UNAIDS Urges Other Countries to Follow Namibia’s Example and Repeal anti-LGBTQ Laws 27/06/2024 Kerry Cullinan UNAIDS has welcomed the recent ruling by Namibia’s High Court that its laws prohibiting same-sex acts between men are unconstitutional as they unfairly discriminate against gay men. Namibian citizen Friedel Dausab, supported by the Human Dignity Trust, sought to have laws prohibiting sodomy and “unnatural sex acts” and sections of the Immigration Control Act and the Defence Act that criminalised homosexuality declared invalid. He brought the case against the Ministers of Justice, Home Affairs and Defence, the Prosecutor General and the Attorney General. Judges Nate Ndauendapo, Shafimana Ueitele and Claudia Claasen ruled in Dausab’s favour, noting that these laws discriminated as they treated gay men differently from women who have sex with men, and heterosexual men who have sex with women. Dausab told Reuters after the ruling that he was “just happy” after the court’s decision as “it won’t be a crime to love any more.” “The enforcement of private moral views of a section of the community (even if they form the majority of this community), which are based to a large extent on nothing more than prejudice, cannot qualify as such as a legitimate government purpose,” noted the judgement. Anne Githuku-Shongwe, UNAIDS regional director for East and Southern Africa, described the court’s decision as ” a powerful step towards a more inclusive Namibia”. “The colonial-era common law that criminalised same-sex sexual relations perpetuated an environment of discrimination and fear, often hindering access to essential healthcare services for LGBTQ+ individuals. To protect everyone’s health, we need to protect everyone’s human rights,” she said. In sub-Saharan Africa, men who have sex with men in countries where they are criminalised are five times more likely to be living with HIV than in countries that do not criminalise this, according to UNAIDS. Globally, in 2022, men who have sex with men were 23 times more likely to acquire HIV, and transgender women 20 times more likely to acquire HIV than other adults aged 15–49. Project HOPE, which also works to combat HIV in Africa, said that “dismantling discriminatory laws is a crucial step toward ensuring everyone can safely access health care, including HIV testing and treatment”. “While much progress has been made toward mitigating HIV and AIDS, we cannot hope to end the epidemic in Africa unless we fully embrace human rights and provide stigma-free services for all, including LGBTQIA+ communities. Access to evidence-based HIV services are quite literally a matter of life and death,” said Steven Neri, Project HOPE’s Africa director. Iraq outlaws ‘effeminacy’ Namibia’s ruling is similar to that of Botswana’s High Court in 2019, which declared that Section 164 of Botswana’s Penal Code was unconstitutional as it discriminated against LGBTQ people’s right to liberty and privacy. While over half of Africa’s 54 countries prohibit consensual same-sex relations, since 2019, Botswana, Gabon, Angola, and Mauritius have repealed laws that criminalised LGBTQ+ people. Further afield decriminalisation has also happened in Bhutan, Antigua and Barbuda, Barbados, Singapore, Saint Kitts and Nevis, Cook Islands, and Dominica. Namibia’s High Court decision also bucks the trend set by Uganda and Ghana, which have made their colonial anti-LGBTQ laws even more harsh in the past 18 months. Earlier this year, Iraq introduced anti-LGBTQ legislation that imposes a prison sentence of up to 15 years for same-sex sexual relations. Transgender people face up to three years in prison for receiving gender affirmation care, while the “intentional practice of effeminacy” is outlawed, and people who “promote homosexuality” face up to seven years in prison. UNAIDS urged all countries to follow Namibia’s lead, remove punitive laws, and tackle prejudices against LGBTQI people. “Criminalising consensual same-sex relationships and gender expression not only violates fundamental human rights but also undermines efforts to end AIDS by driving marginalised populations underground and away from essential health services, including life-saving HIV prevention, treatment and care services,” according to UNAIDS. “Stigma, discrimination and criminalisation can be lethal,” said Winnie Byanyima, executive director of UNAIDS. “In the response to HIV, we have learnt that a human rights-based approach is critical in responding to a health crisis and leaving no one behind. Countries must remove these discriminatory criminal laws and introduce legislation which protects rights if we are to end AIDS as a public health threat for everyone.” Image Credits: UNAIDS. Nearly a Third of Adults Fail to Meet Global Physical Activity Recommendations 27/06/2024 Sophia Samantaroy The World Health Organization sees physical activity as a “missed opportunity” in combatting noncommunicable diseases. Physical inactivity levels have jumped to 31%, meaning that around 1.8 billion people did not meet the recommended levels of physical activity in 2022 , according to a new report from the World Health Organization (WHO). This is an increase of 10% since 2000, mostly driven by data from lower-middle income countries. Lack of physical activity increases the risk of a host of non-communicable diseases (NCDs) like heart disease and diabetes, poor physical and cognitive function, weight gain, and mental ill-health. Global physical inactivity has risen by 10% in the past two decades. Much of the world’s inactivity is concentrated in lower-middle income countries. The WHO recommends at least 150 minutes of moderate-intensity activity, 75 minutes of vigorous-intensity activity, or an equivalent combination per week. Yet much of the global adult population fails to meet the recommendation. The study, published in The Lancet Global Health Journal, is the first global estimate since 2016, and uses data from over 500 population-based surveys covering 5.7 million participants in 197 countries and territories. The WHO’s physical activity global target aims to reduce the prevalence of insufficient physical activity by 15% from 2018 to 2030. However global trends indicate physical inactivity will instead rise to 35% by 2030. This poses a “silent threat” to global health and drives the burden of chronic diseases, as Dr Rüdiger Krech, WHO director of Health Promotion, noted in a press release. “We need to find innovative ways to motivate people to be more active, considering factors like age, environment, and cultural background. By making physical activity accessible, affordable, and enjoyable for all, we can significantly reduce the risk of noncommunicable diseases and create a population that is healthier and more productive,” said Krech. High levels of inactivity in Asia Pacific and South Asia Japan, the Republic of Korea, and Singapore, considered high-income Asia Pacific countries, had the highest prevalence of insufficient physical activity at 48% in 2022. Second to this region is South Asia, with a 2022 prevalence of 45%. These numbers are especially worrying as those who are physically inactive have 20-30% increased risk of death compared with those who are physically active. Physical inactivity is linked specifically to heart disease, diabetes, stroke, colon and rectal cancer, and breast cancer. However, lower-middle income countries face the highest levels of physical inactivity at 38% in 2022 compared to low (17%), upper-middle (27%), and high income (33%) countries. Gender disparities persist Prevalence of insufficient physical activity among women. Beyond geographic variations, the study warns of widening gender disparities. Globally, 34% of women are physically inactive, compared to 29% of men. In some countries, this difference is as much as 20 percentage points, according to a press release. The gender physical activity gap stems from many complex barriers limiting women’s physical activity: less leisure time, stereotypes, body image insecurities, and the constraints of cultural acceptability. Women and girls’ sports also receive less investment, according to a recent Lancet editorial on the issue. Prevalence of insufficient physical activity in men. These disparities widen as women age, with women over 60 having the highest relative levels of physical inactivity across all regions. Physical inactivity increases as women age across all regions. “These new findings highlight a lost opportunity to reduce cancer, heart disease and improve mental well-being through increased physical activity,” said Dr Tedros Adhanom Ghebreyesus, WHO Director-General in a press statement. “We must renew our commitments to increasing levels of physical activity and prioritize bold action, including strengthened policies and increased funding, to reverse this worrying trend.” Hopes for a more active world The authors note that, although their physical inactivity estimates exceed the WHO targets for many countries, several countries are on track to increase physical activity by 2030. For example, at least six countries in Oceania have seen marked reductions in physical inactivity since 2000, from 23% to 14% in 2022. The WHO recommends at least 150 minutes of moderate-intensity activity, 75 minutes of vigorous-intensity activity, or an equivalent combination per week. An additional 16 countries are on track to reach the global target of reducing inactivity by 15% by 2030 if their trend continues at the same pace. The WHO has called on countries to strengthen their policy implementation to promote and enable physical activity. Listing community sports, active recreation, and better active transport as ways to promote physical activity, the WHO aims to promote its 2030 targets through country-level policies. “Promoting physical activity goes beyond promoting individual lifestyle choice – it will require a whole-of-society approach and creating environments that make it easier and safer for everyone to be more active in ways they enjoy to reap the many health benefits of regular physical activity,” said Dr Fiona Bull, Head of the WHO Unit for Physical Activity in a press statement. Regular and adequate levels of physical activity: 💪helps build strong bones & muscles. ⚕️protects from chronic diseases & many cancers. 👩🎓👨🎓supports learning and prevents cognitive decline. 👴👵supports healthy ageing.#BeActive pic.twitter.com/HHza82XT0b — World Health Organization (WHO) (@WHO) October 5, 2019 Image Credits: Gabin Vallet, The Lancet Global Health, WHO. Critics Blast ‘Inward, Technocratic’ MSF Leadership for Closing Access Campaign 26/06/2024 Kerry Cullinan The MSF’s leadership wants its medicine advocacy to focus on products its field offices need for humanitarian efforts. The leadership of Médecins sans Frontières (MSF) is under significant global pressure to reverse its decision to close its Access Campaign, with indications that the issue may be raised at the organisation’s general assembly that begins in Geneva on Thursday (27th). The decision has been described as a triumph for technocrats within MSF, who want the organisation to be more narrowly focused on humanitarian efforts and less on the wider political issues hampering patients’ access to medicines. Over 100 civil society organisations and 250 individuals have signed a letter addressed to MSF’s leadership and board, urging them to reverse the decision to close the iconic unit, which they say will “cause catastrophic and irreparable damage to access to health technologies for communities served by MSF projects and beyond”. Signatories include past MSF leaders Dr Unni Karunakara (former international president), Kris Torgeson (former international secretary general), Gorik Ooms (former general director) and Dr Tido von Schoen-Angerer (former executive director of the Access Campaign). Dr Mariângela Simão, former World Health Organization (WHO) Assistant Director-General for Access to Medicines and former New Zealand Prime Minister Helen Clark also joined civil society organisations and health experts in their appeal to MSF. “The planned dismantling of the Access Campaign’s core structure, capacities, expertise, and networks will reverberate across the access to medicines movement and beyond,” they write. “It will be yet another setback to the already-shrinking patient activist and civil society space critical to holding pharmaceutical companies and governments accountable so that medicines are never a luxury.” ‘Longstanding power struggle’ Von Schoen-Angerer, who headed the Access Campaign from 2006 to 2012, told Health Policy Watch that the closure was the outcome of “a longstanding power struggle” between MSF’s international office and its five powerful operational centres – Paris, Amsterdam, Brussels, Geneva and Barcelona – and the strong global and somewhat independent Access Campaign. “It’s also a clear move from some people in MSF who want to depoliticise [the organisation], with a stronger focus on a technocratic approach; on products alone, shying away from some of the underlying political issues that determine access,” he added. “They are no longer willing to take up the political battle to really fight these access battles for better prices, more research and development, greater equity. “We’re looking at a more inward, more technocratic MSF that wants to get health products for their patients alone, and is no longer wanting to fight the bigger political battles that need to be fought.” However, an MSF spokesperson told Health Policy Watch that the letter’s concerns were based on “the misleading notion that MSF is halting or reducing its work on access to products for healthcare. “This is 100% wrong. MSF is redoubling its efforts to deliver tangible improvements in access to products for healthcare driven by our new collective vision to expand our efforts to improve access to products for healthcare.” Access Campaign victories MSF’s ‘Europe! Hands Off Our Medicine’ campaign demands removal of harmful provisions from the EU-India trade agreement, which threatens the supply of affordable medicines made in India. The Access Campaign has advocated for lower prices and better access to a range of medicines for over 25 years and won some major victories – particularly for HIV and TB patients. It was launched in 1999, first campaigning for Thai drug companies to be able to produce affordable generic versions of Pfizer’s costly fluconazole, used to treat infections in people with HIV. Its latest triumph was earlier this year when it helped to secure affordable access to bedaquiline for people with multi-drug-resistant TB. In 2003, it helped to launch the Drugs for Neglected Diseases initiative (DNDi), an independent, non-profit drug development organisation focused on developing new treatments for some of the world’s most neglected diseases. The Access Campaign is unique as it has both a global view of issues blocking access to medicines – such as Free Trade Agreements that prevent generic competition – and local knowledge of communities’ needs from MSF’s field offices. But the unit is the victim of a costly two-year restructuring exercise aimed at redirecting resources from global issues to MSF’s work on the ground, according to sources. These sources told Health Policy Watch that around 50 staff are to be cut to 19 and housed in a new unit called “Access to Products for Healthcare”. Current staff will have to compete with one another for the posts. The new unit will advocate for access to specific products needed by MSF’s humanitarian efforts. At present, there is no strategic plan for the new unit, and staff are to be dispersed between five regional offices – Kuala Lumpur in Malaysia; Nairobi, Kenya; Dakar, Senegal; Rio de Janeiro, Brazil; and Brussels, Belgium. Von Schoen-Angerer described as “arrogant” the restructuring process which cost “hundreds of thousands (of Euros)” yet involved “MSF talking entirely to itself, completely ignoring the hundreds of allies in terms of organisations in the Global South, but also the North – the academics, the governments that the Access Campaign has worked with.” “That’s why they have come out with this letter because they’ve never been consulted,” he added. In 2015, MSF’s “A Fair Shot” campaign called on Pfizer and GSK to reduce the price of the pneumonia vaccine – the most expensive standard childhood vaccine – to $5 per child. In 2016, a price of $9 per child is offered to humanitarian organisations like MSF, but only for use in emergencies. MSF International stands its ground An MSF spokesperson told Health Policy Watch on Wednesday that they were not aware of the issue being on the agenda of the general assembly, MSF’s highest decision-making body, or when it would be discussed by the MSF board. Asked what the motivation was for closing the Access Campaign, the spokesperson said that “the new structure will be closer to our medical humanitarian operations, to better support the needs of the communities we assist. Five regional offices will work together with our operational teams and patients as well as with our partners and networks.” They added that populations’ access to healthcare were being affected by new developments including “technological breakthroughs, new political players, and new legal and commercial realities and regulations”. “For our patients and also our networks, we have a duty to ensure that we remain optimally organised to leverage our unique positions for improving access to products for healthcare for those deprived of them.” MSF’s International Office said in statement this week that the organsation’s “focus is on directly addressing the problems our patients and our operational teams face. “We will also continue to work globally to address systemic barriers causing or amplifying these problems. This includes advocating for changes to policies and practices that determine who can or cannot access lifesaving health care products in many of the more than 70 countries around the world where we work.” MSF’s Alexandre Michel boarding a UN Air Service helicopter bound for Les Cayes in southern Haiti following an earthquake. Loss of global advocacy? Many access activists fears that MSF will no longer advocate around HIV, neglected tropical diseases, intellectual property, research and development, trade agreements, transparency, and other cross-cutting access issues However, when asked directly whether MSF would cease its global work on issues such as the pandemic agreement negotiations and global trade agreements, the spokesperson simply responded: “In 2025, MSF’s new structure dedicated to our work with improving access to products for healthcare will continue the work of the Access Campaign that aligns with our new collective access to products for healthcare priorities, including dossiers on vaccines, diabetes, [anti-microbial resistance], TB, and diagnostic tools. Next year will also be dedicated to dedicated to finalising the new structure’s longer-term strategic plan.” The spokesperson added that “around 35 staff are contracted to the Access Campaign” as well as “a number of others with temporary contracts”. “At least 19 of them have the immediate opportunity to work for the new structure. Others may also be absorbed (due to their expertise) by other MSF sections, operational directorates or projects.” But Von Schoen-Angerer expressed concern that there is no strategy in place for the new unit “beyond vague priorities” and it will take at least a year to develop a strategic plan. Loss of unique skills “They are firing all the fantastic staff or humiliating them by making them reapply if they want to be part of the new structure. Allies will be lost, battles will be lost and it will take years before this will become effective.” he added. Fatima Hassan, director of the South African Health Justice Initiative (HJI), described the skills of Access Campaign staff as “unique, unprecedented, and multi-disciplinary.” “There are no other groups right now in the world that can replicate its work or fill its large shoes,” said Hassan, urging MSF not to “dilute” it. Ellen ‘t Hoen, director of Medicines Law & Policy and former policy and research director of the Access Campaign, has also expressed her alarm at the move, describing the campaign as “a pillar of global access to medicines work”. “Access issues have never been more front and centre in global health, as the recent lack of progress in the negotiations of the WHO pandemic accord – and the desperate scramble to access COVID-19 countermeasures that preceded the launching of the accord process – have underlined,” noted ‘t Hoen’s Medicines Law & Policy this week. “If MSF proceeds with this decision, it will leave a significant void in the access movement. Particularly, groups in low and middle-income countries will bear the brunt of this loss. There are no apparent players who can take over the role of the MSF Campaign because most lack the multidisciplinary expertise and resources MSF has.” This week, Unitaid’s executive director, Philippe Duneton, also added his voice to appeals for MSF to continue its access work in an open letter to MSF’s president, Dr Christos Christou. “MSF’s voice and work in access remains more needed than ever, addressing the grassroots causes of inequities whether in HIV or global health emergencies, neglected diseases, and neglected populations that the market keeps failing,” noted Duneton, whose organisation works to ensure low- and middle-income countries have access to treatment and tools to combat major health challenges. Image Credits: MSF, MSF Access Campaign. Framework to Help Curb Visceral Leishmaniasis in East Africa 26/06/2024 Zuzanna Stawiska Delegates during the launch of a WHO visceral leishmaniasis elimination framework WHO framework to eliminate visceral leishmaniasis (VL), a deadly disease most prominent in East Africa, was launched Thursday. It can play an important role in eliminating VL as a public health problem by 2030: a goal key countries of the East African region committed to in last year’s Nairobi Declaration. “The VL elimination framework will offer important direction to countries in the region and provide momentum to reach the finish line of elimination,” said Dr Dereje Duguma, the Health Minister of Ethiopia, a co-host of the launch. “The Government of Ethiopia remains committed to working with partners to develop programs at all levels, from national to community, to expand access to healthcare and achieve the targets of elimination by 2030.” Visceral leishmaniasis, or kala-azar, is a deadly parasitic disease causing fever, weight loss, spleen and liver enlargement, transmitted by the bite of infected female sandflies. Lethal if left untreated, the disease is endemic in 80 countries worldwide, with 73% of the estimated 50,000 to 90,000 cases annually occurring in the Eastern African region in 2022, according to the WHO. Children under 15 account for half of the infections. Malnutrition, but also poor sanitary and housing conditions increase the risk of leishmaniasis infection. Sandflies, which transmit the disease, often live next to crowded buildings or spaces with open sewages or bad waste management. VL outbreaks are also frequent when many people without immunity to the parasite migrate to areas where it is endemic or with environmental changes, such as deforestation, building of dams, but also climate change. Successful elimination thanks to framework A good implementation of a regional Strategic Framework for VL led to a total elimination of the disease in Bangladesh in 2023 – becoming the first country worldwide to achieve the status – and a significant reduction of cases in the region. Eastern Africa wants to follow a similar path. A 2014 plan to eliminating VL in Bangladesh, India and Nepal brought a massive decline in case numbers Between 2004 and 2008, Bangladesh, India and Nepal accounted for 70% of global visceral leishmaniasis cases. The regional framework adopted in 2005, paired with sustained stakeholder support and a political will for an accelerated program implementation contributed to a successful case reduction. The combined number of cases for the three countries decreased almost forty times, from 39,809 in 2005 to only 1,074 in 2022, according to WHO data. Nairobi Declaration commitments Representatives of eight East African countries pledged to follow the path to VL elimination, signing the Nairobi Declaration in 2023. The ministries of health of Chad, Eritrea, Ethiopia, Kenya, Somalia, South Sudan, Sudan, and Uganda, along with key stakeholders in the region set the goal of significantly curbing VL cases by 2030. Djibouti has also signed the declaration and co-hosted the WHO elimination framework launch last Thursday. The framework, developed in partnership with the Drugs for Neglected Diseases initiative (DNDi) and Ministries of Health across the region, outlines five main strategies for VL elimination: early diagnosis and treatment, vector management, surveillance, social mobilisation, and operational research. It also features a step-by-step guide through elimination phases as well as sets regional and country targets, such as a 90% reduction in VL burden in Eastern Africa by 2030, decreasing the number of cases to 1,500 annually. “By providing countries with tailored tools and strategies, we are laying a strong foundation for sustained progress in the fight against this neglected tropical disease,” said Dr Saurabh Jain, WHO’s Focal Point for VL. Image Credits: WHO. Urgent Global Action is Needed to Address Alcohol and Drug Consumption 25/06/2024 Kerry Cullinan The WHO stresses that there is no safe level of alcohol consumption. Romania, Georgia and Czechia have the highest alcohol consumption rates in the world while, in the best-case scenario, only 14% of those who abuse alcohol have access to treatment. These are some of the insights from the World Health Organization’s (WHO) global status report on alcohol and substance use disorders, based on 2019 data from 154 countries. In 2019, 2.6 million deaths were caused by alcohol ⚠️ 2 million were among men ⚠️ 13% of deaths were among younger people aged 20-39 yearshttps://t.co/zk0WbU47Rc pic.twitter.com/FX7kGODhIi — World Health Organization (WHO) (@WHO) June 25, 2024 Around 400 million people lived with alcohol and drug use disorders, with 209 million of these being people with alcohol dependence. Those living in the vast WHO European region, which includes Russia, consumed the most alcohol – 9.2 litres of pure alcohol per person annually. The Region of the Americas, which includes North and South America and the Caribbean, followed with 7.5 litres. In Romania, the average daily pure alcohol consumption per capita was a staggering 36.9 grammes, the highest in the world. Georgia (31.1g), Czechia (28.8) and Latvia (28.4) – all in the European region – were not far behind. Despite Australia’s hard-drinking image, its drinkers averaged 21.9 g per capita per day, the third highest in the West Pacific region after Laos (25) and the Cook Islands (22.9). In the region of the Americas, Canada (21.5) and the USA (20.8) topped the list. In Africa, South Africa (19) had the highest alcohol consumption, while Thailand (17) was the highest in the South East Asia region. Alcohol consumption was low in the Muslim-dominated Eastern Mediterranean region, topped by the United Arab Emirates (5). Severe harms; ‘No safe level’ “Substance use severely harms individual health, increasing the risk of chronic diseases, mental health conditions, and tragically resulting in millions of preventable deaths every year. It places a heavy burden on families and communities, increasing exposure to accidents, injuries, and violence,” wrote WHO Director-General Dr Tedros Adhanom Ghebreyesus in the report’s foreword. Dr Vladimir Pozniak, WHO’s head of alcohol, drugs and addictive behaviours “The level of alcohol consumption per capita among drinkers amounts to an average of 27 grammes of pure alcohol per day, which is roughly equivalent to two glasses of wine, two bottles of beer or two servings of spirits,” Dr Vladimir Pozniak, WHO’s head of alcohol, drugs and addictive behaviours, told a media briefing this week. Of all deaths attributable to alcohol in 2019, an estimated 1.6 million deaths were from non-communicable diseases (NCDs), including 474,000 deaths from cardiovascular diseases and 401,000 from cancer. Some 724 000 deaths were due to injuries, such as those from traffic crashes, self-harm and interpersonal violence. Another 284 000 deaths were linked to communicable diseases. For example, alcohol consumption has been shown to increase the risk of HIV/AIDS as people are more likely to have unprotected sex, and increase tuberculosis and lower respiratory infections by suppressing a wide range of immune responses. The highest proportion (13%) of alcohol-attributable deaths in 2019 were young people aged 20-39 years. Globally, almost a quarter (23.5%) of all 15 to 19 year olds were current drinkers, with the highest rates in the European region (45.9%) followed by the Americas (43.9%). Pozniak stressed that “there is no risk free levels of alcohol consumption”. “The WHO has not produced guidelines [on safe alcohol consumption] because the diversity of countries, the diversity of populations, their exposure to alcohol, are so different, that to come up with universal levels of risks would be an unmanageable task,” said Pozniak. “It’s advisable to consult with a health professionals on the risks associated with level or pattern of consumption, taking into consideration the individual characteristics of a person [such as] pre-existing disorders or current health conditions because the risks varies substantially, depending on all these factors.” Lack of treatment options The total alcohol per capita consumption decreased slightly from 5.7 litres in 2010 to 5.5 litres in 2019. But the world is far from reaching the Sustainable Development Goal (SDG) target 3.5 by 2030 of reducing alcohol and drug consumption and improving access to quality treatment for substance use disorders. Although effective treatment options for substance use disorders exists, treatment coverage is incredibly low. The proportion of people in contact with substance use treatment services ranged from less than 1% to a maximum of 35% in 2019. This was even lower for alcohol-related treatment, with up to 14% of people who needed it, accessing treatment. “Most of the 145 countries that reported data did not have a specific budget line or data on governmental expenditures for treatment of substance use disorders. Although mutual help and peer support groups are useful resources for people with substance use disorders, almost half of responding countries reported that they do not offer such support groups for substance use disorders,” according to the WHO. “Stigma, discrimination and misconceptions about the efficacy of treatment contribute to these critical gaps in treatment provision, as well as the continued low prioritisation of substance use disorders by health and development agencies.” A significant number of countries reported interference from the alcohol industry in their efforts to develop effective alcohol policies, according to the report. Industry interference was highest in countries that were effectively increasing the price of alcohol. “Industry interference was most frequently reported in the African Region (62.1%). However, across all income groups, between 42% and 50% of countries pointed to this interference as a barrier to move forward,” it notes. Actions for progress To accelerate progress towards achievement of SDG target 3.5 and reduce the health and social burden attributable to substance use, the WHO recommends action in eight areas. These include increased awareness through a coordinated global advocacy campaign, and the re-commitment to implement the Global Alcohol Action Plan 2022-2030 with a focus on the SAFER package. It also calls for increased capacity of health and social care systems to deal with substance abuse, more training of health professionals, better monitoring and research and more engagement with civil society organisations, professional associations and people with lived experience. Image Credits: Stanislav Ivanitskiy/ Unsplash. Health and Finance Leaders Call for Strengthened Primary Health Care to Tackle NCDs and Mental Health 25/06/2024 Sophia Samantaroy Breast cancer is among the many non-communicable diseases growing in lower-and-middle-income countries, where funding for prevention is often diverted to other health concerns. When Felicia Knaul met Tonya Rosa, a Mexican woman undergoing chemotherapy for breast cancer, “she was there with a big smile on her face…even though her cancer had recurred.” But Rosa told Knaul that her first round of treatment had impoverished her family, “they had to sell their business, their home, their assets to be able to pay for her care.” But now, she had a card that gives her access to Mexico’s public insurance to cover her treatments. Rosa’s story was one of many shared at a two-day international financing dialogue for NCDs and mental health hosted by the World Health Organization (WHO) and the World Bank in Washington, DC. The meeting convened as part of the preparation for the United Nations High-Level on these issues in 2025. For Knaul, a global health economist, cancer researcher and advocate, providing care for NCDs and mental health patients requires “a health system that could deal with the whole gamut of issues that go through, from primary prevention all the way through to end-of-life care.” Representatives from over 30 countries reiterated this call for strengthened, affordable health coverage as the means to address NCDs and bolster mental health. Adriana Alfonso, Director of Health Surveillance with Uruguay’s Ministry of Health, credits the country’s recent mental health successes to its decree in making psychiatric care obligatory in an affordable and universal manner at health centers. These interventions were only possible through concerted government cooperation and willpower. Primary care financing as a sustainable solution Health and finance leaders from over 30 countries met to discuss a path forward to sustainable NCDs and mental health financing. “In the past, when we prepared annual budgets, we didn’t really take into account the mental health issues. In the case of Uruguay, we have a yearly budget that is discussed at the parliament level, and we needed to make sure that we had a mental health budget that was sustainable,” Alfonso noted. Providing dedicated funds for mental health has translated into co-payment reductions and increases in beds in mental health facilities and halfway homes. Lester Tan, director of Health Policy, Development, and Planning at the Department of Health in the Philippines, echoed this sentiment in describing the economics of mental health in the Philippines. In 2021, mental health conditions cost the Philippine economy an estimated $1.37 billion dollars, equivalent to 0.4% of GDP. Yet, investing in more treatment of epilepsy and depression would have an incredibly high return on investment – 6.6 and 5.3 times respectively. “This evidence, together with the implementation of a mental health law passed in 2018 have contributed to the scaling up of mental health services in the country. There are now 362 mental health access sites nationwide, which have served 124,000 users in 2022,” said Tan. These mental health successes hinge on expanded financing of primary health care, the “how” of NCDs and mental health care, as a panelist noted. Tan notes that the Philippines benefitted from expanding the number of health professionals trained in mental health at the primary care level. “This capacity building prioritized depression, epilepsy, self harm and psychosis.” A multi-sectoral approach to overcome ‘fragmentation’ Increased primary health care investment has the potential to reduce the global burden of NCDs through prevention, treatment, and care. Other panelists noted the urgency for multisectoral approaches to financing NCDs and mental health care – working across government institutions and ministries. An NCD expert from the Tunisia Ministry of Health, noted that her ministry recruited the help of the Ministry of Youth, Sport, and Heritage to organize a national day of exercise. “During this National Day, everybody was invited to exercise, and we talked about the importance of physical activity. The Ministry of Health decided to do screenings for hypertension and diabetes on this day, and we, of course, had a very large media campaign and awareness raising campaign in the entirety of the country,” she said. Beyond the more straightforward partnerships between adjacent ministries, the health sector must work more closely with ministries of finance, noted Aleksandra Altievska, head of fund budgets at North Macedonia’s Ministry of Finance. “I recommend that every Ministry of Health always keep in mind that the Minister of Finance has other priorities.” Working with ministries of finance to fund NCDs and mental health interventions is critical because, as Joanna Ralston of the World Obesity Federation explained, NCDs are challenges that “can’t be targeted by one sector.” “We have a global health system that really was built around single vector diseases, just to oversimplify, and yet, now we’re coming in with something that has these commercial elements, [environmental] elements, all these factors, this great level of complexity that that has to be respected,” Ralston said. Obesity, as just one example, continues to impact nations across all age levels, because of the fragmentation of the response, said Ralston. “The increase of obesity is around 100% in the past couple of years, when the goal was a 0% increase.” Fragmented, under-resourced responses undermine progress on NCDs and mental health – something that advocates hope can be overcome by renewed multi-sectorial frameworks and partnerships. Leveraging patient experiences Several panelists shared their own experiences living with an NCD at the Washington, D.C conference. Knaul, who founded the Mexico-based breast cancer advocacy organization Cancer de mama: Tomatelo a Pecho, notes that the numbers alone won’t sway policymakers – bringing in patient narratives is paramount to the future of non-communicable disease prevention, treatment, and care. “Health systems repeatedly fail patients with cancer and other NCDs,” she said. Engaging people with lived experiences of NCDs or mental health challenges bolsters local and international support, argued Charity Muturi, an NCDs and mental health policy advocate in Kenya. “When a national task force on mental health was formed, we felt that, as patients, our voices needed to be on the table,” said Muturi, who discussed her own challenges navigating mental health care in Kenya. Ralston summed up the struggle with communicating the burden of NCDs and mental health. “Evidence and narrative are what are needed to be successful. We need to be rooted in evidence, but we need to have a way of communicating that story to decision makers, policy makers, and the wider public. And that has been a challenge with NCDs.” Image Credits: Roche, WHO. Scientists in West Africa Tackle Malaria and Schistosomiasis 25/06/2024 Zsofia Hesketh Dr Mamy Andrianirina Rakotondratsara (centre) distributing antimalarials in rural Madagascar. Malaria has long been at the heart of public health efforts in Africa. As a preventable but potentially fatal disease, it is caused by a parasite transmitted by mosquitoes. In 2022, the WHO African Region accounted for about 94% of cases globally. WHO says 78% of deaths in the region are among children under 5 years of age. That’s why Dr Mamy Andrianirina Rakotondratsara, a medical doctor and research technician for Madagascar’s National Institute of Public and Community Health (INSPC), wanted to dedicate his TDR-supported studies for a Masters in Public Health to malaria research. Originally from an endemic region in eastern Madagascar, Rakotondratsara has been personally affected by malaria as he lost his older brother to the disease. “I lost someone close and beloved to me from this disease,” he told Health Policy Watch in an interview. That reinforced his determination to address the disease in the course of his studies. Dr Mamy Andrianirina Rakotondratsara lost his brother to malaria and is passionate about addressing the disease. In 2021, during the course of his Masters studies at the Cheikh Anta Diop University of Dakar (UCAD), Rakotondratsara also completed TDR’s Massive Open Online Course (MOOC) on implementation research. As part of this course, he designed a study around the relationship between the frequency of malaria episodes and mosquito bed net coverage, working with other researchers and doctors that specialize in malaria. This research is still ongoing and specifically targets the rural population of Madagascar’s Anosibe An’Ala district. Although results are still pending, designing such a study has laid the foundations for Rakotondratsara to put the research findings into practice in his home region and disease context, complementing his prior work on malnutrition. Sub-regional training centre for Francophone Africa Students engaged in a field training in participatory epidemiology organised by the National Institute of Public and Community Health Madagascar. Rakotondratsara was able to undertake this research thanks to TDR’s global postgraduate training scheme – which focuses on building students’ skills to do interdisciplinary forms of research that look at barriers and opportunities for better uptake of available preventative and treatment methods. For physicians, researchers and other professionals interested in local public health, the fellowships supported by TDR – the global research programme on diseases of poverty co-sponsored by UNICEF, UNDP, WHO and the World Bank – provides essential skills for health programme management and implementation. It is particularly important for addressing infectious diseases affecting vulnerable and underserved populations and promoting engagement in research from the local to global levels. UCAD is one of the two universities in French-speaking West Africa to collaborate with TDR in the programme. It has been hosting students since 2021, to conduct research into how to control infectious diseases found across the region. In 2022, University of Sciences, Techniques and Technologies in Bamako, Mali, joined the programme with the support of Germany’s Deutsche Gesellschaft für Technische Zusammenarbeit. “The TDR training allowed us to have a new vision of the health system,” Rakotondratsara observes. It changed my way of asking questions when faced with poor health indicators. Regarding my Master’s thesis, it gave me an idea of issues to be explored in the mosquito net distribution process, starting with the quantification of needs to end point use.” He strives to integrate such lessons learnt into his current role with the INSPC. And he is also planning to pursue a PhD with a specialization in implementation research. “The INSPC is a public health training and research