Obesity, Climate, Reliance on Imported Foods: Small Islands’ Declaration Spells Out a Litany of Challenges

16/06/2023 Kerry Cullinan

One of the 340 islands that make up Palau in the Western Pacific

Overburdened by non-communicable diseases (NCDs) and threatened by climate change, health ministers of Small Islands Developing States (SIDS) met in Barbados over the past few days and adopted the Bridgetown Declaration on NCDs and Mental Health.

The declaration commits the SIDS to a number of actions including implementing the World Health Organization’s (WHO) recommended “Best Buys”, a menu of policy options to prevent and control of NCDs and mental health. These include regulation and taxation of harmful products such as tobacco, alcohol and junk food.

The SIDS comprise 39 countries and 18 associate members of the UN situated in the Caribbean, the Pacific, and the Atlantic, Indian Ocean and South China Sea (AIS), and have a combined population of around 65 million.

A new WHO report shows that eight of the 15 countries with more than a 30% risk of premature death from cardiovascular disease, cancer, diabetes, or chronic respiratory disease are SIDS. The 10 countries with the highest obesity rates globally are all SIDS in the Pacific, where over 45% of adults live with obesity.

Cry for help

Small Island Developing States face unique problems

While the Bridgetown Declaration is a call to action, it is also a cry for help as it lays bare the problems facing these small nations – one percent of the world – that rely primarily on tourism and workers’ remittances for survival.

Over half of the deaths in SIDS are premature and from NCDs, including cardiovascular diseases, cancer, diabetes, chronic respiratory diseases, and mental health conditions, according to the declaration.

Nauru, Cook Islands and Palau have the highest rates of obesity in the world, while childhood obesity in all SIDS is increasing exponentially.

The highest prevalence of adult diabetes is also projected to be in SIDS, with prevalence in the Caribbean double the global average. Meanwhile, over 30% of adults have hypertension.

In Guyana, premature mortality from cardiovascular disease is the highest in the region of the Americas. Rates of mental health conditions reach as high as 15% in the Caribbean and the Pacific.

The SIDS attribute the drivers of these problems to “disproportionate commercial influence and trade-related challenges. Negative commercial influences are driving high rates of smoking, obesity and sedentary behaviour across these countries.”

The islands are a captive audience for these commercial forces. They’re reliant on imported food, which is often ultra-processed and high in sugar, salt and fat – and comes wrapped in plastic that pollutes the environment.

With climate change negatively affecting local fishing and agriculture, this dependence is likely to increase.

The declaration also speaks of “the disproportionate and repetitive impact of disasters, whose frequency and intensity are further exacerbated by climate change”. This causes economic losses and drives people away from the islands.

Funding to mitigate challenges

One of the reasons for the meeting, which was hosted by the World Health Organization (WHO), its regional counterpart, the Pan-American Health Organization (PAHO) and the Barbados government, is to prepare for the UN General Assembly high-level meeting on universal health coverage in September.

The intention is to engage governments, international agencies and donors to assist SIDS to address their unique problems.

“Bold action for our climate, good health, and wellbeing relies on redressing and reorganising global financing to unlock billions in investment while making it less punishing for developing countries to pay their debts,” said Mia Mottley, Prime Minister of Barbados, at a media briefing on Thursday.

“Funding for climate change adaptation and mitigation in the most vulnerable countries is also key, with noncommunicable diseases and mental health accounted for.”

Dr Tedros Adhanom Ghebreyesus, WHO Director-General, praised the SIDS for showing “remarkable resilience, despite their limited resources and geographical constraints”.

He pledged that WHO would work to mobilize financial resources to develop climate-resilient, environmentally sustainable healthcare facilities in the SIDS. WHO will also continue to advocate for “loss and damage” funding for climate change adaptation and mitigation investments in lower-income countries.

Image Credits: Rick Bajornas/ UN Photo.

Preventative Seasonal Malaria Treatment is Saving Thousands of Children

16/06/2023 Jean Louis Ndiaye & Andre Marie Tchouatieu

A doctor examines a child with malaria.

For years, malaria has ruled mercilessly in certain regions of the world. Especially in Africa. Yet over the past decade, despite the absence of a malaria vaccine, one anti-malarial strategy sought to make a difference: more than 700 million doses of Seasonal Malaria Chemoprevention (SMC) were distributed to young children, globally.

The evidence is now clear: SMC has helped to save hundreds of thousands of their lives. So much so, that more countries have now begun to implement SMC, which involves the intermittent administration of a curative dose of antimalarial medicine to children at high risk of severe malaria living in areas with seasonal transmission, regardless of whether they are infected with malaria.

As we mark the International Day of the African Child on 16 June, it’s important to recall how far we’ve come. At the dawn of the new millennium, malaria was infecting several hundred million people every year – and killing almost 900,000, annually. Although gains have been made to rein in its lethal impact, malaria continues to kill at an alarming rate: it took 619,000 lives in 2021, according to the World Health Organization (WHO) and its World Malaria Report 2022.

Tragically, it’s children under the age of five who constitute the vast majority of malaria-related deaths; therefore, they are most in need of protection from this deadly disease. Their immune systems are not fully developed to fight off malaria parasites, which makes them easy prey.

