media briefing on Sunday.

“Gaza is running out of water, and Gaza is running out of life.  Soon, I believe, with this there will be no food or medicine either.”

Gaza’s only power plant ran out of fuel Wednesday afternoon, shutting down electricity, water and wastewater treatment, according to UNICEF spokesperson James Elder.

“Most residents can no longer get drinking water from service providers or household water through pipelines,” said Elder. “At least six water wells, three water pumping stations, one water reservoir, and one desalination plant serving more than 1 million people have been damaged by airstrikes.”

In its situation report on Monday, UNRWA said that over one million people – almost half the total population of Gaza – have been displaced. 

“Some 600,000 Internally Displaced Persons (IDPs) are in the Middle Area, Khan Yunis and Rafah, of those, nearly 400,000 are in UNRWA facilities – much exceeding our capacity to assist in any meaningful way, including with space in our shelters, food, water or psychological support.    

“Despite the Israeli Forces’ evacuation order, an unknown number of IDPs remain in UNRWA schools in Gaza City and the north. UNRWA is no longer able to assist or protect them. Over 160,000 IDPs were sheltering in 57 UNRWA premises, including – but not only – Designated Emergency Shelters in these areas at the time of the Israeli evacuation order.” 

UN Secretary-General Antonio Guterres said on Monday that the UN had food, water, medical supplies and fuel in Egypt, Jordan, the West Bank and Israel that could be “dispatched within hours” but “our staff need to be able to bring these supplies into and throughout Gaza safely, and without impediment”.

Guterres also said that “all hostages in Gaza must be released. Civilians must not be used as human shields,” in a New York Times article last Friday.

“International humanitarian law — including the Geneva Conventions — must be respected and upheld. Civilians on both sides must be protected at all times. Hospitals, schools, clinics and United Nations premises must never be targeted.”

At least 14 UNRWA staff members have been killed in the past week, while the International Federation of Red Cross and Red Crescent Societies (IFRC) said that five of its members had been killed in attacks on ambulances.

“It is clear that the two sides in this conflict cannot achieve a solution without concerted action and strong support from us, the international community. That is the only way to save any chance of security and opportunity for both Israelis and Palestinians,” Guterres concluded.

Image Credits: UNRWA.

BERLIN, Germany — Hours before the release of the second draft of the Pandemic Accord on Monday, German Health Minister Karl Lauterbach told the World Health Summit that a pandemic agreement with “major limitations” on intellectual property (IP)  rights protection will “not fly” for Germany and most of its fellow European Union (EU) members. 

“For countries like Germany and most European countries, it is clear that such an agreement will not fly if there is a major limitation on intellectual property rights,” said Lauterbach. “That is a part of our DNA … we need intellectual property security in order to invest into vaccines, invest into therapeutics, diagnostics, and so forth.” 

Lauterbach’s announcement is a victory for the pharmaceutical industry, which has been lobbying hard to influence negotiations on the pandemic treaty at the World Health Organization’s (WHO) International Negotiating Body (INB). 

“We need to be open about what can move forward and what cannot be moved forward,” said Lauterbach. 

Pharmaceutical companies like Pfizer and Moderna, which developed the most widely used mRNA COVID-19 vaccines, argue that IP protections were fundamental to them being able to take the financial risks that resulted in record-speed vaccine development at the height of the pandemic.

“The record speed at which new vaccines and treatments were developed in response to COVID-19 was the result of an innovation ecosystem, underpinned by intellectual property,” Thomas Cueni, Director General of the International Federation of Pharmaceutical Manufacturers & Associations (IFPMA) told Health Policy Watch“In the first year alone, COVID-19 vaccinations saved 20 million lives.” 

Europe and the United States, home to many of the world’s largest pharmaceutical companies, are aligned in their opposition to major limitations on IP protections in a pandemic accord.

Other countries, such as India, South Africa and Brazil, argue that IP waivers are needed for equity and would have saved millions of lives during the COVID-19 pandemic.

Another non-starter for Europe and its allies outlined by the German health minister is any relinquishing of executive power to the treaty.