institution attached to the Ministry of Public Health,” he explains. “Given that it is a research institution, in collaboration with funding bodies, we are often called upon to carry out expert appraisals on their behalf. As a research technician, I accompany this research and bring my contributions to it,” he says. “Based on my experience, it’s my intention to ensure that implementation research finds an important place both in the research and the teaching context.” Towards better management of Schistosomiasis Although less well known, schistosomiasis, also known as bilharzia, is the second most prevalent disease after malaria both in Senegal and much of the rest of sub-Saharan Africa. Its most common form – urogenital schistosomiasis – can result in damage to the bladder, urethra, and kidneys. It is a parasitic disease that occurs in tropical and subtropical regions where there is limited access to clean water, particularly in the Senegal River Basin, a hyper-endemic region for several species of the parasite that causes the disease. The different variants of the disease are classified by WHO according to the NTD principles for which a greater global response is needed, making it an important research target in the TDR program. Oumy Kaltome Boh, a physician originally from Dakar, has been interested in the burden of NTDs in Senegal since her formative years, and hopes to see their eradication by 2030. Dr Oumy Kaltome Boh “Faced with the impact of these diseases on the health of the population,” she says, her main objective is to contribute to their management “through the implementation of innovative interventions.” This is what led Boh to undertake a Masters degree in management of health programmes at UCAD, as well as an International Inter-University Diploma in emerging infections. Benefiting from a TDR grant in December 2020, Boh was able to conduct a study examining the day-to-day lifestyle practices and environmental factors that make schistosomiasis transmission more likely in endemic areas of her home country. As part of this study, done in collaboration with Senegal’s national bilharziasis programme, she also aimed to verify the effectiveness of schistosomiasis treatment with praziquantel, the only available treatment option currently. A total of 287 children were followed over the course of three weeks, with ‘Day Zero’ representing the date of administration of a single praziquantel dose. Between days 14 and 21, both the effects of the drug on disease progression were assessed and a favourable efficacy profile was found, with a 98% reduction in parasite eggs by day 21. Today, Boh holds the position of deputy chief medical officer in the health district of Saint-Louis, Senegal, and is mainly involved in care and prevention activities for people living with HIV or tuberculosis. Recruited into this position by the Ministry of Health, she stresses that it was through the support of the TDR postgraduate training scheme that she acquired the skills she needed to manage the public health challenges in this district. In particular, learning about community-based approaches allowed her to better “understand the specific needs and problems” of the districts. New research and management approaches As a key aspect of disease control, students supported by TDR can learn to apply new health research and management approaches previously unknown in Senegal, Boh says. Among these is the One Health approach, which aims to assess how diseases emerge from a holistic and ecosystem-oriented perspective, taking into account the reciprocal role of humans, animals, plants, and microorganisms such as the aforementioned pests. By combining scientific, strategic, and rigorous implementation training, the TDR grants offered through UCAD enable their recipients to evaluate and propose improvements to health interventions against poverty-related infectious diseases. These opportunities are game-changers for both UCAD students and the future of implementation research in French-speaking Africa. With the help of TDR grants, Boh emphasises, students can gain exposure to critical health programmes and “pool their skills in order to end the neglect of poverty-related diseases and to achieve the Sustainable Development Goals.” This is the second article in a series on TDR’s research capacity strengthening programme – building skills of public health researchers, implementers, health practitioners and policy-makers in the fast-developing field of implementation research for improving uptake of effective health interventions. Gilead Urged to Prioritise Access as Injection Trial Proves 100% Successful in Preventing HIV 24/06/2024 Kerry Cullinan None of the over 2,000 young women and girls injected twice a year with a new drug, lenacapavir, contracted HIV in one of the most important advances in HIV prevention. Gilead Sciences announced these results last Friday, reporting that its Phase 3 PURPOSE 1 trial, conducted in South Africa and Uganda involving 2,134 women and girls aged 16-25, had been so successful that it was terminating early. Its announcement has been widely hailed as a huge breakthrough in the HIV sector where a vaccine has been elusive, and a range of groups urged Gilead to priorise early access to lenacapavir. The injectable was compared with Truvada and Descovy, two pills taken daily that have proven successful as pre-exposure HIV prophylaxis (PrEP). Sixteen of the 1,068 women in the Truvada group and 39 of the 2,136 women in the Descovy group contracted HIV during the trial. During a scheduled review of results, the trial’s independent data and safety monitoring board (DSMB) found the lenacapavir regimen was safe and highly effective. The trial, expected to run until September, was terminated early based on its success. Results of the trial have not been peer-reviewed yet. The age group targeted by the trial is the worst affected by HIV in southern Africa. In 2022, over three-quarters of infections in 15 to 24-year-olds in the region were girls and women, according to UNAIDS. “Every week, 4,000 adolescent girls and young women aged 15–24 years became infected with HIV globally in 2022, and 3,100 of these infections occurred in sub-Saharan Africa,” added UNAIDS. One of the ‘most important results’ “This is one of the most important results we’ve seen to date in an HIV prevention study,” said Mitchell Warren, executive director of AVAC, a non-profit HIV prevention advocacy organisation. “Adding additional HIV prevention options means more people may find an option that is right for them. Beyond expanded choice, a twice-yearly injection has the potential to transform the way we deliver HIV prevention to people who need and want it most – from an easier-to-follow regimen for individuals to a decreased burden on healthcare systems that are stretched to the limit.” Professor Linda-Gail Bekker, director of the Desmond Tutu HIV Centre in South Africa, said that the twice-a-year injectable could provide a “critical new choice” to prevent HIV. “While we know traditional HIV prevention options are highly effective when taken as prescribed, twice-yearly lenacapavir for PrEP could help address the stigma and discrimination some people may face when taking or storing oral PrEP pills, as well as potentially help increase PrEP adherence and persistence given its twice-yearly dosing schedule,” added Bekker. Gilead expects results by early 2025 from the programme’s other trial, PURPOSE 2, which is assessing twice-yearly lenacapavir for PrEP in men who have sex with men, transgender and non-binary people, currently underway in Argentina, Brazil, Mexico, Peru, South Africa, Thailand and the US. Access to lenacapavir, marketed as Sunlenca in the US, still needs to be worked out once it is approved by regulatory authorities. Cost of access? Lenacapavir (marketed as Sunlenca) was approved in the US in 2022 for “heavily treatment-experienced adults with multi-drug resistant HIV-1 infection and for treatment of people living with HIV who have been on other HIV treatment regimes which are currently failing”. However, Gilead charges $40,000 per patient per year in the US, reports aidsmap. When announcing the PURPOSE 2 results, Gilead acknowledged the “importance of helping to enable access in order for twice-yearly lenacapavir for PrEP, if approved by regulatory authorities, to achieve the broadest impact”. “In light of today’s milestone and the company’s ongoing commitment to communities affected by HIV, Gilead intends to brief community partners and provide a public statement regarding its planned access approach for high-incidence, resource-limited countries, which are primarily low- and lower-middle-income countries,” said the company. Gilead’s statement was welcomed by African HIV medicines access group AfroCAB in an open letter to its CEO, Daniel O’Day. “Replacing 365 pills of oral PrEP with just two injections is a life-changing transition and urgently needed option, as millions of our brothers and sisters, friends, and neighbours face challenges of stigma, pill burden, and adherence, leaving them unprotected against HIV acquisition,” said AfroCAB. “To forge a new pathway forward for [lenacapavir], we call on stakeholders to act now. After thousands of our community members have taken part in clinical trials for LEN and other injectable PrEP products, it is time that pharmaceutical companies, governments, and donors play their part in driving access among the communities that supported the science.” “We expect to see a timeline that takes into account a full analysis of PURPOSE 1 data and the coming data from PURPOSE 2 from Gilead as soon as possible, and we urge regulatory agencies to prepare to fast track regulatory review,” Warren added. “We also call on [the World Health Organization] to be prepared to quickly include lenacapavir, if approved by regulatory agencies, in HIV prevention guidelines. There is no time to waste if we are to translate these exciting clinical trial results into actual public health impact and expand the toolbox of HIV prevention choices.” Meanwhile, Unitaid urged Gilead to make access to lenacapavir a priority, calling for “the terms of their access strategies – including any voluntary licensing agreements – [to be] transparent, global health-oriented, and equitable”. “Lack of prompt and broad action would jeopardise translating the clinical trial results into real-life impact,” said Unitaid, which offered to work with Gilead to enable access, including “quality-assured, low-cost generics”. “Unitaid is dedicated to leveraging its recent investment through the Wits Reproductive Health and HIV Institute to facilitate market shaping interventions on long-acting PrEP options (in partnership with the Clinton Health Access Initiative), as well as its continued support to enabling elements such as the key work of WHO and the WHO Prequalification program, the Medicines Patent Pool and other intellectual property grants, to ensure access to this life-saving product is as broad as possible,” the organisation said in a statement last week. Image Credits: Gilead, Diana Polekhina/ Unsplash. Gavi Includes Ebola, Meningitis, Rabies and Hepatitis B Vaccines in its Portfolio 24/06/2024 Zuzanna Stawiska A member of the ring vaccination team vaccinates a man in Bosolo village. Vaccines offered as part of Gavi’s portfolio now also include preventive Ebola vaccines for care workers. Gavi, the Vaccine Alliance, announced last week that it will offer high risk countries the option of obtaining preventative Ebola vaccines, particularly for health workers, as part of the rollout of new vaccine offerings, which also include meningitis, rabies and hepatitis B vaccines. Plans to add the vaccines to the basket of available products were initially drawn up before the COVID-19 pandemic, but put on hold due to lack of appropriate supply or regulations, with applications opening only now to eligible countries. “Gavi’s ability as an alliance to protect health and save lives hinges on its ability to ensure vaccines are accessible, as quickly as possible, to those who need them the most,” said Gavi CEO Dr Sania Nishtar. “The new programmes launching today demonstrate the impact of this work.” Ebola is a rare but dangerous viral disease, with a 50-60% mortality rate. Infections may be transmitted through close contact with infected animals – for instance, fruit bats – but also through human-to-human contact. Gavi first offered Ebola vaccine candidates to health workers and suspected Ebola contacts during the 2014-2016 West Africa outbreak as an outbreak response. Two vaccines subsequently received regulatory approval and in May 2024 WHO’s Strategic Advisory Group of Experts on Immunisation (SAGE) decided to recommend the vaccines for preventive use, as well, in high-risk groups, such as health care providers in areas of endemic transmission. Meningitis vaccine rollout aims for elimination Gavi will also roll out a newly-approved vaccine for five strains of meningitis: meningococcal serogroups A, C, W, Y, and X. Central and Western African countries most prone to meningitis infections in the so-called “meningitis belt” The vaccine is a likely game-changer in the fight against the disease, experts say, noting that in the so-called “meningitis belt” of sub-Saharan African countries, the bacterial form of the diseases, regarded as the most dangerous, could potentially be eliminated. The product, MenFive, received WHO pre-qualification in July 2023 and has already been implemented in standard childhood immunisation programmes in Nigeria and Niger. In 2019, there were about 236,000 meningitis deaths, with the greatest burden in children younger than five years, with 112,000 deaths. Hepatitis B and rabies post-exposure jabs Other new vaccines include hepatitis B vaccines for newborns, granting infants critical additional protection in their first months of life, when they are at high risk of infection: including from maternal transmission. According to Gavi, nine out of ten infants infected with hepatitis B will develop chronic forms of the disease, while a quarter develop severe liver disease, which currently kills 884,000 people a year. Human rabies post exposure prophylaxis (PEP) vaccines are the last of the new package. The initiative aims to build more stockpiles of the rabies vaccine, which are often scarce and inaccessible, especially in remote areas, for post-exposure use. Rabies, which has an almost 100% mortality rate, remains a serious health problem in some 150 countries, where it is transmitted by infected dogs. But vaccines alone are not enough to stop the disease, experts underlined. “To stop human rabies deaths completely, we urgently need better data and surveillance, dog populations must be vaccinated, and people must be educated about what to do if bitten, and how to avoid being bitten in the first place,” said Professor Lucille Blumberg, Chair of United Against Rabies, pointing out to several blind spots of the human immunisation programme. Image Credits: WHO/L. Mackenzie , CDC. What Role Does Capacity Development Play in Transforming Health Research? 22/06/2024 Maayan Hoffman The latest episode of the Global Health Matters podcast, hosted by Dr Garry Aslanyan, delves into the extraordinary careers of two global health leaders and the crucial role that capacity development has played in their journeys. This episode, produced to celebrate the 50th anniversary of TDR, the Special Programme for Research and Training in Tropical Diseases, features insights from Dr Wilfried Mutombo, Head of Clinical Operations at the Drugs for Neglected Diseases Initiative (DNDi) in the Democratic Republic of the Congo, and Dr Yasmine Belkaid, President of the Institut Pasteur in France. Both leaders share their experiences and the impact of TDR’s support on their professional growth. Dr John Reeder, the Director of TDR, reflects on the importance of capacity development in fostering the potential of researchers in low- and middle-income countries. Reeder highlights his transition from hands-on research to global leadership, emphasising the value of putting research into action and nurturing talent at the grassroots level. He underscores that effective capacity development goes beyond providing resources; it involves empowering individuals to fulfil their potential and significantly contribute to their fields. To mark the 50th anniversary of @TDRnews, this episode of #GlobalHealthMatters features TDR Director John Reeder. Together, @GarryAslanyan and John discuss the challenges and future frontiers of capacity development. Listen to the episode here👉 https://t.co/K26H7vQV69#TDR50 pic.twitter.com/srEZeWErH9 — TDR (@TDRnews) June 18, 2024 “When you’re looking at science and laboratory science particularly, people get fixated on the expensive equipment and the fancy technology that surrounds this,” Reeder says. “But the most important investment in a laboratory is the scientist who is in that laboratory because, all other things aside, the ability to see the problem, think of innovative solutions to test them critically and to have the open mind to be able to see the discovery coming through that, you invest in that, and you’ve got great science.” From left: Dr John Reeder, the Director of TDR; Dr Yasmine Belkaid, President of the Institut Pasteur in France; and Dr Wilfried Mutombo, Head of Clinical Operations at the Drugs for Neglected Diseases Initiative (DNDi) in the Democratic Republic of the Congo Clinical Trials in Remote Areas: Three Challenges Mutombo’s story is a testament to the transformative power of research capacity development. Starting as a medical doctor in a small village in the DRC, Mutombo faced the challenge of treating sleeping sickness with toxic drugs. His clinical research fellowship from TDR enabled him to lead the first clinical trial in the DRC for fexinidazole, a safer oral drug for sleeping sickness. He discusses the immense challenges of conducting high-quality clinical trials in remote areas with inadequate infrastructure and highlights the importance of sustained support and training for local health workers. “The first challenge is to reach those areas because to perform a clinical trial, you need to go there in those areas, in those remote areas, and as you may know, we have bad roads, and sometimes this is not very safe,” Mutombo says. “The second challenge is, when you are in those areas, you can imagine in what state those health facilities are… So we had to improve these health facilities.” Another challenge, he says, is the health workers. “Health workers are there, but they are not aware of what a clinical trial is,” according to Mutombo. “To have a high-quality clinical trial, they needed to train them and have a very, very close supervision of their activities. So we organised all this.” Finally, “We need our governments … to give more support and more money to maintain those facilities. This is very important for the government because the first and very important step has been done, but now we need to maintain them at that level.” Building Research Capacity: Support is Crucial In many ways, Belkaid’s journey from Algeria to leading the Institut Pasteur in France exemplifies the global impact of TDR’s fellowships. She speaks about the crucial support she received, which allowed her to pursue her PhD and establish a notable research career. Belkaid emphasises creating environments that nurture talent and passion, enabling researchers to address pressing global health issues. Her vision as President of Institut Pasteur includes fostering international collaboration and continuing to build research capacities that can address future health challenges. Belkaid says if there is anything she can do over the next few years, it will hopefully be helping in any way she can to grow and nurture the leaders of tomorrow internationally. The episode underscores the ongoing need for international organisations like TDR and WHO to prioritise capacity building in low- and middle-income countries. Reeder points out the shift towards in-country training and the importance of sustainable research systems driven by local needs and priorities. He says this approach helps ensure research capacity development and is not just about immediate results but about long-term, sustainable growth that empowers countries to tackle their health challenges effectively. Read related Inside View by Dr John Reeder. Listen to the Global Health Matters podcast on Health Policy Watch. Visit the podcast website. Image Credits: TDR. Posts navigation Older postsNewer posts This site uses cookies to help give you the best experience on our website. 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Nearly a Third of Adults Fail to Meet Global Physical Activity Recommendations 27/06/2024 Sophia Samantaroy The World Health Organization sees physical activity as a “missed opportunity” in combatting noncommunicable diseases. Physical inactivity levels have jumped to 31%, meaning that around 1.8 billion people did not meet the recommended levels of physical activity in 2022 , according to a new report from the World Health Organization (WHO). This is an increase of 10% since 2000, mostly driven by data from lower-middle income countries. Lack of physical activity increases the risk of a host of non-communicable diseases (NCDs) like heart disease and diabetes, poor physical and cognitive function, weight gain, and mental ill-health. Global physical inactivity has risen by 10% in the past two decades. Much of the world’s inactivity is concentrated in lower-middle income countries. The WHO recommends at least 150 minutes of moderate-intensity activity, 75 minutes of vigorous-intensity activity, or an equivalent combination per week. Yet much of the global adult population fails to meet the recommendation. The study, published in The Lancet Global Health Journal, is the first global estimate since 2016, and uses data from over 500 population-based surveys covering 5.7 million participants in 197 countries and territories. The WHO’s physical activity global target aims to reduce the prevalence of insufficient physical activity by 15% from 2018 to 2030. However global trends indicate physical inactivity will instead rise to 35% by 2030. This poses a “silent threat” to global health and drives the burden of chronic diseases, as Dr Rüdiger Krech, WHO director of Health Promotion, noted in a press release. “We need to find innovative ways to motivate people to be more active, considering factors like age, environment, and cultural background. By making physical activity accessible, affordable, and enjoyable for all, we can significantly reduce the risk of noncommunicable diseases and create a population that is healthier and more productive,” said Krech. High levels of inactivity in Asia Pacific and South Asia Japan, the Republic of Korea, and Singapore, considered high-income Asia Pacific countries, had the highest prevalence of insufficient physical activity at 48% in 2022. Second to this region is South Asia, with a 2022 prevalence of 45%. These numbers are especially worrying as those who are physically inactive have 20-30% increased risk of death compared with those who are physically active. Physical inactivity is linked specifically to heart disease, diabetes, stroke, colon and rectal cancer, and breast cancer. However, lower-middle income countries face the highest levels of physical inactivity at 38% in 2022 compared to low (17%), upper-middle (27%), and high income (33%) countries. Gender disparities persist Prevalence of insufficient physical activity among women. Beyond geographic variations, the study warns of widening gender disparities. Globally, 34% of women are physically inactive, compared to 29% of men. In some countries, this difference is as much as 20 percentage points, according to a press release. The gender physical activity gap stems from many complex barriers limiting women’s physical activity: less leisure time, stereotypes, body image insecurities, and the constraints of cultural acceptability. Women and girls’ sports also receive less investment, according to a recent Lancet editorial on the issue. Prevalence of insufficient physical activity in men. These disparities widen as women age, with women over 60 having the highest relative levels of physical inactivity across all regions. Physical inactivity increases as women age across all regions. “These new findings highlight a lost opportunity to reduce cancer, heart disease and improve mental well-being through increased physical activity,” said Dr Tedros Adhanom Ghebreyesus, WHO Director-General in a press statement. “We must renew our commitments to increasing levels of physical activity and prioritize bold action, including strengthened policies and increased funding, to reverse this worrying trend.” Hopes for a more active world The authors note that, although their physical inactivity estimates exceed the WHO targets for many countries, several countries are on track to increase physical activity by 2030. For example, at least six countries in Oceania have seen marked reductions in physical inactivity since 2000, from 23% to 14% in 2022. The WHO recommends at least 150 minutes of moderate-intensity activity, 75 minutes of vigorous-intensity activity, or an equivalent combination per week. An additional 16 countries are on track to reach the global target of reducing inactivity by 15% by 2030 if their trend continues at the same pace. The WHO has called on countries to strengthen their policy implementation to promote and enable physical activity. Listing community sports, active recreation, and better active transport as ways to promote physical activity, the WHO aims to promote its 2030 targets through country-level policies. “Promoting physical activity goes beyond promoting individual lifestyle choice – it will require a whole-of-society approach and creating environments that make it easier and safer for everyone to be more active in ways they enjoy to reap the many health benefits of regular physical activity,” said Dr Fiona Bull, Head of the WHO Unit for Physical Activity in a press statement. Regular and adequate levels of physical activity: 💪helps build strong bones & muscles. ⚕️protects from chronic diseases & many cancers. 👩🎓👨🎓supports learning and prevents cognitive decline. 👴👵supports healthy ageing.#BeActive pic.twitter.com/HHza82XT0b — World Health Organization (WHO) (@WHO) October 5, 2019 Image Credits: Gabin Vallet, The Lancet Global Health, WHO. Critics Blast ‘Inward, Technocratic’ MSF Leadership for Closing Access Campaign 26/06/2024 Kerry Cullinan The MSF’s leadership wants its medicine advocacy to focus on products its field offices need for humanitarian efforts. The leadership of Médecins sans Frontières (MSF) is under significant global pressure to reverse its decision to close its Access Campaign, with indications that the issue may be raised at the organisation’s general assembly that begins in Geneva on Thursday (27th). The decision has been described as a triumph for technocrats within MSF, who want the organisation to be more narrowly focused on humanitarian efforts and less on the wider political issues hampering patients’ access to medicines. Over 100 civil society organisations and 250 individuals have signed a letter addressed to MSF’s leadership and board, urging them to reverse the decision to close the iconic unit, which they say will “cause catastrophic and irreparable damage to access to health technologies for communities served by MSF projects and beyond”. Signatories include past MSF leaders Dr Unni Karunakara (former international president), Kris Torgeson (former international secretary general), Gorik Ooms (former general director) and Dr Tido von Schoen-Angerer (former executive director of the Access Campaign). Dr Mariângela Simão, former World Health Organization (WHO) Assistant Director-General for Access to Medicines and former New Zealand Prime Minister Helen Clark also joined civil society organisations and health experts in their appeal to MSF. “The planned dismantling of the Access Campaign’s core structure, capacities, expertise, and networks will reverberate across the access to medicines movement and beyond,” they write. “It will be yet another setback to the already-shrinking patient activist and civil society space critical to holding pharmaceutical companies and governments accountable so that medicines are never a luxury.” ‘Longstanding power struggle’ Von Schoen-Angerer, who headed the Access Campaign from 2006 to 2012, told Health Policy Watch that the closure was the outcome of “a longstanding power struggle” between MSF’s international office and its five powerful operational centres – Paris, Amsterdam, Brussels, Geneva and Barcelona – and the strong global and somewhat independent Access Campaign. “It’s also a clear move from some people in MSF who want to depoliticise [the organisation], with a stronger focus on a technocratic approach; on products alone, shying away from some of the underlying political issues that determine access,” he added. “They are no longer willing to take up the political battle to really fight these access battles for better prices, more research and development, greater equity. “We’re looking at a more inward, more technocratic MSF that wants to get health products for their patients alone, and is no longer wanting to fight the bigger political battles that need to be fought.” However, an MSF spokesperson told Health Policy Watch that the letter’s concerns were based on “the misleading notion that MSF is halting or reducing its work on access to products for healthcare. “This is 100% wrong. MSF is redoubling its efforts to deliver tangible improvements in access to products for healthcare driven by our new collective vision to expand our efforts to improve access to products for healthcare.” Access Campaign victories MSF’s ‘Europe! Hands Off Our Medicine’ campaign demands removal of harmful provisions from the EU-India trade agreement, which threatens the supply of affordable medicines made in India. The Access Campaign has advocated for lower prices and better access to a range of medicines for over 25 years and won some major victories – particularly for HIV and TB patients. It was launched in 1999, first campaigning for Thai drug companies to be able to produce affordable generic versions of Pfizer’s costly fluconazole, used to treat infections in people with HIV. Its latest triumph was earlier this year when it helped to secure affordable access to bedaquiline for people with multi-drug-resistant TB. In 2003, it helped to launch the Drugs for Neglected Diseases initiative (DNDi), an independent, non-profit drug development organisation focused on developing new treatments for some of the world’s most neglected diseases. The Access Campaign is unique as it has both a global view of issues blocking access to medicines – such as Free Trade Agreements that prevent generic competition – and local knowledge of communities’ needs from MSF’s field offices. But the unit is the victim of a costly two-year restructuring exercise aimed at redirecting resources from global issues to MSF’s work on the ground, according to sources. These sources told Health Policy Watch that around 50 staff are to be cut to 19 and housed in a new unit called “Access to Products for Healthcare”. Current staff will have to compete with one another for the posts. The new unit will advocate for access to specific products needed by MSF’s humanitarian efforts. At present, there is no strategic plan for the new unit, and staff are to be dispersed between five regional offices – Kuala Lumpur in Malaysia; Nairobi, Kenya; Dakar, Senegal; Rio de Janeiro, Brazil; and Brussels, Belgium. Von Schoen-Angerer described as “arrogant” the restructuring process which cost “hundreds of thousands (of Euros)” yet involved “MSF talking entirely to itself, completely ignoring the hundreds of allies in terms of organisations in the Global South, but also the North – the academics, the governments that the Access Campaign has worked with.” “That’s why they have come out with this letter because they’ve never been consulted,” he added. In 2015, MSF’s “A Fair Shot” campaign called on Pfizer and GSK to reduce the price of the pneumonia vaccine – the most expensive standard childhood vaccine – to $5 per child. In 2016, a price of $9 per child is offered to humanitarian organisations like MSF, but only for use in emergencies. MSF International stands its ground An MSF spokesperson told Health Policy Watch on Wednesday that they were not aware of the issue being on the agenda of the general assembly, MSF’s highest decision-making body, or when it would be discussed by the MSF board. Asked what the motivation was for closing the Access Campaign, the spokesperson said that “the new structure will be closer to our medical humanitarian operations, to better support the needs of the communities we assist. Five regional offices will work together with our operational teams and patients as well as with our partners and networks.” They added that populations’ access to healthcare were being affected by new developments including “technological breakthroughs, new political players, and new legal and commercial realities and regulations”. “For our patients and also our networks, we have a duty to ensure that we remain optimally organised to leverage our unique positions for improving access to products for healthcare for those deprived of them.” MSF’s International Office said in statement this week that the organsation’s “focus is on directly addressing the problems our patients and our operational teams face. “We will also continue to work globally to address systemic barriers causing or amplifying these problems. This includes advocating for changes to policies and practices that determine who can or cannot access lifesaving health care products in many of the more than 70 countries around the world where we work.” MSF’s Alexandre Michel boarding a UN Air Service helicopter bound for Les Cayes in southern Haiti following an earthquake. Loss of global advocacy? Many access activists fears that MSF will no longer advocate around HIV, neglected tropical diseases, intellectual property, research and development, trade agreements, transparency, and other cross-cutting access issues However, when asked directly whether MSF would cease its global work on issues such as the pandemic agreement negotiations and global trade agreements, the spokesperson simply responded: “In 2025, MSF’s new structure dedicated to our work with improving access to products for healthcare will continue the work of the Access Campaign that aligns with our new collective access to products for healthcare priorities, including dossiers on vaccines, diabetes, [anti-microbial resistance], TB, and diagnostic tools. Next year will also be dedicated to dedicated to finalising the new structure’s longer-term strategic plan.” The spokesperson added that “around 35 staff are contracted to the Access Campaign” as well as “a number of others with temporary contracts”. “At least 19 of them have the immediate opportunity to work for the new structure. Others may also be absorbed (due to their expertise) by other MSF sections, operational directorates or projects.” But Von Schoen-Angerer expressed concern that there is no strategy in place for the new unit “beyond vague priorities” and it will take at least a year to develop a strategic plan. Loss of unique skills “They are firing all the fantastic staff or humiliating them by making them reapply if they want to be part of the new structure. Allies will be lost, battles will be lost and it will take years before this will become effective.” he added. Fatima Hassan, director of the South African Health Justice Initiative (HJI), described the skills of Access Campaign staff as “unique, unprecedented, and multi-disciplinary.” “There are no other groups right now in the world that can replicate its work or fill its large shoes,” said Hassan, urging MSF not to “dilute” it. Ellen ‘t Hoen, director of Medicines Law & Policy and former policy and research director of the Access Campaign, has also expressed her alarm at the move, describing the campaign as “a pillar of global access to medicines work”. “Access issues have never been more front and centre in global health, as the recent lack of progress in the negotiations of the WHO pandemic accord – and the desperate scramble to access COVID-19 countermeasures that preceded the launching of the accord process – have underlined,” noted ‘t Hoen’s Medicines Law & Policy this week. “If MSF proceeds with this decision, it will leave a significant void in the access movement. Particularly, groups in low and middle-income countries will bear the brunt of this loss. There are no apparent players who can take over the role of the MSF Campaign because most lack the multidisciplinary expertise and resources MSF has.” This week, Unitaid’s executive director, Philippe Duneton, also added his voice to appeals for MSF to continue its access work in an open letter to MSF’s president, Dr Christos Christou. “MSF’s voice and work in access remains more needed than ever, addressing the grassroots causes of inequities whether in HIV or global health emergencies, neglected diseases, and neglected populations that the market keeps failing,” noted Duneton, whose organisation works to ensure low- and middle-income countries have access to treatment and tools to combat major health challenges. Image Credits: MSF, MSF Access Campaign. Framework to Help Curb Visceral Leishmaniasis in East Africa 26/06/2024 Zuzanna Stawiska Delegates during the launch of a WHO visceral leishmaniasis elimination framework WHO framework to eliminate visceral leishmaniasis (VL), a deadly disease most prominent in East Africa, was launched Thursday. It can play an important role in eliminating VL as a public health problem by 2030: a goal key countries of the East African region committed to in last year’s Nairobi Declaration. “The VL elimination framework will offer important direction to countries in the region and provide momentum to reach the finish line of elimination,” said Dr Dereje Duguma, the Health Minister of Ethiopia, a co-host of the launch. “The Government of Ethiopia remains committed to working with partners to develop programs at all levels, from national to community, to expand access to healthcare and achieve the targets of elimination by 2030.” Visceral leishmaniasis, or kala-azar, is a deadly parasitic disease causing fever, weight loss, spleen and liver enlargement, transmitted by the bite of infected female sandflies. Lethal if left untreated, the disease is endemic in 80 countries worldwide, with 73% of the estimated 50,000 to 90,000 cases annually occurring in the Eastern African region in 2022, according to the WHO. Children under 15 account for half of the infections. Malnutrition, but also poor sanitary and housing conditions increase the risk of leishmaniasis infection. Sandflies, which transmit the disease, often live next to crowded buildings or spaces with open sewages or bad waste management. VL outbreaks are also frequent when many people without immunity to the parasite migrate to areas where it is endemic or with environmental changes, such as deforestation, building of dams, but also climate change. Successful elimination thanks to framework A good implementation of a regional Strategic Framework for VL led to a total elimination of the disease in Bangladesh in 2023 – becoming the first country worldwide to achieve the status – and a significant reduction of cases in the region. Eastern Africa wants to follow a similar path. A 2014 plan to eliminating VL in Bangladesh, India and Nepal brought a massive decline in case numbers Between 2004 and 2008, Bangladesh, India and Nepal accounted for 70% of global visceral leishmaniasis cases. The regional framework adopted in 2005, paired with sustained stakeholder support and a political will for an accelerated program implementation contributed to a successful case reduction. The combined number of cases for the three countries decreased almost forty times, from 39,809 in 2005 to only 1,074 in 2022, according to WHO data. Nairobi Declaration commitments Representatives of eight East African countries pledged to follow the path to VL elimination, signing the Nairobi Declaration in 2023. The ministries of health of Chad, Eritrea, Ethiopia, Kenya, Somalia, South Sudan, Sudan, and Uganda, along with key stakeholders in the region set the goal of significantly curbing VL cases by 2030. Djibouti has also signed the declaration and co-hosted the WHO elimination framework launch last Thursday. The framework, developed in partnership with the Drugs for Neglected Diseases initiative (DNDi) and Ministries of Health across the region, outlines five main strategies for VL elimination: early diagnosis and treatment, vector management, surveillance, social mobilisation, and operational research. It also features a step-by-step guide through elimination phases as well as sets regional and country targets, such as a 90% reduction in VL burden in Eastern Africa by 2030, decreasing the number of cases to 1,500 annually. “By providing countries with tailored tools and strategies, we are laying a strong foundation for sustained progress in the fight against this neglected tropical disease,” said Dr Saurabh Jain, WHO’s Focal Point for VL. Image Credits: WHO. Urgent Global Action is Needed to Address Alcohol and Drug Consumption 25/06/2024 Kerry Cullinan The WHO stresses that there is no safe level of alcohol consumption. Romania, Georgia and Czechia have the highest alcohol consumption rates in the world while, in the best-case scenario, only 14% of those who abuse alcohol have access to treatment. These are some of the insights from the World Health Organization’s (WHO) global status report on alcohol and substance use disorders, based on 2019 data from 154 countries. In 2019, 2.6 million deaths were caused by alcohol ⚠️ 2 million were among men ⚠️ 13% of deaths were among younger people aged 20-39 yearshttps://t.co/zk0WbU47Rc pic.twitter.com/FX7kGODhIi — World Health Organization (WHO) (@WHO) June 25, 2024 Around 400 million people lived with alcohol and drug use disorders, with 209 million of these being people with alcohol dependence. Those living in the vast WHO European region, which includes Russia, consumed the most alcohol – 9.2 litres of pure alcohol per person annually. The Region of the Americas, which includes North and South America and the Caribbean, followed with 7.5 litres. In Romania, the average daily pure alcohol consumption per capita was a staggering 36.9 grammes, the highest in the world. Georgia (31.1g), Czechia (28.8) and Latvia (28.4) – all in the European region – were not far behind. Despite Australia’s hard-drinking image, its drinkers averaged 21.9 g per capita per day, the third highest in the West Pacific region after Laos (25) and the Cook Islands (22.9). In the region of the Americas, Canada (21.5) and the USA (20.8) topped the list. In Africa, South Africa (19) had the highest alcohol consumption, while