Averting millions of cases

So how did this SMC intervention avert millions of malaria cases and so many needless deaths?

The idea behind it was simple: Let’s protect children with existing drugs during the malaria season, commencing just before cases start to climb. The implementation was more complicated, though, as it required strong technical and financial partnerships – which continue to deliver, up through today.

The intervention started out slowly. National health authorities had to be convinced of SMC effectiveness. A considerable, consistent supply had to be acquired of Sulfadoxine-Pyrimethamine Amodiaquine (popularly known as SPAQ), which is the antimalarial combination therapy administered in SMC campaigns.

A child-friendly formulation also had to be developed, with the drugs then distributed. Healthcare workers had to be trained in its administration. Parents had to be persuaded that three, four even five doses of the drug would protect their children for the entire malaria season.

In response, African researchers played a pivotal leadership role in the rapid SMC policy adoption, then its large-scale implementation. From 2002-2008, researchers in Senegal, Gambia, Mali and Ghana ensured that the results of landmark SMC studies were widely disseminated, and then they designed and implemented new research that provided additional evidence of SMC effectiveness. Their efforts led to the initial WHO recommendation, in 2012.

As for partnerships, together with Roll Back Malaria, an SMC working group was created to help countries fast-track policy adoption. This working group eventually became the SMC Alliance.

Meanwhile, Unitaid has also been a key player: it funded the ACCESS SMC project, which demonstrated the feasibility of scaling up and dramatically expanding SMC, by evaluating its effectiveness and cost.

Effective and inexpensive

Children under the age of five are most at risk from malaria.

As supportive evidence mounted, SMC uptake rapidly increased. Today, 15 countries in the Sahel region of Western Africa are on board, implementing regular SMC campaigns during malaria season. In 2021 alone, despite Covid-related delivery challenges, 45 million children received SMC. Then in 2022, 48 million kids received it. This protected them during the rainy season, when deadly female Anopheles mosquitoes lurk in the shadows, ready to pounce on their next blood meal.

As if saving lives were not enough, SMC has also proved to be highly cost-effective. A 2021 analysis revealed that SMC had so far saved participating health systems as much as $66 million.

An additional tool to protect young children appeared in 2021 with the arrival of the RTS, S/AS01 malaria vaccine, Mosquirix, which also received a WHO recommendation. A study last year showed that SMC, when combined with this vaccine, provided significantly greater protection than either intervention alone.

SMC has shown such remarkable efficacy in the Sahel region of West Africa, other parts of the continent are now beginning adopt it: This year, Mozambique became the first country in southern Africa to pilot SMC; while in East Africa, Uganda, Tanzania and South Sudan are engaged in early SMC efforts.

And it doesn’t stop there. From 2009 onwards, researchers in Senegal began to explore whether SMC could benefit older children; they confirmed it could also protect children aged 5 to 10 years old. This led the WHO to review the guidelines in June 2022 to allow SMC to extend beyond the Sahel and reach children older than 5. This potentially protects millions more.

All this is excellent news for the donors who have invested in SMC. It is equally welcome news for those national health systems in Africa that experience seasonal malaria transmission, as they are keen to save the lives of future citizens and are attracted to SMC’s cost-effectiveness. However, despite its rapid rise in popularity, SMC brings challenges of its own: mainly, how to secure uninterrupted supplies of SPAQ and develop new drugs to respond to resistance.

African manufacturing boost

Indeed, reaching older children requires more supplies of WHO-approved SPAQ. To resolve this problem, international partners, including MMV, are supporting the local African production of SPAQ. By the end of 2023, SPAQ will be manufactured for the first time in Africa to WHO-quality standards – another landmark worth celebrating.

Meanwhile, as more countries outside the Sahel region are keen to roll out SMC, unfortunately, in parts of eastern Africa, there are signs of drug resistance to Sulfadoxine Pyrimethamine. Undeterred, researchers and national malaria teams in these countries are exploring alternative drug combinations for SMC regimens, in case resistance renders SPAQ completely ineffective. The spectre of drug resistance always looms.

So far, though, given the determination of countries’ malaria programs and the malaria community, no problem has been insurmountable. Yet a major barrier remains: sustainable funding. Stagnant funding for malaria, especially malaria-drug research, might not only slow the development of new antimalarials but place millions of young lives at risk. We cannot allow this to happen.

We, in the malaria community, are confident that these 10 years of success in protecting and saving countless young African children is all the evidence we need to continue supporting SMC until no child or family ever suffers from this disease.

Prof Jean Louis Ndiaye is a Professor of Parasitology and Head of the Research and Innovation Division at the University Iba Der Thiam of Thiès, in Senegal. He is co-chair of the SMC Alliance research sub-group.

Dr André Marie Tchouatieu is the Director of Chemoprevention Access and Product Management at MMV and General Secretary of the SMC Alliance.

Image Credits: UNICEF USA , Damien Schumann / MMV.

Extraordinary ‘Culture War’ Clash at ILO over LGBTQ Rights

15/06/2023 Kerry Cullinan

Late-night screaming matches and days of delays dogged the adoption of the budget of the International Labour Organization (ILO) this week after some Arab and African member states objected to a clause related to LGBTQ rights.