“An agreement is not likely to be successful if there is even the slightest impression that executive power moves from the countries to the agreement or the World Health Organization,” said Lauterbach. “It must be quite clear that all the countries that sign up to the pandemic agreement when there is a pandemic, their full executive power is by no means curtailed or infringed upon.

“This is an agreement on standards, on norms and on responsibilities,” he added. “Executive power is always within the countries where the action takes place.”

Big Pharma and medicines access groups deadlock on vaccines 

Hemal Shah, Gilead’s Public Policy Director, speaking at an IFPMA panel at the World Health Summit on Sunday.

Shortly after the World Health Summit kicked off in the glitzy ballrooms of the Mariott Hotel in central Berlin on Sunday,  medicines access groups and big pharma had their first major clash over vaccines. 

At a panel organized by the IFPMA, executives from Pfizer and Gilead retold a familiar story about the pandemic: Historically rapid innovation, spurred by strong intellectual property protections, saved millions of lives and restarted the global economy.

Gilead’s Public Policy Director, Hemal Shah, described the company’s antiviral remdesivir as a triumph of IP protections, arguing that the company’s ability to provide an important treatment option in the early days of the pandemic was enabled by its existing research on remdesivir’s potential antiviral activity against coronaviruses.

“[Remdesivir] is a story about how intellectual property protections enabled Gilead to provide an important treatment option … when we had no vaccines available,” said Shah. “It’s also a story of how IP protections actually enable the risky undertaking of emerging viruses research.” 

Killian Mullett, Senior Director of Commercial Supply Strategy at Pfizer, pointed to the 280 different components required to create its mRNA vaccine and the record speed at which pharma was able to mount supply chains to produce vaccines. 

“When we start looking at COVID, a lot of the supply chain had to be built up from scratch,” said Mullett. “We literally have gotten up to 4.7 million doses of the vaccine, which even for Pfizer, is an incredible amount.” 

Over the three years of the pandemic, the 20 largest pharmaceutical companies amassed profits of $455.4 billion, equivalent to nearly $5,000 every second, according to the People’s Vaccine Alliance.

Meanwhile, the People’s Vaccine Alliance released a scathing report on the eve of the World Health Summit, pointing out that the world’s 20 largest pharmaceutical companies paid out nearly as much money to shareholders and executives as they claim to have spent on developing new vaccines and medicines during the COVID-19 pandemic.

The top 20 pharma companies handed shareholders and executives more than $1 million every five minutes between 2020 and 2022, spending a combined $377.6 billion on dividends, share buybacks, and executive compensation. This adds up to more than 90% of their reported research and development spending.

“There is a rewriting of history going on here,” Anna Marriott, Senior Health Policy Lead at Oxfam International, told the panel. “There was monopoly control over the successful vaccines, and that monopoly led to pharmaceutical companies paying out a million dollars every five minutes to executives and shareholders.” 

Moderna and BioNtech, companies responsible for the two most widely used COVID-19 vaccines, reaped incredible profit margins of 51% and 54%, respectively, during the COVID-19 pandemic – far higher than any other major industry. 

In comparison, ExxonMobil, which generated record-breaking profits of $56 billion in 2022, averaged a net profit margin of just 19%. The notoriously high-profit margins of the oil and gas sector as a whole averaged 17% in 2022.

The record profits of Moderna and BioNTech have come at a time when global inequality has soared. The world’s richest 10% of people now own more than 76% of global wealth, while the poorest 50% of people own just 2%. Both the CEOs of Moderna and BioNTech were among the new billionaires minted during the pandemic.

“Corporations have never stopped trying to capture the policymaking process, using misleading arguments to enable the continuation of profiteering,” former UN Secretary-General Ban-Ki Moon said of the report.

“We see this in climate policy, with the increasing presence of fossil fuel lobbyists at COP, and we can see it in global health, with pharmaceutical companies trying to hollow out equity from the Pandemic Treaty,” said Moon, “Tackling the great challenges of our age requires standing up to vested interests and placing the needs of all humanity above the wealth of a few corporations.” 