Thailand (17) was the highest in the South East Asia region. Alcohol consumption was low in the Muslim-dominated Eastern Mediterranean region, topped by the United Arab Emirates (5). Severe harms; ‘No safe level’ “Substance use severely harms individual health, increasing the risk of chronic diseases, mental health conditions, and tragically resulting in millions of preventable deaths every year. It places a heavy burden on families and communities, increasing exposure to accidents, injuries, and violence,” wrote WHO Director-General Dr Tedros Adhanom Ghebreyesus in the report’s foreword. Dr Vladimir Pozniak, WHO’s head of alcohol, drugs and addictive behaviours “The level of alcohol consumption per capita among drinkers amounts to an average of 27 grammes of pure alcohol per day, which is roughly equivalent to two glasses of wine, two bottles of beer or two servings of spirits,” Dr Vladimir Pozniak, WHO’s head of alcohol, drugs and addictive behaviours, told a media briefing this week. Of all deaths attributable to alcohol in 2019, an estimated 1.6 million deaths were from non-communicable diseases (NCDs), including 474,000 deaths from cardiovascular diseases and 401,000 from cancer. Some 724 000 deaths were due to injuries, such as those from traffic crashes, self-harm and interpersonal violence. Another 284 000 deaths were linked to communicable diseases. For example, alcohol consumption has been shown to increase the risk of HIV/AIDS as people are more likely to have unprotected sex, and increase tuberculosis and lower respiratory infections by suppressing a wide range of immune responses. The highest proportion (13%) of alcohol-attributable deaths in 2019 were young people aged 20-39 years. Globally, almost a quarter (23.5%) of all 15 to 19 year olds were current drinkers, with the highest rates in the European region (45.9%) followed by the Americas (43.9%). Pozniak stressed that “there is no risk free levels of alcohol consumption”. “The WHO has not produced guidelines [on safe alcohol consumption] because the diversity of countries, the diversity of populations, their exposure to alcohol, are so different, that to come up with universal levels of risks would be an unmanageable task,” said Pozniak. “It’s advisable to consult with a health professionals on the risks associated with level or pattern of consumption, taking into consideration the individual characteristics of a person [such as] pre-existing disorders or current health conditions because the risks varies substantially, depending on all these factors.” Lack of treatment options The total alcohol per capita consumption decreased slightly from 5.7 litres in 2010 to 5.5 litres in 2019. But the world is far from reaching the Sustainable Development Goal (SDG) target 3.5 by 2030 of reducing alcohol and drug consumption and improving access to quality treatment for substance use disorders. Although effective treatment options for substance use disorders exists, treatment coverage is incredibly low. The proportion of people in contact with substance use treatment services ranged from less than 1% to a maximum of 35% in 2019. This was even lower for alcohol-related treatment, with up to 14% of people who needed it, accessing treatment. “Most of the 145 countries that reported data did not have a specific budget line or data on governmental expenditures for treatment of substance use disorders. Although mutual help and peer support groups are useful resources for people with substance use disorders, almost half of responding countries reported that they do not offer such support groups for substance use disorders,” according to the WHO. “Stigma, discrimination and misconceptions about the efficacy of treatment contribute to these critical gaps in treatment provision, as well as the continued low prioritisation of substance use disorders by health and development agencies.” A significant number of countries reported interference from the alcohol industry in their efforts to develop effective alcohol policies, according to the report. Industry interference was highest in countries that were effectively increasing the price of alcohol. “Industry interference was most frequently reported in the African Region (62.1%). However, across all income groups, between 42% and 50% of countries pointed to this interference as a barrier to move forward,” it notes. Actions for progress To accelerate progress towards achievement of SDG target 3.5 and reduce the health and social burden attributable to substance use, the WHO recommends action in eight areas. These include increased awareness through a coordinated global advocacy campaign, and the re-commitment to implement the Global Alcohol Action Plan 2022-2030 with a focus on the SAFER package. It also calls for increased capacity of health and social care systems to deal with substance abuse, more training of health professionals, better monitoring and research and more engagement with civil society organisations, professional associations and people with lived experience. Image Credits: Stanislav Ivanitskiy/ Unsplash. Health and Finance Leaders Call for Strengthened Primary Health Care to Tackle NCDs and Mental Health 25/06/2024 Sophia Samantaroy Breast cancer is among the many non-communicable diseases growing in lower-and-middle-income countries, where funding for prevention is often diverted to other health concerns. When Felicia Knaul met Tonya Rosa, a Mexican woman undergoing chemotherapy for breast cancer, “she was there with a big smile on her face…even though her cancer had recurred.” But Rosa told Knaul that her first round of treatment had impoverished her family, “they had to sell their business, their home, their assets to be able to pay for her care.” But now, she had a card that gives her access to Mexico’s public insurance to cover her treatments. Rosa’s story was one of many shared at a two-day international financing dialogue for NCDs and mental health hosted by the World Health Organization (WHO) and the World Bank in Washington, DC. The meeting convened as part of the preparation for the United Nations High-Level on these issues in 2025. For Knaul, a global health economist, cancer researcher and advocate, providing care for NCDs and mental health patients requires “a health system that could deal with the whole gamut of issues that go through, from primary prevention all the way through to end-of-life care.” Representatives from over 30 countries reiterated this call for strengthened, affordable health coverage as the means to address NCDs and bolster mental health. Adriana Alfonso, Director of Health Surveillance with Uruguay’s Ministry of Health, credits the country’s recent mental health successes to its decree in making psychiatric care obligatory in an affordable and universal manner at health centers. These interventions were only possible through concerted government cooperation and willpower. Primary care financing as a sustainable solution Health and finance leaders from over 30 countries met to discuss a path forward to sustainable NCDs and mental health financing. “In the past, when we prepared annual budgets, we didn’t really take into account the mental health issues. In the case of Uruguay, we have a yearly budget that is discussed at the parliament level, and we needed to make sure that we had a mental health budget that was sustainable,” Alfonso noted. Providing dedicated funds for mental health has translated into co-payment reductions and increases in beds in mental health facilities and halfway homes. Lester Tan, director of Health Policy, Development, and Planning at the Department of Health in the Philippines, echoed this sentiment in describing the economics of mental health in the Philippines. In 2021, mental health conditions cost the Philippine economy an estimated $1.37 billion dollars, equivalent to 0.4% of GDP. Yet, investing in more treatment of epilepsy and depression would have an incredibly high return on investment – 6.6 and 5.3 times respectively. “This evidence, together with the implementation of a mental health law passed in 2018 have contributed to the scaling up of mental health services in the country. There are now 362 mental health access sites nationwide, which have served 124,000 users in 2022,” said Tan. These mental health successes hinge on expanded financing of primary health care, the “how” of NCDs and mental health care, as a panelist noted. Tan notes that the Philippines benefitted from expanding the number of health professionals trained in mental health at the primary care level. “This capacity building prioritized depression, epilepsy, self harm and psychosis.” A multi-sectoral approach to overcome ‘fragmentation’ Increased primary health care investment has the potential to reduce the global burden of NCDs through prevention, treatment, and care. Other panelists noted the urgency for multisectoral approaches to financing NCDs and mental health care – working across government institutions and ministries. An NCD expert from the Tunisia Ministry of Health, noted that her ministry recruited the help of the Ministry of Youth, Sport, and Heritage to organize a national day of exercise. “During this National Day, everybody was invited to exercise, and we talked about the importance of physical activity. The Ministry of Health decided to do screenings for hypertension and diabetes on this day, and we, of course, had a very large media campaign and awareness raising campaign in the entirety of the country,” she said. Beyond the more straightforward partnerships between adjacent ministries, the health sector must work more closely with ministries of finance, noted Aleksandra Altievska, head of fund budgets at North Macedonia’s Ministry of Finance. “I recommend that every Ministry of Health always keep in mind that the Minister of Finance has other priorities.” Working with ministries of finance to fund NCDs and mental health interventions is critical because, as Joanna Ralston of the World Obesity Federation explained, NCDs are challenges that “can’t be targeted by one sector.” “We have a global health system that really was built around single vector diseases, just to oversimplify, and yet, now we’re coming in with something that has these commercial elements, [environmental] elements, all these factors, this great level of complexity that that has to be respected,” Ralston said. Obesity, as just one example, continues to impact nations across all age levels, because of the fragmentation of the response, said Ralston. “The increase of obesity is around 100% in the past couple of years, when the goal was a 0% increase.” Fragmented, under-resourced responses undermine progress on NCDs and mental health – something that advocates hope can be overcome by renewed multi-sectorial frameworks and partnerships. Leveraging patient experiences Several panelists shared their own experiences living with an NCD at the Washington, D.C conference. Knaul, who founded the Mexico-based breast cancer advocacy organization Cancer de mama: Tomatelo a Pecho, notes that the numbers alone won’t sway policymakers – bringing in patient narratives is paramount to the future of non-communicable disease prevention, treatment, and care. “Health systems repeatedly fail patients with cancer and other NCDs,” she said. Engaging people with lived experiences of NCDs or mental health challenges bolsters local and international support, argued Charity Muturi, an NCDs and mental health policy advocate in Kenya. “When a national task force on mental health was formed, we felt that, as patients, our voices needed to be on the table,” said Muturi, who discussed her own challenges navigating mental health care in Kenya. Ralston summed up the struggle with communicating the burden of NCDs and mental health. “Evidence and narrative are what are needed to be successful. We need to be rooted in evidence, but we need to have a way of communicating that story to decision makers, policy makers, and the wider public. And that has been a challenge with NCDs.” Image Credits: Roche, WHO. Scientists in West Africa Tackle Malaria and Schistosomiasis 25/06/2024 Zsofia Hesketh Dr Mamy Andrianirina Rakotondratsara (centre) distributing antimalarials in rural Madagascar. Malaria has long been at the heart of public health efforts in Africa. As a preventable but potentially fatal disease, it is caused by a parasite transmitted by mosquitoes. In 2022, the WHO African Region accounted for about 94% of cases globally. WHO says 78% of deaths in the region are among children under 5 years of age. That’s why Dr Mamy Andrianirina Rakotondratsara, a medical doctor and research technician for Madagascar’s National Institute of Public and Community Health (INSPC), wanted to dedicate his TDR-supported studies for a Masters in Public Health to malaria research. Originally from an endemic region in eastern Madagascar, Rakotondratsara has been personally affected by malaria as he lost his older brother to the disease. “I lost someone close and beloved to me from this disease,” he told Health Policy Watch in an interview. That reinforced his determination to address the disease in the course of his studies. Dr Mamy Andrianirina Rakotondratsara lost his brother to malaria and is passionate about addressing the disease. In 2021, during the course of his Masters studies at the Cheikh Anta Diop University of Dakar (UCAD), Rakotondratsara also completed TDR’s Massive Open Online Course (MOOC) on implementation research. As part of this course, he designed a study around the relationship between the frequency of malaria episodes and mosquito bed net coverage, working with other researchers and doctors that specialize in malaria. This research is still ongoing and specifically targets the rural population of Madagascar’s Anosibe An’Ala district. Although results are still pending, designing such a study has laid the foundations for Rakotondratsara to put the research findings into practice in his home region and disease context, complementing his prior work on malnutrition. Sub-regional training centre for Francophone Africa Students engaged in a field training in participatory epidemiology organised by the National Institute of Public and Community Health Madagascar. Rakotondratsara was able to undertake this research thanks to TDR’s global postgraduate training scheme – which focuses on building students’ skills to do interdisciplinary forms of research that look at barriers and opportunities for better uptake of available preventative and treatment methods. For physicians, researchers and other professionals interested in local public health, the fellowships supported by TDR – the global research programme on diseases of poverty co-sponsored by UNICEF, UNDP, WHO and the World Bank – provides essential skills for health programme management and implementation. It is particularly important for addressing infectious diseases affecting vulnerable and underserved populations and promoting engagement in research from the local to global levels. UCAD is one of the two universities in French-speaking West Africa to collaborate with TDR in the programme. It has been hosting students since 2021, to conduct research into how to control infectious diseases found across the region. In 2022, University of Sciences, Techniques and Technologies in Bamako, Mali, joined the programme with the support of Germany’s Deutsche Gesellschaft für Technische Zusammenarbeit. “The TDR training allowed us to have a new vision of the health system,” Rakotondratsara observes. It changed my way of asking questions when faced with poor health indicators. Regarding my Master’s thesis, it gave me an idea of issues to be explored in the mosquito net distribution process, starting with the quantification of needs to end point use.” He strives to integrate such lessons learnt into his current role with the INSPC. And he is also planning to pursue a PhD with a specialization in implementation research. “The INSPC is a public health training and research institution attached to the Ministry of Public Health,” he explains. “Given that it is a research institution, in collaboration with funding bodies, we are often called upon to carry out expert appraisals on their behalf. As a research technician, I accompany this research and bring my contributions to it,” he says. “Based on my experience, it’s my intention to ensure that implementation research finds an important place both in the research and the teaching context.” Towards better management of Schistosomiasis Although less well known, schistosomiasis, also known as bilharzia, is the second most prevalent disease after malaria both in Senegal and much of the rest of sub-Saharan Africa. Its most common form – urogenital schistosomiasis – can result in damage to the bladder, urethra, and kidneys. It is a parasitic disease that occurs in tropical and subtropical regions where there is limited access to clean water, particularly in the Senegal River Basin, a hyper-endemic region for several species of the parasite that causes the disease. The different variants of the disease are classified by WHO according to the NTD principles for which a greater global response is needed, making it an important research target in the TDR program. Oumy Kaltome Boh, a physician originally from Dakar, has been interested in the burden of NTDs in Senegal since her formative years, and hopes to see their eradication by 2030. Dr Oumy Kaltome Boh “Faced with the impact of these diseases on the health of the population,” she says, her main objective is to contribute to their management “through the implementation of innovative interventions.” This is what led Boh to undertake a Masters degree in management of health programmes at UCAD, as well as an International Inter-University Diploma in emerging infections. Benefiting from a TDR grant in December 2020, Boh was able to conduct a study examining the day-to-day lifestyle practices and environmental factors that make schistosomiasis transmission more likely in endemic areas of her home country. As part of this study, done in collaboration with Senegal’s national bilharziasis programme, she also aimed to verify the effectiveness of schistosomiasis treatment with praziquantel, the only available treatment option currently. A total of 287 children were followed over the course of three weeks, with ‘Day Zero’ representing the date of administration of a single praziquantel dose. Between days 14 and 21, both the effects of the drug on disease progression were assessed and a favourable efficacy profile was found, with a 98% reduction in parasite eggs by day 21. Today, Boh holds the position of deputy chief medical officer in the health district of Saint-Louis, Senegal, and is mainly involved in care and prevention activities for people living with HIV or tuberculosis. Recruited into this position by the Ministry of Health, she stresses that it was through the support of the TDR postgraduate training scheme that she acquired the skills she needed to manage the public health challenges in this district. In particular, learning about community-based approaches allowed her to better “understand the specific needs and problems” of the districts. New research and management approaches As a key aspect of disease control, students supported by TDR can learn to apply new health research and management approaches previously unknown in Senegal, Boh says. Among these is the One Health approach, which aims to assess how diseases emerge from a holistic and ecosystem-oriented perspective, taking into account the reciprocal role of humans, animals, plants, and microorganisms such as the aforementioned pests. By combining scientific, strategic, and rigorous implementation training, the TDR grants offered through UCAD enable their recipients to evaluate and propose improvements to health interventions against poverty-related infectious diseases. These opportunities are game-changers for both UCAD students and the future of implementation research in French-speaking Africa. With the help of TDR grants, Boh emphasises, students can gain exposure to critical health programmes and “pool their skills in order to end the neglect of poverty-related diseases and to achieve the Sustainable Development Goals.” This is the second article in a series on TDR’s research capacity strengthening programme – building skills of public health researchers, implementers, health practitioners and policy-makers in the fast-developing field of implementation research for improving uptake of effective health interventions. Gilead Urged to Prioritise Access as Injection Trial Proves 100% Successful in Preventing HIV 24/06/2024 Kerry Cullinan None of the over 2,000 young women and girls injected twice a year with a new drug, lenacapavir, contracted HIV in one of the most important advances in HIV prevention. Gilead Sciences announced these results last Friday, reporting that its Phase 3 PURPOSE 1 trial, conducted in South Africa and Uganda involving 2,134 women and girls aged 16-25, had been so successful that it was terminating early. Its announcement has been widely hailed as a huge breakthrough in the HIV sector where a vaccine has been elusive, and a range of groups urged Gilead to priorise early access to lenacapavir. The injectable was compared with Truvada and Descovy, two pills taken daily that have proven successful as pre-exposure HIV prophylaxis (PrEP). Sixteen of the 1,068 women in the Truvada group and 39 of the 2,136 women in the Descovy group contracted HIV during the trial. During a scheduled review of results, the trial’s independent data and safety monitoring board (DSMB) found the lenacapavir regimen was safe and highly effective. The trial, expected to run until September, was terminated early based on its success. Results of the trial have not been peer-reviewed yet. The age group targeted by the trial is the worst affected by HIV in southern Africa. In 2022, over three-quarters of infections in 15 to 24-year-olds in the region were girls and women, according to UNAIDS. “Every week, 4,000 adolescent girls and young women aged 15–24 years became infected with HIV globally in 2022, and 3,100 of these infections occurred in sub-Saharan Africa,” added UNAIDS. One of the ‘most important results’ “This is one of the most important results we’ve seen to date in an HIV prevention study,” said Mitchell Warren, executive director of AVAC, a non-profit HIV prevention advocacy organisation. “Adding additional HIV prevention options means more people may find an option that is right for them. Beyond expanded choice, a twice-yearly injection has the potential to transform the way we deliver HIV prevention to people who need and want it most – from an easier-to-follow regimen for individuals to a decreased burden on healthcare systems that are stretched to the limit.” Professor Linda-Gail Bekker, director of the Desmond Tutu HIV Centre in South Africa, said that the twice-a-year injectable could provide a “critical new choice” to prevent HIV. “While we know traditional HIV prevention options are highly effective when taken as prescribed, twice-yearly lenacapavir for PrEP could help address the stigma and discrimination some people may face when taking or storing oral PrEP pills, as well as potentially help increase PrEP adherence and persistence given its twice-yearly dosing schedule,” added Bekker. Gilead expects results by early 2025 from the programme’s other trial, PURPOSE 2, which is assessing twice-yearly lenacapavir for PrEP in men who have sex with men, transgender and non-binary people, currently underway in Argentina, Brazil, Mexico, Peru, South Africa, Thailand and the US. Access to lenacapavir, marketed as Sunlenca in the US, still needs to be worked out once it is approved by regulatory authorities. Cost of access? Lenacapavir (marketed as Sunlenca) was approved in the US in 2022 for “heavily treatment-experienced adults with multi-drug resistant HIV-1 infection and for treatment of people living with HIV who have been on other HIV treatment regimes which are currently failing”. However, Gilead charges $40,000 per patient per year in the US, reports aidsmap. When announcing the PURPOSE 2 results, Gilead acknowledged the “importance of helping to enable access in order for twice-yearly lenacapavir for PrEP, if approved by regulatory authorities, to achieve the broadest impact”. “In light of today’s milestone and the company’s ongoing commitment to communities affected by HIV, Gilead intends to brief community partners and provide a public statement regarding its planned access approach for high-incidence, resource-limited countries, which are primarily low- and lower-middle-income countries,” said the company. Gilead’s statement was welcomed by African HIV medicines access group AfroCAB in an open letter to its CEO, Daniel O’Day. “Replacing 365 pills of oral PrEP with just two injections is a life-changing transition and urgently needed option, as millions of our brothers and sisters, friends, and neighbours face challenges of stigma, pill burden, and adherence, leaving them unprotected against HIV acquisition,” said AfroCAB. “To forge a new pathway forward for [lenacapavir], we call on stakeholders to act now. After thousands of our community members have taken part in clinical trials for LEN and other injectable PrEP products, it is time that pharmaceutical companies, governments, and donors play their part in driving access among the communities that supported the science.” “We expect to see a timeline that takes into account a full analysis of PURPOSE 1 data and the coming data from PURPOSE 2 from Gilead as soon as possible, and we urge regulatory agencies to prepare to fast track regulatory review,” Warren added. “We also call on [the World Health Organization] to be prepared to quickly include lenacapavir, if approved by regulatory agencies, in HIV prevention guidelines. There is no time to waste if we are to translate these exciting clinical trial results into actual public health impact and expand the toolbox of HIV prevention choices.” Meanwhile, Unitaid urged Gilead to make access to lenacapavir a priority, calling for “the terms of their access strategies – including any voluntary licensing agreements – [to be] transparent, global health-oriented, and equitable”. “Lack of prompt and broad action would jeopardise translating the clinical trial results into real-life impact,” said Unitaid, which offered to work with Gilead to enable access, including “quality-assured, low-cost generics”. “Unitaid is dedicated to leveraging its recent investment through the Wits Reproductive Health and HIV Institute to facilitate market shaping interventions on long-acting PrEP options (in partnership with the Clinton Health Access Initiative), as well as its continued support to enabling elements such as the key work of WHO and the WHO Prequalification program, the Medicines Patent Pool and other intellectual property grants, to ensure access to this life-saving product is as broad as possible,” the organisation said in a statement last week. Image Credits: Gilead, Diana Polekhina/ Unsplash. Gavi Includes Ebola, Meningitis, Rabies and Hepatitis B Vaccines in its Portfolio 24/06/2024 Zuzanna Stawiska A member of the ring vaccination team vaccinates a man in Bosolo village. Vaccines offered as part of Gavi’s portfolio now also include preventive Ebola vaccines for care workers. Gavi, the Vaccine Alliance, announced last week that it will offer high risk countries the option of obtaining preventative Ebola vaccines, particularly for health workers, as part of the rollout of new vaccine offerings, which also include meningitis, rabies and hepatitis B vaccines. Plans to add the vaccines to the basket of available products were initially drawn up before the COVID-19 pandemic, but put on hold due to lack of appropriate supply or regulations, with applications opening only now to eligible countries. “Gavi’s ability as an alliance to protect health and save lives hinges on its ability to ensure vaccines are accessible, as quickly as possible, to those who need them the most,” said Gavi CEO Dr Sania Nishtar. “The new programmes launching today demonstrate the impact of this work.” Ebola is a rare but dangerous viral disease, with a 50-60% mortality rate. Infections may be transmitted through close contact with infected animals – for instance, fruit bats – but also through human-to-human contact. Gavi first offered Ebola vaccine candidates to health workers and suspected Ebola contacts during the 2014-2016 West Africa outbreak as an outbreak response. Two vaccines subsequently received regulatory approval and in May 2024 WHO’s Strategic Advisory Group of Experts on Immunisation (SAGE) decided to recommend the vaccines for preventive use, as well, in high-risk groups, such as health care providers in areas of endemic transmission. Meningitis vaccine rollout aims for elimination Gavi will also roll out a newly-approved vaccine for five strains of meningitis: meningococcal serogroups A, C, W, Y, and X. Central and Western African countries most prone to meningitis infections in the so-called “meningitis belt” The vaccine is a likely game-changer in the fight against the disease, experts say, noting that in the so-called “meningitis belt” of sub-Saharan African countries, the bacterial form of the diseases, regarded as the most dangerous, could potentially be eliminated. The product, MenFive, received WHO pre-qualification in July 2023 and has already been implemented in standard childhood immunisation programmes in Nigeria and Niger. In 2019, there were about 236,000 meningitis deaths, with the greatest burden in children younger than five years, with 112,000 deaths. Hepatitis B and rabies post-exposure jabs Other new vaccines include hepatitis B vaccines for newborns, granting infants critical additional protection in their first months of life, when they are at high risk of infection: including from maternal transmission. According to Gavi, nine out of ten infants infected with hepatitis B will develop chronic forms of the disease, while a quarter develop severe liver disease, which currently kills 884,000 people a year. Human rabies post exposure prophylaxis (PEP) vaccines are the last of the new package. The initiative aims to build more stockpiles of the rabies vaccine, which are often scarce and inaccessible, especially in remote areas, for post-exposure use. Rabies, which has an almost 100% mortality rate, remains a serious health problem in some 150 countries, where it is transmitted by infected dogs. But vaccines alone are not enough to stop the disease, experts underlined. “To stop human rabies deaths completely, we urgently need better data and surveillance, dog populations must be vaccinated, and people must be educated about what to do if bitten, and how to avoid being bitten in the first place,” said Professor Lucille Blumberg, Chair of United Against Rabies, pointing out to several blind spots of the human immunisation programme. Image Credits: WHO/L. Mackenzie , CDC. What Role Does Capacity Development Play in Transforming Health Research? 22/06/2024 Maayan Hoffman The latest episode of the Global Health Matters podcast, hosted by Dr Garry Aslanyan, delves into the extraordinary careers of two global health leaders and the crucial role that capacity development has played in their journeys. This episode, produced to celebrate the 50th anniversary of TDR, the Special Programme for Research and Training in Tropical Diseases, features insights from Dr Wilfried Mutombo, Head of Clinical Operations at the Drugs for Neglected Diseases Initiative (DNDi) in the Democratic Republic of the Congo, and Dr Yasmine Belkaid, President of the Institut Pasteur in France. Both leaders share their experiences and the impact of TDR’s support on their professional growth. Dr John Reeder, the Director of TDR, reflects on the importance of capacity development in fostering the potential of researchers in low- and middle-income countries. Reeder highlights his transition from hands-on research to global leadership, emphasising the value of putting research into action and nurturing talent at the grassroots level. He underscores that effective capacity development goes beyond providing resources; it involves empowering individuals to fulfil their potential and significantly contribute to their fields. To mark the 50th anniversary of @TDRnews, this episode of #GlobalHealthMatters features TDR Director John Reeder. Together, @GarryAslanyan and John discuss the challenges and future frontiers of capacity development. Listen to the episode here👉 https://t.co/K26H7vQV69#TDR50 pic.twitter.com/srEZeWErH9 — TDR (@TDRnews) June 18, 2024 “When you’re looking at science and laboratory science particularly, people get fixated on the expensive equipment and the fancy technology that surrounds this,” Reeder says. “But the most important investment in a laboratory is the scientist who is in that laboratory because, all other things aside, the ability to see the problem, think of innovative solutions to test them critically and to have the open mind to be able to see the discovery coming through that, you invest in that, and you’ve got great science.” From left: Dr John Reeder, the Director of TDR; Dr Yasmine Belkaid, President of the Institut Pasteur in France; and Dr Wilfried Mutombo, Head of Clinical Operations at the Drugs for Neglected Diseases Initiative (DNDi) in the Democratic Republic of the Congo Clinical Trials in Remote Areas: Three Challenges Mutombo’s story is a testament to the transformative power of research capacity development. Starting as a medical doctor in a small village in the DRC, Mutombo faced the challenge of treating sleeping sickness with toxic drugs. His clinical research fellowship from TDR enabled him to lead the first clinical trial in the DRC for fexinidazole, a safer oral drug for sleeping sickness. He discusses the immense challenges of conducting high-quality clinical trials in remote areas with inadequate infrastructure and highlights the importance of sustained support and training for local health workers. “The first challenge is to reach those areas because to perform a clinical trial, you need to go there in those areas, in those remote areas, and as you may know, we have bad roads, and sometimes this is not very safe,” Mutombo says. “The second challenge is, when you are in those areas, you can imagine in what state those health facilities are… So we had to improve these health facilities.” Another challenge, he says, is the health workers. “Health workers are there, but they are not aware of what a clinical trial is,” according to Mutombo. “To have a high-quality clinical trial, they needed to train them and have a very, very close supervision of their activities. So we organised all this.” Finally, “We need our governments … to give more support and more money to maintain those facilities. This is very important for the government because the first and very important step has been done, but now we need to maintain them at that level.” Building Research Capacity: Support is Crucial In many ways, Belkaid’s journey from Algeria to leading the Institut Pasteur in France exemplifies the global impact of TDR’s fellowships. She speaks about the crucial support she received, which allowed her to pursue her PhD and establish a notable research career. Belkaid emphasises creating environments that nurture talent and passion, enabling researchers to address pressing global health issues. Her vision as President of Institut Pasteur includes fostering international collaboration and continuing to build research capacities that can address future health challenges. Belkaid says if there is anything she can do over the next few years, it will hopefully be helping in any way she can to grow and nurture the leaders of tomorrow internationally. The episode underscores the ongoing need for international organisations like TDR and WHO to prioritise capacity building in low- and middle-income countries. Reeder points out the shift towards in-country training and the importance of sustainable research systems driven by local needs and priorities. He says this approach helps ensure research capacity development and is not just about immediate results but about long-term, sustainable growth that empowers countries to tackle their health challenges effectively. Read related Inside View by Dr John Reeder. Listen to the Global Health Matters podcast on Health Policy Watch. Visit the podcast website. Image Credits: TDR. Posts navigation Older postsNewer posts This site uses cookies to help give you the best experience on our website. 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Critics Blast ‘Inward, Technocratic’ MSF Leadership for Closing Access Campaign 26/06/2024 Kerry Cullinan The MSF’s leadership wants its medicine advocacy to focus on products its field offices need for humanitarian efforts. The leadership of Médecins sans Frontières (MSF) is under significant global pressure to reverse its decision to close its Access Campaign, with indications that the issue may be raised at the organisation’s general assembly that begins in Geneva on Thursday (27th). The decision has been described as a triumph for technocrats within MSF, who want the organisation to be more narrowly focused on humanitarian efforts and less on the wider political issues hampering patients’ access to medicines. Over 100 civil society organisations and 250 individuals have signed a letter addressed to MSF’s leadership and board, urging them to reverse the decision to close the iconic unit, which they say will “cause catastrophic and irreparable damage to access to health technologies for communities served by MSF projects and beyond”. Signatories include past MSF leaders Dr Unni Karunakara (former international president), Kris Torgeson (former international secretary general), Gorik Ooms (former general director) and Dr Tido von Schoen-Angerer (former executive director of the Access Campaign). Dr Mariângela Simão, former World Health Organization (WHO) Assistant Director-General for Access to Medicines and former New Zealand Prime Minister Helen Clark also joined civil society organisations and health experts in their appeal to MSF. “The planned dismantling of the Access Campaign’s core structure, capacities, expertise, and networks will reverberate across the access to medicines movement and beyond,” they write. “It will be yet another setback to the already-shrinking patient activist and civil society space critical to holding pharmaceutical companies and governments accountable so that medicines are never a luxury.” ‘Longstanding power struggle’ Von Schoen-Angerer, who headed the Access Campaign from 2006 to 2012, told Health Policy Watch that the closure was the outcome of “a longstanding power struggle” between MSF’s international office and its five powerful operational centres – Paris, Amsterdam, Brussels, Geneva and Barcelona – and the strong global and somewhat independent Access Campaign. “It’s also a clear move from some people in MSF who want to depoliticise [the organisation], with a stronger focus on a technocratic approach; on products alone, shying away from some of the underlying political issues that determine access,” he added. “They are no longer willing to take up the political battle to really fight these access battles for better prices, more research and development, greater equity. “We’re looking at a more inward, more technocratic MSF that wants to get health products for their patients alone, and is no longer wanting to fight the bigger political battles that need to be fought.” However, an MSF spokesperson told Health Policy Watch that the letter’s concerns were based on “the misleading notion that MSF is halting or reducing its work on access to products for healthcare. “This is 100% wrong. MSF is redoubling its efforts to deliver tangible improvements in access to products for healthcare driven by our new collective vision to expand our efforts to improve access to products for healthcare.” Access Campaign victories MSF’s ‘Europe! Hands Off Our Medicine’ campaign demands removal of harmful provisions from the EU-India trade agreement, which threatens the supply of affordable medicines made in India. The Access Campaign has advocated for lower prices and better access to a range of medicines for over 25 years and won some major victories – particularly for HIV and TB patients. It was launched in 1999, first campaigning for Thai drug companies to be able to produce affordable generic versions of Pfizer’s costly fluconazole, used to treat infections in people with HIV. Its latest triumph was earlier this year when it helped to secure affordable access to bedaquiline for people with multi-drug-resistant TB. In 2003, it helped to launch the Drugs for Neglected Diseases initiative (DNDi), an independent, non-profit drug development organisation focused on developing new treatments for some of the world’s most neglected diseases. The Access Campaign is unique as it has both a global view of issues blocking access to medicines – such as Free Trade Agreements that prevent generic competition – and local knowledge of communities’ needs from MSF’s field offices. But the unit is the victim of a costly two-year restructuring exercise aimed at redirecting resources from global issues to MSF’s work on the ground, according to sources. These sources told Health Policy Watch that around 50 staff are to be cut to 19 and housed in a new unit called “Access to Products for Healthcare”. Current staff will have to compete with one another for the posts. The new unit will advocate for access to specific products needed by MSF’s humanitarian efforts. At present, there is no strategic plan for the new unit, and staff are to be dispersed between five regional offices – Kuala Lumpur in Malaysia; Nairobi, Kenya; Dakar, Senegal; Rio de Janeiro, Brazil; and Brussels, Belgium. Von Schoen-Angerer described as “arrogant” the restructuring process which cost “hundreds of thousands (of Euros)” yet involved “MSF talking entirely to itself, completely ignoring the hundreds of allies in terms of organisations in the Global South, but also the North – the academics, the governments that the Access Campaign has worked with.” “That’s why they have come out with this letter because they’ve never been consulted,” he added. In 2015, MSF’s “A Fair Shot” campaign called on Pfizer and GSK to reduce the price of the pneumonia vaccine – the most expensive standard childhood vaccine – to $5 per child. In 2016, a price of $9 per child is offered to humanitarian organisations like MSF, but only for use in emergencies. MSF International stands its ground An MSF spokesperson told Health Policy Watch on Wednesday that they were not aware of the issue being on the agenda of the general assembly, MSF’s highest decision-making body, or when it would be discussed by the MSF board. Asked what the motivation was for closing the Access Campaign, the spokesperson said that “the new structure will be closer to our medical humanitarian operations, to better support the needs of the communities we assist. Five regional