The single offending clause committed the body to support those “affected by discrimination and exclusion, including on the grounds of race, sexual orientation and gender identity” and to “implementing measures conducive to promoting equality of opportunity and treatment”.

While the clause was retained in the budget that was finally passed this week at the body’s plenary, the compromise involved the insertion of a note that recorded the differences on some issues, according to AFP, which also reported on the late-night drama and yelling matches.

The 2024/25 budget and programme of work was finally overwhelmingly passed by 477 votes, with 11 against and seven abstentions. The hold-out ‘no’ votes included Bahrain, Belarus, Egypt, Gabon, Maldives, Niger and Oman. Pakistan and Morocco had led the initial objections, but Pakistan voted in favour of the compromise while Morocco abstained.

Speaking after the adoption of the budget, Sweden’s Thomas Janson on behalf of the European Union, pointed out that LGBTI reference had been in the ILO’s programme of work and budget since 2018/19.

“The EU and its member states to reiterate our commitment to equality and non-discrimination and to the entitlement of all persons to enjoy the full range of human rights and fundamental freedoms,” said Janson.

Canada’s Leslie Norton at the ILO

Canada’s Leslie Norton, speaking on behalf of 37 countries largely from Europe, Latin America and North America, said that the programme and budget document provides the framework for ILO staff to advance its work, and that “groups in the most vulnerable situations must be recognised and named”.

“This includes those discriminated on the grounds of their sexual orientation and gender identity,” added Norton.

“LGBTI persons disproportionately experience violence, harassment, discrimination, and exclusion throughout the employment cycle, from education to access to the labour market, conditions of work and security of employment,” she noted.

“The ILO is a UN organisation with social justice and rights at its centre, including the universally accepted fundamental principle on the Elimination of Discrimination in Employment, particularly for those who are historically or disproportionately discriminated against.”

The 37 countries would not accede to the removal of references to LGBTI people as this would be a “regression” that would “compromise on the key mandate of the ILO to promote the elimination of discrimination on any grounds, including on the grounds of sexual orientation and gender identity”, she added.

US representative Bathsheba Crocker noted that the ILO’s requested budget increase – the total ask is almost $885m – was “high in nominal terms and we appreciate the office’s efforts to identify additional budgetary efficiencies”.

Crocker also expressed the US government’s “unequivocal support for the ILO’s uncontested and universally agreed mandate to promote the elimination of discrimination in employment for all workers as a fundamental right and principle at work”, and that this mandate “is inclusive of any grounds for discrimination, including on the basis of sexual orientation, gender identity and expression and sex characteristics”.

The ILO’s Director-General, Gilbert Houngbo from Togo, the first African to hold this position, thanked delegates for passing the budget, noting that despite “intense discussions”, delegates “did come together”.

Ironically, the budget was passed shortly before the start of the ILO’s World of Work Summit that is themed “social justice for all”.

Heightening global tension over LGBTQ rights

Many UN agencies have experienced deadlocked over LGBTQ issues in recent years. For example, at last year´s World Health Assembly (WHA), an unexpected and protracted standoff over references to “sexuality”, “sexual orientation” and “men who have sex with men” in a technical guideline on HIV and hepatitis – pushed member states into an overnight session, delaying the close of the entire event.

Last year, the Eastern Mediterranean Region (EMRO), supported by key North African countries, led the charge, with Saudi Arabia, Egypt and Nigeria vociferous in their condemnation of behaviours they deemed antithetical to their cultures. The standoff resulted in an unprecedented vote on the guide.

Pharma Shares COVID-19 Voluntary Licensing Lessons Amid Debate Over Best Path to Access Pandemic Products

15/06/2023 Megha Kaveri

Business leaders and experts from pharmaceutical companies across the world shared their experiences in voluntary licensing during the COVID-19 pandemic.

One of the most intense debates in the pandemic accord negotiations is over how to fast-track the development and equitable rollout of vaccines and medicines, with pharmaceutical companies insisting that any infringement on intellectual property (IP) rights will stifle innovation and that voluntary arrangements are the way forward.

A recent event to showcase voluntary licensing arrangements during the COVID-19 pandemic was organised by the International Federation of Pharmaceutical Manufacturers & Associations (IFPMA).

It brought a range of pharma companies and their licensees, including MSD and licensee Dr Reddy’s Laboratories, Gilead and Ferozsons Laboratories, Pfizer and Biovac, and Johnson & Johnson and its licensee, Aspen Pharmacare.

The panellists expanded on how they voluntarily collaborated with each other and with governments across the world despite lockdowns and supply chain breakages – in an evident rebuttal to their critics who have cast IP rights as a key barrier to more equitable medicines access, saying that IP sharing must be mandatory, not voluntary, in future crises.

Expedited innovation – in difficult conditions

Since the beginning of the COVID pandemic, a total of 59 vaccines and 44 therapeutics have been approved, said Rasmus Hansen, CEO and founder of the global health analytics firm Airfinity.

In addition, 177 collaborations were created to manufacture and commercialise COVID-19 treatments, including 93 voluntary licensing agreements for COVID-19 treatments. Of the 93 voluntary licensing agreements, 84 are currently active, including 80 in developing countries.