Fighting words 

The World Health Summit kicked off on Sunday in Berlin.

In response to a request for comment on the People’s Vaccine report, IFPMA’s Cueni defended the pharmaceutical industry but did not comment on the profit margins or shareholder and executive compensation numbers highlighted by the report.

“These medical countermeasures were central to bringing to an end the pandemic which cost millions of lives and an economic cost of 13 trillion dollars,” Cueni told Health Policy Watch.  

“To question the very foundation of the innovation system which got us out of the COVID-19 pandemic, as the People’s Vaccine Alliance does, would severely hamper our ability to prevent, prepare, and respond to a future pandemic.” 

On Monday, BioNTech wrote down around €900mn in expected earnings from its COVID-19 vaccines due to low demand. The majority of write-offs were the result of expired raw materials needed to make the vaccines purchased during the pandemic, BioNTech said. 

To the pharmaceutical industry, BioNTech’s write-off is an example of the high-risk game of vaccine development. But to critics, €900mn is a drop in the bucket compared to the historic profits reaped during the pandemic. 

“Listening to the pharmaceutical industry, it is as though they are trying to wipe from history the decades of publicly funded research that went into COVID-19 countermeasures, and the brutal inequity of the global pandemic response,” Valentina Montanaro, global campaign head of the People’s Vaccine Alliance, told Health Policy Watch

“If humanity had worked together to combat COVID-19, instead of monopolising vaccine technology and withholding it from the global south, the human and economic costs of the pandemic would have been far less tragic,” said Montanaro. “Today’s panel was a masterclass in disingenuous spin.” 

Finger-pointing continues as the next pandemic looms 

A strong pandemic defence system could reduce the chance of another COVID like pandemic in the next ten years from 27.5% to 8%, according to modelling from Airfinity.

There is a 27.5% chance that a pandemic as deadly as COVID-19 will take place in the next decade, according to modelling from Airfinity, a health company that specializes in monitoring and forecasting trends in the global disease. 

Airfinity’s modelling also shows that if the original COVID-19 wild type had been as transmissible as Omicron, more than 300,000 people would have died in the UK alone, nearly three times more than the actual death toll.

Despite the looming threat, the world is not yet any better prepared than it was for COVID-19. Airfinity estimates that a “strong pandemic defence system” which enables effective vaccines to be rolled out within 100 days after the emergence of a new pathogen could decrease the threat of a COVID-19-like pandemic in the next ten years to 8.1%. 

“A robust pandemic preparedness system is the world’s insurance against a COVID-19-like pandemic or something even worse,” said Airfinity CEO Rasmus Bech Hansen. “We have calculated the real risks, but also the potential risk reduction that can be achieved. This can help inform decision-makers to the level of ongoing pre-emptive investment in the space to keep people safe.”

The Pandemic Fund, the key instrument established under the auspices of the World Bank to improve the resilience of low- and middle-income countries to the next pandemic, is vastly underfunded. It has only raised $2 billion of the $10 billion minimum annual budget it needs to meet its goals – and officials fear this could drop even further as the memory of the pandemic fades. 

“The pandemic fund is based on a recognition that the world has suffered from this cycle of panic and neglect: from SARS, to MERS, to avian influenza, to Zika, to Ebola, to COVID,” Priya Basu, executive director of the Pandemic Fund told the World Health Summit on Sunday.

“And each time we panic, and then there’s neglect. So this time around we really have to make those investments during peacetime, so to speak, so that the world is better prepared,” said Basu. 

The investment case, Basu said, is simple: the Pandemic Fund needs $30 billion per year over five years to get low and middle-income countries ready for the next pandemic. 

“That’s $150 billion over five years. Compare that with the trillions of dollars that the world just lost because we were not prepared, not to mention the millions of lives that were lost,” said Basu. “That is the investment case: the enormous economic and social returns that are produced from just getting the world better prepared.

“If any corner of the world is not prepared, then the rest of the world can suffer,” she added. 

Image Credits: World Health Summit.