offices will work together with our operational teams and patients as well as with our partners and networks.” They added that populations’ access to healthcare were being affected by new developments including “technological breakthroughs, new political players, and new legal and commercial realities and regulations”. “For our patients and also our networks, we have a duty to ensure that we remain optimally organised to leverage our unique positions for improving access to products for healthcare for those deprived of them.” MSF’s International Office said in statement this week that the organsation’s “focus is on directly addressing the problems our patients and our operational teams face. “We will also continue to work globally to address systemic barriers causing or amplifying these problems. This includes advocating for changes to policies and practices that determine who can or cannot access lifesaving health care products in many of the more than 70 countries around the world where we work.” MSF’s Alexandre Michel boarding a UN Air Service helicopter bound for Les Cayes in southern Haiti following an earthquake. Loss of global advocacy? Many access activists fears that MSF will no longer advocate around HIV, neglected tropical diseases, intellectual property, research and development, trade agreements, transparency, and other cross-cutting access issues However, when asked directly whether MSF would cease its global work on issues such as the pandemic agreement negotiations and global trade agreements, the spokesperson simply responded: “In 2025, MSF’s new structure dedicated to our work with improving access to products for healthcare will continue the work of the Access Campaign that aligns with our new collective access to products for healthcare priorities, including dossiers on vaccines, diabetes, [anti-microbial resistance], TB, and diagnostic tools. Next year will also be dedicated to dedicated to finalising the new structure’s longer-term strategic plan.” The spokesperson added that “around 35 staff are contracted to the Access Campaign” as well as “a number of others with temporary contracts”. “At least 19 of them have the immediate opportunity to work for the new structure. Others may also be absorbed (due to their expertise) by other MSF sections, operational directorates or projects.” But Von Schoen-Angerer expressed concern that there is no strategy in place for the new unit “beyond vague priorities” and it will take at least a year to develop a strategic plan. Loss of unique skills “They are firing all the fantastic staff or humiliating them by making them reapply if they want to be part of the new structure. Allies will be lost, battles will be lost and it will take years before this will become effective.” he added. Fatima Hassan, director of the South African Health Justice Initiative (HJI), described the skills of Access Campaign staff as “unique, unprecedented, and multi-disciplinary.” “There are no other groups right now in the world that can replicate its work or fill its large shoes,” said Hassan, urging MSF not to “dilute” it. Ellen ‘t Hoen, director of Medicines Law & Policy and former policy and research director of the Access Campaign, has also expressed her alarm at the move, describing the campaign as “a pillar of global access to medicines work”. “Access issues have never been more front and centre in global health, as the recent lack of progress in the negotiations of the WHO pandemic accord – and the desperate scramble to access COVID-19 countermeasures that preceded the launching of the accord process – have underlined,” noted ‘t Hoen’s Medicines Law & Policy this week. “If MSF proceeds with this decision, it will leave a significant void in the access movement. Particularly, groups in low and middle-income countries will bear the brunt of this loss. There are no apparent players who can take over the role of the MSF Campaign because most lack the multidisciplinary expertise and resources MSF has.” This week, Unitaid’s executive director, Philippe Duneton, also added his voice to appeals for MSF to continue its access work in an open letter to MSF’s president, Dr Christos Christou. “MSF’s voice and work in access remains more needed than ever, addressing the grassroots causes of inequities whether in HIV or global health emergencies, neglected diseases, and neglected populations that the market keeps failing,” noted Duneton, whose organisation works to ensure low- and middle-income countries have access to treatment and tools to combat major health challenges. Image Credits: MSF, MSF Access Campaign. Framework to Help Curb Visceral Leishmaniasis in East Africa 26/06/2024 Zuzanna Stawiska Delegates during the launch of a WHO visceral leishmaniasis elimination framework WHO framework to eliminate visceral leishmaniasis (VL), a deadly disease most prominent in East Africa, was launched Thursday. It can play an important role in eliminating VL as a public health problem by 2030: a goal key countries of the East African region committed to in last year’s Nairobi Declaration. “The VL elimination framework will offer important direction to countries in the region and provide momentum to reach the finish line of elimination,” said Dr Dereje Duguma, the Health Minister of Ethiopia, a co-host of the launch. “The Government of Ethiopia remains committed to working with partners to develop programs at all levels, from national to community, to expand access to healthcare and achieve the targets of elimination by 2030.” Visceral leishmaniasis, or kala-azar, is a deadly parasitic disease causing fever, weight loss, spleen and liver enlargement, transmitted by the bite of infected female sandflies. Lethal if left untreated, the disease is endemic in 80 countries worldwide, with 73% of the estimated 50,000 to 90,000 cases annually occurring in the Eastern African region in 2022, according to the WHO. Children under 15 account for half of the infections. Malnutrition, but also poor sanitary and housing conditions increase the risk of leishmaniasis infection. Sandflies, which transmit the disease, often live next to crowded buildings or spaces with open sewages or bad waste management. VL outbreaks are also frequent when many people without immunity to the parasite migrate to areas where it is endemic or with environmental changes, such as deforestation, building of dams, but also climate change. Successful elimination thanks to framework A good implementation of a regional Strategic Framework for VL led to a total elimination of the disease in Bangladesh in 2023 – becoming the first country worldwide to achieve the status – and a significant reduction of cases in the region. Eastern Africa wants to follow a similar path. A 2014 plan to eliminating VL in Bangladesh, India and Nepal brought a massive decline in case numbers Between 2004 and 2008, Bangladesh, India and Nepal accounted for 70% of global visceral leishmaniasis cases. The regional framework adopted in 2005, paired with sustained stakeholder support and a political will for an accelerated program implementation contributed to a successful case reduction. The combined number of cases for the three countries decreased almost forty times, from 39,809 in 2005 to only 1,074 in 2022, according to WHO data. Nairobi Declaration commitments Representatives of eight East African countries pledged to follow the path to VL elimination, signing the Nairobi Declaration in 2023. The ministries of health of Chad, Eritrea, Ethiopia, Kenya, Somalia, South Sudan, Sudan, and Uganda, along with key stakeholders in the region set the goal of significantly curbing VL cases by 2030. Djibouti has also signed the declaration and co-hosted the WHO elimination framework launch last Thursday. The framework, developed in partnership with the Drugs for Neglected Diseases initiative (DNDi) and Ministries of Health across the region, outlines five main strategies for VL elimination: early diagnosis and treatment, vector management, surveillance, social mobilisation, and operational research. It also features a step-by-step guide through elimination phases as well as sets regional and country targets, such as a 90% reduction in VL burden in Eastern Africa by 2030, decreasing the number of cases to 1,500 annually. “By providing countries with tailored tools and strategies, we are laying a strong foundation for sustained progress in the fight against this neglected tropical disease,” said Dr Saurabh Jain, WHO’s Focal Point for VL. Image Credits: WHO. Urgent Global Action is Needed to Address Alcohol and Drug Consumption 25/06/2024 Kerry Cullinan The WHO stresses that there is no safe level of alcohol consumption. Romania, Georgia and Czechia have the highest alcohol consumption rates in the world while, in the best-case scenario, only 14% of those who abuse alcohol have access to treatment. These are some of the insights from the World Health Organization’s (WHO) global status report on alcohol and substance use disorders, based on 2019 data from 154 countries. In 2019, 2.6 million deaths were caused by alcohol ⚠️ 2 million were among men ⚠️ 13% of deaths were among younger people aged 20-39 yearshttps://t.co/zk0WbU47Rc pic.twitter.com/FX7kGODhIi — World Health Organization (WHO) (@WHO) June 25, 2024 Around 400 million people lived with alcohol and drug use disorders, with 209 million of these being people with alcohol dependence. Those living in the vast WHO European region, which includes Russia, consumed the most alcohol – 9.2 litres of pure alcohol per person annually. The Region of the Americas, which includes North and South America and the Caribbean, followed with 7.5 litres. In Romania, the average daily pure alcohol consumption per capita was a staggering 36.9 grammes, the highest in the world. Georgia (31.1g), Czechia (28.8) and Latvia (28.4) – all in the European region – were not far behind. Despite Australia’s hard-drinking image, its drinkers averaged 21.9 g per capita per day, the third highest in the West Pacific region after Laos (25) and the Cook Islands (22.9). In the region of the Americas, Canada (21.5) and the USA (20.8) topped the list. In Africa, South Africa (19) had the highest alcohol consumption, while Thailand (17) was the highest in the South East Asia region. Alcohol consumption was low in the Muslim-dominated Eastern Mediterranean region, topped by the United Arab Emirates (5). Severe harms; ‘No safe level’ “Substance use severely harms individual health, increasing the risk of chronic diseases, mental health conditions, and tragically resulting in millions of preventable deaths every year. It places a heavy burden on families and communities, increasing exposure to accidents, injuries, and violence,” wrote WHO Director-General Dr Tedros Adhanom Ghebreyesus in the report’s foreword. Dr Vladimir Pozniak, WHO’s head of alcohol, drugs and addictive behaviours “The level of alcohol consumption per capita among drinkers amounts to an average of 27 grammes of pure alcohol per day, which is roughly equivalent to two glasses of wine, two bottles of beer or two servings of spirits,” Dr Vladimir Pozniak, WHO’s head of alcohol, drugs and addictive behaviours, told a media briefing this week. Of all deaths attributable to alcohol in 2019, an estimated 1.6 million deaths were from non-communicable diseases (NCDs), including 474,000 deaths from cardiovascular diseases and 401,000 from cancer. Some 724 000 deaths were due to injuries, such as those from traffic crashes, self-harm and interpersonal violence. Another 284 000 deaths were linked to communicable diseases. For example, alcohol consumption has been shown to increase the risk of HIV/AIDS as people are more likely to have unprotected sex, and increase tuberculosis and lower respiratory infections by suppressing a wide range of immune responses. The highest proportion (13%) of alcohol-attributable deaths in 2019 were young people aged 20-39 years. Globally, almost a quarter (23.5%) of all 15 to 19 year olds were current drinkers, with the highest rates in the European region (45.9%) followed by the Americas (43.9%). Pozniak stressed that “there is no risk free levels of alcohol consumption”. “The WHO has not produced guidelines [on safe alcohol consumption] because the diversity of countries, the diversity of populations, their exposure to alcohol, are so different, that to come up with universal levels of risks would be an unmanageable task,” said Pozniak. “It’s advisable to consult with a health professionals on the risks associated with level or pattern of consumption, taking into consideration the individual characteristics of a person [such as] pre-existing disorders or current health conditions because the risks varies substantially, depending on all these factors.” Lack of treatment options The total alcohol per capita consumption decreased slightly from 5.7 litres in 2010 to 5.5 litres in 2019. But the world is far from reaching the Sustainable Development Goal (SDG) target 3.5 by 2030 of reducing alcohol and drug consumption and improving access to quality treatment for substance use disorders. Although effective treatment options for substance use disorders exists, treatment coverage is incredibly low. The proportion of people in contact with substance use treatment services ranged from less than 1% to a maximum of 35% in 2019. This was even lower for alcohol-related treatment, with up to 14% of people who needed it, accessing treatment. “Most of the 145 countries that reported data did not have a specific budget line or data on governmental expenditures for treatment of substance use disorders. Although mutual help and peer support groups are useful resources for people with substance use disorders, almost half of responding countries reported that they do not offer such support groups for substance use disorders,” according to the WHO. “Stigma, discrimination and misconceptions about the efficacy of treatment contribute to these critical gaps in treatment provision, as well as the continued low prioritisation of substance use disorders by health and development agencies.” A significant number of countries reported interference from the alcohol industry in their efforts to develop effective alcohol policies, according to the report. Industry interference was highest in countries that were effectively increasing the price of alcohol. “Industry interference was most frequently reported in the African Region (62.1%). However, across all income groups, between 42% and 50% of countries pointed to this interference as a barrier to move forward,” it notes. Actions for progress To accelerate progress towards achievement of SDG target 3.5 and reduce the health and social burden attributable to substance use, the WHO recommends action in eight areas. These include increased awareness through a coordinated global advocacy campaign, and the re-commitment to implement the Global Alcohol Action Plan 2022-2030 with a focus on the SAFER package. It also calls for increased capacity of health and social care systems to deal with substance abuse, more training of health professionals, better monitoring and research and more engagement with civil society organisations, professional associations and people with lived experience. Image Credits: Stanislav Ivanitskiy/ Unsplash. Health and Finance Leaders Call for Strengthened Primary Health Care to Tackle NCDs and Mental Health 25/06/2024 Sophia Samantaroy Breast cancer is among the many non-communicable diseases growing in lower-and-middle-income countries, where funding for prevention is often diverted to other health concerns. When Felicia Knaul met Tonya Rosa, a Mexican woman undergoing chemotherapy for breast cancer, “she was there with a big smile on her face…even though her cancer had recurred.” But Rosa told Knaul that her first round of treatment had impoverished her family, “they had to sell their business, their home, their assets to be able to pay for her care.” But now, she had a card that gives her access to Mexico’s public insurance to cover her treatments. Rosa’s story was one of many shared at a two-day international financing dialogue for NCDs and mental health hosted by the World Health Organization (WHO) and the World Bank in Washington, DC. The meeting convened as part of the preparation for the United Nations High-Level on these issues in 2025. For Knaul, a global health economist, cancer researcher and advocate, providing care for NCDs and mental health patients requires “a health system that could deal with the whole gamut of issues that go through, from primary prevention all the way through to end-of-life care.” Representatives from over 30 countries reiterated this call for strengthened, affordable health coverage as the means to address NCDs and bolster mental health. Adriana Alfonso, Director of Health Surveillance with Uruguay’s Ministry of Health, credits the country’s recent mental health successes to its decree in making psychiatric care obligatory in an affordable and universal manner at health centers. These interventions were only possible through concerted government cooperation and willpower. Primary care financing as a sustainable solution Health and finance leaders from over 30 countries met to discuss a path forward to sustainable NCDs and mental health financing. “In the past, when we prepared annual budgets, we didn’t really take into account the mental health issues. In the case of Uruguay, we have a yearly budget that is discussed at the parliament level, and we needed to make sure that we had a mental health budget that was sustainable,” Alfonso noted. Providing dedicated funds for mental health has translated into co-payment reductions and increases in beds in mental health facilities and halfway homes. Lester Tan, director of Health Policy, Development, and Planning at the Department of Health in the Philippines, echoed this sentiment in describing the economics of mental health in the Philippines. In 2021, mental health conditions cost the Philippine economy an estimated $1.37 billion dollars, equivalent to 0.4% of GDP. Yet, investing in more treatment of epilepsy and depression would have an incredibly high return on investment – 6.6 and 5.3 times respectively. “This evidence, together with the implementation of a mental health law passed in 2018 have contributed to the scaling up of mental health services in the country. There are now 362 mental health access sites nationwide, which have served 124,000 users in 2022,” said Tan. These mental health successes hinge on expanded financing of primary health care, the “how” of NCDs and mental health care, as a panelist noted. Tan notes that the Philippines benefitted from expanding the number of health professionals trained in mental health at the primary care level. “This capacity building prioritized depression, epilepsy, self harm and psychosis.” A multi-sectoral approach to overcome ‘fragmentation’ Increased primary health care investment has the potential to reduce the global burden of NCDs through prevention, treatment, and care. Other panelists noted the urgency for multisectoral approaches to financing NCDs and mental health care – working across government institutions and ministries. An NCD expert from the Tunisia Ministry of Health, noted that her ministry recruited the help of the Ministry of Youth, Sport, and Heritage to organize a national day of exercise. “During this National Day, everybody was invited to exercise, and we talked about the importance of physical activity. The Ministry of Health decided to do screenings for hypertension and diabetes on this day, and we, of course, had a very large media campaign and awareness raising campaign in the entirety of the country,” she said. Beyond the more straightforward partnerships between adjacent ministries, the health sector must work more closely with ministries of finance, noted Aleksandra Altievska, head of fund budgets at North Macedonia’s Ministry of Finance. “I recommend that every Ministry of Health always keep in mind that the Minister of Finance has other priorities.” Working with ministries of finance to fund NCDs and mental health interventions is critical because, as Joanna Ralston of the World Obesity Federation explained, NCDs are challenges that “can’t be targeted by one sector.” “We have a global health system that really was built around single vector diseases, just to oversimplify, and yet, now we’re coming in with something that has these commercial elements, [environmental] elements, all these factors, this great level of complexity that that has to be respected,” Ralston said. Obesity, as just one example, continues to impact nations across all age levels, because of the fragmentation of the response, said Ralston. “The increase of obesity is around 100% in the past couple of years, when the goal was a 0% increase.” Fragmented, under-resourced responses undermine progress on NCDs and mental health – something that advocates hope can be overcome by renewed multi-sectorial frameworks and partnerships. Leveraging patient experiences Several panelists shared their own experiences living with an NCD at the Washington, D.C conference. Knaul, who founded the Mexico-based breast cancer advocacy organization Cancer de mama: Tomatelo a Pecho, notes that the numbers alone won’t sway policymakers – bringing in patient narratives is paramount to the future of non-communicable disease prevention, treatment, and care. “Health systems repeatedly fail patients with cancer and other NCDs,” she said. Engaging people with lived experiences of NCDs or mental health challenges bolsters local and international support, argued Charity Muturi, an NCDs and mental health policy advocate in Kenya. “When a national task force on mental health was formed, we felt that, as patients, our voices needed to be on the table,” said Muturi, who discussed her own challenges navigating mental health care in Kenya. Ralston summed up the struggle with communicating the burden of NCDs and mental health. “Evidence and narrative are what are needed to be successful. We need to be rooted in evidence, but we need to have a way of communicating that story to decision makers, policy makers, and the wider public. And that has been a challenge with NCDs.” Image Credits: Roche, WHO. Scientists in West Africa Tackle Malaria and Schistosomiasis 25/06/2024 Zsofia Hesketh Dr Mamy Andrianirina Rakotondratsara (centre) distributing antimalarials in rural Madagascar. Malaria has long been at the heart of public health efforts in Africa. As a preventable but potentially fatal disease, it is caused by a parasite transmitted by mosquitoes. In 2022, the WHO African Region accounted for about 94% of cases globally. WHO says 78% of deaths in the region are among children under 5 years of age. That’s why Dr Mamy Andrianirina Rakotondratsara, a medical doctor and research technician for Madagascar’s National Institute of Public and Community Health (INSPC), wanted to dedicate his TDR-supported studies for a Masters in Public Health to malaria research. Originally from an endemic region in eastern Madagascar, Rakotondratsara has been personally affected by malaria as he lost his older brother to the disease. “I lost someone close and beloved to me from this disease,” he told Health Policy Watch in an interview. That reinforced his determination to address the disease in the course of his studies. Dr Mamy Andrianirina Rakotondratsara lost his brother to malaria and is passionate about addressing the disease. In 2021, during the course of his Masters studies at the Cheikh Anta Diop University of Dakar (UCAD), Rakotondratsara also completed TDR’s Massive Open Online Course (MOOC) on implementation research. As part of this course, he designed a study around the relationship between the frequency of malaria episodes and mosquito bed net coverage, working with other researchers and doctors that specialize in malaria. This research is still ongoing and specifically targets the rural population of Madagascar’s Anosibe An’Ala district. Although results are still pending, designing such a study has laid the foundations for Rakotondratsara to put the research findings into practice in his home region and disease context, complementing his prior work on malnutrition. Sub-regional training centre for Francophone Africa Students engaged in a field training in participatory epidemiology organised by the National Institute of Public and Community Health Madagascar. Rakotondratsara was able to undertake this research thanks to TDR’s global postgraduate training scheme – which focuses on building students’ skills to do interdisciplinary forms of research that look at barriers and opportunities for better uptake of available preventative and treatment methods. For physicians, researchers and other professionals interested in local public health, the fellowships supported by TDR – the global research programme on diseases of poverty co-sponsored by UNICEF, UNDP, WHO and the World Bank – provides essential skills for health programme management and implementation. It is particularly important for addressing infectious diseases affecting vulnerable and underserved populations and promoting engagement in research from the local to global levels. UCAD is one of the two universities in French-speaking West Africa to collaborate with TDR in the programme. It has been hosting students since 2021, to conduct research into how to control infectious diseases found across the region. In 2022, University of Sciences, Techniques and Technologies in Bamako, Mali, joined the programme with the support of Germany’s Deutsche Gesellschaft für Technische Zusammenarbeit. “The TDR training allowed us to have a new vision of the health system,” Rakotondratsara observes. It changed my way of asking questions when faced with poor health indicators. Regarding my Master’s thesis, it gave me an idea of issues to be explored in the mosquito net distribution process, starting with the quantification of needs to end point use.” He strives to integrate such lessons learnt into his current role with the INSPC. And he is also planning to pursue a PhD with a specialization in implementation research. “The INSPC is a public health training and research institution attached to the Ministry of Public Health,” he explains. “Given that it is a research institution, in collaboration with funding bodies, we are often called upon to carry out expert appraisals on their behalf. As a research technician, I accompany this research and bring my contributions to it,” he says. “Based on my experience, it’s my intention to ensure that implementation research finds an important place both in the research and the teaching context.” Towards better management of Schistosomiasis Although less well known, schistosomiasis, also known as bilharzia, is the second most prevalent disease after malaria both in Senegal and much of the rest of sub-Saharan Africa. Its most common form – urogenital schistosomiasis – can result in damage to the bladder, urethra, and kidneys. It is a parasitic disease that occurs in tropical and subtropical regions where there is limited access to clean water, particularly in the Senegal River Basin, a hyper-endemic region for several species of the parasite that causes the disease. The different variants of the disease are classified by WHO according to the NTD principles for which a greater global response is needed, making it an important research target in the TDR program. Oumy Kaltome Boh, a physician originally from Dakar, has been interested in the burden of NTDs in Senegal since her formative years, and hopes to see their eradication by 2030. Dr Oumy Kaltome Boh “Faced with the impact of these diseases on the health of the population,” she says, her main objective is to contribute to their management “through the implementation of innovative interventions.” This is what led Boh to undertake a Masters degree in management of health programmes at UCAD, as well as an International Inter-University Diploma in emerging infections. Benefiting from a TDR grant in December 2020, Boh was able to conduct a study examining the day-to-day lifestyle practices and environmental factors that make schistosomiasis transmission more likely in endemic areas of her home country. As part of this study, done in collaboration with Senegal’s national bilharziasis programme, she also aimed to verify the effectiveness of schistosomiasis treatment with praziquantel, the only available treatment option currently. A total of 287 children were followed over the course of three weeks, with ‘Day Zero’ representing the date of administration of a single praziquantel dose. Between days 14 and 21, both the effects of the drug on disease progression were assessed and a favourable efficacy profile was found, with a 98% reduction in parasite eggs by day 21. Today, Boh holds the position of deputy chief medical officer in the health district of Saint-Louis, Senegal, and is mainly involved in care and prevention activities for people living with HIV or tuberculosis. Recruited into this position by the Ministry of Health, she stresses that it was through the support of the TDR postgraduate training scheme that she acquired the skills she needed to manage the public health challenges in this district. In particular, learning about community-based approaches allowed her to better “understand the specific needs and problems” of the districts. New research and management approaches As a key aspect of disease control, students supported by TDR can learn to apply new health research and management approaches previously unknown in Senegal, Boh says. Among these is the One Health approach, which aims to assess how diseases emerge from a holistic and ecosystem-oriented perspective, taking into account the reciprocal role of humans, animals, plants, and microorganisms such as the aforementioned pests. By combining scientific, strategic, and rigorous implementation training, the TDR grants offered through UCAD enable their recipients to evaluate and propose improvements to health interventions against poverty-related infectious diseases. These opportunities are game-changers for both UCAD students and the future of implementation research in French-speaking Africa. With the help of TDR grants, Boh emphasises, students can gain exposure to critical health programmes and “pool their skills in order to end the neglect of poverty-related diseases and to achieve the Sustainable Development Goals.” This is the second article in a series on TDR’s research capacity strengthening programme – building skills of public health researchers, implementers, health practitioners and policy-makers in the fast-developing field of implementation research for improving uptake of effective health interventions. Gilead Urged to Prioritise Access as Injection Trial Proves 100% Successful in Preventing HIV 24/06/2024 Kerry Cullinan None of the over 2,000 young women and girls injected twice a year with a new drug, lenacapavir, contracted HIV in one of the most important advances in HIV prevention. Gilead Sciences announced these results last Friday, reporting that its Phase 3 PURPOSE 1 trial, conducted in South Africa and Uganda involving 2,134 women and girls aged 16-25, had been so successful that it was terminating early. Its announcement has been widely hailed as a huge breakthrough in the HIV sector where a vaccine has been elusive, and a range of groups urged Gilead to priorise early access to lenacapavir. The injectable was compared with Truvada and Descovy, two pills taken daily that have proven successful as pre-exposure HIV prophylaxis (PrEP). Sixteen of the 1,068 women in the Truvada group and 39 of the 2,136 women in the Descovy group contracted HIV during the trial. During a scheduled review of results, the trial’s independent data and safety monitoring board (DSMB) found the lenacapavir regimen was safe and highly effective. The trial, expected to run until September, was terminated early based on its success. Results of the trial have not been peer-reviewed yet. The age group targeted by the trial is the worst affected by HIV in southern Africa. In 2022, over three-quarters of infections in 15 to 24-year-olds in the region were girls and women, according to UNAIDS. “Every week, 4,000 adolescent girls and young women aged 15–24 years became infected with HIV globally in 2022, and 3,100 of these infections occurred in sub-Saharan Africa,” added UNAIDS. One of the ‘most important results’ “This is one of the most important results we’ve seen to date in an HIV prevention study,” said Mitchell Warren, executive director of AVAC, a non-profit HIV prevention advocacy organisation. “Adding additional HIV prevention options means more people may find an option that is right for them. Beyond expanded choice, a twice-yearly injection has the potential to transform the way we deliver HIV prevention to people who need and want it most – from an easier-to-follow regimen for individuals to a decreased burden on healthcare systems that are stretched to the limit.” Professor Linda-Gail Bekker, director of the Desmond Tutu HIV Centre in South Africa, said that the twice-a-year injectable could provide a “critical new choice” to prevent HIV. “While we know traditional HIV prevention options are highly effective when taken as prescribed, twice-yearly lenacapavir for PrEP could help address the stigma and discrimination some people may face when taking or storing oral PrEP pills, as well as potentially help increase PrEP adherence and persistence given its twice-yearly dosing schedule,” added Bekker. Gilead expects results by early 2025 from the programme’s other trial, PURPOSE 2, which is assessing twice-yearly lenacapavir for PrEP in men who have sex with men, transgender and non-binary people, currently underway in Argentina, Brazil, Mexico, Peru, South Africa, Thailand and the US. Access to lenacapavir, marketed as Sunlenca in the US, still needs to be worked out once it is approved by regulatory authorities. Cost of access? Lenacapavir (marketed as Sunlenca) was approved in the US in 2022 for “heavily treatment-experienced adults with multi-drug resistant HIV-1 infection and for treatment of people living with HIV who have been on other HIV treatment regimes which are currently failing”. However, Gilead charges $40,000 per patient per year in the US, reports aidsmap. When announcing the PURPOSE 2 results, Gilead acknowledged the “importance of helping to enable access in order for twice-yearly lenacapavir for PrEP, if approved by regulatory authorities, to achieve the broadest impact”. “In light of today’s milestone and the company’s ongoing commitment to communities affected by HIV, Gilead intends to brief community partners and provide a public statement regarding its planned access approach for high-incidence, resource-limited countries, which are primarily low- and lower-middle-income countries,” said the company. Gilead’s statement was welcomed by African HIV medicines access group AfroCAB in an open letter to its CEO, Daniel O’Day. “Replacing 365 pills of oral PrEP with just two injections is a life-changing transition and urgently needed option, as millions of our brothers and sisters, friends, and neighbours face challenges of stigma, pill burden, and adherence, leaving them unprotected against HIV acquisition,” said AfroCAB. “To forge a new pathway forward for [lenacapavir], we call on stakeholders to act now. After thousands of our community members have taken part in clinical trials for LEN and other injectable PrEP products, it is time that pharmaceutical companies, governments, and donors play their part in driving access among the communities that supported the science.” “We expect to see a timeline that takes into account a full analysis of PURPOSE 1 data and the coming data from PURPOSE 2 from Gilead as soon as possible, and we urge regulatory agencies to prepare to fast track regulatory review,” Warren added. “We also call on [the World Health Organization] to be prepared to quickly include lenacapavir, if approved by regulatory agencies, in HIV prevention guidelines. There is no time to waste if we are to translate these exciting clinical trial results into actual public health impact and expand the toolbox of HIV prevention choices.” Meanwhile, Unitaid urged Gilead to make access to lenacapavir a priority, calling for “the terms of their access strategies – including any voluntary licensing agreements – [to be] transparent, global health-oriented, and equitable”. “Lack of prompt and broad action would jeopardise translating the clinical trial results into real-life impact,” said Unitaid, which offered to work with Gilead to enable access, including “quality-assured, low-cost generics”. “Unitaid is dedicated to leveraging its recent investment through the Wits Reproductive Health and HIV Institute to facilitate market shaping interventions on long-acting PrEP options (in partnership with the Clinton Health Access Initiative), as well as its continued support to enabling elements such as the key work of WHO and the WHO Prequalification program, the Medicines Patent Pool and other intellectual property grants, to ensure access to this life-saving product is as broad as possible,” the organisation said in a statement last week. Image Credits: Gilead, Diana Polekhina/ Unsplash. Gavi Includes Ebola, Meningitis, Rabies and Hepatitis B Vaccines in its Portfolio 24/06/2024 Zuzanna Stawiska A member of the ring vaccination team vaccinates a man in Bosolo village. Vaccines offered as part of Gavi’s portfolio now also include preventive Ebola vaccines for care workers. Gavi, the Vaccine Alliance, announced last week that it will offer high risk countries the option of obtaining preventative Ebola vaccines, particularly for health workers, as part of the rollout of new vaccine offerings, which also include meningitis, rabies and hepatitis B vaccines. Plans to add the vaccines to the basket of available products were initially drawn up before the COVID-19 pandemic, but put on hold due to lack of appropriate supply or regulations, with applications opening only now to eligible countries. “Gavi’s ability as an alliance to protect health and save lives hinges on its ability to ensure vaccines are accessible, as quickly as possible, to those who need them the most,” said Gavi CEO Dr Sania Nishtar. “The new programmes launching today demonstrate the impact of this work.” Ebola is a rare but dangerous viral disease, with a 50-60% mortality rate. Infections may be transmitted through close contact with infected animals – for instance, fruit bats – but also through human-to-human contact. Gavi first offered Ebola vaccine candidates to health workers and suspected Ebola contacts during the 2014-2016 West Africa outbreak as an outbreak response. Two vaccines subsequently received regulatory approval and in May 2024 WHO’s Strategic Advisory Group of Experts on Immunisation (SAGE) decided to recommend the vaccines for preventive use, as well, in high-risk groups, such as health care providers in areas of endemic transmission. Meningitis vaccine rollout aims for elimination Gavi will also roll out a newly-approved vaccine for five strains of meningitis: meningococcal serogroups A, C, W, Y, and X. Central and Western African countries most prone to meningitis infections in the so-called “meningitis belt” The vaccine is a likely game-changer in the fight against the disease, experts say, noting that in the so-called “meningitis belt” of sub-Saharan African countries, the bacterial form of the diseases, regarded as the most dangerous, could potentially be eliminated. The product, MenFive, received WHO pre-qualification in July 2023 and has already been implemented in standard childhood immunisation programmes in Nigeria and Niger. In 2019, there were about 236,000 meningitis deaths, with the greatest burden in children younger than five years, with 112,000 deaths. Hepatitis B and rabies post-exposure jabs Other new vaccines include hepatitis B vaccines for newborns, granting infants critical additional protection in their first months of life, when they are at high risk of infection: including from maternal transmission. According to Gavi, nine out of ten infants infected with hepatitis B will develop chronic forms of the disease, while a quarter develop severe liver disease, which currently kills 884,000 people a year. Human rabies post exposure prophylaxis (PEP) vaccines are the last of the new package. The initiative aims to build more stockpiles of the rabies vaccine, which are often scarce and inaccessible, especially in remote areas, for post-exposure use. Rabies, which has an almost 100% mortality rate, remains a serious health problem in some 150 countries, where it is transmitted by infected dogs. But vaccines alone are not enough to stop the disease, experts underlined. “To stop human rabies deaths completely, we urgently need better data and surveillance, dog populations must be vaccinated, and people must be educated about what to do if bitten, and how to avoid being bitten in the first place,” said Professor Lucille Blumberg, Chair of United Against Rabies, pointing out to several blind spots of the human immunisation programme. Image Credits: WHO/L. Mackenzie , CDC. What Role Does Capacity Development Play in Transforming Health Research? 