Manufacturing agreements for therapeutics and vaccines were signed in parallel during the COVID-19 pandemic. (Source: Airfinity)

“What we are finding here is pretty much all of the manufacturing announcements involved some kind of collaboration,” Hansen remarked. “I remember we looked at the numbers week on week, and were really astonished to see the output coming from the manufacturers at that point.”

Voluntary licensing facilitated swift action

The COVID-19 pandemic laid the existing inequity in access to vaccines and therapeutics threadbare. While high-income countries were able to enter into advance purchase agreements with big pharma companies long before the vaccines were ready, low and middle-income countries were forced to navigate arrangements for the local production of new vaccines and medicines that had been developed by the large pharma innovators.

South Africa’s Aspen Pharmacare collaborated with Johnson & Johnson to manufacture its COVID-19 vaccine under the name “Aspenovax”, for instance, while Biovac partnered with Pfizer to manufacture mRNA vaccines.

“The J&J vaccine was the one that was demonstrating the best prospects for Africa, given Africa’s idiosyncrasies, geographic supply chain and otherwise. We got into discussions with J&J and we were able to move very swiftly to concluding an agreement,” explained Stavros Nicolaou, Aspen’s group senior executive for strategic trade.

Aspen was attractive to established companies, said Nicolaou, because of its “strong track record and also a blueprint in the form of voluntary licensing and technology transfers that existed already” as well as two decades of experience.

The technology transfer was completed five and a half months after the agreement was signed in December 2021, which was “not an easy task given the severe lockdowns” at that stage.

“It’s not like J&J colleagues could jump on a plane and, and travel down south and inspect facilities and do audits,” Nicolaou pointed out, adding that Aspen staff worked 24/7 doing on-camera audits “to give certainty and assurance around quality, safety and efficacy of our manufacturing”.

Political complications

However, due to a lack of demand for COVID-19 vaccines as the pandemic evolved and the company getting caught in the middle of a political crossfire between Africa and Europe that delayed production, Aspen Pharmacare did not sell a single vial of the vaccine, as reported previously by Health Policy Watch.

The political storm revolved around millions of J&J vaccines being produced in Aspen that were due for export to Europe at a time when only 7% of South Africans were vaccinated.

South Africa’s President Cyril Ramaphosa intervened, appealing to the Europe Commission head Ursula von der Leyen to prevent this and by September, European countries had agreed to return the J&J vaccines produced by Aspen for distribution in Africa.

“There was a standoff between Europe and the African Union in terms of where these vaccines would finally land,” Nicolaou explained at a previous webinar organised by Brown University. “And it took quite significant negotiating and eventually, an agreement was settled between the EU and Africa for some of these vaccines, initially 60% and eventually 90%, to be retained on the African continent.”

Therapeutics partnerships

Later in the pandemic, as therapeutics also came online, Indian firm Dr Reddy’s Laboratories entered into a licensing agreement with the US-based MSD for the production of the antiviral drug molnupiravir, in January 2022. A Pakistani company, Ferozsons Laboratories Limited, also partnered with the US-based Gilead Sciences to manufacture Remdesivir. Both agreements were signed as voluntary licenses and as part of a long-term collaboration between these companies.

Vignesh Shivnath, director of business development alliance management at Dr Reddy’s Laboratories.

Despite bitter criticism that developing country markets still got access to such drugs much later and in far more limited quantities, the voluntary partnerships helped to build the capacity of firms in the global south to produce new forms of treatment, panelists said.

For instance, early engagement and a bilateral partnership with MSD helped Dr Reddy’s Laboratories mobilise the materials needed to manufacture molnupiravir swiftly, said Vignesh Shivnath, the company’s director of business development alliance management. Dr Reddy’s Laboratories was one of eight generic manufacturers chosen by MSD for establishing bilateral manufacturing agreements.

“The direct agreements with Gilead helped us to ramp up technology transfers, quality control and manufacturing roll-out at breakneck speed,” said Osman Khalid Waheed, CEO of Ferozsons Laboratories Limited, about his company’s partnership for the production of remdesivir in Pakistan.

Osman Khalid Waheed, CEO of Ferozsons Laboratories Limited (left) and Hemal Shah, Director for Public Policy at Gilead.

“I think it was 6 May 2020, when Gilead first reached out to us, and within a week, we had an agreement. Within 12 weeks of that, we were able to start rolling out the product, and sharing information on production and quality control with our partners around the world,” said Waheed.

Under the looming shadow of the pandemic accord

Referring to the latest draft text of the pandemic accord, Thomas Cueni, IFPMA Director-General, said that he is concerned that, should IP protections for innovative drugs and vaccines be weakened, there is a risk that more “unlicensed, substandard, low quality and counterfeit” drugs and vaccines might be produced in the next pandemic.

The risk that new drugs and vaccines might enjoy weakened IP protections could also stymie investments in health tools that would be needed to confront the next pandemic, he warned.

“In terms of the pandemic treaty, I have to admit, I’m deeply concerned that the zero-draft is potentially undermining innovation,” Cueni said.

Member states of the World Health Organization (WHO) are currently in the process of negotiating a binding instrument for pandemic preparedness, prevention and response.

At the Intergovernmental Negotiating Body’s (INB) sessions this week in Geneva, African countries criticised the latest draft text, produced by a guiding body of six member states called the “Bureau”. They called it “weak”, especially in matters concerning equity.

