As the global count of COVID-19 cases hit the sobering 1 million mark Thursday midnight, countries should not have to face the choice of protecting lives or protecting livelihoods, World Health Organization Director-General Dr Tedros Adhanom Ghebreyesus and International Monetary Fund Managing Director Kristalina Georgieva said at a Friday press briefing.

More than half of the new cases reported worldwide were still in WHO’s Europe Region, but an explosion of cases in low- and middle-income countries points to a looming health and economic crises in some of the world’s weakest health systems.

“We know that this is much more than a health crisis. We are all aware of the profound social and economic consequences of the pandemic,” said Dr Tedros. “The restrictions many countries have put in place to protect health are taking a heavy toll on the income of individuals and families, the economies of communities and nations”.

Countries around the globe have enacted widespread lockdowns in an effort to slow the spread of the virus, forcing businesses and employers to close or scale back operations. Millions of workers, particularly day wage workers, have lost their jobs overnight.

“This is a crisis like no other, never in the history of the IMF we have witnessed the world economy coming to a standstill,” said Georgieva. “We are now in recession, it is way worse than the global financial crisis.” 

Of particular concern are “emerging markets” in developing countries, said IMF’s Georgieva, which are hardest hit and have less resources to protect themselves from both the virus and the global recession. Since the beginning of the pandemic, nearly US $90 billion in capital has left such emerging economies.

“Many countries are facing this dilemma of do they provide support to people to survive, or fight the virus,”  said Georgieva. “We want to fight this false dilemma.”

“The issue of debt in developing countries must be addressed urgently,” she added. The IMF is providing debt relief for its poorest countries through a catastrophic containment relief trust support. Along with the World Bank, the IMF is also calling on bilateral creditors to place a moratorium on official debt payments to provide space for countries to address immediate priorities.

Georgieva’s message on debt echoed the moratorium on debt for developing countries put forward by the United Nations Conference on Trade and Development (UNCTD) in Monday’s $2.5 trillion coronavirus crisis package for developing countries.

So far, more than 90 countries have applied for emergency financing from the IMF. Rwanda’s request was granted today – and two other African countries requests will likely be approved today, said Georgieva. The IMF aims to double the normal amount of emergency financing offered to countries.

On where the funds should be directed in the short term response, Dr Tedros said that governments should be strengthening the foundations of the health system, paying their healthcare workers and removing financial barriers to care, and setting up social welfare support for the most vulnerable.

The WHO also voiced their concern today about lifting restrictions too quickly, and the importance of developing effective transition strategies as outbreaks in countries begin to dampen. “If countries rush to lift restrictions quickly, the coronavirus could resurge, and the economic impact could be more severe and prolonged”, said Dr. Tedros.

“We don’t want to have cycles of lockdown and release. This is not what anybody needs right now. The way to avoid that is a transition strategy to get ahead of the virus . Like this, we can protect our economies”, said Mike Ryan, Executive Director of the WHO’s Health Emergencies Programme.

COVID-19 Surge Past 1,000,000 Cases Worldwide

COVID-19 infections hit the one million mark on Thursday evening, according to latest reports by Worldometer, an independent digital team tracking case counts by official national and global sources.

COVID-19 hits the one million mark today.

More than half of the new cases worldwide over the past 24 hours were still being recorded in WHO’s European region. New cases in Europe totaled 38 809, with Spain, Germany, France, Italy and the UK accounting for almost three quarters of new cases.

As France approached the tipping point in demand for intensive care units, a National Ethics Consultation Committee had established “ethical support units” to “help doctors make difficult choices about which patients with “COVID-19 to treat in intensive care”. A summary of the new guidance was also published in English by the British Medical Journal

In the Americas, meanwhile, there were 28 161 new cases over the 24-hour period between 1 April -2 April, largely in the United States. As the USA’s numbers continue to increase to almost 245,573 confirmed cases, the Governor of Florida finally bent to national directives and issued stay-at-home orders for state residents yesterday. Overall, almost 90% (290 million people) of the USA’s population scattered across 37 states have received orders to remain at home. 

Indian Authorities Call For Provision of Food, Medical Facilities & Clean Drinking Water to Internal Migrants

Trends in India as of 13:04 CET. Confirmed cases increase exponentially. Logarithmic curve shown.

As India witnessed a massive internal migration of laborers from cities to their rural homes in response to a nation-wide lockdown, India’s Chief Secretary of State, Preeti Sudan, issued an order on behalf of the Ministry of Health and Family Welfare, calling on State Governments to provide adequate medical facilities, food, clean drinking water and sanitation for people on the move. 

The “anxiety and fear of the migrants should be understood by the police and other authorities and they should deal with the migrants in a humane manner,” stated the order, based on directives issued by India’s Supreme Court.  She called on “all concerned to appreciate the trepidation of the poor men, women and children and treat them with kindness.”  

The migration was occurring as South East Asia experienced a 7-fold increase in new cases in just 24 hours (31 March1 April). Just three of South-East Asia’s 11 countries, including India (2640), Indonesia (1986) and Thailand (1978) account for about 96% of the cases reported in the region so far. 

Prime Minister Narendra Modi had earlier announced $US 24 billion package to support India’s vulnerable populations during the COVID-19 crisis; the PM-CARES Fund is supposed to include free food rations for 800 million disadvantaged people, cash transfers for 204 million poor women, and free cooking gas for 80 million households. 

The fund is being financed by various contributions from other government branches, such as the military and the railways authority, as well as by contributions from government employees and celebrities. 

Africa’s cases have also increased exponentially in the past week, according to a weekly bulletin the WHO African Regional Office. In comparison to two weeks ago, new cases have almost doubled in the past week (185%), with three more countries reporting COVID-19 (Botswana, Burundi, and Sierra Leone). Currently, most member states in the WHO Africa region (42/45) have confirmed cases of COVID-19. The African region has exceeded 7000 cases today, says Africa’s Centre for Disease Control.