22/06/2024 Maayan Hoffman The latest episode of the Global Health Matters podcast, hosted by Dr Garry Aslanyan, delves into the extraordinary careers of two global health leaders and the crucial role that capacity development has played in their journeys. This episode, produced to celebrate the 50th anniversary of TDR, the Special Programme for Research and Training in Tropical Diseases, features insights from Dr Wilfried Mutombo, Head of Clinical Operations at the Drugs for Neglected Diseases Initiative (DNDi) in the Democratic Republic of the Congo, and Dr Yasmine Belkaid, President of the Institut Pasteur in France. Both leaders share their experiences and the impact of TDR’s support on their professional growth. Dr John Reeder, the Director of TDR, reflects on the importance of capacity development in fostering the potential of researchers in low- and middle-income countries. Reeder highlights his transition from hands-on research to global leadership, emphasising the value of putting research into action and nurturing talent at the grassroots level. He underscores that effective capacity development goes beyond providing resources; it involves empowering individuals to fulfil their potential and significantly contribute to their fields. To mark the 50th anniversary of @TDRnews, this episode of #GlobalHealthMatters features TDR Director John Reeder. Together, @GarryAslanyan and John discuss the challenges and future frontiers of capacity development. Listen to the episode here👉 https://t.co/K26H7vQV69#TDR50 pic.twitter.com/srEZeWErH9 — TDR (@TDRnews) June 18, 2024 “When you’re looking at science and laboratory science particularly, people get fixated on the expensive equipment and the fancy technology that surrounds this,” Reeder says. “But the most important investment in a laboratory is the scientist who is in that laboratory because, all other things aside, the ability to see the problem, think of innovative solutions to test them critically and to have the open mind to be able to see the discovery coming through that, you invest in that, and you’ve got great science.” From left: Dr John Reeder, the Director of TDR; Dr Yasmine Belkaid, President of the Institut Pasteur in France; and Dr Wilfried Mutombo, Head of Clinical Operations at the Drugs for Neglected Diseases Initiative (DNDi) in the Democratic Republic of the Congo Clinical Trials in Remote Areas: Three Challenges Mutombo’s story is a testament to the transformative power of research capacity development. Starting as a medical doctor in a small village in the DRC, Mutombo faced the challenge of treating sleeping sickness with toxic drugs. His clinical research fellowship from TDR enabled him to lead the first clinical trial in the DRC for fexinidazole, a safer oral drug for sleeping sickness. He discusses the immense challenges of conducting high-quality clinical trials in remote areas with inadequate infrastructure and highlights the importance of sustained support and training for local health workers. “The first challenge is to reach those areas because to perform a clinical trial, you need to go there in those areas, in those remote areas, and as you may know, we have bad roads, and sometimes this is not very safe,” Mutombo says. “The second challenge is, when you are in those areas, you can imagine in what state those health facilities are… So we had to improve these health facilities.” Another challenge, he says, is the health workers. “Health workers are there, but they are not aware of what a clinical trial is,” according to Mutombo. “To have a high-quality clinical trial, they needed to train them and have a very, very close supervision of their activities. So we organised all this.” Finally, “We need our governments … to give more support and more money to maintain those facilities. This is very important for the government because the first and very important step has been done, but now we need to maintain them at that level.” Building Research Capacity: Support is Crucial In many ways, Belkaid’s journey from Algeria to leading the Institut Pasteur in France exemplifies the global impact of TDR’s fellowships. She speaks about the crucial support she received, which allowed her to pursue her PhD and establish a notable research career. Belkaid emphasises creating environments that nurture talent and passion, enabling researchers to address pressing global health issues. Her vision as President of Institut Pasteur includes fostering international collaboration and continuing to build research capacities that can address future health challenges. Belkaid says if there is anything she can do over the next few years, it will hopefully be helping in any way she can to grow and nurture the leaders of tomorrow internationally. The episode underscores the ongoing need for international organisations like TDR and WHO to prioritise capacity building in low- and middle-income countries. Reeder points out the shift towards in-country training and the importance of sustainable research systems driven by local needs and priorities. He says this approach helps ensure research capacity development and is not just about immediate results but about long-term, sustainable growth that empowers countries to tackle their health challenges effectively. Read related Inside View by Dr John Reeder. Listen to the Global Health Matters podcast on Health Policy Watch. Visit the podcast website. Image Credits: TDR. Posts navigation Older postsNewer posts This site uses cookies to help give you the best experience on our website. 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Framework to Help Curb Visceral Leishmaniasis in East Africa 26/06/2024 Zuzanna Stawiska Delegates during the launch of a WHO visceral leishmaniasis elimination framework WHO framework to eliminate visceral leishmaniasis (VL), a deadly disease most prominent in East Africa, was launched Thursday. It can play an important role in eliminating VL as a public health problem by 2030: a goal key countries of the East African region committed to in last year’s Nairobi Declaration. “The VL elimination framework will offer important direction to countries in the region and provide momentum to reach the finish line of elimination,” said Dr Dereje Duguma, the Health Minister of Ethiopia, a co-host of the launch. “The Government of Ethiopia remains committed to working with partners to develop programs at all levels, from national to community, to expand access to healthcare and achieve the targets of elimination by 2030.” Visceral leishmaniasis, or kala-azar, is a deadly parasitic disease causing fever, weight loss, spleen and liver enlargement, transmitted by the bite of infected female sandflies. Lethal if left untreated, the disease is endemic in 80 countries worldwide, with 73% of the estimated 50,000 to 90,000 cases annually occurring in the Eastern African region in 2022, according to the WHO. Children under 15 account for half of the infections. Malnutrition, but also poor sanitary and housing conditions increase the risk of leishmaniasis infection. Sandflies, which transmit the disease, often live next to crowded buildings or spaces with open sewages or bad waste management. VL outbreaks are also frequent when many people without immunity to the parasite migrate to areas where it is endemic or with environmental changes, such as deforestation, building of dams, but also climate change. Successful elimination thanks to framework A good implementation of a regional Strategic Framework for VL led to a total elimination of the disease in Bangladesh in 2023 – becoming the first country worldwide to achieve the status – and a significant reduction of cases in the region. Eastern Africa wants to follow a similar path. A 2014 plan to eliminating VL in Bangladesh, India and Nepal brought a massive decline in case numbers Between 2004 and 2008, Bangladesh, India and Nepal accounted for 70% of global visceral leishmaniasis cases. The regional framework adopted in 2005, paired with sustained stakeholder support and a political will for an accelerated program implementation contributed to a successful case reduction. The combined number of cases for the three countries decreased almost forty times, from 39,809 in 2005 to only 1,074 in 2022, according to WHO data. Nairobi Declaration commitments Representatives of eight East African countries pledged to follow the path to VL elimination, signing the Nairobi Declaration in 2023. The ministries of health of Chad, Eritrea, Ethiopia, Kenya, Somalia, South Sudan, Sudan, and Uganda, along with key stakeholders in the region set the goal of significantly curbing VL cases by 2030. Djibouti has also signed the declaration and co-hosted the WHO elimination framework launch last Thursday. The framework, developed in partnership with the Drugs for Neglected Diseases initiative (DNDi) and Ministries of Health across the region, outlines five main strategies for VL elimination: early diagnosis and treatment, vector management, surveillance, social mobilisation, and operational research. It also features a step-by-step guide through elimination phases as well as sets regional and country targets, such as a 90% reduction in VL burden in Eastern Africa by 2030, decreasing the number of cases to 1,500 annually. “By providing countries with tailored tools and strategies, we are laying a strong foundation for sustained progress in the fight against this neglected tropical disease,” said Dr Saurabh Jain, WHO’s Focal Point for VL. Image Credits: WHO. Urgent Global Action is Needed to Address Alcohol and Drug Consumption 25/06/2024 Kerry Cullinan The WHO stresses that there is no safe level of alcohol consumption. Romania, Georgia and Czechia have the highest alcohol consumption rates in the world while, in the best-case scenario, only 14% of those who abuse alcohol have access to treatment. These are some of the insights from the World Health Organization’s (WHO) global status report on alcohol and substance use disorders, based on 2019 data from 154 countries. In 2019, 2.6 million deaths were caused by alcohol ⚠️ 2 million were among men ⚠️ 13% of deaths were among younger people aged 20-39 yearshttps://t.co/zk0WbU47Rc pic.twitter.com/FX7kGODhIi — World Health Organization (WHO) (@WHO) June 25, 2024 Around 400 million people lived with alcohol and drug use disorders, with 209 million of these being people with alcohol dependence. Those living in the vast WHO European region, which includes Russia, consumed the most alcohol – 9.2 litres of pure alcohol per person annually. The Region of the Americas, which includes North and South America and the Caribbean, followed with 7.5 litres. In Romania, the average daily pure alcohol consumption per capita was a staggering 36.9 grammes, the highest in the world. Georgia (31.1g), Czechia (28.8) and Latvia (28.4) – all in the European region – were not far behind. Despite Australia’s hard-drinking image, its drinkers averaged 21.9 g per capita per day, the third highest in the West Pacific region after Laos (25) and the Cook Islands (22.9). In the region of the Americas, Canada (21.5) and the USA (20.8) topped the list. In Africa, South Africa (19) had the highest alcohol consumption, while Thailand (17) was the highest in the South East Asia region. Alcohol consumption was low in the Muslim-dominated Eastern Mediterranean region, topped by the United Arab Emirates (5). Severe harms; ‘No safe level’ “Substance use severely harms individual health, increasing the risk of chronic diseases, mental health conditions, and tragically resulting in millions of preventable deaths every year. It places a heavy burden on families and communities, increasing exposure to accidents, injuries, and violence,” wrote WHO Director-General Dr Tedros Adhanom Ghebreyesus in the report’s foreword. Dr Vladimir Pozniak, WHO’s head of alcohol, drugs and addictive behaviours “The level of alcohol consumption per capita among drinkers amounts to an average of 27 grammes of pure alcohol per day, which is roughly equivalent to two glasses of wine, two bottles of beer or two servings of spirits,” Dr Vladimir Pozniak, WHO’s head of alcohol, drugs and addictive behaviours, told a media briefing this week. Of all deaths attributable to alcohol in 2019, an estimated 1.6 million deaths were from non-communicable diseases (NCDs), including 474,000 deaths from cardiovascular diseases and 401,000 from cancer. Some 724 000 deaths were due to injuries, such as those from traffic crashes, self-harm and interpersonal violence. Another 284 000 deaths were linked to communicable diseases. For example, alcohol consumption has been shown to increase the risk of HIV/AIDS as people are more likely to have unprotected sex, and increase tuberculosis and lower respiratory infections by suppressing a wide range of immune responses. The highest proportion (13%) of alcohol-attributable deaths in 2019 were young people aged 20-39 years. Globally, almost a quarter (23.5%) of all 15 to 19 year olds were current drinkers, with the highest rates in the European region (45.9%) followed by the Americas (43.9%). Pozniak stressed that “there is no risk free levels of alcohol consumption”. “The WHO has not produced guidelines [on safe alcohol consumption] because the diversity of countries, the diversity of populations, their exposure to alcohol, are so different, that to come up with universal levels of risks would be an unmanageable task,” said Pozniak. “It’s advisable to consult with a health professionals on the risks associated with level or pattern of consumption, taking into consideration the individual characteristics of a person [such as] pre-existing disorders or current health conditions because the risks varies substantially, depending on all these factors.” Lack of treatment options The total alcohol per capita consumption decreased slightly from 5.7 litres in 2010 to 5.5 litres in 2019. But the world is far from reaching the Sustainable Development Goal (SDG) target 3.5 by 2030 of reducing alcohol and drug consumption and improving access to quality treatment for substance use disorders. Although effective treatment options for substance use disorders exists, treatment coverage is incredibly low. The proportion of people in contact with substance use treatment services ranged from less than 1% to a maximum of 35% in 2019. This was even lower for alcohol-related treatment, with up to 14% of people who needed it, accessing treatment. “Most of the 145 countries that reported data did not have a specific budget line or data on governmental expenditures for treatment of substance use disorders. Although mutual help and peer support groups are useful resources for people with substance use disorders, almost half of responding countries reported that they do not offer such support groups for substance use disorders,” according to the WHO. “Stigma, discrimination and misconceptions about the efficacy of treatment contribute to these critical gaps in treatment provision, as well as the continued low prioritisation of substance use disorders by health and development agencies.” A significant number of countries reported interference from the alcohol industry in their efforts to develop effective alcohol policies, according to the report. Industry interference was highest in countries that were effectively increasing the price of alcohol. “Industry interference was most frequently reported in the African Region (62.1%). However, across all income groups, between 42% and 50% of countries pointed to this interference as a barrier to move forward,” it notes. Actions for progress To accelerate progress towards achievement of SDG target 3.5 and reduce the health and social burden attributable to substance use, the WHO recommends action in eight areas. These include increased awareness through a coordinated global advocacy campaign, and the re-commitment to implement the Global Alcohol Action Plan 2022-2030 with a focus on the SAFER package. It also calls for increased capacity of health and social care systems to deal with substance abuse, more training of health professionals, better monitoring and research and more engagement with civil society organisations, professional associations and people with lived experience. Image Credits: Stanislav Ivanitskiy/ Unsplash. Health and Finance Leaders Call for Strengthened Primary Health Care to Tackle NCDs and Mental Health 25/06/2024 Sophia Samantaroy Breast cancer is among the many non-communicable diseases growing in lower-and-middle-income countries, where funding for prevention is often diverted to other health concerns. When Felicia Knaul met Tonya Rosa, a Mexican woman undergoing chemotherapy for breast cancer, “she was there with a big smile on her face…even though her cancer had recurred.” But Rosa told Knaul that her first round of treatment had impoverished her family, “they had to sell their business, their home, their assets to be able to pay for her care.” But now, she had a card that gives her access to Mexico’s public insurance to cover her treatments. Rosa’s story was one of many shared at a two-day international financing dialogue for NCDs and mental health hosted by the World Health Organization (WHO) and the World Bank in Washington, DC. The meeting convened as part of the preparation for the United Nations High-Level on these issues in 2025. For Knaul, a global health economist, cancer researcher and advocate, providing care for NCDs and mental health patients requires “a health system that could deal with the whole gamut of issues that go through, from primary prevention all the way through to end-of-life care.” Representatives from over 30 countries reiterated this call for strengthened, affordable health coverage as the means to address NCDs and bolster mental health. Adriana Alfonso, Director of Health Surveillance with Uruguay’s Ministry of Health, credits the country’s recent mental health successes to its decree in making psychiatric care obligatory in an affordable and universal manner at health centers. These interventions were only possible through concerted government cooperation and willpower. Primary care financing as a sustainable solution Health and finance leaders from over 30 countries met to discuss a path forward to sustainable NCDs and mental health financing. “In the past, when we prepared annual budgets, we didn’t really take into account the mental health issues. In the case of Uruguay, we have a yearly budget that is discussed at the parliament level, and we needed to make sure that we had a mental health budget that was sustainable,” Alfonso noted. Providing dedicated funds for mental health has translated into co-payment reductions and increases in beds in mental health facilities and halfway homes. Lester Tan, director of Health Policy, Development, and Planning at the Department of Health in the Philippines, echoed this sentiment in describing the economics of mental health in the Philippines. In 2021, mental health conditions cost the Philippine economy an estimated $1.37 billion dollars, equivalent to 0.4% of GDP. Yet, investing in more treatment of epilepsy and depression would have an incredibly high return on investment – 6.6 and 5.3 times respectively. “This evidence, together with the implementation of a mental health law passed in 2018 have contributed to the scaling up of mental health services in the country. There are now 362 mental health access sites nationwide, which have served 124,000 users in 2022,” said Tan. These mental health successes hinge on expanded financing of primary health care, the “how” of NCDs and mental health care, as a panelist noted. Tan notes that the Philippines benefitted from expanding the number of health professionals trained in mental health at the primary care level. “This capacity building prioritized depression, epilepsy, self harm and psychosis.” A multi-sectoral approach to overcome ‘fragmentation’ Increased primary health care investment has the potential to reduce the global burden of NCDs through prevention, treatment, and care. Other panelists noted the urgency for multisectoral approaches to financing NCDs and mental health care – working across government institutions and ministries. An NCD expert from the Tunisia Ministry of Health, noted that her ministry recruited the help of the Ministry of Youth, Sport, and Heritage to organize a national day of exercise. “During this National Day, everybody was invited to exercise, and we talked about the importance of physical activity. The Ministry of Health decided to do screenings for hypertension and diabetes on this day, and we, of course, had a very large media campaign and awareness raising campaign in the entirety of the country,” she said. Beyond the more straightforward partnerships between adjacent ministries, the health sector must work more closely with ministries of finance, noted Aleksandra Altievska, head of fund budgets at North Macedonia’s Ministry of Finance. “I recommend that every Ministry of Health always keep in mind that the Minister of Finance has other priorities.” Working with ministries of finance to fund NCDs and mental health interventions is critical because, as Joanna Ralston of the World Obesity Federation explained, NCDs are challenges that “can’t be targeted by one sector.” “We have a global health system that really was built around single vector diseases, just to oversimplify, and yet, now we’re coming in with something that has these commercial elements, [environmental] elements, all these factors, this great level of complexity that that has to be respected,” Ralston said. Obesity, as just one example, continues to impact nations across all age levels, because of the fragmentation of the response, said Ralston. “The increase of obesity is around 100% in the past couple of years, when the goal was a 0% increase.” Fragmented, under-resourced responses undermine progress on NCDs and mental health – something that advocates hope can be overcome by renewed multi-sectorial frameworks and partnerships. Leveraging patient experiences Several panelists shared their own experiences living with an NCD at the Washington, D.C conference. Knaul, who founded the Mexico-based breast cancer advocacy organization Cancer de mama: Tomatelo a Pecho, notes that the numbers alone won’t sway policymakers – bringing in patient narratives is paramount to the future of non-communicable disease prevention, treatment, and care. “Health systems repeatedly fail patients with cancer and other NCDs,” she said. Engaging people with lived experiences of NCDs or mental health challenges bolsters local and international support, argued Charity Muturi, an NCDs and mental health policy advocate in Kenya. “When a national task force on mental health was formed, we felt that, as patients, our voices needed to be on the table,” said Muturi, who discussed her own challenges navigating mental health care in Kenya. Ralston summed up the struggle with communicating the burden of NCDs and mental health. “Evidence and narrative are what are needed to be successful. We need to be rooted in evidence, but we need to have a way of communicating that story to decision makers, policy makers, and the wider public. And that has been a challenge with NCDs.” Image Credits: Roche, WHO. Scientists in West Africa Tackle Malaria and Schistosomiasis 25/06/2024 Zsofia Hesketh Dr Mamy Andrianirina Rakotondratsara (centre) distributing antimalarials in rural Madagascar. Malaria has long been at the heart of public health efforts in Africa. As a preventable but potentially fatal disease, it is caused by a parasite transmitted by mosquitoes. In 2022, the WHO African Region accounted for about 94% of cases globally. WHO says 78% of deaths in the region are among children under 5 years of age. That’s why Dr Mamy Andrianirina Rakotondratsara, a medical doctor and research technician for Madagascar’s National Institute of Public and Community Health (INSPC), wanted to dedicate his TDR-supported studies for a Masters in Public Health to malaria research. Originally from an endemic region in eastern Madagascar, Rakotondratsara has been personally affected by malaria as he lost his older brother to the disease. “I lost someone close and beloved to me from this disease,” he told Health Policy Watch in an interview. That reinforced his determination to address the disease in the course of his studies. Dr Mamy Andrianirina Rakotondratsara lost his brother to malaria and is passionate about addressing the disease. In 2021, during the course of his Masters studies at the Cheikh Anta Diop University of Dakar (UCAD), Rakotondratsara also completed TDR’s Massive Open Online Course (MOOC) on implementation research. As part of this course, he designed a study around the relationship between the frequency of malaria episodes and mosquito bed net coverage, working with other researchers and doctors that specialize in malaria. This research is still ongoing and specifically targets the rural population of Madagascar’s Anosibe An’Ala district. Although results are still pending, designing such a study has laid the foundations for Rakotondratsara to put the research findings into practice in his home region and disease context, complementing his prior work on malnutrition. Sub-regional training centre for Francophone Africa Students engaged in a field training in participatory epidemiology organised by the National Institute of Public and Community Health Madagascar. Rakotondratsara was able to undertake this research thanks to TDR’s global postgraduate training scheme – which focuses on building students’ skills to do interdisciplinary forms of research that look at barriers and opportunities for better uptake of available preventative and treatment methods. For physicians, researchers and other professionals interested in local public health, the fellowships supported by TDR – the global research programme on diseases of poverty co-sponsored by UNICEF, UNDP, WHO and the World Bank – provides essential skills for health programme management and implementation. It is particularly important for addressing infectious diseases affecting vulnerable and underserved populations and promoting engagement in research from the local to global levels. UCAD is one of the two universities in French-speaking West Africa to collaborate with TDR in the programme. It has been hosting students since 2021, to conduct research into how to control infectious diseases found across the region. In 2022, University of Sciences, Techniques and Technologies in Bamako, Mali, joined the programme with the support of Germany’s Deutsche Gesellschaft für Technische Zusammenarbeit. “The TDR training allowed us to have a new vision of the health system,” Rakotondratsara observes. It changed my way of asking questions when faced with poor health indicators. Regarding my Master’s thesis, it gave me an idea of issues to be explored in the mosquito net distribution process, starting with the quantification of needs to end point use.” He strives to integrate such lessons learnt into his current role with the INSPC. And he is also planning to pursue a PhD with a specialization in implementation research. “The INSPC is a public health training and research institution attached to the Ministry of Public Health,” he explains. “Given that it is a research institution, in collaboration with funding bodies, we are often called upon to carry out expert appraisals on their behalf. As a research technician, I accompany this research and bring my contributions to it,” he says. “Based on my experience, it’s my intention to ensure that implementation research finds an important place both in the research and the teaching context.” Towards better management of Schistosomiasis Although less well known, schistosomiasis, also known as bilharzia, is the second most prevalent disease after malaria both in Senegal and much of the rest of sub-Saharan Africa. Its most common form – urogenital schistosomiasis – can result in damage to the bladder, urethra, and kidneys. It is a parasitic disease that occurs in tropical and subtropical regions where there is limited access to clean water, particularly in the Senegal River Basin, a hyper-endemic region for several species of the parasite that causes the disease. The different variants of the disease are classified by WHO according to the NTD principles for which a greater global response is needed, making it an important research target in the TDR program. Oumy Kaltome Boh, a physician originally from Dakar, has been interested in the burden of NTDs in Senegal since her formative years, and hopes to see their eradication by 2030. Dr Oumy Kaltome Boh “Faced with the impact of these diseases on the health of the population,” she says, her main objective is to contribute to their management “through the implementation of innovative interventions.” This is what led Boh to undertake a Masters degree in management of health programmes at UCAD, as well as an International Inter-University Diploma in emerging infections. Benefiting from a TDR grant in December 2020, Boh was able to conduct a study examining the day-to-day lifestyle practices and environmental factors that make schistosomiasis transmission more likely in endemic areas of her home country. As part of this study, done in collaboration with Senegal’s national bilharziasis programme, she also aimed to verify the effectiveness of schistosomiasis treatment with praziquantel, the only available treatment option currently. A total of 287 children were followed over the course of three weeks, with ‘Day Zero’ representing the date of administration of a single praziquantel dose. Between days 14 and 21, both the effects of the drug on disease progression were assessed and a favourable efficacy profile was found, with a 98% reduction in parasite eggs by day 21. Today, Boh holds the position of deputy chief medical officer in the health district of Saint-Louis, Senegal, and is mainly involved in care and prevention activities for people living with HIV or tuberculosis. Recruited into this position by the Ministry of Health, she stresses that it was through the support of the TDR postgraduate training scheme that she acquired the skills she needed to manage the public health challenges in this district. In particular, learning about community-based approaches allowed her to better “understand the specific needs and problems” of the districts. New research and management approaches As a key aspect of disease control, students supported by TDR can learn to apply new health research and management approaches previously unknown in Senegal, Boh says. Among these is the One Health approach, which aims to assess how diseases emerge from a holistic and ecosystem-oriented perspective, taking into account the reciprocal role of humans, animals, plants, and microorganisms such as the aforementioned pests. By combining scientific, strategic, and rigorous implementation training, the TDR grants offered through UCAD enable their recipients to evaluate and propose improvements to health interventions against poverty-related infectious diseases. These opportunities are game-changers for both UCAD students and the future of implementation research in French-speaking Africa. With the help of TDR grants, Boh emphasises, students can gain exposure to critical health programmes and “pool their skills in order to end the neglect of poverty-related diseases and to achieve the Sustainable Development Goals.” This is the second article in a series on TDR’s research capacity strengthening programme – building skills of public health researchers, implementers, health practitioners and policy-makers in the fast-developing field of implementation research for improving uptake of effective health interventions. Gilead Urged to Prioritise Access as Injection Trial Proves 100% Successful in Preventing HIV 24/06/2024 Kerry Cullinan None of the over 2,000 young women and girls injected twice a year with a new drug, lenacapavir, contracted HIV in one of the most important advances in HIV prevention. Gilead Sciences announced these results last Friday, reporting that its Phase 3 PURPOSE 1 trial, conducted in South Africa and Uganda involving 2,134 women and girls aged 16-25, had been so successful that it was terminating early. Its announcement has been widely hailed as a huge breakthrough in the HIV sector where a vaccine has been elusive, and a range of groups urged Gilead to priorise early access to lenacapavir. The injectable was compared with Truvada and Descovy, two pills taken daily that have proven successful as pre-exposure HIV prophylaxis (PrEP). Sixteen of the 1,068 women in the Truvada group and 39 of the 2,136 women in the Descovy group contracted HIV during the trial. During a scheduled review of results, the trial’s independent data and safety monitoring board (DSMB) found the lenacapavir regimen was safe and highly effective. The trial, expected to run until September, was terminated early based on its success. Results of the trial have not been peer-reviewed yet. The age group targeted by the trial is the worst affected by HIV in southern Africa. In 2022, over three-quarters of infections in 15 to 24-year-olds in the region were girls and women, according to UNAIDS. “Every week, 4,000 adolescent girls and young women aged 15–24 years became infected with HIV globally in 2022, and 3,100 of these infections occurred in sub-Saharan Africa,” added UNAIDS. One of the ‘most important results’ “This is one of the most important results we’ve seen to date in an HIV prevention study,” said Mitchell Warren, executive director of AVAC, a non-profit HIV prevention advocacy organisation. “Adding additional HIV prevention options means more people may find an option that is right for them. Beyond expanded choice, a twice-yearly injection has the potential to transform the way we deliver HIV prevention to people who need and want it most – from an easier-to-follow regimen for individuals to a decreased burden on healthcare systems that are stretched to the limit.” Professor Linda-Gail Bekker, director of the Desmond Tutu HIV Centre in South Africa, said that the twice-a-year injectable could provide a “critical new choice” to prevent HIV. “While we know traditional HIV prevention options are highly effective when taken as prescribed, twice-yearly lenacapavir for PrEP could help address the stigma and discrimination some people may face when taking or storing oral PrEP pills, as well as potentially help increase PrEP adherence and persistence given its twice-yearly dosing schedule,” added Bekker. Gilead expects results by early 2025 from the programme’s other trial, PURPOSE 2, which is assessing twice-yearly lenacapavir for PrEP in men who have sex with men, transgender and non-binary people, currently underway in Argentina, Brazil, Mexico, Peru, South Africa, Thailand and the US. Access to lenacapavir, marketed as Sunlenca in the US, still needs to be worked out once it is approved by regulatory authorities. Cost of access? Lenacapavir (marketed as Sunlenca) was approved in the US in 2022 for “heavily treatment-experienced adults with multi-drug resistant HIV-1 infection and for treatment of people living with HIV who have been on other HIV treatment regimes which are currently failing”. However, Gilead charges $40,000 per patient per year in the US, reports aidsmap. When announcing the PURPOSE 2 results, Gilead acknowledged the “importance of helping to enable access in order for twice-yearly lenacapavir for PrEP, if approved by regulatory authorities, to achieve the broadest impact”. “In light of today’s milestone and the company’s ongoing commitment to communities affected by HIV, Gilead intends to brief community partners and provide a public statement regarding its planned access approach for high-incidence, resource-limited countries, which are primarily low- and lower-middle-income countries,” said the company. Gilead’s statement was welcomed by African HIV medicines access group AfroCAB in an open letter to its CEO, Daniel O’Day. “Replacing 365 pills of oral PrEP with just two injections is a life-changing transition and urgently needed option, as millions of our brothers and sisters, friends, and neighbours face challenges of stigma, pill burden, and adherence, leaving them unprotected against HIV acquisition,” said AfroCAB. “To forge a new pathway forward for [lenacapavir], we call on stakeholders to act now. After thousands of our community members have taken part in clinical trials for LEN and other injectable PrEP products, it is time that pharmaceutical companies, governments, and donors play their part in driving access among the communities that supported the science.” “We expect to see a timeline that takes into account a full analysis of PURPOSE 1 data and the coming data from PURPOSE 2 from Gilead as soon as possible, and we urge regulatory agencies to prepare to fast track regulatory review,” Warren added. “We also call on [the World Health Organization] to be prepared to quickly include lenacapavir, if approved by regulatory agencies, in HIV prevention guidelines. There is no time to waste if we are to translate these exciting clinical trial results into actual public health impact and expand the toolbox of HIV prevention choices.” Meanwhile, Unitaid urged Gilead to make access to lenacapavir a priority, calling for “the terms of their access strategies – including any voluntary licensing agreements – [to be] transparent, global health-oriented, and equitable”. “Lack of prompt and broad action would jeopardise translating the clinical trial results into real-life impact,” said Unitaid, which offered to work with Gilead to enable access, including “quality-assured, low-cost generics”. “Unitaid is dedicated to leveraging its recent investment through the Wits Reproductive Health and HIV Institute to facilitate market shaping interventions on long-acting PrEP options (in partnership with the Clinton Health Access Initiative), as well as its continued support to enabling elements such as the key work of WHO and the WHO Prequalification program, the Medicines Patent Pool and other intellectual property grants, to ensure access to this life-saving product is as broad as possible,” the organisation said in a statement last week. Image Credits: Gilead, Diana Polekhina/ Unsplash. Gavi Includes Ebola, Meningitis, Rabies and Hepatitis B Vaccines in its Portfolio 24/06/2024 Zuzanna Stawiska A member of the ring vaccination team vaccinates a man in Bosolo village. Vaccines offered as part of Gavi’s portfolio now also include preventive Ebola vaccines for care workers. Gavi, the Vaccine Alliance, announced last week that it will offer high risk countries the option of obtaining preventative Ebola vaccines, particularly for health workers, as part of the rollout of new vaccine offerings, which also include meningitis, rabies and hepatitis B vaccines. Plans to add the vaccines to the basket of available products were initially drawn up before the COVID-19 pandemic, but put on hold due to lack of appropriate supply or regulations, with applications opening only now to eligible countries. “Gavi’s ability as an alliance to protect health and save lives hinges on its ability to ensure vaccines are accessible, as quickly as possible, to those who need them the most,” said Gavi CEO Dr Sania Nishtar. “The new programmes launching today demonstrate the impact of this work.” Ebola is a rare but dangerous viral disease, with a 50-60% mortality rate. Infections may be transmitted through close contact with infected animals – for instance, fruit bats – but also through human-to-human contact. Gavi first offered Ebola vaccine candidates to health workers and suspected Ebola contacts during the 2014-2016 West Africa outbreak as an outbreak response. Two vaccines subsequently received regulatory approval and in May 2024 WHO’s Strategic Advisory Group of Experts on Immunisation (SAGE) decided to recommend the vaccines for preventive use, as well, in high-risk groups, such as health care providers in areas of endemic transmission. Meningitis vaccine rollout aims for elimination Gavi will also roll out a newly-approved vaccine for five strains of meningitis: meningococcal serogroups A, C, W, Y, and X. Central and Western African countries most prone to meningitis infections in the so-called “meningitis belt” The vaccine is a likely game-changer in the fight against the disease, experts say, noting that in the so-called “meningitis belt” of sub-Saharan African countries, the bacterial form of the diseases, regarded as the most dangerous, could potentially be eliminated. The product, MenFive, received WHO pre-qualification in July 2023 and has already been implemented in standard childhood immunisation programmes in Nigeria and Niger. In 2019, there were about 236,000 meningitis deaths, with the greatest burden in children younger than five years, with 112,000 deaths. Hepatitis B and rabies post-exposure jabs Other new vaccines include hepatitis B vaccines for newborns, granting infants critical additional protection in their first months of life, when they are at high risk of infection: including from maternal transmission. According to Gavi, nine out of ten infants infected with hepatitis B will develop chronic forms of the disease, while a quarter develop severe liver disease, which currently kills 884,000 people a year. Human rabies post exposure prophylaxis (PEP) vaccines are the last of the new package. The initiative aims to build more stockpiles of the rabies vaccine, which are often scarce and inaccessible, especially in remote areas, for post-exposure use. Rabies, which has an almost 100% mortality rate, remains a serious health problem in some 150 countries, where it is transmitted by infected dogs. But vaccines alone are not enough to stop the disease, experts underlined. “To stop human rabies deaths completely, we urgently need better data and surveillance, dog populations must be vaccinated, and people must be educated about what to do if bitten, and how to avoid being bitten in the first place,” said Professor Lucille Blumberg, Chair of United Against Rabies, pointing out to several blind spots of the human immunisation programme. Image Credits: WHO/L. Mackenzie , CDC. What Role Does Capacity Development Play in Transforming Health Research? 