“The African member states recognise the hard position that the bureau finds itself in trying to keep everyone at the negotiating table…

“However, it is unfortunate that, in that process, the core of what this instrument is supposed to address, namely equity, has been presented in a weakened or reduced format, especially in those articles that would result in a meaningful realization of equity,” Ethiopia said, on behalf of the 47 countries in Africa.

Additional reporting by Kerry Cullinan.

Eight Killed and 18 Injured in Attacks on Sudan’s Healthcare System

15/06/2023 Megha Kaveri

Violence erupted between a paramilitary group and the armed forces in Khartoum on 15 April 2023.

There have been 46 attacks on Sudan’s healthcare infrastructure during which eight people have been killed and 18 injured, and two-thirds of the hospitals in affected areas are closed as a result of the heightened attacks, the World Health Organization (WHO) said.

Clashes erupted in mid-April in Khartoum between the country’s armed forces and a paramilitary group, Rapid Support Forces (RSF), headed by General Mohamed Hamdan Dagalo, currently deputy leader of the country’s Sovereign Council. The RSF appeared to attempt to stage a coup following conflict over the planned integration of the RSF into the Sudanese army.

“Overall, the greatest public health risks remain the ongoing violence resulting in trauma injuries, major disruptions to health care and repeated attacks on the health system, and poor access to clean water, sanitation and food, increasing the risk of malnutrition and water- and vector-borne diseases,” said the WHO in its first situation report on the conflict.

“According to the Preliminary Committee of Sudan Doctor’s Trade Union, 67% (60 out of 89) of all main hospitals in affected areas were out of service as of 31 May,” the report pointed out.

“The 29 hospitals operating fully or partially (some providing emergency medical services only) are at risk of closure due to shortage of medical staff, supplies, water, and electricity.”

Among the healthcare assets compromised in the violence are the National Public Health Laboratory, and the Federal Ministry of Health’s National Medical Supply Funds Warehouse.

Condemning the continued attacks on healthcare facilities, workers and assets, the WHO urged the parties in the conflict to uphold ceasefire agreements, in order to “guarantee the safety of humanitarians and safe passage of humanitarian aid in the country as well as protection of health workers and health facilities to ensure health facilities remain functional and accessible, and supplies are delivered without impediment so the population can receive the health care they need and deserve”.

Since 15 April, 866 people have been killed across the country, and over 6000 people have been injured. At least a million people had fled, including over 250,000 people who have taken refuge in neighboring countries.

The WHO had earlier flagged the occupation of the National Public Health Laboratory, which housed a wide variety of chemical and biological materials, and disease pathogens, and added that it was conducting risk assessment around the situation.

The agency added that the revised Sudan Humanitarian Response Plan (HRP) needs $2.6 billion to help the people in Sudan and that 24.7 million people were in need of humanitarian aid. WHO’s Contingency Fund for Emergencies (CFE) has released $3.6 million towards emergency response in the region, days after violence erupted.

On 21 May, the RSF and the Sudanese military agreed to a seven-day ceasefire agreement in Jeddah to allow delivery of humanitarian aid to the affected people in Khartoum and regions torn by violence. Although the warring parties agreed to extend the ceasefire by another five days, intense clashes were reported in Khartoum a day after the extension was agreed upon.

Image Credits: UN Human Rights.

Small Island Developing States at Nexus of Climate, Unhealthy Foods and Mental Health Challenges

14/06/2023 Elaine Ruth Fletcher

(From left) Bente Mikkelsen, WHO; Health Ministers of Anguilla Ellis Webster; Fiji (Ratu Lalabalavu) and Jamaica (Christopher Tufton); Katie Dain, NCD Alliance, Jumana Qamruddin, World Bank, and Kenneth Connell, Healthy Caribbean Coalition.

The burgeoning health issues of small island developing states – which are on the front lines of climate change, but also awash in handguns and ultra-processed food imports – is the focus of a high level ministerial meeting taking place in the Caribbean island of Barbados today and tomorrow.

The SIDS Ministerial Conference on NCDs and Mental Health, co-sponsored by the World Health Organization, has brought together more than three dozen small island states that face not only climate precarity, but also globally high levels of hypertension and obesity as well as mental health disorders – in a complex web of issues that is both unique but also representative of broader global trends in unhealthy foods, environments and lifestyles.

The conference also represents a first attempt by WHO to more squarely confront what it calls the “commercial determinants of health” – such as the enormous dependence of small and isolated states on big food imports that are leading to more and more chronic diseases.

Barbados PM Mia Mottley laid out her Bridgetown agenda at COP 27

“We are not just the canaries in the mines for the climate crisis,” asserted Prime Minister Mia Amor Mottley at the opening session Tuesday evening. She asserted that her “Bridgetown Agenda” for financial reform aimed at low- and middle-income countries was also critical to reforming development policies, agriculture and trade so as to allow SIDS countries to become more healthy, sustainable and self-sufficient.

“The world has to summon the political will to be able to put the structures in place that will allow us to be able to finance global public goods, not with short term capital. But with long term capital that makes sense. And that allows us to have the elbow room still to meet the other challenges that we face,” Mottley said.