Total cases of COVID-19 exceed 1 million as of 7:01:32 PM CET, with active case distribution globally. Numbers change rapidly.

New Guidance Issued For Preventing COVID-19 In Refugee And Migrant Camps 

A new strategy called “shielding”, that aims to limit transmission of COVID-19 in migrant and refugee camps, has been proposed by the London School of Tropical Hygiene and Medicine’s Health in Humanitarian Crises Centre

The strategy recommends that people at high-risk from COVID-19 be identified and separated from other camp members in so-called ‘green-zones’ for an extended period of time, so as to reduce their risks of serious illness and possible death. The zones, ideally, would be located as close as possible to primary health care and other essential services, to minimize their need for movement. 

The guidance notes that the kinds of ‘stay-at-home’ orders and self-isolation tactics that have been widely adopted in developed countries are unworkable in migrant camps and camp-like settings. And at the same time, overcrowding, poor access to safe water, sanitation and limited access to health services could also lead to very high rates of infection among camp residents.

In the guidance, high-risk individuals are defined as those over the age of 60, as well as individuals that have low immunity due to genetic conditions or chronic diseases (e.g. HIV) or non-communicable diseases (NCDs) such as high blood pressure, lung diseases or cancers. 

“Green Zones” can be established at the household level, as well as at the neighborhood level, or as part of a broader community approach.

“Green Zones” can in fact be established at the household level, for older or weaker family members, as well as at the neighborhood level, or as part of a broader community approach – depending on the characteristics of the migrant camp or settlement, the document suggests.  

The guidance document suggests that “social care committees” can coordinate the shielding response and facilitate acceptance of and adherence to the shielding measures.

Grace Ren, Tsering Llamo, and Zixuan Yang contributed to this story

Image Credits: London School of Hygiene and Tropical Medicine , COVID-19 India , London School of Hygiene and Tropical Medicine.

Iceberg melting in Iceland

The critical UN Climate Conference of Parties (COP26) that was scheduled to take place in Glasgow, in November, has been postponed until 2021 as a result of the COVID-19 emergency.

“The COP26 UN climate change conference set to take place in Glasgow in November has been postponed due to COVID-19,” stated an official message by the UN Framework Convention on Climate Change to UN member states and observers.

“This decision has been taken by the COP Bureau of the UNFCCC, with the UK and its Italian partners.  Dates for a rescheduled conference in 2021, hosted in Glasgow by the UK in partnership with Italy, will be set out in due course following further discussion with parties. In light of the ongoing, worldwide effects of COVID-19, holding an ambitious, inclusive COP26 in November 2020 is no longer possible. Rescheduling will ensure all parties can focus on the issues to be discussed at this vital conference and allow more time for the necessary preparations to take place. We will continue to work with all involved to increase climate ambition, build resilience and lower emissions.”

Patricia Espinosa,  UNFCC Executive Secretary said that the decision had been reached after receiving “a detailed assessment from the representative of the United Kingdom of Great Britain and Northern Ireland, the host of COP 26.

Patricia Espinoza, Executive Secretary of UN Climate Change.

“COVID-19 is the most urgent threat facing humanity today, but we cannot forget that climate change is the biggest threat facing humanity over the long term”. Espinoza added. However, she named no future date for the meeting, saying only: “The Government of the United Kingdom will initiate consultations with Parties and stakeholders to identify a suitable new date for the Conference which will be presented to the Bureau for its endorsement,” said the official message to UN member states and observer organizations.

The COP26 meeting has been viewed as particularly critical both in light of the speed at which climate change is occuring, and the huge gap in mitigation commitments to slow its current pace. As the five year mark since the 2015 Paris Climate Agreement, countries were due to submit new, more ambitious long-term goals to reduce emissions at COP26. 

Despite the delay, the head of the European Green Deal initiative of the European Commission, pledged to continue efforts towards dramatic reductions in carbon emissions by 2030. “We will not slow down our work domestically or internationally to prepare for an ambitious COP26, when it takes place”, said Frans Timmermans, executive vice-president for the European Green Deal in a statement.

The European Commission’s plans are “on track” to present by September 2020 a detailed plan to cut greenhouse gas emissions by 50-55% compared to 1990 levels, in line with EU’s 2030 ambitions, he added. 

“At home, we have put in place the key EU laws to meet our existing 2030 climate and energy targets. In the long-term, we have committed to climate neutrality by 2050 and proposed a climate law that will make this objective legally binding. The legislative work on this proposal has started, even in these challenging circumstances.

“An impact assessed plan to raise the EU’s 2030 ambitions and cut greenhouse gas emissions by 50-55% compared to 1990 levels is on track, and the Commission will stick to that. The same goes for the work necessary to submit an enhanced Nationally Determined Contribution to the UNFCCC in line with our commitment under the Paris Agreement,” he said.

Countries are “not off the hook and will be held accountable” to display greater climate ambition when the COP26 finally does convene, said Tassnem Essop, Executive Director of Climate Action Network International, a worldwide network of some 1300 NGOs in over 120 countries. “The postponement of the COP does not mean a postponement in climate ambition”, he said.  

Experts Debate Long-Term Impacts of Pandemic on Political Will For Climate Action 

Rooftop assembly of solar panels in New York City has given way to makeshift construction of COVID-19 hospital tents.

Some observers of the COVID-19 emergency, including billionaire philanthropist Bill Gates, have recently asserted that the crisis can be a catalyst for more coherent action on other global challenges because it is facilitating innovation, and more direct, daily collaboration amongst scientists and between scientists and policymakers.

“Until we get out of this crisis, COVID will dominate, and so some of the climate stuff, although it will still go on, it won’t get that same focus,” Gates said in a recent Ted Talk, but he added that, “As we get past this, yes, that idea of innovation and science and the world working together, that is totally common between these two problems. And so I don’t think this has to be a huge setback for climate.” 