22/06/2024 Maayan Hoffman The latest episode of the Global Health Matters podcast, hosted by Dr Garry Aslanyan, delves into the extraordinary careers of two global health leaders and the crucial role that capacity development has played in their journeys. This episode, produced to celebrate the 50th anniversary of TDR, the Special Programme for Research and Training in Tropical Diseases, features insights from Dr Wilfried Mutombo, Head of Clinical Operations at the Drugs for Neglected Diseases Initiative (DNDi) in the Democratic Republic of the Congo, and Dr Yasmine Belkaid, President of the Institut Pasteur in France. Both leaders share their experiences and the impact of TDR’s support on their professional growth. Dr John Reeder, the Director of TDR, reflects on the importance of capacity development in fostering the potential of researchers in low- and middle-income countries. Reeder highlights his transition from hands-on research to global leadership, emphasising the value of putting research into action and nurturing talent at the grassroots level. He underscores that effective capacity development goes beyond providing resources; it involves empowering individuals to fulfil their potential and significantly contribute to their fields. To mark the 50th anniversary of @TDRnews, this episode of #GlobalHealthMatters features TDR Director John Reeder. Together, @GarryAslanyan and John discuss the challenges and future frontiers of capacity development. Listen to the episode here👉 https://t.co/K26H7vQV69#TDR50 pic.twitter.com/srEZeWErH9 — TDR (@TDRnews) June 18, 2024 “When you’re looking at science and laboratory science particularly, people get fixated on the expensive equipment and the fancy technology that surrounds this,” Reeder says. “But the most important investment in a laboratory is the scientist who is in that laboratory because, all other things aside, the ability to see the problem, think of innovative solutions to test them critically and to have the open mind to be able to see the discovery coming through that, you invest in that, and you’ve got great science.” From left: Dr John Reeder, the Director of TDR; Dr Yasmine Belkaid, President of the Institut Pasteur in France; and Dr Wilfried Mutombo, Head of Clinical Operations at the Drugs for Neglected Diseases Initiative (DNDi) in the Democratic Republic of the Congo Clinical Trials in Remote Areas: Three Challenges Mutombo’s story is a testament to the transformative power of research capacity development. Starting as a medical doctor in a small village in the DRC, Mutombo faced the challenge of treating sleeping sickness with toxic drugs. His clinical research fellowship from TDR enabled him to lead the first clinical trial in the DRC for fexinidazole, a safer oral drug for sleeping sickness. He discusses the immense challenges of conducting high-quality clinical trials in remote areas with inadequate infrastructure and highlights the importance of sustained support and training for local health workers. “The first challenge is to reach those areas because to perform a clinical trial, you need to go there in those areas, in those remote areas, and as you may know, we have bad roads, and sometimes this is not very safe,” Mutombo says. “The second challenge is, when you are in those areas, you can imagine in what state those health facilities are… So we had to improve these health facilities.” Another challenge, he says, is the health workers. “Health workers are there, but they are not aware of what a clinical trial is,” according to Mutombo. “To have a high-quality clinical trial, they needed to train them and have a very, very close supervision of their activities. So we organised all this.” Finally, “We need our governments … to give more support and more money to maintain those facilities. This is very important for the government because the first and very important step has been done, but now we need to maintain them at that level.” Building Research Capacity: Support is Crucial In many ways, Belkaid’s journey from Algeria to leading the Institut Pasteur in France exemplifies the global impact of TDR’s fellowships. She speaks about the crucial support she received, which allowed her to pursue her PhD and establish a notable research career. Belkaid emphasises creating environments that nurture talent and passion, enabling researchers to address pressing global health issues. Her vision as President of Institut Pasteur includes fostering international collaboration and continuing to build research capacities that can address future health challenges. Belkaid says if there is anything she can do over the next few years, it will hopefully be helping in any way she can to grow and nurture the leaders of tomorrow internationally. The episode underscores the ongoing need for international organisations like TDR and WHO to prioritise capacity building in low- and middle-income countries. Reeder points out the shift towards in-country training and the importance of sustainable research systems driven by local needs and priorities. He says this approach helps ensure research capacity development and is not just about immediate results but about long-term, sustainable growth that empowers countries to tackle their health challenges effectively. Read related Inside View by Dr John Reeder. Listen to the Global Health Matters podcast on Health Policy Watch. Visit the podcast website. Image Credits: TDR. Posts navigation Older postsNewer posts This site uses cookies to help give you the best experience on our website. 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Urgent Global Action is Needed to Address Alcohol and Drug Consumption 25/06/2024 Kerry Cullinan The WHO stresses that there is no safe level of alcohol consumption. Romania, Georgia and Czechia have the highest alcohol consumption rates in the world while, in the best-case scenario, only 14% of those who abuse alcohol have access to treatment. These are some of the insights from the World Health Organization’s (WHO) global status report on alcohol and substance use disorders, based on 2019 data from 154 countries. In 2019, 2.6 million deaths were caused by alcohol ⚠️ 2 million were among men ⚠️ 13% of deaths were among younger people aged 20-39 yearshttps://t.co/zk0WbU47Rc pic.twitter.com/FX7kGODhIi — World Health Organization (WHO) (@WHO) June 25, 2024 Around 400 million people lived with alcohol and drug use disorders, with 209 million of these being people with alcohol dependence. Those living in the vast WHO European region, which includes Russia, consumed the most alcohol – 9.2 litres of pure alcohol per person annually. The Region of the Americas, which includes North and South America and the Caribbean, followed with 7.5 litres. In Romania, the average daily pure alcohol consumption per capita was a staggering 36.9 grammes, the highest in the world. Georgia (31.1g), Czechia (28.8) and Latvia (28.4) – all in the European region – were not far behind. Despite Australia’s hard-drinking image, its drinkers averaged 21.9 g per capita per day, the third highest in the West Pacific region after Laos (25) and the Cook Islands (22.9). In the region of the Americas, Canada (21.5) and the USA (20.8) topped the list. In Africa, South Africa (19) had the highest alcohol consumption, while Thailand (17) was the highest in the South East Asia region. Alcohol consumption was low in the Muslim-dominated Eastern Mediterranean region, topped by the United Arab Emirates (5). Severe harms; ‘No safe level’ “Substance use severely harms individual health, increasing the risk of chronic diseases, mental health conditions, and tragically resulting in millions of preventable deaths every year. It places a heavy burden on families and communities, increasing exposure to accidents, injuries, and violence,” wrote WHO Director-General Dr Tedros Adhanom Ghebreyesus in the report’s foreword. Dr Vladimir Pozniak, WHO’s head of alcohol, drugs and addictive behaviours “The level of alcohol consumption per capita among drinkers amounts to an average of 27 grammes of pure alcohol per day, which is roughly equivalent to two glasses of wine, two bottles of beer or two servings of spirits,” Dr Vladimir Pozniak, WHO’s head of alcohol, drugs and addictive behaviours, told a media briefing this week. Of all deaths attributable to alcohol in 2019, an estimated 1.6 million deaths were from non-communicable diseases (NCDs), including 474,000 deaths from cardiovascular diseases and 401,000 from cancer. Some 724 000 deaths were due to injuries, such as those from traffic crashes, self-harm and interpersonal violence. Another 284 000 deaths were linked to communicable diseases. For example, alcohol consumption has been shown to increase the risk of HIV/AIDS as people are more likely to have unprotected sex, and increase tuberculosis and lower respiratory infections by suppressing a wide range of immune responses. The highest proportion (13%) of alcohol-attributable deaths in 2019 were young people aged 20-39 years. Globally, almost a quarter (23.5%) of all 15 to 19 year olds were current drinkers, with the highest rates in the European region (45.9%) followed by the Americas (43.9%). Pozniak stressed that “there is no risk free levels of alcohol consumption”. “The WHO has not produced guidelines [on safe alcohol consumption] because the diversity of countries, the diversity of populations, their exposure to alcohol, are so different, that to come up with universal levels of risks would be an unmanageable task,” said Pozniak. “It’s advisable to consult with a health professionals on the risks associated with level or pattern of consumption, taking into consideration the individual characteristics of a person [such as] pre-existing disorders or current health conditions because the risks varies substantially, depending on all these factors.” Lack of treatment options The total alcohol per capita consumption decreased slightly from 5.7 litres in 2010 to 5.5 litres in 2019. But the world is far from reaching the Sustainable Development Goal (SDG) target 3.5 by 2030 of reducing alcohol and drug consumption and improving access to quality treatment for substance use disorders. Although effective treatment options for substance use disorders exists, treatment coverage is incredibly low. The proportion of people in contact with substance use treatment services ranged from less than 1% to a maximum of 35% in 2019. This was even lower for alcohol-related treatment, with up to 14% of people who needed it, accessing treatment. “Most of the 145 countries that reported data did not have a specific budget line or data on governmental expenditures for treatment of substance use disorders. Although mutual help and peer support groups are useful resources for people with substance use disorders, almost half of responding countries reported that they do not offer such support groups for substance use disorders,” according to the WHO. “Stigma, discrimination and misconceptions about the efficacy of treatment contribute to these critical gaps in treatment provision, as well as the continued low prioritisation of substance use disorders by health and development agencies.” A significant number of countries reported interference from the alcohol industry in their efforts to develop effective alcohol policies, according to the report. Industry interference was highest in countries that were effectively increasing the price of alcohol. “Industry interference was most frequently reported in the African Region (62.1%). However, across all income groups, between 42% and 50% of countries pointed to this interference as a barrier to move forward,” it notes. Actions for progress To accelerate progress towards achievement of SDG target 3.5 and reduce the health and social burden attributable to substance use, the WHO recommends action in eight areas. These include increased awareness through a coordinated global advocacy campaign, and the re-commitment to implement the Global Alcohol Action Plan 2022-2030 with a focus on the SAFER package. It also calls for increased capacity of health and social care systems to deal with substance abuse, more training of health professionals, better monitoring and research and more engagement with civil society organisations, professional associations and people with lived experience. Image Credits: Stanislav Ivanitskiy/ Unsplash. Health and Finance Leaders Call for Strengthened Primary Health Care to Tackle NCDs and Mental Health 25/06/2024 Sophia Samantaroy Breast cancer is among the many non-communicable diseases growing in lower-and-middle-income countries, where funding for prevention is often diverted to other health concerns. When Felicia Knaul met Tonya Rosa, a Mexican woman undergoing chemotherapy for breast cancer, “she was there with a big smile on her face…even though her cancer had recurred.” But Rosa told Knaul that her first round of treatment had impoverished her family, “they had to sell their business, their home, their assets to be able to pay for her care.” But now, she had a card that gives her access to Mexico’s public insurance to cover her treatments. Rosa’s story was one of many shared at a two-day international financing dialogue for NCDs and mental health hosted by the World Health Organization (WHO) and the World Bank in Washington, DC. The meeting convened as part of the preparation for the United Nations High-Level on these issues in 2025. For Knaul, a global health economist, cancer researcher and advocate, providing care for NCDs and mental health patients requires “a health system that could deal with the whole gamut of issues that go through, from primary prevention all the way through to end-of-life care.” Representatives from over 30 countries reiterated this call for strengthened, affordable health coverage as the means to address NCDs and bolster mental health. Adriana Alfonso, Director of Health Surveillance with Uruguay’s Ministry of Health, credits the country’s recent mental health successes to its decree in making psychiatric care obligatory in an affordable and universal manner at health centers. These interventions were only possible through concerted government cooperation and willpower. Primary care financing as a sustainable solution Health and finance leaders from over 30 countries met to discuss a path forward to sustainable NCDs and mental health financing. “In the past, when we prepared annual budgets, we didn’t really take into account the mental health issues. In the case of Uruguay, we have a yearly budget that is discussed at the parliament level, and we needed to make sure that we had a mental health budget that was sustainable,” Alfonso noted. Providing dedicated funds for mental health has translated into co-payment reductions and increases in beds in mental health facilities and halfway homes. Lester Tan, director of Health Policy, Development, and Planning at the Department of Health in the Philippines, echoed this sentiment in describing the economics of mental health in the Philippines. In 2021, mental health conditions cost the Philippine economy an estimated $1.37 billion dollars, equivalent to 0.4% of GDP. Yet, investing in more treatment of epilepsy and depression would have an incredibly high return on investment – 6.6 and 5.3 times respectively. “This evidence, together with the implementation of a mental health law passed in 2018 have contributed to the scaling up of mental health services in the country. There are now 362 mental health access sites nationwide, which have served 124,000 users in 2022,” said Tan. These mental health successes hinge on expanded financing of primary health care, the “how” of NCDs and mental health care, as a panelist noted. Tan notes that the Philippines benefitted from expanding the number of health professionals trained in mental health at the primary care level. “This capacity building prioritized depression, epilepsy, self harm and psychosis.” A multi-sectoral approach to overcome ‘fragmentation’ Increased primary health care investment has the potential to reduce the global burden of NCDs through prevention, treatment, and care. Other panelists noted the urgency for multisectoral approaches to financing NCDs and mental health care – working across government institutions and ministries. An NCD expert from the Tunisia Ministry of Health, noted that her ministry recruited the help of the Ministry of Youth, Sport, and Heritage to organize a national day of exercise. “During this National Day, everybody was invited to exercise, and we talked about the importance of physical activity. The Ministry of Health decided to do screenings for hypertension and diabetes on this day, and we, of course, had a very large media campaign and awareness raising campaign in the entirety of the country,” she said. Beyond the more straightforward partnerships between adjacent ministries, the health sector must work more closely with ministries of finance, noted Aleksandra Altievska, head of fund budgets at North Macedonia’s Ministry of Finance. “I recommend that every Ministry of Health always keep in mind that the Minister of Finance has other priorities.” Working with ministries of finance to fund NCDs and mental health interventions is critical because, as Joanna Ralston of the World Obesity Federation explained, NCDs are challenges that “can’t be targeted by one sector.” “We have a global health system that really was built around single vector diseases, just to oversimplify, and yet, now we’re coming in with something that has these commercial elements, [environmental] elements, all these factors, this great level of complexity that that has to be respected,” Ralston said. Obesity, as just one example, continues to impact nations across all age levels, because of the fragmentation of the response, said Ralston. “The increase of obesity is around 100% in the past couple of years, when the goal was a 0% increase.” Fragmented, under-resourced responses undermine progress on NCDs and mental health – something that advocates hope can be overcome by renewed multi-sectorial frameworks and partnerships. Leveraging patient experiences Several panelists shared their own experiences living with an NCD at the Washington, D.C conference. Knaul, who founded the Mexico-based breast cancer advocacy organization Cancer de mama: Tomatelo a Pecho, notes that the numbers alone won’t sway policymakers – bringing in patient narratives is paramount to the future of non-communicable disease prevention, treatment, and care. “Health systems repeatedly fail patients with cancer and other NCDs,” she said. Engaging people with lived experiences of NCDs or mental health challenges bolsters local and international support, argued Charity Muturi, an NCDs and mental health policy advocate in Kenya. “When a national task force on mental health was formed, we felt that, as patients, our voices needed to be on the table,” said Muturi, who discussed her own challenges navigating mental health care in Kenya. Ralston summed up the struggle with communicating the burden of NCDs and mental health. “Evidence and narrative are what are needed to be successful. We need to be rooted in evidence, but we need to have a way of communicating that story to decision makers, policy makers, and the wider public. And that has been a challenge with NCDs.” Image Credits: Roche, WHO. Scientists in West Africa Tackle Malaria and Schistosomiasis 25/06/2024 Zsofia Hesketh Dr Mamy Andrianirina Rakotondratsara (centre) distributing antimalarials in rural Madagascar. Malaria has long been at the heart of public health efforts in Africa. As a preventable but potentially fatal disease, it is caused by a parasite transmitted by mosquitoes. In 2022, the WHO African Region accounted for about 94% of cases globally. WHO says 78% of deaths in the region are among children under 5 years of age. That’s why Dr Mamy Andrianirina Rakotondratsara, a medical doctor and research technician for Madagascar’s National Institute of Public and Community Health (INSPC), wanted to dedicate his TDR-supported studies for a Masters in Public Health to malaria research. Originally from an endemic region in eastern Madagascar, Rakotondratsara has been personally affected by malaria as he lost his older brother to the disease. “I lost someone close and beloved to me from this disease,” he told Health Policy Watch in an interview. That reinforced his determination to address the disease in the course of his studies. Dr Mamy Andrianirina Rakotondratsara lost his brother to malaria and is passionate about addressing the disease. In 2021, during the course of his Masters studies at the Cheikh Anta Diop University of Dakar (UCAD), Rakotondratsara also completed TDR’s Massive Open Online Course (MOOC) on implementation research. As part of this course, he designed a study around the relationship between the frequency of malaria episodes and mosquito bed net coverage, working with other researchers and doctors that specialize in malaria. This research is still ongoing and specifically targets the rural population of Madagascar’s Anosibe An’Ala district. Although results are still pending, designing such a study has laid the foundations for Rakotondratsara to put the research findings into practice in his home region and disease context, complementing his prior work on malnutrition. Sub-regional training centre for Francophone Africa Students engaged in a field training in participatory epidemiology organised by the National Institute of Public and Community Health Madagascar. Rakotondratsara was able to undertake this research thanks to TDR’s global postgraduate training scheme – which focuses on building students’ skills to do interdisciplinary forms of research that look at barriers and opportunities for better uptake of available preventative and treatment methods. For physicians, researchers and other professionals interested in local public health, the fellowships supported by TDR – the global research programme on diseases of poverty co-sponsored by UNICEF, UNDP, WHO and the World Bank – provides essential skills for health programme management and implementation. It is particularly important for addressing infectious diseases affecting vulnerable and underserved populations and promoting engagement in research from the local to global levels. UCAD is one of the two universities in French-speaking West Africa to collaborate with TDR in the programme. It has been hosting students since 2021, to conduct research into how to control infectious diseases found across the region. In 2022, University of Sciences, Techniques and Technologies in Bamako, Mali, joined the programme with the support of Germany’s Deutsche Gesellschaft für Technische Zusammenarbeit. “The TDR training allowed us to have a new vision of the health system,” Rakotondratsara observes. It changed my way of asking questions when faced with poor health indicators. Regarding my Master’s thesis, it gave me an idea of issues to be explored in the mosquito net distribution process, starting with the quantification of needs to end point use.” He strives to integrate such lessons learnt into his current role with the INSPC. And he is also planning to pursue a PhD with a specialization in implementation research. “The INSPC is a public health training and research institution attached to the Ministry of Public Health,” he explains. “Given that it is a research institution, in collaboration with funding bodies, we are often called upon to carry out expert appraisals on their behalf. As a research technician, I accompany this research and bring my contributions to it,” he says. “Based on my experience, it’s my intention to ensure that implementation research finds an important place both in the research and the teaching context.” Towards better management of Schistosomiasis Although less well known, schistosomiasis, also known as bilharzia, is the second most prevalent disease after malaria both in Senegal and much of the rest of sub-Saharan Africa. Its most common form – urogenital schistosomiasis – can result in damage to the bladder, urethra, and kidneys. It is a parasitic disease that occurs in tropical and subtropical regions where there is limited access to clean water, particularly in the Senegal River Basin, a hyper-endemic region for several species of the parasite that causes the disease. The different variants of the disease are classified by WHO according to the NTD principles for which a greater global response is needed, making it an important research target in the TDR program. Oumy Kaltome Boh, a physician originally from Dakar, has been interested in the burden of NTDs in Senegal since her formative years, and hopes to see their eradication by 2030. Dr Oumy Kaltome Boh “Faced with the impact of these diseases on the health of the population,” she says, her main objective is to contribute to their management “through the implementation of innovative interventions.” This is what led Boh to undertake a Masters degree in management of health programmes at UCAD, as well as an International Inter-University Diploma in emerging infections. Benefiting from a TDR grant in December 2020, Boh was able to conduct a study examining the day-to-day lifestyle practices and environmental factors that make schistosomiasis transmission more likely in endemic areas of her home country. As part of this study, done in collaboration with Senegal’s national bilharziasis programme, she also aimed to verify the effectiveness of schistosomiasis treatment with praziquantel, the only available treatment option currently. A total of 287 children were followed over the course of three weeks, with ‘Day Zero’ representing the date of administration of a single praziquantel dose. Between days 14 and 21, both the effects of the drug on disease progression were assessed and a favourable efficacy profile was found, with a 98% reduction in parasite eggs by day 21. Today, Boh holds the position of deputy chief medical officer in the health district of Saint-Louis, Senegal, and is mainly involved in care and prevention activities for people living with HIV or tuberculosis. Recruited into this position by the Ministry of Health, she stresses that it was through the support of the TDR postgraduate training scheme that she acquired the skills she needed to manage the public health challenges in this district. In particular, learning about community-based approaches allowed her to better “understand the specific needs and problems” of the districts. New research and management approaches As a key aspect of disease control, students supported by TDR can learn to apply new health research and management approaches previously unknown in Senegal, Boh says. Among these is the One Health approach, which aims to assess how diseases emerge from a holistic and ecosystem-oriented perspective, taking into account the reciprocal role of humans, animals, plants, and microorganisms such as the aforementioned pests. By combining scientific, strategic, and rigorous implementation training, the TDR grants offered through UCAD enable their recipients to evaluate and propose improvements to health interventions against poverty-related infectious diseases. These opportunities are game-changers for both UCAD students and the future of implementation research in French-speaking Africa. With the help of TDR grants, Boh emphasises, students can gain exposure to critical health programmes and “pool their skills in order to end the neglect of poverty-related diseases and to achieve the Sustainable Development Goals.” This is the second article in a series on TDR’s research capacity strengthening programme – building skills of public health researchers, implementers, health practitioners and policy-makers in the fast-developing field of implementation research for improving uptake of effective health interventions. Gilead Urged to Prioritise Access as Injection Trial Proves 100% Successful in Preventing HIV 24/06/2024 Kerry Cullinan None of the over 2,000 young women and girls injected twice a year with a new drug, lenacapavir, contracted HIV in one of the most important advances in HIV prevention. Gilead Sciences announced these results last Friday, reporting that its Phase 3 PURPOSE 1 trial, conducted in South Africa and Uganda involving 2,134 women and girls aged 16-25, had been so successful that it was terminating early. Its announcement has been widely hailed as a huge breakthrough in the HIV sector where a vaccine has been elusive, and a range of groups urged Gilead to priorise early access to lenacapavir. The injectable was compared with Truvada and Descovy, two pills taken daily that have proven successful as pre-exposure HIV prophylaxis (PrEP). Sixteen of the 1,068 women in the Truvada group and 39 of the 2,136 women in the Descovy group contracted HIV during the trial. During a scheduled review of results, the trial’s independent data and safety monitoring board (DSMB) found the lenacapavir regimen was safe and highly effective. The trial, expected to run until September, was terminated early based on its success. Results of the trial have not been peer-reviewed yet. The age group targeted by the trial is the worst affected by HIV in southern Africa. In 2022, over three-quarters of infections in 15 to 24-year-olds in the region were girls and women, according to UNAIDS. “Every week, 4,000 adolescent girls and young women aged 15–24 years became infected with HIV globally in 2022, and 3,100 of these infections occurred in sub-Saharan Africa,” added UNAIDS. One of the ‘most important results’ “This is one of the most important results we’ve seen to date in an HIV prevention study,” said Mitchell Warren, executive director of AVAC, a non-profit HIV prevention advocacy organisation. “Adding additional HIV prevention options means more people may find an option that is right for them. Beyond expanded choice, a twice-yearly injection has the potential to transform the way we deliver HIV prevention to people who need and want it most – from an easier-to-follow regimen for individuals to a decreased burden on healthcare systems that are stretched to the limit.” Professor Linda-Gail Bekker, director of the Desmond Tutu HIV Centre in South Africa, said that the twice-a-year injectable could provide a “critical new choice” to prevent HIV. “While we know traditional HIV prevention options are highly effective when taken as prescribed, twice-yearly lenacapavir for PrEP could help address the stigma and discrimination some people may face when taking or storing oral PrEP pills, as well as potentially help increase PrEP adherence and persistence given its twice-yearly dosing schedule,” added Bekker. Gilead expects results by early 2025 from the programme’s other trial, PURPOSE 2, which is assessing twice-yearly lenacapavir for PrEP in men who have sex with men, transgender and non-binary people, currently underway in Argentina, Brazil, Mexico, Peru, South Africa, Thailand and the US. Access to lenacapavir, marketed as Sunlenca in the US, still needs to be worked out once it is approved by regulatory authorities. Cost of access? Lenacapavir (marketed as Sunlenca) was approved in the US in 2022 for “heavily treatment-experienced adults with multi-drug resistant HIV-1 infection and for treatment of people living with HIV who have been on other HIV treatment regimes which are currently failing”. However, Gilead charges $40,000 per patient per year in the US, reports aidsmap. When announcing the PURPOSE 2 results, Gilead acknowledged the “importance of helping to enable access in order for twice-yearly lenacapavir for PrEP, if approved by regulatory authorities, to achieve the broadest impact”. “In light of today’s milestone and the company’s ongoing commitment to communities affected by HIV, Gilead intends to brief community partners and provide a public statement regarding its planned access approach for high-incidence, resource-limited countries, which are primarily low- and lower-middle-income countries,” said the company. Gilead’s statement was welcomed by African HIV medicines access group AfroCAB in an open letter to its CEO, Daniel O’Day. “Replacing 365 pills of oral PrEP with just two injections is a life-changing transition and urgently needed option, as millions of our brothers and sisters, friends, and neighbours face challenges of stigma, pill burden, and adherence, leaving them unprotected against HIV acquisition,” said AfroCAB. “To forge a new pathway forward for [lenacapavir], we call on stakeholders to act now. After thousands of our community members have taken part in clinical trials for LEN and other injectable PrEP products, it is time that pharmaceutical companies, governments, and donors play their part in driving access among the communities that supported the science.” “We expect to see a timeline that takes into account a full analysis of PURPOSE 1 data and the coming data from PURPOSE 2 from Gilead as soon as possible, and we urge regulatory agencies to prepare to fast track regulatory review,” Warren added. “We also call on [the World Health Organization] to be prepared to quickly include lenacapavir, if approved by regulatory agencies, in HIV prevention guidelines. There is no time to waste if we are to translate these exciting clinical trial results into actual public health impact and expand the toolbox of HIV prevention choices.” Meanwhile, Unitaid urged Gilead to make access to lenacapavir a priority, calling for “the terms of their access strategies – including any voluntary licensing agreements – [to be] transparent, global health-oriented, and equitable”. “Lack of prompt and broad action would jeopardise translating the clinical trial results into real-life impact,” said Unitaid, which offered to work with Gilead to enable access, including “quality-assured, low-cost generics”. “Unitaid is dedicated to leveraging its recent investment through the Wits Reproductive Health and HIV Institute to facilitate market shaping interventions on long-acting PrEP options (in partnership with the Clinton Health Access Initiative), as well as its continued support to enabling elements such as the key work of WHO and the WHO Prequalification program, the Medicines Patent Pool and other intellectual property grants, to ensure access to this life-saving product is as broad as possible,” the organisation said in a statement last week. Image Credits: Gilead, Diana Polekhina/ Unsplash. Gavi Includes Ebola, Meningitis, Rabies and Hepatitis B Vaccines in its Portfolio 24/06/2024 Zuzanna Stawiska A member of the ring vaccination team vaccinates a man in Bosolo village. Vaccines offered as part of Gavi’s portfolio now also include preventive Ebola vaccines for care workers. Gavi, the Vaccine Alliance, announced last week that it will offer high risk countries the option of obtaining preventative Ebola vaccines, particularly for health workers, as part of the rollout of new vaccine offerings, which also include meningitis, rabies and hepatitis B vaccines. Plans to add the vaccines to the basket of available products were initially drawn up before the COVID-19 pandemic, but put on hold due to lack of appropriate supply or regulations, with applications opening only now to eligible countries. “Gavi’s ability as an alliance to protect health and save lives hinges on its ability to ensure vaccines are accessible, as quickly as possible, to those who need them the most,” said Gavi CEO Dr Sania Nishtar. “The new programmes launching today demonstrate the impact of this work.” Ebola is a rare but dangerous viral disease, with a 50-60% mortality rate. Infections may be transmitted through close contact with infected animals – for instance, fruit bats – but also through human-to-human contact. Gavi first offered Ebola vaccine candidates to health workers and suspected Ebola contacts during the 2014-2016 West Africa outbreak as an outbreak response. Two vaccines subsequently received regulatory approval and in May 2024 WHO’s Strategic Advisory Group of Experts on Immunisation (SAGE) decided to recommend the vaccines for preventive use, as well, in high-risk groups, such as health care providers in areas of endemic transmission. Meningitis vaccine rollout aims for elimination Gavi will also roll out a newly-approved vaccine for five strains of meningitis: meningococcal serogroups A, C, W, Y, and X. Central and Western African countries most prone to meningitis infections in the so-called “meningitis belt” The vaccine is a likely game-changer in the fight against the disease, experts say, noting that in the so-called “meningitis belt” of sub-Saharan African countries, the bacterial form of the diseases, regarded as the most dangerous, could potentially be eliminated. The product, MenFive, received WHO pre-qualification in July 2023 and has already been implemented in standard childhood immunisation programmes in Nigeria and Niger. In 2019, there were about 236,000 meningitis deaths, with the greatest burden in children younger than five years, with 112,000 deaths. Hepatitis B and rabies post-exposure jabs Other new vaccines include hepatitis B vaccines for newborns, granting infants critical additional protection in their first months of life, when they are at high risk of infection: including from maternal transmission. According to Gavi, nine out of ten infants infected with hepatitis B will develop chronic forms of the disease, while a quarter develop severe liver disease, which currently kills 884,000 people a year. Human rabies post exposure prophylaxis (PEP) vaccines are the last of the new package. The initiative aims to build more stockpiles of the rabies vaccine, which are often scarce and inaccessible, especially in remote areas, for post-exposure use. Rabies, which has an almost 100% mortality rate, remains a serious health problem in some 150 countries, where it is transmitted by infected dogs. But vaccines alone are not enough to stop the disease, experts underlined. “To stop human rabies deaths completely, we urgently need better data and surveillance, dog populations must be vaccinated, and people must be educated about what to do if bitten, and how to avoid being bitten in the first place,” said Professor Lucille Blumberg, Chair of United Against Rabies, pointing out to several blind spots of the human immunisation programme. Image Credits: WHO/L. Mackenzie , CDC. What Role Does Capacity Development Play in Transforming Health Research? 22/06/2024 Maayan Hoffman The latest episode of the Global Health Matters podcast, hosted by Dr Garry Aslanyan, delves into the extraordinary careers of two global health leaders and the crucial role that capacity development has played in their journeys. This episode, produced to celebrate the 50th anniversary of TDR, the Special Programme for Research and Training in Tropical Diseases, features insights from Dr Wilfried Mutombo, Head of Clinical Operations at the Drugs for Neglected Diseases Initiative (DNDi) in the Democratic Republic of the Congo, and Dr Yasmine Belkaid, President of the Institut Pasteur in France. Both leaders share their experiences and the impact of TDR’s support on their professional growth. Dr John Reeder, the Director of TDR, reflects on the importance of capacity development in fostering the potential of researchers in low- and middle-income countries. Reeder highlights his transition from hands-on research to global leadership, emphasising the value of putting research into action and nurturing talent at the grassroots level. He underscores that effective capacity development goes beyond providing resources; it involves empowering individuals to fulfil their potential and significantly contribute to their fields. To mark the 50th anniversary of @TDRnews, this episode of #GlobalHealthMatters features TDR Director John Reeder. Together, @GarryAslanyan and John discuss the challenges and future frontiers of capacity development. Listen to the episode here👉 https://t.co/K26H7vQV69#TDR50 pic.twitter.com/srEZeWErH9 — TDR (@TDRnews) June 18, 2024 “When you’re looking at science and laboratory science particularly, people get fixated on the expensive equipment and the fancy technology that surrounds this,” Reeder says. “But the most important investment in a laboratory is the scientist who is in that laboratory because, all other things aside, the ability to see the problem, think of innovative solutions to test them critically and to have the open mind to be able to see the discovery coming through that, you invest in that, and you’ve got great science.” From left: Dr John Reeder, the Director of TDR; Dr Yasmine Belkaid, President of the Institut Pasteur in France; and Dr Wilfried Mutombo, Head of Clinical Operations at the Drugs for Neglected Diseases Initiative (DNDi) in the Democratic Republic of the Congo Clinical Trials in Remote Areas: Three Challenges Mutombo’s story is a testament to the transformative power of research capacity development. Starting as a medical doctor in a small village in the DRC, Mutombo faced the challenge of treating sleeping sickness with toxic drugs. His clinical research fellowship from TDR enabled him to lead the first clinical trial in the DRC for fexinidazole, a safer oral drug for sleeping sickness. He discusses the immense challenges of conducting high-quality clinical trials in remote areas with inadequate infrastructure and highlights the importance of sustained support and training for local health workers. “The first challenge is to reach those areas because to perform a clinical trial, you need to go there in those areas, in those remote areas, and as you may know, we have bad roads, and sometimes this is not very safe,” Mutombo says. “The second challenge is, when you are in those areas, you can imagine in what state those health facilities are… So we had to improve these health facilities.” Another challenge, he says, is the health workers. “Health workers are there, but they are not aware of what a clinical trial is,” according to Mutombo. “To have a high-quality clinical trial, they needed to train them and have a very, very close supervision of their activities. So we organised all this.” Finally, “We need our governments … to give more support and more money to maintain those facilities. This is very important for the government because the first and very important step has been done, but now we need to maintain them at that level.” Building Research Capacity: Support is Crucial In many ways, Belkaid’s journey from Algeria to leading the Institut Pasteur in France exemplifies the global impact of TDR’s fellowships. She speaks about the crucial support she received, which allowed her to pursue her PhD and establish a notable research career. Belkaid emphasises creating environments that nurture talent and passion, enabling researchers to address pressing global health issues. Her vision as President of Institut Pasteur includes fostering international collaboration and continuing to build research capacities that can address future health challenges. Belkaid says if there is anything she can do over the next few years, it will hopefully be helping in any way she can to grow and nurture the leaders of tomorrow internationally. The episode underscores the ongoing need for international organisations like TDR and WHO to prioritise capacity building in low- and middle-income countries. Reeder points out the shift towards in-country training and the importance of sustainable research systems driven by local needs and priorities. He says this approach helps ensure research capacity development and is not just about immediate results but about long-term, sustainable growth that empowers countries to tackle their health challenges effectively. Read related Inside View by Dr John Reeder. Listen to the Global Health Matters podcast on Health Policy Watch. Visit the podcast website. Image Credits: TDR. Posts navigation Older postsNewer posts This site uses cookies to help give you the best experience on our website. 