Geographically remote and vulnerable to global markets

Bente Mikkelsen, director of WHOs NCDs department.

“I think we really need to absorb the geographical remoteness, the domestic market and the diverse economies that is happening in the SIDS,” said Bente Mikkelsen, WHO’s head of noncommunicable diseases.

“We have three threats coming together here, mental health, NCDs and climate change,” she observed, “and also to add to the the experience from COVID-19 and the need for better preparedness.”

She noted that small island states – scattered from the Pacific to the Caribbean – “are highly depending on international relationships” and that dependence has made them particularly vulnerable to cheap, ultra-processed food imports.

“What you will see is a lot of nutrition related diseases in the SIDS countries… and we have already heard mention of the commercial determinants of health,” she added. “The prevalence of hypertension exceeds 30% in all SIDS countries. The prevalence of diabetes is among the highest in the world. And very remarkably and very scary, I would say is the high obesity rates.”

She called for stronger regulatory measures, such as higher taxes on unhealthy foods, along with measures “supporting the healthy forms of trade” that incentivize local production and imports of healthier alternatives.

Economic and commercial drivers of health in the spotlight

NCDS – primarily cardiovascular diseases, cancer, diabetes and chronic respiratory diseases – cause 74% of premature deaths in the world (before the age of 70), including 8 million deaths linked to unhealthy diets, points out a WHO briefing paper on the intertwined challenges of climate change and NCDs in the small island nations, published at the start of the conference.

“The NCD epidemic has grown earlier and faster in SIDS than elsewhere in the world due to commercial influences and trade challenges, which undermine access to fresh, nutritional food,” the brief points out.

Now, climate change is making things even trends worse:

“Heat-related mortality from NCDs such as cardiovascular and kidney diseases in SIDS is projected to increase with higher temperatures. The elderly, children, pregnant women, outdoor workers, the poor and marginalized and people living with NCDs and obesity are among the worst affected,” the paper points out.

Not only that, but “damage to crops and livestock from rising sea levels and extreme weather events and reduced fish catches because of higher ocean temperatures and acidity,” could increase food insecurity as well as the already heavy reliance on unhealthy imported foods.

Another WHO “discussion” paper on the economic drivers of the NCD epidemic in the SIDS provides further detail on how food imports have swamped the SIDS, which tend to be debt-ridden and vulnerable trading partners.

“Obesity rates in SIDS continue to increase, in part due to the over-availability, widespread marketing, reliance and entrenchment of importing foods and non-alcoholic beverages that are high in saturated fatty acids, trans-fatty acids, free sugars and/or sodium, and typically highly processed (HFSS foods), and their relatively high consumption,” the WHO paper notes.

“Five of the top 10 countries with the highest overweight and obesity rates in the world in 2016, and seven of the 10 countries with the highest rates of diabetes, are Pacific Island countries and areas.” Over 60% of adults in the Caribbean, and up to 80% in some Pacific Island states are obese, the paper adds, referring to the two regions that together, comprise most small island developing states.

Colonialism, climate change and unsustainable fishing combined

Shifts from traditional diets based on local fresh foods to ultraprocessed imported foods is one of the main reasons behind the rise of NCDs.

It wasn’t always that way. Traditional diets were fibre-rich, with plenty of seasonal fruits, legumes, nuts, seeds and other indigenous plants, the WHO notes. But current obesity trends are being driven by a “change in the diets of local populations from traditional, locally grown staples to imported, energy-dense, HFSS foods and beverages.

“This shift away from agricultural production has been shaped by economic and commercial factors… , including the colonial legacy of land ownership and land division, land loss and pressures, as well as increasing migration and urbanization,” states the WHO paper on economic determinants. “It is also impacted by climate change and increasing droughts within the countries, as well as prohibitive inter-SIDS trade provision and shipping costs and other barriers, when compared to importing food internationally.

“As noted in a regional UN Conference on Trade and Development (UNCTAD) meeting, fishing remains a mainstay of economic activity, but remains challenged by issues such as illegal fishing. Unsustainable fishing or fishing insufficiently regulated to protect local fisheries and local consumption has direct impacts on health, as depleted stocks require island fishermen to work longer hours, farther from shore, in less safe conditions.”

“In contrast to the urban populations, people in rural areas of Pacific SIDS have a more varied diet which is more likely to meet WHO recommendations of consuming more than 400 grams of non-starchy fruits and vegetables daily,” the paper notes. Government policies are historically weak: “In 2021, only 13 of the 38 Member States SIDS had food based dietary guidelines (FBDGs) to inform and guide policy work along the food system, and no FBDGs explicitly incorporated environmental sustainability elements.”

Reducing taxes and duties on fresh foods and promoting healthy school lunches

Christopher Tufton, Minister of Health and Wellness, Jamaica

“I anticipate that in a few years time, we’re going to see premature mortality increase and it’s going to have a negative impact, I believe on the labor force and on the quality of life,” said Christopher Tufton – Minister of Health and Wellness, of Jamaica in a panel discussion on Wednesday. “What do we need to reduce this trend? I think we have to target all stakeholders and not just the converted.. From an economic modeling perspective and from a quality of life perspective.