Observed Espinosa in her statement on the COP-26 postponement. “This is an opportunity for nations to green their recovery packages, an opportunity to include the most vulnerable in those plans, and an opportunity to shape the 21st century economy in ways that are clean, green, health, just, safe and more resilient. In the meantime, we continue to urge nations to significantly boost climate ambition in line with the Paris Agreement.” 

Leading scientists and environmentalist have also pointed out that the illegal hunting and consumption of endangered wild animal species, such as the pangolin, were in fact drivers that contributed to the leap of the coronavirus from bats to other animals in China’s wild animal markets, and then to humans.

Logically then, ecosystem stability should be considered more seriously by policymakers in the wake of COVID-19. “Nature is sending us a message,” Inger Andersen, head of the United Nations Environment Programme said in a recent interview, noting that some  75% of new infectious diseases originate from animals.  Longstanding environmental campaigns to halt illegal wildlife trade and the destruction of habitats are all the more improtant now, so as to prevent future outbreaks like Covid-19. 

Still, the pandemic is also a bitter reminder of the barriers to coherent global action, as well as the fact that the public as well as most politicians tend to avoid dealing with long-term and unseen environmental health threats – at least until the moment when people are literally, dropping dead in hospital corridors.

Writing in Foreign Policy,  one senior official to former US President Barack Obama said that the extreme measures governments are taking on COVIVD-19 may have given hope to “climate activists that similarly ambitious policies might be possible to address global warming, which many consider a similar existential threat.

“Yet that would be the wrong lesson to draw, as the very same barriers preventing an effective COVID-19 response continue to keep climate change action out of reach,” “said Jason Bordoff, a former U.S. National Security Council senior director in the Obama White House.

“Cities across the world are shutting down businesses and events, at great cost. Yet the effectiveness of any one government’s action is limited if there are weak links in the global effort to curb the pandemic—such as from states with conflict or poor governance—even if the world is in agreement that eradicating a pandemic is in every country’s best interest,” he said.

“Climate change is even harder to solve because it results from the sum of all greenhouse gas emissions and thus requires aggregate effort, a problem particularly vulnerable to free-riding,” added Bordoff, now a professor and founding director of the Center on Global Energy Policy at Columbia University’s School of International and Public Affairs.

“The pandemic is a reminder of just how wicked a problem climate change is because it requires collective action, public understanding and buy-in, and decarbonizing the energy mix while supporting economic growth and energy use around the world,” said Bordoff.

Cleaner Skies Now – Dirtier Ones Later

Of course, COVID-19 may deliver some short-term climate benefits by “curbing energy use, or even longer-term benefits if economic stimulus is linked to climate goals — or if people get used to telecommuting and thus use less oil in the future,” Bordoff acknowleged.  “Yet any climate benefits from the COVID-19 crisis are likely to be fleeting and negligible.”

Historically, building political will around environmental goals is usually more difficult during periods of economic downturn, he added.  “Historically, there is an inverse relationship in the United States and Europe between public concern about the environment and worries about economic conditions. Similarly, concern about economic growth has often caused China to ratchet back its environmental ambitions.  Just last week, China was reportedly considering relaxing emissions standards to help struggling automakers,” he noted.

A similar pattern is also emerging, in the United States.

On Monday, the US Environmental Protection Agency announced that it would relax vehicle fuel economy standards for vehicles for model year 2021, as well as for model years 2022-2026, which had been approved under the Obama administration. The rules, which would lead to the release of 900 million more tons of CO2  every year, are being opposed by the State of Califorinia, but the Trump administration is also trying to strip states of the authority to enact stricter vehicle emissions rules.

And last Thursday, the US Environmental Protection said that it would suspend enforcement of a wide range of environmental regulations regarding, air, water, wastewater and even hazardous waste emissions – until the COVID-19 crisis is over, noting that companies violating emissions rules might be excused from their violations if they were somehow associated to COVID-19.

“During this extraordinary time, EPA believes that it is more important for facilities to ensure that their pollution control equipment remains up and running and the facilities are operating safely, than to carry out routine sampling and reporting” said EPA Administrator Andrew Wheeler in a statement.

“The Trump administration is cynically abusing this crisis to achieve its pre-COVID-19 goal of gutting US environmental regulations. The decision to indefinitely suspend the protections afforded by environmental laws will kill or compromise the health of large numbers of people”, warned Richard Pearshouse, Amnesty International’s head of Crisis and Environment, in a statement

-Tsering Llhamo and Zixuan Yang contributed to this story. 

 

Image Credits: Andrew Bowden, Patricia Espinosa C., Renovus Solar.

Temporary COVID-19 treatment unit being set up in Central Park, New York City

The COVID-19 pandemic is the biggest challenge the world has faced since the Second World War, said United Nations’ Secretary-General Antonio Guterres. He spoke during the launch of a report on the potential socioeconomic impact of the outbreak, Shared Responsibility, Global Solidarity

Speaking from the UN Headquarters in New York on Tuesday, Guterres said thatthe new coronavirus disease is attacking societies at their core, claiming lives and people’s livelihoods.” The economic fallout of the outbreak could trigger a recession of unprecedented scale, as up to 25 million jobs could be lost globally as well as a 40% reduction in global foreign direct investment flows. 

In his statement, Guterres also called upon the G-20 to move ahead with a special Africa initiative, discussed at the extraordinary G20 Summit last week. And he called upon developed countries more generally to bolster health systems and response capacity in lower income nations, saying that, “Otherwise we face the nightmare of the disease spreading like wildfire in the global South with millions of deaths and the prospect of the disease re-emerging where it was previously suppressed.  “Millions and millions” could die in Africa without intervention, he later told France 24.

Just a day later on Wednesday, the African Development Bank group approved a $2 million emergency grant for countries of the WHO African Region boost surveillance systems, procure and distribute laboratory test kits and reagents, and support coordination mechanisms at national and regional levels. The regional office of  WHO Africa reported 3762 confirmed cases and 92 deaths on Tuesday night; South Africa remained the most heavily affected country with 1353 cases but Algeria had the most deaths at 35.