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Health and Finance Leaders Call for Strengthened Primary Health Care to Tackle NCDs and Mental Health 25/06/2024 Sophia Samantaroy Breast cancer is among the many non-communicable diseases growing in lower-and-middle-income countries, where funding for prevention is often diverted to other health concerns. When Felicia Knaul met Tonya Rosa, a Mexican woman undergoing chemotherapy for breast cancer, “she was there with a big smile on her face…even though her cancer had recurred.” But Rosa told Knaul that her first round of treatment had impoverished her family, “they had to sell their business, their home, their assets to be able to pay for her care.” But now, she had a card that gives her access to Mexico’s public insurance to cover her treatments. Rosa’s story was one of many shared at a two-day international financing dialogue for NCDs and mental health hosted by the World Health Organization (WHO) and the World Bank in Washington, DC. The meeting convened as part of the preparation for the United Nations High-Level on these issues in 2025. For Knaul, a global health economist, cancer researcher and advocate, providing care for NCDs and mental health patients requires “a health system that could deal with the whole gamut of issues that go through, from primary prevention all the way through to end-of-life care.” Representatives from over 30 countries reiterated this call for strengthened, affordable health coverage as the means to address NCDs and bolster mental health. Adriana Alfonso, Director of Health Surveillance with Uruguay’s Ministry of Health, credits the country’s recent mental health successes to its decree in making psychiatric care obligatory in an affordable and universal manner at health centers. These interventions were only possible through concerted government cooperation and willpower. Primary care financing as a sustainable solution Health and finance leaders from over 30 countries met to discuss a path forward to sustainable NCDs and mental health financing. “In the past, when we prepared annual budgets, we didn’t really take into account the mental health issues. In the case of Uruguay, we have a yearly budget that is discussed at the parliament level, and we needed to make sure that we had a mental health budget that was sustainable,” Alfonso noted. Providing dedicated funds for mental health has translated into co-payment reductions and increases in beds in mental health facilities and halfway homes. Lester Tan, director of Health Policy, Development, and Planning at the Department of Health in the Philippines, echoed this sentiment in describing the economics of mental health in the Philippines. In 2021, mental health conditions cost the Philippine economy an estimated $1.37 billion dollars, equivalent to 0.4% of GDP. Yet, investing in more treatment of epilepsy and depression would have an incredibly high return on investment – 6.6 and 5.3 times respectively. “This evidence, together with the implementation of a mental health law passed in 2018 have contributed to the scaling up of mental health services in the country. There are now 362 mental health access sites nationwide, which have served 124,000 users in 2022,” said Tan. These mental health successes hinge on expanded financing of primary health care, the “how” of NCDs and mental health care, as a panelist noted. Tan notes that the Philippines benefitted from expanding the number of health professionals trained in mental health at the primary care level. “This capacity building prioritized depression, epilepsy, self harm and psychosis.” A multi-sectoral approach to overcome ‘fragmentation’ Increased primary health care investment has the potential to reduce the global burden of NCDs through prevention, treatment, and care. Other panelists noted the urgency for multisectoral approaches to financing NCDs and mental health care – working across government institutions and ministries. An NCD expert from the Tunisia Ministry of Health, noted that her ministry recruited the help of the Ministry of Youth, Sport, and Heritage to organize a national day of exercise. “During this National Day, everybody was invited to exercise, and we talked about the importance of physical activity. The Ministry of Health decided to do screenings for hypertension and diabetes on this day, and we, of course, had a very large media campaign and awareness raising campaign in the entirety of the country,” she said. Beyond the more straightforward partnerships between adjacent ministries, the health sector must work more closely with ministries of finance, noted Aleksandra Altievska, head of fund budgets at North Macedonia’s Ministry of Finance. “I recommend that every Ministry of Health always keep in mind that the Minister of Finance has other priorities.” Working with ministries of finance to fund NCDs and mental health interventions is critical because, as Joanna Ralston of the World Obesity Federation explained, NCDs are challenges that “can’t be targeted by one sector.” “We have a global health system that really was built around single vector diseases, just to oversimplify, and yet, now we’re coming in with something that has these commercial elements, [environmental] elements, all these factors, this great level of complexity that that has to be respected,” Ralston said. Obesity, as just one example, continues to impact nations across all age levels, because of the fragmentation of the response, said Ralston. “The increase of obesity is around 100% in the past couple of years, when the goal was a 0% increase.” Fragmented, under-resourced responses undermine progress on NCDs and mental health – something that advocates hope can be overcome by renewed multi-sectorial frameworks and partnerships. Leveraging patient experiences Several panelists shared their own experiences living with an NCD at the Washington, D.C conference. Knaul, who founded the Mexico-based breast cancer advocacy organization Cancer de mama: Tomatelo a Pecho, notes that the numbers alone won’t sway policymakers – bringing in patient narratives is paramount to the future of non-communicable disease prevention, treatment, and care. “Health systems repeatedly fail patients with cancer and other NCDs,” she said. Engaging people with lived experiences of NCDs or mental health challenges bolsters local and international support, argued Charity Muturi, an NCDs and mental health policy advocate in Kenya. “When a national task force on mental health was formed, we felt that, as patients, our voices needed to be on the table,” said Muturi, who discussed her own challenges navigating mental health care in Kenya. Ralston summed up the struggle with communicating the burden of NCDs and mental health. “Evidence and narrative are what are needed to be successful. We need to be rooted in evidence, but we need to have a way of communicating that story to decision makers, policy makers, and the wider public. And that has been a challenge with NCDs.” Image Credits: Roche, WHO. Scientists in West Africa Tackle Malaria and Schistosomiasis 25/06/2024 Zsofia Hesketh Dr Mamy Andrianirina Rakotondratsara (centre) distributing antimalarials in rural Madagascar. Malaria has long been at the heart of public health efforts in Africa. As a preventable but potentially fatal disease, it is caused by a parasite transmitted by mosquitoes. In 2022, the WHO African Region accounted for about 94% of cases globally. WHO says 78% of deaths in the region are among children under 5 years of age. That’s why Dr Mamy Andrianirina Rakotondratsara, a medical doctor and research technician for Madagascar’s National Institute of Public and Community Health (INSPC), wanted to dedicate his TDR-supported studies for a Masters in Public Health to malaria research. Originally from an endemic region in eastern Madagascar, Rakotondratsara has been personally affected by malaria as he lost his older brother to the disease. “I lost someone close and beloved to me from this disease,” he told Health Policy Watch in an interview. That reinforced his determination to address the disease in the course of his studies. Dr Mamy Andrianirina Rakotondratsara lost his brother to malaria and is passionate about addressing the disease. In 2021, during the course of his Masters studies at the Cheikh Anta Diop University of Dakar (UCAD), Rakotondratsara also completed TDR’s Massive Open Online Course (MOOC) on implementation research. As part of this course, he designed a study around the relationship between the frequency of malaria episodes and mosquito bed net coverage, working with other researchers and doctors that specialize in malaria. This research is still ongoing and specifically targets the rural population of Madagascar’s Anosibe An’Ala district. Although results are still pending, designing such a study has laid the foundations for Rakotondratsara to put the research findings into practice in his home region and disease context, complementing his prior work on malnutrition. Sub-regional training centre for Francophone Africa Students engaged in a field training in participatory epidemiology organised by the National Institute of Public and Community Health Madagascar. Rakotondratsara was able to undertake this research thanks to TDR’s global postgraduate training scheme – which focuses on building students’ skills to do interdisciplinary forms of research that look at barriers and opportunities for better uptake of available preventative and treatment methods. For physicians, researchers and other professionals interested in local public health, the fellowships supported by TDR – the global research programme on diseases of poverty co-sponsored by UNICEF, UNDP, WHO and the World Bank – provides essential skills for health programme management and implementation. It is particularly important for addressing infectious diseases affecting vulnerable and underserved populations and promoting engagement in research from the local to global levels. UCAD is one of the two universities in French-speaking West Africa to collaborate with TDR in the programme. It has been hosting students since 2021, to conduct research into how to control infectious diseases found across the region. In 2022, University of Sciences, Techniques and Technologies in Bamako, Mali, joined the programme with the support of Germany’s Deutsche Gesellschaft für Technische Zusammenarbeit. “The TDR training allowed us to have a new vision of the health system,” Rakotondratsara observes. It changed my way of asking questions when faced with poor health indicators. Regarding my Master’s thesis, it gave me an idea of issues to be explored in the mosquito net distribution process, starting with the quantification of needs to end point use.” He strives to integrate such lessons learnt into his current role with the INSPC. And he is also planning to pursue a PhD with a specialization in implementation research. “The INSPC is a public health training and research institution attached to the Ministry of Public Health,” he explains. “Given that it is a research institution, in collaboration with funding bodies, we are often called upon to carry out expert appraisals on their behalf. As a research technician, I accompany this research and bring my contributions to it,” he says. “Based on my experience, it’s my intention to ensure that implementation research finds an important place both in the research and the teaching context.” Towards better management of Schistosomiasis Although less well known, schistosomiasis, also known as bilharzia, is the second most prevalent disease after malaria both in Senegal and much of the rest of sub-Saharan Africa. Its most common form – urogenital schistosomiasis – can result in damage to the bladder, urethra, and kidneys. It is a parasitic disease that occurs in tropical and subtropical regions where there is limited access to clean water, particularly in the Senegal River Basin, a hyper-endemic region for several species of the parasite that causes the disease. The different variants of the disease are classified by WHO according to the NTD principles for which a greater global response is needed, making it an important research target in the TDR program. Oumy Kaltome Boh, a physician originally from Dakar, has been interested in the burden of NTDs in Senegal since her formative years, and hopes to see their eradication by 2030. Dr Oumy Kaltome Boh “Faced with the impact of these diseases on the health of the population,” she says, her main objective is to contribute to their management “through the implementation of innovative interventions.” This is what led Boh to undertake a Masters degree in management of health programmes at UCAD, as well as an International Inter-University Diploma in emerging infections. Benefiting from a TDR grant in December 2020, Boh was able to conduct a study examining the day-to-day lifestyle practices and environmental factors that make schistosomiasis transmission more likely in endemic areas of her home country. As part of this study, done in collaboration with Senegal’s national bilharziasis programme, she also aimed to verify the effectiveness of schistosomiasis treatment with praziquantel, the only available treatment option currently. A total of 287 children were followed over the course of three weeks, with ‘Day Zero’ representing the date of administration of a single praziquantel dose. Between days 14 and 21, both the effects of the drug on disease progression were assessed and a favourable efficacy profile was found, with a 98% reduction in parasite eggs by day 21. Today, Boh holds the position of deputy chief medical officer in the health district of Saint-Louis, Senegal, and is mainly involved in care and prevention activities for people living with HIV or tuberculosis. Recruited into this position by the Ministry of Health, she stresses that it was through the support of the TDR postgraduate training scheme that she acquired the skills she needed to manage the public health challenges in this district. In particular, learning about community-based approaches allowed her to better “understand the specific needs and problems” of the districts. New research and management approaches As a key aspect of disease control, students supported by TDR can learn to apply new health research and management approaches previously unknown in Senegal, Boh says. Among these is the One Health approach, which aims to assess how diseases emerge from a holistic and ecosystem-oriented perspective, taking into account the reciprocal role of humans, animals, plants, and microorganisms such as the aforementioned pests. By combining scientific, strategic, and rigorous implementation training, the TDR grants offered through UCAD enable their recipients to evaluate and propose improvements to health interventions against poverty-related infectious diseases. These opportunities are game-changers for both UCAD students and the future of implementation research in French-speaking Africa. With the help of TDR grants, Boh emphasises, students can gain exposure to critical health programmes and “pool their skills in order to end the neglect of poverty-related diseases and to achieve the Sustainable Development Goals.” This is the second article in a series on TDR’s research capacity strengthening programme – building skills of public health researchers, implementers, health practitioners and policy-makers in the fast-developing field of implementation research for improving uptake of effective health interventions. Gilead Urged to Prioritise Access as Injection Trial Proves 100% Successful in Preventing HIV 24/06/2024 Kerry Cullinan None of the over 2,000 young women and girls injected twice a year with a new drug, lenacapavir, contracted HIV in one of the most important advances in HIV prevention. Gilead Sciences announced these results last Friday, reporting that its Phase 3 PURPOSE 1 trial, conducted in South Africa and Uganda involving 2,134 women and girls aged 16-25, had been so successful that it was terminating early. Its announcement has been widely hailed as a huge breakthrough in the HIV sector where a vaccine has been elusive, and a range of groups urged Gilead to priorise early access to lenacapavir. The injectable was compared with Truvada and Descovy, two pills taken daily that have proven successful as pre-exposure HIV prophylaxis (PrEP). Sixteen of the 1,068 women in the Truvada group and 39 of the 2,136 women in the Descovy group contracted HIV during the trial. During a scheduled review of results, the trial’s independent data and safety monitoring board (DSMB) found the lenacapavir regimen was safe and highly effective. The trial, expected to run until September, was terminated early based on its success. Results of the trial have not been peer-reviewed yet. The age group targeted by the trial is the worst affected by HIV in southern Africa. In 2022, over three-quarters of infections in 15 to 24-year-olds in the region were girls and women, according to UNAIDS. “Every week, 4,000 adolescent girls and young women aged 15–24 years became infected with HIV globally in 2022, and 3,100 of these infections occurred in sub-Saharan Africa,” added UNAIDS. One of the ‘most important results’ “This is one of the most important results we’ve seen to date in an HIV prevention study,” said Mitchell Warren, executive director of AVAC, a non-profit HIV prevention advocacy organisation. “Adding additional HIV prevention options means more people may find an option that is right for them. Beyond expanded choice, a twice-yearly injection has the potential to transform the way we deliver HIV prevention to people who need and want it most – from an easier-to-follow regimen for individuals to a decreased burden on healthcare systems that are stretched to the limit.” Professor Linda-Gail Bekker, director of the Desmond Tutu HIV Centre in South Africa, said that the twice-a-year injectable could provide a “critical new choice” to prevent HIV. “While we know traditional HIV prevention options are highly effective when taken as prescribed, twice-yearly lenacapavir for PrEP could help address the stigma and discrimination some people may face when taking or storing oral PrEP pills, as well as potentially help increase PrEP adherence and persistence given its twice-yearly dosing schedule,” added Bekker. Gilead expects results by early 2025 from the programme’s other trial, PURPOSE 2, which is assessing twice-yearly lenacapavir for PrEP in men who have sex with men, transgender and non-binary people, currently underway in Argentina, Brazil, Mexico, Peru, South Africa, Thailand and the US. Access to lenacapavir, marketed as Sunlenca in the US, still needs to be worked out once it is approved by regulatory authorities. Cost of access? Lenacapavir (marketed as Sunlenca) was approved in the US in 2022 for “heavily treatment-experienced adults with multi-drug resistant HIV-1 infection and for treatment of people living with HIV who have been on other HIV treatment regimes which are currently failing”. However, Gilead charges $40,000 per patient per year in the US, reports aidsmap. When announcing the PURPOSE 2 results, Gilead acknowledged the “importance of helping to enable access in order for twice-yearly lenacapavir for PrEP, if approved by regulatory authorities, to achieve the broadest impact”. “In light of today’s milestone and the company’s ongoing commitment to communities affected by HIV, Gilead intends to brief community partners and provide a public statement regarding its planned access approach for high-incidence, resource-limited countries, which are primarily low- and lower-middle-income countries,” said the company. Gilead’s statement was welcomed by African HIV medicines access group AfroCAB in an open letter to its CEO, Daniel O’Day. “Replacing 365 pills of oral PrEP with just two injections is a life-changing transition and urgently needed option, as millions of our brothers and sisters, friends, and neighbours face challenges of stigma, pill burden, and adherence, leaving them unprotected against HIV acquisition,” said AfroCAB. “To forge a new pathway forward for [lenacapavir], we call on stakeholders to act now. After thousands of our community members have taken part in clinical trials for LEN and other injectable PrEP products, it is time that pharmaceutical companies, governments, and donors play their part in driving access among the communities that supported the science.” “We expect to see a timeline that takes into account a full analysis of PURPOSE 1 data and the coming data from PURPOSE 2 from Gilead as soon as possible, and we urge regulatory agencies to prepare to fast track regulatory review,” Warren added. “We also call on [the World Health Organization] to be prepared to quickly include lenacapavir, if approved by regulatory agencies, in HIV prevention guidelines. There is no time to waste if we are to translate these exciting clinical trial results into actual public health impact and expand the toolbox of HIV prevention choices.” Meanwhile, Unitaid urged Gilead to make access to lenacapavir a priority, calling for “the terms of their access strategies – including any voluntary licensing agreements – [to be] transparent, global health-oriented, and equitable”. “Lack of prompt and broad action would jeopardise translating the clinical trial results into real-life impact,” said Unitaid, which offered to work with Gilead to enable access, including “quality-assured, low-cost generics”. “Unitaid is dedicated to leveraging its recent investment through the Wits Reproductive Health and HIV Institute to facilitate market shaping interventions on long-acting PrEP options (in partnership with the Clinton Health Access Initiative), as well as its continued support to enabling elements such as the key work of WHO and the WHO Prequalification program, the Medicines Patent Pool and other intellectual property grants, to ensure access to this life-saving product is as broad as possible,” the organisation said in a statement last week. Image Credits: Gilead, Diana Polekhina/ Unsplash. Gavi Includes Ebola, Meningitis, Rabies and Hepatitis B Vaccines in its Portfolio 24/06/2024 Zuzanna Stawiska A member of the ring vaccination team vaccinates a man in Bosolo village. Vaccines offered as part of Gavi’s portfolio now also include preventive Ebola vaccines for care workers. Gavi, the Vaccine Alliance, announced last week that it will offer high risk countries the option of obtaining preventative Ebola vaccines, particularly for health workers, as part of the rollout of new vaccine offerings, which also include meningitis, rabies and hepatitis B vaccines. Plans to add the vaccines to the basket of available products were initially drawn up before the COVID-19 pandemic, but put on hold due to lack of appropriate supply or regulations, with applications opening only now to eligible countries. “Gavi’s ability as an alliance to protect health and save lives hinges on its ability to ensure vaccines are accessible, as quickly as possible, to those who need them the most,” said Gavi CEO Dr Sania Nishtar. “The new programmes launching today demonstrate the impact of this work.” Ebola is a rare but dangerous viral disease, with a 50-60% mortality rate. Infections may be transmitted through close contact with infected animals – for instance, fruit bats – but also through human-to-human contact. Gavi first offered Ebola vaccine candidates to health workers and suspected Ebola contacts during the 2014-2016 West Africa outbreak as an outbreak response. Two vaccines subsequently received regulatory approval and in May 2024 WHO’s Strategic Advisory Group of Experts on Immunisation (SAGE) decided to recommend the vaccines for preventive use, as well, in high-risk groups, such as health care providers in areas of endemic transmission. Meningitis vaccine rollout aims for elimination Gavi will also roll out a newly-approved vaccine for five strains of meningitis: meningococcal serogroups A, C, W, Y, and X. Central and Western African countries most prone to meningitis infections in the so-called “meningitis belt” The vaccine is a likely game-changer in the fight against the disease, experts say, noting that in the so-called “meningitis belt” of sub-Saharan African countries, the bacterial form of the diseases, regarded as the most dangerous, could potentially be eliminated. The product, MenFive, received WHO pre-qualification in July 2023 and has already been implemented in standard childhood immunisation programmes in Nigeria and Niger. In 2019, there were about 236,000 meningitis deaths, with the greatest burden in children younger than five years, with 112,000 deaths. Hepatitis B and rabies post-exposure jabs Other new vaccines include hepatitis B vaccines for newborns, granting infants critical additional protection in their first months of life, when they are at high risk of infection: including from maternal transmission. According to Gavi, nine out of ten infants infected with hepatitis B will develop chronic forms of the disease, while a quarter develop severe liver disease, which currently kills 884,000 people a year. Human rabies post exposure prophylaxis (PEP) vaccines are the last of the new package. The initiative aims to build more stockpiles of the rabies vaccine, which are often scarce and inaccessible, especially in remote areas, for post-exposure use. Rabies, which has an almost 100% mortality rate, remains a serious health problem in some 150 countries, where it is transmitted by infected dogs. But vaccines alone are not enough to stop the disease, experts underlined. “To stop human rabies deaths completely, we urgently need better data and surveillance, dog populations must be vaccinated, and people must be educated about what to do if bitten, and how to avoid being bitten in the first place,” said Professor Lucille Blumberg, Chair of United Against Rabies, pointing out to several blind spots of the human immunisation programme. Image Credits: WHO/L. Mackenzie , CDC. What Role Does Capacity Development Play in Transforming Health Research? 22/06/2024 Maayan Hoffman The latest episode of the Global Health Matters podcast, hosted by Dr Garry Aslanyan, delves into the extraordinary careers of two global health leaders and the crucial role that capacity development has played in their journeys. This episode, produced to celebrate the 50th anniversary of TDR, the Special Programme for Research and Training in Tropical Diseases, features insights from Dr Wilfried Mutombo, Head of Clinical Operations at the Drugs for Neglected Diseases Initiative (DNDi) in the Democratic Republic of the Congo, and Dr Yasmine Belkaid, President of the Institut Pasteur in France. Both leaders share their experiences and the impact of TDR’s support on their professional growth. Dr John Reeder, the Director of TDR, reflects on the importance of capacity development in fostering the potential of researchers in low- and middle-income countries. Reeder highlights his transition from hands-on research to global leadership, emphasising the value of putting research into action and nurturing talent at the grassroots level. He underscores that effective capacity development goes beyond providing resources; it involves empowering individuals to fulfil their potential and significantly contribute to their fields. To mark the 50th anniversary of @TDRnews, this episode of #GlobalHealthMatters features TDR Director John Reeder. Together, @GarryAslanyan and John discuss the challenges and future frontiers of capacity development. Listen to the episode here👉 https://t.co/K26H7vQV69#TDR50 pic.twitter.com/srEZeWErH9 — TDR (@TDRnews) June 18, 2024 “When you’re looking at science and laboratory science particularly, people get fixated on the expensive equipment and the fancy technology that surrounds this,” Reeder says. “But the most important investment in a laboratory is the scientist who is in that laboratory because, all other things aside, the ability to see the problem, think of innovative solutions to test them critically and to have the open mind to be able to see the discovery coming through that, you invest in that, and you’ve got great science.” From left: Dr John Reeder, the Director of TDR; Dr Yasmine Belkaid, President of the Institut Pasteur in France; and Dr Wilfried Mutombo, Head of Clinical Operations at the Drugs for Neglected Diseases Initiative (DNDi) in the Democratic Republic of the Congo Clinical Trials in Remote Areas: Three Challenges Mutombo’s story is a testament to the transformative power of research capacity development. Starting as a medical doctor in a small village in the DRC, Mutombo faced the challenge of treating sleeping sickness with toxic drugs. His clinical research fellowship from TDR enabled him to lead the first clinical trial in the DRC for fexinidazole, a safer oral drug for sleeping sickness. He discusses the immense challenges of conducting high-quality clinical trials in remote areas with inadequate infrastructure and highlights the importance of sustained support and training for local health workers. “The first challenge is to reach those areas because to perform a clinical trial, you need to go there in those areas, in those remote areas, and as you may know, we have bad roads, and sometimes this is not very safe,” Mutombo says. “The second challenge is, when you are in those areas, you can imagine in what state those health facilities are… So we had to improve these health facilities.” Another challenge, he says, is the health workers. “Health workers are there, but they are not aware of what a clinical trial is,” according to Mutombo. “To have a high-quality clinical trial, they needed to train them and have a very, very close supervision of their activities. So we organised all this.” Finally, “We need our governments … to give more support and more money to maintain those facilities. This is very important for the government because the first and very important step has been done, but now we need to maintain them at that level.” Building Research Capacity: Support is Crucial In many ways, Belkaid’s journey from Algeria to leading the Institut Pasteur in France exemplifies the global impact of TDR’s fellowships. She speaks about the crucial support she received, which allowed her to pursue her PhD and establish a notable research career. Belkaid emphasises creating environments that nurture talent and passion, enabling researchers to address pressing global health issues. Her vision as President of Institut Pasteur includes fostering international collaboration and continuing to build research capacities that can address future health challenges. Belkaid says if there is anything she can do over the next few years, it will hopefully be helping in any way she can to grow and nurture the leaders of tomorrow internationally. The episode underscores the ongoing need for international organisations like TDR and WHO to prioritise capacity building in low- and middle-income countries. Reeder points out the shift towards in-country training and the importance of sustainable research systems driven by local needs and priorities. He says this approach helps ensure research capacity development and is not just about immediate results but about long-term, sustainable growth that empowers countries to tackle their health challenges effectively. Read related Inside View by Dr John Reeder. Listen to the Global Health Matters podcast on Health Policy Watch. Visit the podcast website. Image Credits: TDR. Posts navigation Older postsNewer posts This site uses cookies to help give you the best experience on our website. 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Scientists in West Africa Tackle Malaria and Schistosomiasis 25/06/2024 Zsofia Hesketh Dr Mamy Andrianirina Rakotondratsara (centre) distributing antimalarials in rural Madagascar. Malaria has long been at the heart of public health efforts in Africa. As a preventable but potentially fatal disease, it is caused by a parasite transmitted by mosquitoes. In 2022, the WHO African Region accounted for about 94% of cases globally. WHO says 78% of deaths in the region are among children under 5 years of age. That’s why Dr Mamy Andrianirina Rakotondratsara, a medical doctor and research technician for Madagascar’s National Institute of Public and Community Health (INSPC), wanted to dedicate his TDR-supported studies for a Masters in Public Health to malaria research. Originally from an endemic region in eastern Madagascar, Rakotondratsara has been personally affected by malaria as he lost his older brother to the disease. “I lost someone close and beloved to me from this disease,” he told Health Policy Watch in an interview. That reinforced his determination to address the disease in the course of his studies. Dr Mamy Andrianirina Rakotondratsara lost his brother to malaria and is passionate about addressing the disease. In 2021, during the course of his Masters studies at the Cheikh Anta Diop University of Dakar (UCAD), Rakotondratsara also completed TDR’s Massive Open Online Course (MOOC) on implementation research. As part of this course, he designed a study around the relationship between the frequency of malaria episodes and mosquito bed net coverage, working with other researchers and doctors that specialize in malaria. This research is still ongoing and specifically targets the rural population of Madagascar’s Anosibe An’Ala district. Although results are still pending, designing such a study has laid the foundations for Rakotondratsara to put the research findings into practice in his home region and disease context, complementing his prior work on malnutrition. Sub-regional training centre for Francophone Africa Students engaged in a field training in participatory epidemiology organised by the National Institute of Public and Community Health Madagascar. Rakotondratsara was able to undertake this research thanks to TDR’s global postgraduate training scheme – which focuses on building students’ skills to do interdisciplinary forms of research that look at barriers and opportunities for better uptake of available preventative and treatment methods. For physicians, researchers and other professionals interested in local public health, the fellowships supported by TDR – the global research programme on diseases of poverty co-sponsored by UNICEF, UNDP, WHO and the World Bank – provides essential skills for health programme management and implementation. It is particularly important for addressing infectious diseases affecting vulnerable and underserved populations and promoting engagement in research from the local to global levels. UCAD is one of the two universities in French-speaking West Africa to collaborate with TDR in the programme. It has been hosting students since 2021, to conduct research into how to control infectious diseases found across the region. In 2022, University of Sciences, Techniques and Technologies in Bamako, Mali, joined the programme with the support of Germany’s Deutsche Gesellschaft für Technische Zusammenarbeit. “The TDR training allowed us to have a new vision of the health system,” Rakotondratsara observes. It changed my way of asking questions when faced with poor health indicators. Regarding my Master’s thesis, it gave me an idea of issues to be explored in the mosquito net distribution process, starting with the quantification of needs to end point use.” He strives to integrate such lessons learnt into his current role with the INSPC. And he is also planning to pursue a PhD with a specialization in implementation research. “The INSPC is a public health training and research institution attached to the Ministry of Public Health,” he explains. “Given that it is a research institution, in collaboration with funding bodies, we are often called upon to carry out expert appraisals on their behalf. As a research technician, I accompany this research and bring my contributions to it,” he says. “Based on my experience, it’s my intention to ensure that implementation research finds an important place both in the research and the teaching context.” Towards better management of Schistosomiasis Although less well known, schistosomiasis, also known as bilharzia, is the second most prevalent disease after malaria both in Senegal and much of the rest of sub-Saharan Africa. Its most common form – urogenital schistosomiasis – can result in damage to the bladder, urethra, and kidneys. It is a parasitic disease that occurs in tropical and subtropical regions where there is limited access to clean water, particularly in the Senegal River Basin, a hyper-endemic region for several species of the parasite that causes the disease. The different variants of the disease are classified by WHO according to the NTD principles for which a greater global response is needed, making it an important research target in the TDR program. Oumy Kaltome Boh, a physician originally from Dakar, has been interested in the burden of NTDs in Senegal since her formative years, and hopes to see their eradication by 2030. Dr Oumy Kaltome Boh “Faced with the impact of these diseases on the health of the population,” she says, her main objective is to contribute to their management “through the implementation of innovative interventions.” This is what led Boh to undertake a Masters degree in management of health programmes at UCAD, as well as an International Inter-University Diploma in emerging infections. Benefiting from a TDR grant in December 2020, Boh was able to conduct a study examining the day-to-day lifestyle practices and environmental factors that make schistosomiasis transmission more likely in endemic areas of her home country. As part of this study, done in collaboration with Senegal’s national bilharziasis programme, she also aimed to verify the effectiveness of schistosomiasis treatment with praziquantel, the only available treatment option currently. A total of 287 children were followed over the course of three weeks, with ‘Day Zero’ representing the date of administration of a single praziquantel dose. Between days 14 and 21, both the effects of the drug on disease progression were assessed and a favourable efficacy profile was found, with a 98% reduction in parasite eggs by day 21. Today, Boh holds the position of deputy chief medical officer in the health district of Saint-Louis, Senegal, and is mainly involved in care and prevention activities for people living with HIV or tuberculosis. Recruited into this position by the Ministry of Health, she stresses that it was through the support of the TDR postgraduate training scheme that she acquired the skills she needed to manage the public health challenges in this district. In particular, learning about community-based approaches allowed her to better “understand the specific needs and problems” of the districts. New research and management approaches As a key aspect of disease control, students supported by TDR can learn to apply new health research and management approaches previously unknown in Senegal, Boh says. Among these is the One Health approach, which aims to assess how diseases emerge from a holistic and ecosystem-oriented perspective, taking into account the reciprocal role of humans, animals, plants, and microorganisms such as the aforementioned pests. By combining scientific, strategic, and rigorous implementation training, the TDR grants offered through UCAD enable their recipients to evaluate and propose improvements to health interventions against poverty-related infectious diseases. These opportunities are game-changers for both UCAD students and the future of implementation research in French-speaking Africa. With the help of TDR grants, Boh emphasises, students can gain exposure to critical health programmes and “pool their skills in order to end the neglect of poverty-related diseases and to achieve the Sustainable Development Goals.” This is the second article in a series on TDR’s research capacity strengthening programme – building skills of public health researchers, implementers, health practitioners and policy-makers in the fast-developing field of implementation research for improving uptake of effective health interventions. Gilead Urged to Prioritise Access as Injection Trial Proves 100% Successful in Preventing HIV 24/06/2024 Kerry Cullinan None of the over 2,000 young women and girls injected twice a year with a new drug, lenacapavir, contracted HIV in one of the most important advances in HIV prevention. Gilead Sciences announced these results last Friday, reporting that its Phase 3 PURPOSE 1 trial, conducted in South Africa and Uganda involving 2,134 women and girls aged 16-25, had been so successful that it was terminating early. Its announcement has been widely hailed as a huge breakthrough in the HIV sector where a vaccine has been elusive, and a range of groups urged Gilead to priorise early access to lenacapavir. The injectable was compared with Truvada and Descovy, two pills taken daily that have proven successful as pre-exposure HIV prophylaxis (PrEP). Sixteen of the 1,068 women in the Truvada group and 39 of the 2,136 women in the Descovy group contracted HIV during the trial. During a scheduled review of results, the trial’s independent data and safety monitoring board (DSMB) found the lenacapavir regimen was safe and highly effective. The trial, expected to run until September, was terminated early based on its success. Results of the trial have not been peer-reviewed yet. The age group targeted by the trial is the worst affected by HIV in southern Africa. In 2022, over three-quarters of infections in 15 to 24-year-olds in the region were girls and women, according to UNAIDS. “Every week, 4,000 adolescent girls and young women aged 15–24 years became infected with HIV globally in 2022, and 3,100 of these infections occurred in sub-Saharan Africa,” added UNAIDS. One of the ‘most important results’ “This is one of the most important results we’ve seen to date in an HIV prevention study,” said Mitchell Warren, executive director of AVAC, a non-profit HIV prevention advocacy organisation. “Adding additional HIV prevention options means more people may find an option that is right for them. Beyond expanded choice, a twice-yearly injection has the potential to transform the way we deliver HIV prevention to people who need and want it most – from an easier-to-follow regimen for individuals to a decreased burden on healthcare systems that are stretched to the limit.” Professor Linda-Gail Bekker, director of the Desmond Tutu HIV Centre in South Africa, said that the twice-a-year injectable could provide a “critical new choice” to prevent HIV. “While we know traditional HIV prevention options are highly effective when taken as prescribed, twice-yearly lenacapavir for PrEP could help address the stigma and discrimination some people may face when taking or storing oral PrEP pills, as well as potentially help increase PrEP adherence and persistence given its twice-yearly dosing schedule,” added Bekker. Gilead expects results by early 2025 from the programme’s other trial, PURPOSE 2, which is assessing twice-yearly lenacapavir for PrEP in men who have sex with men, transgender and non-binary people, currently underway in Argentina, Brazil, Mexico, Peru, South Africa, Thailand and the US. Access to lenacapavir, marketed as Sunlenca in the US, still needs to be worked out once it is approved by regulatory authorities. Cost of access? Lenacapavir (marketed as Sunlenca) was approved in the US in 2022 for “heavily treatment-experienced adults with multi-drug resistant HIV-1 infection and for treatment of people living with HIV who have been on other HIV treatment regimes which are currently failing”. However, Gilead charges $40,000 per patient per year in the US, reports aidsmap. When announcing the PURPOSE 2 results, Gilead acknowledged the “importance of helping to enable access in order for twice-yearly lenacapavir for PrEP, if approved by regulatory authorities, to achieve the broadest impact”. “In light of today’s milestone and the company’s ongoing commitment to communities affected by HIV, Gilead intends to brief community partners and provide a public statement regarding its planned access approach for high-incidence, resource-limited countries, which are primarily low- and lower-middle-income countries,” said the company. Gilead’s statement was welcomed by African HIV medicines access group AfroCAB in an open letter to its CEO, Daniel O’Day. “Replacing 365 pills of oral PrEP with just two injections is a life-changing transition and urgently needed option, as millions of our brothers and sisters, friends, and neighbours face challenges of stigma, pill burden, and adherence, leaving them unprotected against HIV acquisition,” said AfroCAB. “To forge a new pathway forward for [lenacapavir], we call on stakeholders to act now. After thousands of our community members have taken part in clinical trials for LEN and other injectable PrEP products, it is time that pharmaceutical companies, governments, and donors play their part in driving access among the communities that supported the science.” “We expect to see a timeline that takes into account a full analysis of PURPOSE 1 data and the coming data from PURPOSE 2 from Gilead as soon as possible, and we urge regulatory agencies to prepare to fast track regulatory review,” Warren added. “We also call on [the World Health Organization] to be prepared to quickly include lenacapavir, if approved by regulatory agencies, in HIV prevention guidelines. There is no time to waste if we are to translate these exciting clinical trial results into actual public health impact and expand the toolbox of HIV prevention choices.” Meanwhile, Unitaid urged Gilead to make access to lenacapavir a priority, calling for “the terms of their access strategies – including any voluntary licensing agreements – [to be] transparent, global health-oriented, and equitable”. “Lack of prompt and broad action would jeopardise translating the clinical trial results into real-life impact,” said Unitaid, which offered to work with Gilead to enable access, including “quality-assured, low-cost generics”. “Unitaid is dedicated to leveraging its recent investment through the Wits Reproductive Health and HIV Institute to facilitate market shaping interventions on long-acting PrEP options (in partnership with the Clinton Health Access Initiative), as well as its continued support to enabling elements such as the key work of WHO and the WHO Prequalification program, the Medicines Patent Pool and other intellectual property grants, to ensure access to this life-saving product is as broad as possible,” the organisation said in a statement last week. Image Credits: Gilead, Diana Polekhina/ Unsplash. Gavi Includes Ebola, Meningitis, Rabies and Hepatitis B Vaccines in its Portfolio 24/06/2024 Zuzanna Stawiska A member of the ring vaccination team vaccinates a man in Bosolo village. Vaccines offered as part of Gavi’s portfolio now also include preventive Ebola vaccines for care workers. Gavi, the Vaccine Alliance, announced last week that it will offer high risk countries the option of obtaining preventative Ebola vaccines, particularly for health workers, as part of the rollout of new vaccine offerings, which also include meningitis, rabies and hepatitis B vaccines. Plans to add the vaccines to the basket of available products were initially drawn up before the COVID-19 pandemic, but put on hold due to lack of appropriate supply or regulations, with applications opening only now to eligible countries. “Gavi’s ability as an alliance to protect health and save lives hinges on its ability to ensure vaccines are accessible, as quickly as possible, to those who need them the most,” said Gavi CEO Dr Sania Nishtar. “The new programmes launching today demonstrate the impact of this work.” Ebola is a rare but dangerous viral disease, with a 50-60% mortality rate. Infections may be transmitted through close contact with infected animals – for instance, fruit bats – but also through human-to-human contact. Gavi first offered Ebola vaccine candidates to health workers and suspected Ebola contacts during the 2014-2016 West Africa outbreak as an outbreak response. Two vaccines subsequently received regulatory approval and in May 2024 WHO’s Strategic Advisory Group of Experts on Immunisation (SAGE) decided to recommend the vaccines for preventive use, as well, in high-risk groups, such as health care providers in areas of endemic transmission. Meningitis vaccine rollout aims for elimination Gavi will also roll out a newly-approved vaccine for five strains of meningitis: meningococcal serogroups A, C, W, Y, and X. Central and Western African countries most prone to meningitis infections in the so-called “meningitis belt” The vaccine is a likely game-changer in the fight against the disease, experts say, noting that in the so-called “meningitis belt” of sub-Saharan African countries, the bacterial form of the diseases, regarded as the most dangerous, could potentially be eliminated. The product, MenFive, received WHO pre-qualification in July 2023 and has already been implemented in standard childhood immunisation programmes in Nigeria and Niger. In 2019, there were about 236,000 meningitis deaths, with the greatest burden in children younger than five years, with 112,000 deaths. Hepatitis B and rabies post-exposure jabs Other new vaccines include hepatitis B vaccines for newborns, granting infants critical additional protection in their first months of life, when they are at high risk of infection: including from maternal transmission. According to Gavi, nine out of ten infants infected with hepatitis B will develop chronic forms of the disease, while a quarter develop severe liver disease, which currently kills 884,000 people a year. Human rabies post exposure prophylaxis (PEP) vaccines are the last of the new package. The initiative aims to build more stockpiles of the rabies vaccine, which are often scarce and inaccessible, especially in remote areas, for post-exposure use. Rabies, which has an almost 100% mortality rate, remains a serious health problem in some 150 countries, where it is transmitted by infected dogs. But vaccines alone are not enough to stop the disease, experts underlined. “To stop human rabies deaths completely, we urgently need better data and surveillance, dog populations must be vaccinated, and people must be educated about what to do if bitten, and how to avoid being bitten in the first place,” said Professor Lucille Blumberg, Chair of United Against Rabies, pointing out to several blind spots of the human immunisation programme. Image Credits: WHO/L. Mackenzie , CDC. What Role Does Capacity Development Play in Transforming Health Research? 