“Particularly in terms of nutrition, we are import-dependent,” he noted, asking “how do we impact the global commodity chains to influence behavioural change?” Schools offer one point of focus, Tufton said.

“We are starting at the level of schools to influence behavioural change..We are pursuing nutrition policy because our children are our future. They’re a captive audience,” Tufton. Another panel member Ellis Webster, Minister of Health of Anguilla, agreed that school feeding programmes are a good starting point.

A key aim of the conference is to consolidate SIDS inputs into a upcoming high level UN meeting on Universal Health Coverage, scheduled for September, WHO says. Traditionally, NCDs and mental health have been poorly represented within countries’ UHC plans, with inadequate attention to prevention as well as to diagnosis and treatment.

The conference also follows on from the SIDS High-level technical meeting on NCDs and mental health held in January 2023, where representatives from SIDS countries discussed the progress and challenges to meet the Sustainable Development Goal 3.4 related to NCDs and mental health.

An outcome document to be issued at the close of the conference aims to reafirm SIDS political commitments to putting NCDs and mental health front and center, stimulating both increased domestic action and more international cooperation.

Image Credits: WHO.

African Union Signs Agreement with Rwanda to Host the African Medicines Agency

13/06/2023 Kerry Cullinan

Rwanda’s health minister, Sabin Nsanzimana (centre) receives the AMA Host Agreement from the AU.

The African Medicine Agency (AMA) came a small step closer to reality over the weekend when Rwanda signed a Host Country Agreement with the African Union (AU) Commission.

The AMA will serve as a continental body that provides regulatory leadership on medicines, enabling a harmonized regulatory system on the continent – but it has still to be ratified by most of Africa’s powerhouses.

At the signing ceremony, Rwandan Health Minister Sabin Nsanzimana said that the AMA will build confidence in the quality of health products, promote cooperation and mutual recognition in regulatory decisions and facilitate the movement of health products on the African continent.

Historic milestone today Saturday 10th June, as @_AfricanUnion Commission signs the African Medicine Agency (AMA) Host Agreement with the government of Rwanda.

AMA will serve as a continental body providing regulatory leadership for a harmonized regulatory systems in Africa. https://t.co/h27q02Yi73 pic.twitter.com/9NY1towM8L

— Rwanda Food and Drugs Authority (@RwandaFDA) June 10, 2023

Thomas Cueni, Director-General of the International Federation of Pharmaceutical Manufacturers and Associations (IFPMA) recently described the AMA as “a bit of a mess” because it had not yet been ratified by Africa’s most powerful nations, including Nigeria, Ethiopia and South Africa.

However, in late May, South Africa’s Parliamentary Health Portfolio Committee recommended that the country’s parliament ratifies the AMA Treaty. The issue had been tabled in Parliament in mid-May and referred to the committee for further discussion.

In its presentation to the committee, the South African Department of Health highlighted that the AMA would add value to the country and the continents by, amongst other things, reducing the prevalence of substandard and falsified medicines and vaccines, providing a consistent voice on regulatory issues, pool expertise from across the continent and ensure regulatory harmonisation and convergence on standards, and guidelines for quality, safety, and efficacy.

The issue will now be put to a vote in that country’s Parliament.

Gavi is On Track to Vaccinate 300 Million More Children by 2025

13/06/2023 Disha Shetty

Dr Seth Berkley, CEO of Gavi (left) and Marie-Ange Saraka-Yao, Managing Director for Resource Mobilisation, Private Sector Partnerships and Innovative Finance (right).

International vaccine alliance Gavi is on track to immunize 300 million more children by 2025 despite setbacks caused by the COVID-19 pandemic, it announced on Tuesday.

“Despite the huge strain placed on countries’ health systems by the COVID-19 pandemic, we’re on or ahead of schedule on eight of the 11 key commitments that we made for the period 2021 to 2025. These include efforts to immunize a further 300 million children, prevent between seven to eight million future deaths, and unlock $80 to $100 million in economic benefits,” said Gavi CEO Dr Seth Berkley

The alliance released its mid-term review report that tracks the progress of its goals for the 2021-2025 period. Every year Gavi provides vaccines to protect nearly half of all children on the planet.

The report coincides with a meeting of world leaders in Spain’s capital of Madrid for the Global Vaccine Impact Conference, where they are discussing the lessons from the COVID-19 vaccine access platform, COVAX, which was co-led by Gavi.

Improving Africa’s manufacturing capacity is a long-term goal

In the coming years, countries in Africa have pledged to improve vaccine manufacturing capacity as COVID-19 exposed their vulnerability.

While Gavi expressed confidence in the continent’s ability to scale up, it tempered expectations by adding that this was likely to be a long-term process.

“This is a long road. It is important to acknowledge that it takes time,” said Marie-Ange Saraka-Yao, Gavi’s Managing Director for Resource Mobilisation, Private Sector Partnerships and Innovative Finance. “A lot of pieces have come into play,”

Gavi also said it is working to ensure there is enough advance procurement so that manufacturers can produce vaccines at scale while keeping the cost low.

Gavi played a key role in improving vaccine access during COVID-19 in 92 countries.

Neonatal deaths, weak malaria vaccines are challenges

Gavi flagged neonates’ deaths, the low efficacy of malaria vaccines and climate change as key challenges.