The White House Predicts Over 100,000 Coronavirus Deaths in the US

Meanwhile, top United States health authorities said that a “best-case scenario” for the pandemic would see the deaths of nearly 100,000 to 240,000 people in the United States. Anthony Fauci and Deborah Birx, leading experts on President Donald Trump’s COVID-19 Task Force, issued the warnings during a White House press conference Tuesday night, with reference to projections produced by the Seattle-based Institute of Health Metrics and Evaluation’s (IHME). Keeping the curve to the lower end of 100,000 deaths or less, will be contingent on effective enforcement of social distancing and other disease control measures, they stressed.

Speaking at the press conference, President Trump warned Americans to brace themselves for a “very, very painful two weeks”, as he announced more severe nationwide measures to be implemented to curb the coronavirus. But he also pointed out that in the absence of such measures, the United States could face as many as 12.2 million deaths, according to projections by Imperial College London cited by Birx earlier in the briefing.

Officials were quick to point out that the death projections are not static, given that hotspots like New York and New Jersey are pulling the estimates upwards, but in other states, such as California and Washington, authorities have managed to reduce infection transmission.   

The state of New York has emerged as the epicentre of the pandemic in the United States, recording over 75,000 confirmed cases and over 1,500 deaths, Governor Andrew Cuomo has said that the outbreak is not expected to peak for another three weeks. “I’m tired of being behind this virus. We’ve been behind this virus from day one. We underestimated this virus. It’s more powerful, it’s more dangerous than we expected,” he said in a press briefing earlier in the day. The United States currently has a total of almost 190,000 confirmed cases with over 4,000 deaths. 

A preliminary report by the US Centres for Disease Control and Prevention (CDC) has estimated that 78% of coronavirus patients admitted in intensive care as well as 94% of those who died in the US had at least one underlying chronic condition. People with diabetes, lung disease and heart disease appear to be at higher risk of severe illness, CDC found, which is consistent with findings from Italy and China. 

As a vivid symbol of the expanding emergency, Mount Sinai Hospital system in New York City was set to open a field hospital in Central Park, in collaboration with Samaritan’s Purse. The tent hospital units, delivered from North Carolina, will provide overflow capacity for Mount Sinai’s COVID-19 patients, with 68 more beds.

Italy Extends Lockdown Measures — Even As Infection Curve Plateaus

Italy’s civil protection authority has reported that the number of reported coronavirus infections is rising at a slower rate — the country has recorded daily increases around 4-5% in the past 4 days, which is 3-4 times less than the rates recorded two weeks ago.

Silvio Brusaferro, the president of Italy’s Higher Health Institute (ISS) told The GuardianThat doesn’t mean we’ve hit the peak and that it’s over, but that we must start the descent … by applying the measures in force”. In an effort to halt the continued rise in cases, lockdown measures currently in place have been extended till April 13; Italy now has over 105,000 cases, and has reported over 12,000 deaths, one of the highest national death rates from the virus. Over 15,000 people have also recovered. Italy’s Health Minister Roberto Speranza said the new trend was a sign that measures are yielding results, but added it would be “unforgivable to assume this was a definitive defeat” of the virus.

Customers queuing in Toulouse, France, as part of social distancing measures taken to reduce crowding in supermarkets during the COVID-19 pandemic.

The rate of infection increases in Spain was also stabilizing somewhat following drastic containment measures. María José Sierra of the centre of health emergencies said “generally speaking, we can say that yesterday’s rise in cases, which was around 8%, tells us that we’re carrying on in the stabilisation phase of the pandemic”. The country has seen a dip in daily infection rates from 20% between 15 to 25 March to below 12% since then. However, in neighboring France, new infections rose overnight by 15%. 

In Switzerland, meanwhile, the Geneva University Hospital (HUG) announced that it was launching a study of serological samples, to be collected from among research volunteers, to examine the extend to which Swiss citizens and residents might be infected with the virus asymptomatically, as well as the degree to which exposure might have conferred immunity.

As many as 83,300 cases, and 720 deaths, could be expected in Switzerland by 11 April 2020 researchers from the Swiss Federal Institute of Technology in Zurich predicted in a paper published Wednesday on the preprint server MedRxiv. Switzerland currently has reported 17,139 confirmed cases and 378 deaths, although it is believed that many cases have gone unreported insofar as testing has so far largely been confined to people at high risk and with serious symptoms.  For the country of 8.5 million people, this still ranks as one of the highest per-capita disease rates in the world, although deaths have remained comparatively low at about .02% of those confirmed ill. In the absence of social distancing interventions,  up to 42.7% of the entire Swiss population would have been infected with COVID-19 by 25 April, the researchers also said. The assessments align with previous studies published on the benefits of “non-pharmaceutical interventions” such as closures and stay-at-home orders on slowing the spread of the virus.

Cumulative cases and global distribution. Numbers change rapidly
Concerns for Vulnerable Populations Increases

As governments take measures to protect their citizens from the rising COVID-19 pandemic, experts were increasingly concerns about potential devastating effects on indigenous peoples, refugees, and others worldwide who lack formal citizenship rights in the countries where they are living. Four UN agencies released a statement Tuesday that called for the protection of those at “heightened risk,” including “refugees, those forcibly displaced, the stateless and migrants.”

According to the statement, “many refugees live in overcrowded camps, settlements, makeshift shelters or reception centres, where they lack adequate access to health services, clean water and sanitation.” Up to three-quarters of the world’s 70.8 million forcibly displaced people are hosted in countries where health systems are “already overwhelmed and under-capacitated.” 

As one example, the 10 cases and 1 death reported so far in war-torn Syria may be a sign of a bigger crisis to come, Mark Lowcock, Under-Secretary-General for Humanitarian Affairs and Emergency Relief Coordinator told the Security Council, warned the UN Security Council in a meeting Monday. 