22/06/2024 Maayan Hoffman The latest episode of the Global Health Matters podcast, hosted by Dr Garry Aslanyan, delves into the extraordinary careers of two global health leaders and the crucial role that capacity development has played in their journeys. This episode, produced to celebrate the 50th anniversary of TDR, the Special Programme for Research and Training in Tropical Diseases, features insights from Dr Wilfried Mutombo, Head of Clinical Operations at the Drugs for Neglected Diseases Initiative (DNDi) in the Democratic Republic of the Congo, and Dr Yasmine Belkaid, President of the Institut Pasteur in France. Both leaders share their experiences and the impact of TDR’s support on their professional growth. Dr John Reeder, the Director of TDR, reflects on the importance of capacity development in fostering the potential of researchers in low- and middle-income countries. Reeder highlights his transition from hands-on research to global leadership, emphasising the value of putting research into action and nurturing talent at the grassroots level. He underscores that effective capacity development goes beyond providing resources; it involves empowering individuals to fulfil their potential and significantly contribute to their fields. To mark the 50th anniversary of @TDRnews, this episode of #GlobalHealthMatters features TDR Director John Reeder. Together, @GarryAslanyan and John discuss the challenges and future frontiers of capacity development. Listen to the episode here👉 https://t.co/K26H7vQV69#TDR50 pic.twitter.com/srEZeWErH9 — TDR (@TDRnews) June 18, 2024 “When you’re looking at science and laboratory science particularly, people get fixated on the expensive equipment and the fancy technology that surrounds this,” Reeder says. “But the most important investment in a laboratory is the scientist who is in that laboratory because, all other things aside, the ability to see the problem, think of innovative solutions to test them critically and to have the open mind to be able to see the discovery coming through that, you invest in that, and you’ve got great science.” From left: Dr John Reeder, the Director of TDR; Dr Yasmine Belkaid, President of the Institut Pasteur in France; and Dr Wilfried Mutombo, Head of Clinical Operations at the Drugs for Neglected Diseases Initiative (DNDi) in the Democratic Republic of the Congo Clinical Trials in Remote Areas: Three Challenges Mutombo’s story is a testament to the transformative power of research capacity development. Starting as a medical doctor in a small village in the DRC, Mutombo faced the challenge of treating sleeping sickness with toxic drugs. His clinical research fellowship from TDR enabled him to lead the first clinical trial in the DRC for fexinidazole, a safer oral drug for sleeping sickness. He discusses the immense challenges of conducting high-quality clinical trials in remote areas with inadequate infrastructure and highlights the importance of sustained support and training for local health workers. “The first challenge is to reach those areas because to perform a clinical trial, you need to go there in those areas, in those remote areas, and as you may know, we have bad roads, and sometimes this is not very safe,” Mutombo says. “The second challenge is, when you are in those areas, you can imagine in what state those health facilities are… So we had to improve these health facilities.” Another challenge, he says, is the health workers. “Health workers are there, but they are not aware of what a clinical trial is,” according to Mutombo. “To have a high-quality clinical trial, they needed to train them and have a very, very close supervision of their activities. So we organised all this.” Finally, “We need our governments … to give more support and more money to maintain those facilities. This is very important for the government because the first and very important step has been done, but now we need to maintain them at that level.” Building Research Capacity: Support is Crucial In many ways, Belkaid’s journey from Algeria to leading the Institut Pasteur in France exemplifies the global impact of TDR’s fellowships. She speaks about the crucial support she received, which allowed her to pursue her PhD and establish a notable research career. Belkaid emphasises creating environments that nurture talent and passion, enabling researchers to address pressing global health issues. Her vision as President of Institut Pasteur includes fostering international collaboration and continuing to build research capacities that can address future health challenges. Belkaid says if there is anything she can do over the next few years, it will hopefully be helping in any way she can to grow and nurture the leaders of tomorrow internationally. The episode underscores the ongoing need for international organisations like TDR and WHO to prioritise capacity building in low- and middle-income countries. Reeder points out the shift towards in-country training and the importance of sustainable research systems driven by local needs and priorities. He says this approach helps ensure research capacity development and is not just about immediate results but about long-term, sustainable growth that empowers countries to tackle their health challenges effectively. Read related Inside View by Dr John Reeder. Listen to the Global Health Matters podcast on Health Policy Watch. Visit the podcast website. Image Credits: TDR. Posts navigation Older postsNewer posts This site uses cookies to help give you the best experience on our website. Cookies enable us to collect information that helps us personalise your experience and improve the functionality and performance of our site. By continuing to read our website, we assume you agree to this, otherwise you can adjust your browser settings. Please read our cookie and Privacy Policy. Our Cookies and Privacy Policy Loading Comments... You must be logged in to post a comment.
Gilead Urged to Prioritise Access as Injection Trial Proves 100% Successful in Preventing HIV 24/06/2024 Kerry Cullinan None of the over 2,000 young women and girls injected twice a year with a new drug, lenacapavir, contracted HIV in one of the most important advances in HIV prevention. Gilead Sciences announced these results last Friday, reporting that its Phase 3 PURPOSE 1 trial, conducted in South Africa and Uganda involving 2,134 women and girls aged 16-25, had been so successful that it was terminating early. Its announcement has been widely hailed as a huge breakthrough in the HIV sector where a vaccine has been elusive, and a range of groups urged Gilead to priorise early access to lenacapavir. The injectable was compared with Truvada and Descovy, two pills taken daily that have proven successful as pre-exposure HIV prophylaxis (PrEP). Sixteen of the 1,068 women in the Truvada group and 39 of the 2,136 women in the Descovy group contracted HIV during the trial. During a scheduled review of results, the trial’s independent data and safety monitoring board (DSMB) found the lenacapavir regimen was safe and highly effective. The trial, expected to run until September, was terminated early based on its success. Results of the trial have not been peer-reviewed yet. The age group targeted by the trial is the worst affected by HIV in southern Africa. In 2022, over three-quarters of infections in 15 to 24-year-olds in the region were girls and women, according to UNAIDS. “Every week, 4,000 adolescent girls and young women aged 15–24 years became infected with HIV globally in 2022, and 3,100 of these infections occurred in sub-Saharan Africa,” added UNAIDS. One of the ‘most important results’ “This is one of the most important results we’ve seen to date in an HIV prevention study,” said Mitchell Warren, executive director of AVAC, a non-profit HIV prevention advocacy organisation. “Adding additional HIV prevention options means more people may find an option that is right for them. Beyond expanded choice, a twice-yearly injection has the potential to transform the way we deliver HIV prevention to people who need and want it most – from an easier-to-follow regimen for individuals to a decreased burden on healthcare systems that are stretched to the limit.” Professor Linda-Gail Bekker, director of the Desmond Tutu HIV Centre in South Africa, said that the twice-a-year injectable could provide a “critical new choice” to prevent HIV. “While we know traditional HIV prevention options are highly effective when taken as prescribed, twice-yearly lenacapavir for PrEP could help address the stigma and discrimination some people may face when taking or storing oral PrEP pills, as well as potentially help increase PrEP adherence and persistence given its twice-yearly dosing schedule,” added Bekker. Gilead expects results by early 2025 from the programme’s other trial, PURPOSE 2, which is assessing twice-yearly lenacapavir for PrEP in men who have sex with men, transgender and non-binary people, currently underway in Argentina, Brazil, Mexico, Peru, South Africa, Thailand and the US. Access to lenacapavir, marketed as Sunlenca in the US, still needs to be worked out once it is approved by regulatory authorities. Cost of access? Lenacapavir (marketed as Sunlenca) was approved in the US in 2022 for “heavily treatment-experienced adults with multi-drug resistant HIV-1 infection and for treatment of people living with HIV who have been on other HIV treatment regimes which are currently failing”. However, Gilead charges $40,000 per patient per year in the US, reports aidsmap. When announcing the PURPOSE 2 results, Gilead acknowledged the “importance of helping to enable access in order for twice-yearly lenacapavir for PrEP, if approved by regulatory authorities, to achieve the broadest impact”. “In light of today’s milestone and the company’s ongoing commitment to communities affected by HIV, Gilead intends to brief community partners and provide a public statement regarding its planned access approach for high-incidence, resource-limited countries, which are primarily low- and lower-middle-income countries,” said the company. Gilead’s statement was welcomed by African HIV medicines access group AfroCAB in an open letter to its CEO, Daniel O’Day. “Replacing 365 pills of oral PrEP with just two injections is a life-changing transition and urgently needed option, as millions of our brothers and sisters, friends, and neighbours face challenges of stigma, pill burden, and adherence, leaving them unprotected against HIV acquisition,” said AfroCAB. “To forge a new pathway forward for [lenacapavir], we call on stakeholders to act now. After thousands of our community members have taken part in clinical trials for LEN and other injectable PrEP products, it is time that pharmaceutical companies, governments, and donors play their part in driving access among the communities that supported the science.” “We expect to see a timeline that takes into account a full analysis of PURPOSE 1 data and the coming data from PURPOSE 2 from Gilead as soon as possible, and we urge regulatory agencies to prepare to fast track regulatory review,” Warren added. “We also call on [the World Health Organization] to be prepared to quickly include lenacapavir, if approved by regulatory agencies, in HIV prevention guidelines. There is no time to waste if we are to translate these exciting clinical trial results into actual public health impact and expand the toolbox of HIV prevention choices.” Meanwhile, Unitaid urged Gilead to make access to lenacapavir a priority, calling for “the terms of their access strategies – including any voluntary licensing agreements – [to be] transparent, global health-oriented, and equitable”. “Lack of prompt and broad action would jeopardise translating the clinical trial results into real-life impact,” said Unitaid, which offered to work with Gilead to enable access, including “quality-assured, low-cost generics”. “Unitaid is dedicated to leveraging its recent investment through the Wits Reproductive Health and HIV Institute to facilitate market shaping interventions on long-acting PrEP options (in partnership with the Clinton Health Access Initiative), as well as its continued support to enabling elements such as the key work of WHO and the WHO Prequalification program, the Medicines Patent Pool and other intellectual property grants, to ensure access to this life-saving product is as broad as possible,” the organisation said in a statement last week. Image Credits: Gilead, Diana Polekhina/ Unsplash. Gavi Includes Ebola, Meningitis, Rabies and Hepatitis B Vaccines in its Portfolio 24/06/2024 Zuzanna Stawiska A member of the ring vaccination team vaccinates a man in Bosolo village. Vaccines offered as part of Gavi’s portfolio now also include preventive Ebola vaccines for care workers. Gavi, the Vaccine Alliance, announced last week that it will offer high risk countries the option of obtaining preventative Ebola vaccines, particularly for health workers, as part of the rollout of new vaccine offerings, which also include meningitis, rabies and hepatitis B vaccines. Plans to add the vaccines to the basket of available products were initially drawn up before the COVID-19 pandemic, but put on hold due to lack of appropriate supply or regulations, with applications opening only now to eligible countries. “Gavi’s ability as an alliance to protect health and save lives hinges on its ability to ensure vaccines are accessible, as quickly as possible, to those who need them the most,” said Gavi CEO Dr Sania Nishtar. “The new programmes launching today demonstrate the impact of this work.” Ebola is a rare but dangerous viral disease, with a 50-60% mortality rate. Infections may be transmitted through close contact with infected animals – for instance, fruit bats – but also through human-to-human contact. Gavi first offered Ebola vaccine candidates to health workers and suspected Ebola contacts during the 2014-2016 West Africa outbreak as an outbreak response. Two vaccines subsequently received regulatory approval and in May 2024 WHO’s Strategic Advisory Group of Experts on Immunisation (SAGE) decided to recommend the vaccines for preventive use, as well, in high-risk groups, such as health care providers in areas of endemic transmission. Meningitis vaccine rollout aims for elimination Gavi will also roll out a newly-approved vaccine for five strains of meningitis: meningococcal serogroups A, C, W, Y, and X. Central and Western African countries most prone to meningitis infections in the so-called “meningitis belt” The vaccine is a likely game-changer in the fight against the disease, experts say, noting that in the so-called “meningitis belt” of sub-Saharan African countries, the bacterial form of the diseases, regarded as the most dangerous, could potentially be eliminated. The product, MenFive, received WHO pre-qualification in July 2023 and has already been implemented in standard childhood immunisation programmes in Nigeria and Niger. In 2019, there were about 236,000 meningitis deaths, with the greatest burden in children younger than five years, with 112,000 deaths. Hepatitis B and rabies post-exposure jabs Other new vaccines include hepatitis B vaccines for newborns, granting infants critical additional protection in their first months of life, when they are at high risk of infection: including from maternal transmission. According to Gavi, nine out of ten infants infected with hepatitis B will develop chronic forms of the disease, while a quarter develop severe liver disease, which currently kills 884,000 people a year. Human rabies post exposure prophylaxis (PEP) vaccines are the last of the new package. The initiative aims to build more stockpiles of the rabies vaccine, which are often scarce and inaccessible, especially in remote areas, for post-exposure use. Rabies, which has an almost 100% mortality rate, remains a serious health problem in some 150 countries, where it is transmitted by infected dogs. But vaccines alone are not enough to stop the disease, experts underlined. “To stop human rabies deaths completely, we urgently need better data and surveillance, dog populations must be vaccinated, and people must be educated about what to do if bitten, and how to avoid being bitten in the first place,” said Professor Lucille Blumberg, Chair of United Against Rabies, pointing out to several blind spots of the human immunisation programme. Image Credits: WHO/L. Mackenzie , CDC. What Role Does Capacity Development Play in Transforming Health Research? 22/06/2024 Maayan Hoffman The latest episode of the Global Health Matters podcast, hosted by Dr Garry Aslanyan, delves into the extraordinary careers of two global health leaders and the crucial role that capacity development has played in their journeys. This episode, produced to celebrate the 50th anniversary of TDR, the Special Programme for Research and Training in Tropical Diseases, features insights from Dr Wilfried Mutombo, Head of Clinical Operations at the Drugs for Neglected Diseases Initiative (DNDi) in the Democratic Republic of the Congo, and Dr Yasmine Belkaid, President of the Institut Pasteur in France. Both leaders share their experiences and the impact of TDR’s support on their professional growth. Dr John Reeder, the Director of TDR, reflects on the importance of capacity development in fostering the potential of researchers in low- and middle-income countries. Reeder highlights his transition from hands-on research to global leadership, emphasising the value of putting research into action and nurturing talent at the grassroots level. He underscores that effective capacity development goes beyond providing resources; it involves empowering individuals to fulfil their potential and significantly contribute to their fields. To mark the 50th anniversary of @TDRnews, this episode of #GlobalHealthMatters features TDR Director John Reeder. Together, @GarryAslanyan and John discuss the challenges and future frontiers of capacity development. Listen to the episode here👉 https://t.co/K26H7vQV69#TDR50 pic.twitter.com/srEZeWErH9 — TDR (@TDRnews) June 18, 2024 “When you’re looking at science and laboratory science particularly, people get fixated on the expensive equipment and the fancy technology that surrounds this,” Reeder says. “But the most important investment in a laboratory is the scientist who is in that laboratory because, all other things aside, the ability to see the problem, think of innovative solutions to test them critically and to have the open mind to be able to see the discovery coming through that, you invest in that, and you’ve got great science.” From left: Dr John Reeder, the Director of TDR; Dr Yasmine Belkaid, President of the Institut Pasteur in France; and Dr Wilfried Mutombo, Head of Clinical Operations at the Drugs for Neglected Diseases Initiative (DNDi) in the Democratic Republic of the Congo Clinical Trials in Remote Areas: Three Challenges Mutombo’s story is a testament to the transformative power of research capacity development. Starting as a medical doctor in a small village in the DRC, Mutombo faced the challenge of treating sleeping sickness with toxic drugs. His clinical research fellowship from TDR enabled him to lead the first clinical trial in the DRC for fexinidazole, a safer oral drug for sleeping sickness. He discusses the immense challenges of conducting high-quality clinical trials in remote areas with inadequate infrastructure and highlights the importance of sustained support and training for local health workers. “The first challenge is to reach those areas because to perform a clinical trial, you need to go there in those areas, in those remote areas, and as you may know, we have bad roads, and sometimes this is not very safe,” Mutombo says. “The second challenge is, when you are in those areas, you can imagine in what state those health facilities are… So we had to improve these health facilities.” Another challenge, he says, is the health workers. “Health workers are there, but they are not aware of what a clinical trial is,” according to Mutombo. “To have a high-quality clinical trial, they needed to train them and have a very, very close supervision of their activities. So we organised all this.” Finally, “We need our governments … to give more support and more money to maintain those facilities. This is very important for the government because the first and very important step has been done, but now we need to maintain them at that level.” Building Research Capacity: Support is Crucial In many ways, Belkaid’s journey from Algeria to leading the Institut Pasteur in France exemplifies the global impact of TDR’s fellowships. She speaks about the crucial support she received, which allowed her to pursue her PhD and establish a notable research career. Belkaid emphasises creating environments that nurture talent and passion, enabling researchers to address pressing global health issues. Her vision as President of Institut Pasteur includes fostering international collaboration and continuing to build research capacities that can address future health challenges. Belkaid says if there is anything she can do over the next few years, it will hopefully be helping in any way she can to grow and nurture the leaders of tomorrow internationally. The episode underscores the ongoing need for international organisations like TDR and WHO to prioritise capacity building in low- and middle-income countries. Reeder points out the shift towards in-country training and the importance of sustainable research systems driven by local needs and priorities. He says this approach helps ensure research capacity development and is not just about immediate results but about long-term, sustainable growth that empowers countries to tackle their health challenges effectively. Read related Inside View by Dr John Reeder. Listen to the Global Health Matters podcast on Health Policy Watch. Visit the podcast website. Image Credits: TDR. Posts navigation Older postsNewer posts This site uses cookies to help give you the best experience on our website. Cookies enable us to collect information that helps us personalise your experience and improve the functionality and performance of our site. By continuing to read our website, we assume you agree to this, otherwise you can adjust your browser settings. Please read our cookie and Privacy Policy. Our Cookies and Privacy Policy Loading Comments... You must be logged in to post a comment.
Gavi Includes Ebola, Meningitis, Rabies and Hepatitis B Vaccines in its Portfolio 24/06/2024 Zuzanna Stawiska A member of the ring vaccination team vaccinates a man in Bosolo village. Vaccines offered as part of Gavi’s portfolio now also include preventive Ebola vaccines for care workers. Gavi, the Vaccine Alliance, announced last week that it will offer high risk countries the option of obtaining preventative Ebola vaccines, particularly for health workers, as part of the rollout of new vaccine offerings, which also include meningitis, rabies and hepatitis B vaccines. Plans to add the vaccines to the basket of available products were initially drawn up before the COVID-19 pandemic, but put on hold due to lack of appropriate supply or regulations, with applications opening only now to eligible countries. “Gavi’s ability as an alliance to protect health and save lives hinges on its ability to ensure vaccines are accessible, as quickly as possible, to those who need them the most,” said Gavi CEO Dr Sania Nishtar. “The new programmes launching today demonstrate the impact of this work.” Ebola is a rare but dangerous viral disease, with a 50-60% mortality rate. Infections may be transmitted through close contact with infected animals – for instance, fruit bats – but also through human-to-human contact. Gavi first offered Ebola vaccine candidates to health workers and suspected Ebola contacts during the 2014-2016 West Africa outbreak as an outbreak response. Two vaccines subsequently received regulatory approval and in May 2024 WHO’s Strategic Advisory Group of Experts on Immunisation (SAGE) decided to recommend the vaccines for preventive use, as well, in high-risk groups, such as health care providers in areas of endemic transmission. Meningitis vaccine rollout aims for elimination Gavi will also roll out a newly-approved vaccine for five strains of meningitis: meningococcal serogroups A, C, W, Y, and X. Central and Western African countries most prone to meningitis infections in the so-called “meningitis belt” The vaccine is a likely game-changer in the fight against the disease, experts say, noting that in the so-called “meningitis belt” of sub-Saharan African countries, the bacterial form of the diseases, regarded as the most dangerous, could potentially be eliminated. The product, MenFive, received WHO pre-qualification in July 2023 and has already been implemented in standard childhood immunisation programmes in Nigeria and Niger. In 2019, there were about 236,000 meningitis deaths, with the greatest burden in children younger than five years, with 112,000 deaths. Hepatitis B and rabies post-exposure jabs Other new vaccines include hepatitis B vaccines for newborns, granting infants critical additional protection in their first months of life, when they are at high risk of infection: including from maternal transmission. According to Gavi, nine out of ten infants infected with hepatitis B will develop chronic forms of the disease, while a quarter develop severe liver disease, which currently kills 884,000 people a year. Human rabies post exposure prophylaxis (PEP) vaccines are the last of the new package. The initiative aims to build more stockpiles of the rabies vaccine, which are often scarce and inaccessible, especially in remote areas, for post-exposure use. Rabies, which has an almost 100% mortality rate, remains a serious health problem in some 150 countries, where it is transmitted by infected dogs. But vaccines alone are not enough to stop the disease, experts underlined. “To stop human rabies deaths completely, we urgently need better data and surveillance, dog populations must be vaccinated, and people must be educated about what to do if bitten, and how to avoid being bitten in the first place,” said Professor Lucille Blumberg, Chair of United Against Rabies, pointing out to several blind spots of the human immunisation programme. Image Credits: WHO/L. Mackenzie , CDC. What Role Does Capacity Development Play in Transforming Health Research? 22/06/2024 Maayan Hoffman The latest episode of the Global Health Matters podcast, hosted by Dr Garry Aslanyan, delves into the extraordinary careers of two global health leaders and the crucial role that capacity development has played in their journeys. This episode, produced to celebrate the 50th anniversary of TDR, the Special Programme for Research and Training in Tropical Diseases, features insights from Dr Wilfried Mutombo, Head of Clinical Operations at the Drugs for Neglected Diseases Initiative (DNDi) in the Democratic Republic of the Congo, and Dr Yasmine Belkaid, President of the Institut Pasteur in France. Both leaders share their experiences and the impact of TDR’s support on their professional growth. Dr John Reeder, the Director of TDR, reflects on the importance of capacity development in fostering the potential of researchers in low- and middle-income countries. Reeder highlights his transition from hands-on research to global leadership, emphasising the value of putting research into action and nurturing talent at the grassroots level. He underscores that effective capacity development goes beyond providing resources; it involves empowering individuals to fulfil their potential and significantly contribute to their fields. To mark the 50th anniversary of @TDRnews, this episode of #GlobalHealthMatters features TDR Director John Reeder. Together, @GarryAslanyan and John discuss the challenges and future frontiers of capacity development. Listen to the episode here👉 https://t.co/K26H7vQV69#TDR50 pic.twitter.com/srEZeWErH9 — TDR (@TDRnews) June 18, 2024 “When you’re looking at science and laboratory science particularly, people get fixated on the expensive equipment and the fancy technology that surrounds this,” Reeder says. “But the most important investment in a laboratory is the scientist who is in that laboratory because, all other things aside, the ability to see the problem, think of innovative solutions to test them critically and to have the open mind to be able to see the discovery coming through that, you invest in that, and you’ve got great science.” From left: Dr John Reeder, the Director of TDR; Dr Yasmine Belkaid, President of the Institut Pasteur in France; and Dr Wilfried Mutombo, Head of Clinical Operations at the Drugs for Neglected Diseases Initiative (DNDi) in the Democratic Republic of the Congo Clinical Trials in Remote Areas: Three Challenges Mutombo’s story is a testament to the transformative power of research capacity development. Starting as a medical doctor in a small village in the DRC, Mutombo faced the challenge of treating sleeping sickness with toxic drugs. His clinical research fellowship from TDR enabled him to lead the first clinical trial in the DRC for fexinidazole, a safer oral drug for sleeping sickness. He discusses the immense challenges of conducting high-quality clinical trials in remote areas with inadequate infrastructure and highlights the importance of sustained support and training for local health workers. “The first challenge is to reach those areas because to perform a clinical trial, you need to go there in those areas, in those remote areas, and as you may know, we have bad roads, and sometimes this is not very safe,” Mutombo says. “The second challenge is, when you are in those areas, you can imagine in what state those health facilities are… So we had to improve these health facilities.” Another challenge, he says, is the health workers. “Health workers are there, but they are not aware of what a clinical trial is,” according to Mutombo. “To have a high-quality clinical trial, they needed to train them and have a very, very close supervision of their activities. So we organised all this.” Finally, “We need our governments … to give more support and more money to maintain those facilities. This is very important for the government because the first and very important step has been done, but now we need to maintain them at that level.” Building Research Capacity: Support is Crucial In many ways, Belkaid’s journey from Algeria to leading the Institut Pasteur in France exemplifies the global impact of TDR’s fellowships. She speaks about the crucial support she received, which allowed her to pursue her PhD and establish a notable research career. Belkaid emphasises creating environments that nurture talent and passion, enabling researchers to address pressing global health issues. Her vision as President of Institut Pasteur includes fostering international collaboration and continuing to build research capacities that can address future health challenges. Belkaid says if there is anything she can do over the next few years, it will hopefully be helping in any way she can to grow and nurture the leaders of tomorrow internationally. The episode underscores the ongoing need for international organisations like TDR and WHO to prioritise capacity building in low- and middle-income countries. Reeder points out the shift towards in-country training and the importance of sustainable research systems driven by local needs and priorities. He says this approach helps ensure research capacity development and is not just about immediate results but about long-term, sustainable growth that empowers countries to tackle their health challenges effectively. Read related Inside View by Dr John Reeder. Listen to the Global Health Matters podcast on Health Policy Watch. Visit the podcast website. Image Credits: TDR. Posts navigation Older postsNewer posts This site uses cookies to help give you the best experience on our website. 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What Role Does Capacity Development Play in Transforming Health Research? 22/06/2024 Maayan Hoffman The latest episode of the Global Health Matters podcast, hosted by Dr Garry Aslanyan, delves into the extraordinary careers of two global health leaders and the crucial role that capacity development has played in their journeys. This episode, produced to celebrate the 50th anniversary of TDR, the Special Programme for Research and Training in Tropical Diseases, features insights from Dr Wilfried Mutombo, Head of Clinical Operations at the Drugs for Neglected Diseases Initiative (DNDi) in the Democratic Republic of the Congo, and Dr Yasmine Belkaid, President of the Institut Pasteur in France. Both leaders share their experiences and the impact of TDR’s support on their professional growth. Dr John Reeder, the Director of TDR, reflects on the importance of capacity development in fostering the potential of researchers in low- and middle-income countries. Reeder highlights his transition from hands-on research to global leadership, emphasising the value of putting research into action and nurturing talent at the grassroots level. He underscores that effective capacity development goes beyond providing resources; it involves empowering individuals to fulfil their potential and significantly contribute to their fields. To mark the 50th anniversary of @TDRnews, this episode of #GlobalHealthMatters features TDR Director John Reeder. Together, @GarryAslanyan and John discuss the challenges and future frontiers of capacity development. Listen to the episode here👉 https://t.co/K26H7vQV69#TDR50 pic.twitter.com/srEZeWErH9 — TDR (@TDRnews) June 18, 2024 “When you’re looking at science and laboratory science particularly, people get fixated on the expensive equipment and the fancy technology that surrounds this,” Reeder says. “But the most important investment in a laboratory is the scientist who is in that laboratory because, all other things aside, the ability to see the problem, think of innovative solutions to test them critically and to have the open mind to be able to see the discovery coming through that, you invest in that, and you’ve got great science.” From left: Dr John Reeder, the Director of TDR; Dr Yasmine Belkaid, President of the Institut Pasteur in France; and Dr Wilfried Mutombo, Head of Clinical Operations at the Drugs for Neglected Diseases Initiative (DNDi) in the Democratic Republic of the Congo Clinical Trials in Remote Areas: Three Challenges Mutombo’s story is a testament to the transformative power of research capacity development. Starting as a medical doctor in a small village in the DRC, Mutombo faced the challenge of treating sleeping sickness with toxic drugs. His clinical research fellowship from TDR enabled him to lead the first clinical trial in the DRC for fexinidazole, a safer oral drug for sleeping sickness. He discusses the immense challenges of conducting high-quality clinical trials in remote areas with inadequate infrastructure and highlights the importance of sustained support and training for local health workers. “The first challenge is to reach those areas because to perform a clinical trial, you need to go there in those areas, in those remote areas, and as you may know, we have bad roads, and sometimes this is not very safe,” Mutombo says. “The second challenge is, when you are in those areas, you can imagine in what state those health facilities are… So we had to improve these health facilities.” Another challenge, he says, is the health workers. “Health workers are there, but they are not aware of what a clinical trial is,” according to Mutombo. “To have a high-quality clinical trial, they needed to train them and have a very, very close supervision of their activities. So we organised all this.” Finally, “We need our governments … to give more support and more money to maintain those facilities. This is very important for the government because the first and very important step has been done, but now we need to maintain them at that level.” Building Research Capacity: Support is Crucial In many ways, Belkaid’s journey from Algeria to leading the Institut Pasteur in France exemplifies the global impact of TDR’s fellowships. She speaks about the crucial support she received, which allowed her to pursue her PhD and establish a notable research career. Belkaid emphasises creating environments that nurture talent and passion, enabling researchers to address pressing global health issues. Her vision as President of Institut Pasteur includes fostering international collaboration and continuing to build research capacities that can address future health challenges. Belkaid says if there is anything she can do over the next few years, it will hopefully be helping in any way she can to grow and nurture the leaders of tomorrow internationally. The episode underscores the ongoing need for international organisations like TDR and WHO to prioritise capacity building in low- and middle-income countries. Reeder points out the shift towards in-country training and the importance of sustainable research systems driven by local needs and priorities. He says this approach helps ensure research capacity development and is not just about immediate results but about long-term, sustainable growth that empowers countries to tackle their health challenges effectively. Read related Inside View by Dr John Reeder. Listen to the Global Health Matters podcast on Health Policy Watch. Visit the podcast website. Image Credits: TDR. Posts navigation Older postsNewer posts