While there has been considerable progress in reducing childhood deaths, deaths of neonates (babies in the first 28 days of life) remain high.

“The RTS,S vaccine which is the first malaria vaccine, had an efficacy rate of 39%. Now that may sound low, but given how prevalent malaria is, for every 200 children vaccinated, you save one life. So, in terms of impact, this vaccine is really important,” Berkley said.

Climate change is compounding challenges. As rainfall patterns change, droughts become more frequent and intense, and food insecurity is expected to rise.

“In my country, where climate change and displacement are making it harder, not easier, to deliver health services – vaccines are an essential way to manage outbreaks and save lives,” said Dr Abdelmadjid Abderahim, Minister of Public Health and Prevention in Chad.

Countries returning to pre-pandemic vaccination

While Gavi has presented an optimistic picture, a number of countries reported their post-pandemic struggles less optimistically at the recently concluded World Health Assembly weren’t so optimistic, including the re-emergence of polio cases in Pakistan and Afghanistan, after the pandemic disrupted routine vaccinations.

Gavi said nearly 57 low- and middle-income countries are on track to return to pre-pandemic level of routine immunization.

“According to the data we’re seeing from countries, we believe there are encouraging signs that resilient health systems in the now 57 Gavi implementing countries are having some success in recovering following the pandemic,” Berkley said.

Call for Legal Reform After UK Woman is Jailed Under 1861 Abortion Law

13/06/2023 Stefan Anderson

The cases of several other women facing similar charges are working their way through UK courts. Another woman is set to stand trial later this year.

There have been calls for abortion law reforms in the UK after a woman was sentenced to 28 months in prison on Monday for carrying out an abortion after the legal term limit.

The 44-year-old mother of three was sentenced under a law passed in 1861 that carries a maximum penalty of life imprisonment, sparking calls for immediate legal reform across the political spectrum.

Abortion was legalised in the United Kingdom in 1967, and is legal up to 24 weeks, while any procedure after the 10-week mark must be carried out in a clinic or hospital.

However, in this case, Carla Foster procured abortion pills by misrepresenting the term of her pregnancy during a COVID-19 lockdown when access to abortion pills was relaxed.

She claimed that she was seven weeks’ pregnant whereas doctors concluded Foster’s foetus was between 32-34 weeks old at the time of her abortion. This means it had a strong chance of survival if it had been born in a medical facility.

However, the British Pregnancy Advisory Service (BPAS), the abortion care provider Foster misled about the term of her pregnancy to acquire the abortion pills, said it was “shocked and appalled” that the case had led to criminal charges, adding: “No woman can ever go through this again.”

“We are now seeing a mother of three prosecuted under laws that do not exist in the same way in any other country,” BPAS chief executive Clare Murphy told the BBC.

A law passed nearly two centuries ago applies in cases where a woman intentionally causes an abortion after the 24-week limit. Foster was initially charged with “child destruction” under the 1929 Infant Life Preservation Act, which she denied. She later plead guilty to charges under the Offences Against the Person Act passed in 1861.

The 162-year-old law states that women in the United Kingdom who use “unlawfully administered” medications to induce an abortion can be kept “in penal servitude for life”.

With another woman set to stand trial later this year, lawmakers say action must be taken before another criminal prosecution occurs.

“Society has moved on, healthcare has moved on, and I think parliament has a role now to look at reforming our abortion laws,” said Labour MP Dame Diana Johnson, who has previously tried to repeal the 1861 act with a backbench bill.

“Removing the criminal law is a very sensible, reasonable step, but it’s not to deregulate abortion care and who can provide it.”

Mifepristone, the medication Foster used to terminate her pregnancy, is also at the centre of court battles in the United States as states seek to outlaw abortion pills following the repeal of Roe v. Wade.

Caroline Nokes, a conservative MP who chairs the Common Women and Equalities Committee told the BBC that parliament should “decide in the 21st century whether we should be relying on legislation that is centuries old”.

“This is not something that has been debated in any great detail for many years now,” Nokes said. “And cases like this, although tragic and thankfully very rare, throw into sharp relief that we are relying on legislation that is very out of date. It makes a case for the parliament to start looking at this issue in detail.”

A spokesperson for British Prime Minister Rushi Sunak said he was “not aware” of any plans to change the current approach to abortion.

“Our laws, as they stand, balance a woman’s right to access safe and legal abortions with the rights of an unborn child,” he said.

Asked to respond to the government’s statement on Sky News, veteran Labour MP Stella Creasy said it is “a bit worrying” that “the government does not even know that abortion is not legal in this country”.

“What many of us are worried about is that this could be the start of many more prosecutions and an attempt to chill a woman’s right to choose in the country,” Creasy said, noting that the cases of several other women facing similar charges to Foster are currently passing through UK courts. “Abortion is not a criminal matter, it’s a healthcare matter.”

Abortion is hotly contested in many parts of the world. While access to abortion has been eased in Colombia and Mexico in recent years, many US states have either banned abortions entirely or reduced the time in which women are able to get abortions. Florida, for example, recently made it illegal for a woman to get an abortion after six weeks of pregnancy when many women are not yet aware that they are pregnant.

Image Credits: Wei-te Wong.