“That is the tip of the iceberg,” he said in a UN press release, warning that only half of Syria’s hospitals and primary health-care centres were fully functional at the end of 2019. And while the UN has assisted in rehabilitating the Central Public Health Laboratory, pre-positioning medical supplies, and upgrading isolation units around the country; the fragility of the health system and critical supply chains further complicate COVID-19 measures.

Cross-border deliveries of aid supplies between Turkey and north-west Syria have more than doubled compared to the same period last year to 2150 trucks per day. Some US $340 million has so far been received by the UN Office of Humanitarian Affairs under a US $500 million funding call.

Meanwhile, as confirmed cases soar beyond 12,000 in South America, indigenous tribes in Brazil, Colombia, Ecuador and Peru have taken matters into their own hands in the face of what they call “a historic danger,” as quoted in the Guardian. The Xingu people in Brazil have sealed off roads into their reserve and are urging locals to leave only for emergencies, as the country’s number of confirmed cases topped 5500 and deaths rose to over 200.

In Colombia, which has almost 900 confirmed cases so far, tribes have been self-isolating and outlawing visits to their ancestral lands while collaborating with local governments to procure adequate supplies. Isolated tribes living in areas with fragile health systems, are particularly susceptible to acute, highly infectious diseases. Outbreaks of measles, smallpox and flu viruses had a long track record of “decimating” indigenous communities. 

Some countries are taking more widespread social welfare measures for vulnerable populations. Indian Prime Minister Narendra Modi announced a US$24 billion welfare package to provide free food rations for 800 million disadvantaged people, cash transfers to 204 million poor women, and free cooking gas for 80 million households for the next 3 months.

Health Experts Revisit Benefits of Wearing Masks in Public 

As the intensity of coronavirus infections rises in many parts of the world, health experts are beginning to reconsider whether the general public should wear face masks after all. 

Until now, the World Health Organization as well as the US Centers for Disease Control and Prevention (CDC) have recommended the use of face coverings only for the sick or for health workers treating those who might be ill. However, CDC director Robert Redfield said that this recommendation is currently under review. 

The US CDC recommendation under consideration would specifically recommend fabric masks, or do-it-yourself type masks for the general public, reports the Washington Post. Medical grade masks such as surgical masks or N95 respirators – which are in desperately short supply around the world – would still be restricted to use by healthcare workers. 

At his press briefing on Tuesday, even President Trump has encouraged the public to cover their faces with scarves when they go out, so that masks may be reserved for healthcare workers. “I can tell you that the data and this issue of whether it’s going to contribute [to prevention] is being aggressively reviewed as we speak,” Redfield told NPR in an interview.

Many prominent healthcare experts have weighed in on the issue, including former FDA Commissioner Scott Gottlieb. In a paper he published with American Enterprise Institute, a conservative US policy think tank, Gottlieb recommended supplementing social distancing measures with the widespread use of facemasks, citing the large numbers of asymptomatic cases that go undetected. 

“Face masks will be most effective at slowing the spread of SARS-CoV-2 if they are widely used, because they may help prevent people who are asymptomatically infected from transmitting the disease unknowingly”, says Gottlieb, citing South Korea and Hong Kong as places where facemasks were widely used, and managed to successfully control the outbreaks. 

Similarly, other individual experts have advocated for the use of facemasks as a socially responsible insurance policy.

And countries are beginning to act as well. Israel’s Prime Minister Benjamin Netanyahu on Wednesday issued a new order that anyone leaving their homes should wear a mask “or other face covering”, making it the first country outside China to adopt mandatory mask usage while out in public. Hungary this week also ordered people visiting supermarkets to wear facemasks in order to risk infection spread in venues that often remain crowded with customers. 

Street scene in France. Universal masking being reconsidered.
Tobacco Industry Joins the COVID-19 Vaccine  Race

British American Tobacco (BAT), the world’s second largest cigarette maker, announced that it would launch an effort to develop a COVID-19 vaccine using tobacco plants, joining a global effort that has generated over 90 potential vaccine candidates so far. 

Using plant-based production, the company claimed in a press release that between 1-3 million doses of vaccine could be manufactured per week by June. The process works by first identifying and cloning an antigen – an immune-response generating portion of SARS-CoV-2, the virus that causes COVID-19 – into a tobacco plant. The antigen can then be purified from grown and harvested tobacco plants in as little as 6 weeks.

The tobacco plant production method was used by BAT’s US bio-tech subsidiary, Kentucky BioProcessing (KBP), to successfully manufacture the Ebola treatment ZMapp in 2014. 

KBP has been exploring alternative uses of the tobacco plant for some time. One such alternative use is the development of plant-based vaccines,” said David O’Reilly, director of Scientific Research at BAT. “We are committed to contributing to the global effort to halt the spread of COVID-19 using this technology.” However, the SARS-CoV-2 antigen that would supposedly be purified and used for the production, is still being evaluated in preclinical tests.

Image Credits: Samaritan's Purse, Wikimedia Commons: Alteo31300.

A new study examining data from nearly 90% of mainland China’s confirmed COVID-19 cases found that the death rate among people older than 80 was 13.4%, as compared to only .32% for people under the age of 60. Almost one in five patients over the age of 80 were likely to require hospitalisation, as compared with around 1% of people under 30, according to an analysis of a subset of 3,665 cases.

The analysis, published Tuesday in the Lancet Journal of Infectious Diseases is the first large-scale study to account for long-presumed underestimation of mild or asymptomatic cases in death rate and hospitalization rate estimates. It is also the first to include data on infections among Wuhan expats who were airlifted out of the city at the outset of the lockdown, as well as cases linked to the Diamond Princess cruise ship.

While the crude case fatality rate was 3.67%, the authors estimated that the true average death rate, including milder, under-reported cases, was around 1.38%. Based on an analysis of cases among Wuhan expats, the authors also proposed that accounting for all COVID-19 infections could yield an even lower infection-fatality rate of about .66%. The Lancet study examined a total of 70,117 laboratory-confirmed and clinically-diagnosed cases in mainland China, or about 80% of cases reported there so far, as well as 689 positive cases among people evacuated from Wuhan on repatriation flights and cases identified on the Diamond Princess cruise ship.

While still considerably higher than the death rates for seasonal flu (.01%), the 1.38% average case fatality ratio is significantly lower than the crude case fatality ratios cited by most sources until now, including the World Health Organization. However, the authors’ assumptions about the widespread circulation of asymptomatic infections also contradicts another large-scale study that examined that issue. The report of some 320,000 Chinese in Guangdong Province, found that only .14% of people tested in fever clinic screenings were infected with the virus. It is therefore likely that the true rate of mild and asymptomatic infections will continue to be debated until more large-scale serological studies are undertaken.

“Our estimates can be applied to any country to inform decisions around the best containment policies for COVID-19,” says Azra Ghani, an author on the paper and professor at the Imperial College London, UK, in a press release.  “There might be outlying cases that get a lot of media attention, but our analysis very clearly shows that at aged 50 and over, hospitalisation is much more likely than in those under 50, and a greater proportion of cases are likely to be fatal.” 

However, the authors caution that up to 50% to 80% of the global population could be infected with COVID-19 in the absence of any interventions, meaning that the number of people needing hospital treatment is likely to overwhelm even the most advanced healthcare systems worldwide. 

According to The Lancet study, after adjusting for underreporting of mild cases, older adults faced the highest risk of requiring hospitalization from the infection at 18.4%, compared to an estimated hospitalization rate of 3.4% in people in their 30s, and 1% for people in their 20s.  

The Lancet study, however, still contrasts sharply with hospitalization and mortality data from confirmed cases in some hotspots such as Italy and the United States. In Italy, WHO officials reported that up to 50% of those hospitalized for COVID-19 are under the age of 50. A report released by the US Centers for Disease Control earlier this month found that 38% of hospitalized cases in the country were under the age of 55.

Case fatality and hospitalization rates can “vary slightly from country to country because of differences in prevention, control, and mitigation policies implemented,” said Shigui Ruan, an infectious disease modeling researcher at the University of Miami in a separate Lancet Comment on the study. Thus, each country’s hospitalization and death rates are ” substantially affected by the preparedness and availability of health care,” he added.

A separate study published Monday by Imperial College, London estimated that across 11 European countries “Non-pharmaceutical interventions” such as case isolation, the closure of schools and universities, widescale social distancing and national lockdowns helped avert up to 59,000 deaths by COVID-19. 

Between 7-43 million individuals had been infected with the SARS-CoV-2 virus that causes COVID-19 as of 28 March, representing between 1.88% and 11.43% of the population, the study concluded. The attack rate – or rate of new infections – caused by the virus is estimated to be highest in Italy and Spain, and lowest in Germany and Norway.  

BARDA Branch Of US Health Agency Takes Over Clinical Trials for 2 Vaccine Candidates

Meanwhile, the Biomedical Advanced Research and Development Authority (BARDA) branch of the U.S. Department of Health and Human Services (HHS) said that it would take over late-stage development of the first COVID-19 vaccine candidate to enter Phase I clinical trials, mRNA-1273. The federal agency will also step in to support early development of another potential vaccine with an eye to rolling it out for emergency use in the US by early 2021. 

Originally created through a collaboration between Moderna, Inc and the US National Institute of Allergies and Infections Diseases (NIAID), the company will now shift to collaborating with the Biomedical Advanced Research and Development Authority (BARDA), part of the HHS Office of the Assistant Secretary for Preparedness and Response (ASPR), to move mRNA-1273 through Phase II and Phase III clinical trials.

3D print of a spike protein of the SARS-CoV-2 virus

In a parallel development, BARDA will collaborate with the Janssen R&D arm of the US pharma firm, Johnson & Johnson (J&J), to accelerate non-clinical trials and Phase I trials of their investigational vaccine, Ad26 SARS-CoV-2.

The Phase 1 clinical trial is set to begin no later than fall of 2020 with the goal of making the COVID-19 vaccine available for emergency use in the United States in early 2021. At the same time, the agency is collaborating with J&J to make plans to produce up to 300 million doses of the vaccine every year for use in the United States.

“Delivering a safe and effective vaccine for a rapidly spreading disease like COVID-19 requires accelerated action with parallel development streams,” said the BARDA Director Rick Bright in a press release

BARDA, as part of the HHS, can wield federal power to fund and coordinate manufacturing of the thousands of doses of investigational vaccine needed for clinical trials. Setting up processes now to run late-phase clinical trials and scale-up manufacturing rather than taking the more traditional sequential approach to vaccine development could “shave months off the timeline for vaccine development,” the agency claims.

BARDA can wield federal power to fund and coordinate manufacturing of the thousands of doses of investigational vaccine needed for clinical trials – although it remains to be seen whether the patent rights associated with any successfully developed vaccines will be held by the US government or private companies.

Depending on the terms and type of contract signed, HHS can do “pretty much anything,” James Love, director of Knowledge Ecology International (KEI) said in an interview with Health Policy Watch. As one example, HHS could use federal funds to “buy-out” patents to contribute to a global “pool” of intellectual property rights, according to one KEI blog

“HHS/BARDA should explain what the contractual terms for data and patent rights were,” added Love.

Experts Say COVID-19 Casts Risks From Climate Change & Environmental Degradation in Sharp Relief 

Meanwhile, looking towards the future, a WHO COVID-19 Special Envoy and the leader of the UN Development Programme’s Health and Development Group, warned that the world needs to meet critical climate and sustainable development goals in order to prevent the recurrence of further COVID-19 pandemics.

“Most outbreaks are zoonotic,” noted Mandeep Dhaliwal – Director of UNDP’s HIV, Health and Development Group, speaking at a webinar on Tuesday organized by the global group, Health Care Without Harm.

“We talk a lot about health system preparedness, readiness, response.  But missing from that conversation are the environmental factors that result from human activity that cause those outbreaks. These are not addressed so we keep lurching from one outbreak to another.”

The coronavirus, which scientists believe originated in bats, was likely transmitted to humans by wild animals, possibly a pangolin, a species that is hunted illegally and sold in live animal markets throughout Asia. Similarly, viruses circulating among gorillas and chimpanzees in Africa, hunted and sold as bushmeat, are believed to have sparked the 2014-16 West African Ebola outbreak as well as the HIV/AIDS epidemic.

“The pace of zoonotic outbreaks is going to increase, and is going to be magnified in the ways that you saw with COVID-19,” Dhaliwal predicted, until stronger linkages were made to prevent the patterns of ecosystem degradation and biodiversity loss, which intensify human contact with wild animals, leading to higher risks of zoonotic infections.

Conversely, she noted that environmental health risks such as air pollution “also make people more vulnerable to COVID-19,” as do climate-related health risks such as climate-induced food and nutrition insecurity. “COVID 19 changes everything from the way we work as a global community,” she said. “We will not be able to ignore this anymore  – we need to do something about the human activity that is driving this [zoonotic infections], and those actions will have to come from outside the health sector. We need integrated solutions to address the climate crisis and zoonotic outbreaks.”

Said David Nabarro, a WHO special envoy on COVID-19. “This is an issue that requires all of the approaches that we developed in the sustainable development agenda, interconnectedness, working across all parts of society.  The principles of the sustainable development have to be at the center of what we are trying to do.  But can leaders manage this, while still having their full attention on their people and the awful political trade-offs that they are having to make?”

According to Health Care Without Harm, the worldwide pandemic and the climate crisis, are converging health emergencies. “With one, disease spreads like wildfire. And with the other, wildfires and other impacts, spread disease. While at first blush these two crises are not necessarily related to one another, there are a series of coronavirus – climate crisis connections that are worthwhile exploring, as they reveal several common causes, synergistic impacts and shared solutions.”

Rate of New COVID-19 Infections Potentially Slowing Down in Europe 

Europe is still COVID-19’s epicentre, with almost 32 000 new cases since yesterday and over 2 500 new deaths. However, there were nearly 5000 fewer new cases in Europe reported on 30 March compared to 29 March, according to Monday night’s WHO situation report. Europe currently has 392,757 confirmed cases and 23,692 deaths.

“Italy and Spain are potentially stabilizing and it is our fervent hope that this is the case. But we have to continue to push the virus down”, said Mike Ryan, executive director of the Health Emergencies Programme, at a WHO press conference yesterday.

Donning gloves in the hospital storage room, Lecco, Lombardy. (Photo: Fabio Fadeli)

Italy, which has about 13% of the world’s confirmed cases, is experiencing a decrease in new cases, with only 4000 new cases on the 30th of March compared to last week’s average of 5 500 new cases a day. Yesterday, the number of new cases in Spain was 6549 in comparison to 8189 new cases reported on the 29 March. To help respond to the unmet and urgent needs to tackle COVID-19, today, the Spanish government approved the distribution of 300 million euros to Spain’s Autonomous Regions.

Israel may also be seeing a slowdown in the increase in cases. Israel which currently has 4831 cases, reported only 448 new cases yesterday compared to the weekend average of 606 new cases a day.

Switzerland on Tuesday recorded 16176 cases and 373 total deaths, 701 more than the previous day. Some 78 new deaths were reported, marking the largest daily increase in deaths in the last seven days. Blood tests that are also able to detect asymptomatic cases are being developed and deployed both in Zurich and Geneva. The University Hospital in Zurich plans to test all incoming patients, whether ill or victims of accidents, to further detect new cases. The country is testing roughly 13,600 per million people, putting its per capita testing rate at higher than even South Korea.

In the Eastern Mediterranean Region, Iran leads with a total of 40 000 total confirmed cases. In an unexpected move last week, Iran rescinded approval for Médecins Sans Frontieres’ (MSF) COVID-19 intervention in Isfahan. MSF’s charter planes, which were carrying material to build an inflatable 50-bed treatment unit, had already landed in Tehran.

In the Americas, cases have steadily increased at about 21 000 new cases per day over the past two days. The USA, which has surpassed any other country in the world, has 164 610 confirmed cases as of today, 40% of which are in New York State. Yesterday, in a statement from New York’ Governor Andrew Cuomo’s Press Office, a new plan was announced to transfer patients between public and private hospitals to balance current demand with local capacity.

Africa has confirmed 3486 cases, and has reported about 400 new cases a day. South Africa, which has about 40% of Africa’s cases, has experienced a dramatic reduction in new cases with a weekend average of 70, which is in stark comparison to numbers reported on 27 March, when the country peaked with 243 new cases. However, WHO experts have cautioned that low weekend reporting patterns and limited testing may lead to underestimates of the true case numbers in the continent. 

According to WHO’s daily situation report, there are 4048 cases in WHO’s Southeast Asia region as of Monday night. By Tuesday night, India, the most populous country in the region, had 1251 confirmed cases with 32 deaths. However, the country has one of the lowest testing rates in the world, at 32 tests per million. Prime Minister Narendra Modi’s 21-day lockdown, which began last Tuesday, has resulted in a mass exodus of daily wage migrant workers after losing their jobs and the order to return home. At least 22 deaths have been reportedly linked to the mass exodus. In anticipation of an upwards surge in cases, the Ministry of Railways has agreed to modify 20000 coaches into quarantine and isolation wards to supplement the country’s facilities.

Total active of COVID-19 as of 7 p.m. CET 31 March. Right column shows confirmed cases. Numbers change rapidly.

 

Gauri Saxena contributed to this story.

Image Credits: NIAID, Johns Hopkins CSSE.

WHO team of technical experts conclude a COVID-19 support mission to Egypt.

The World Health Organization has received more than US $622 million of a US $675 million ask to fund WHO’s first Strategic Preparedness and Response Plan for COVID-19, WHO Director-General Dr Tedros Adhanom Ghebreyesus said on Monday.

 “We continue to be encouraged by the signs of global solidarity to confront and overcome this common threat,” said Dr Tedros, speaking at an afternoon press briefing. 

In a parallel development, Norway is leading an initiative to establish a multi-donor fund for the global COVID-19 response to assist developing countries, coordinating with the United Nations to launch the initiative within the next few days.

“A multi-donor fund under UN auspices will provide predictability for our partners and help to make the efforts more effective,” said Minister of Foreign Affairs Ine Eriksen Søreide in a press release.

‘Experience from other crises shows that the earlier you start long-term response planning, the more precise and successful the effort becomes.”

Unlike the UN Solidarity Fund, which is soliciting donations from individuals and private donors for the response, this fund will collate resources from major bilateral donors and international agencies, similar to the UN Ebola Response Fund set up in 2014 to address the emergency in West Africa. The fund will provide both immediate emergency aid to developing countries, and aid for longer term development initiatives to prop up weak health systems to prepare for future pandemics.

In another meeting Monday with Ministers of Trade from the Group of 20 (G20) richest countries in the world, Dr Tedros also called on G20 countries to significantly their increase production of personal protective equipment (PPE), and ensure its equitable distribution of equipment around the world. 

“Specific attention should be given to low- and middle-income countries in Africa, Asia and Latin America,” said Dr Tedros in a statement. “We call on countries to work with companies to increase production; to ensure the free movement of essential health products; and to ensure equitable distribution of those products, based on need.”

However, hoarding and misappropriation of donated PPE equipment also may loom as a thorny problems that donors need to resolve. At the China-Uganda Friendship Referral Hospital near Kampala, one of three Ugandan reference hospitals for COVID-19 cases, health workers taking throat swabs from suspected COVID-19 patients and managing an isolation ward, lack basic protective gear except gloves, Health Policy Watch learned.  N-95 masks must be purchased by the doctors and nurses out of pocket, and protective gowns and face shields are unavavilable.

Gloves were provided by the hospital after workers threatened to strike, but when supplies run low, patients have to pay for those themselves before they are examined.  WHO did not comment on the report.

154 NGOs Submit Open Letter Calling For Gilead To Retract Remdesivir Patent Applications

Some 154 NGOs released an open letter Monday calling for Gilead Sciences to rescind its patent applications for remdesivir in 70 countries that could grant the company market exclusivity until 2031 on the experiemental drug, a promising potential COVID-19 treatment.

The campaign, coordinated by Médecins Sans Frontières (MSF), aligns closely with a growing movement within the medicines access community to push for mandatory “pooled” rights for COVID-19 technologies. 

In an unusual move, Gilead already asked the US FDA to rescind special “orphan drug” status for remdesivir last week after facing an intense public backlash, just days after recieving the designation. Orphan drug status would have granted Gilead an addition 7 years of market exclusivity. However, according to the MSF statement, the company still has pending patent applications for remdesivir in at least 70 other countries. 

“It is unacceptable for Gilead’s remdesivir to be put under the company’s exclusive control, taking into account that the drug was developed with considerable public funding for both early-stage research and clinical trials; the extraordinary efforts and personal risks that both healthcare workers and patients have faced in using the medicine in clinical trial settings; and the unprecedented disaster all countries are facing for their people, their healthcare systems, and their economies” said Medecins Sans Frontieres (MSF) in a statement today.

In the open letter, Gilead was urged to take immediate action in the public interest by declaring that it will drop all exclusive rights on patents, regulatory and trial data, as well as making all data required for development of generic drug versions publically available to enable their production and supply. Finally, Gilead was requested to improve its transparency by disclosing its existing supply and manufacturing capacity.

“There is a further step to take, as a voluntary pool may not be sufficient, especially when the crisis intensity cools and public approbation for actions like Gilead’s Orphan designation abates,” said Paul Fehlner, President & CEO of reVision Therapeutics, in an interview with Health Policy Watch.

An entity dedicated to the public interest could obtain consequential legal exclusivities (Orphan drug designation, data and market exclusivity) and prevent opportunistic third parties from getting them”.

According to Fehlner, creating a “pool” of rights would take minimum efforts, only requiring a willing coordinator to “aggregate data from ongoing trials worldwide and submit formal applications to health authorities.”

“This crisis presents an immediate and urgent opportunity to wield the tools of exclusivity to promote access to medical products that may combat COVID-19,” said Fehlner.

COVID-19 Trends 

As the United States now leads the world in coronavirus cases with 143,055 confirmed cases and 2,513 deaths according to the Johns Hopkins tracking database, President Trump extended the U.S. social distancing guidelines until the end of April, rescinding his earlier predictions that the lockdown would end by mid-April’s Easter holiday.   

Meanwhile, the UN donated 250,000 protective face masks to the USA from its New York headquarters to help combat the outbreak’s epicenter in New York. 

As the US is faced with rapidly increasing cases, inefficiencies from failed coronavirus tests, and shortage of ventilators, STATNews reports that the Genomics Institute led by Jennifer Doudna, the pioneer of CRISPR gene editing technology, will start running coronavirus tests in order to increase the turnaround time of testings in the San Francisco Bay Area.

Over the weekend, Italy and Spain bolster efforts to curb the spread of the coronavirus and flatten the curve.  Italy, numbers 97,689 cases and 10,779 deaths, and Spain, numbers 85,195 cases and 7,340 deaths, have overtaken China’s 82,198 cases and 3,308 deaths according to the Johns Hopkins coronavirus tracking database. As infection increases, Italy has decided to extend its national lockdown beyond the April 3rd date while Spain tightens the national lockdown for all citizens, except for the workers in the essential sectors until April 9th. 

As the rate of infection within countries intensified, European countries began to depart from longstanding WHO guidance against the wearing of masks by the general public. Notably, Austria made masks obligatory for clients in supermarkets mandatory to curb airborne spread of the coronavirus amongst customers. Crowded supermarkets have been identified in a number of countries as nexus points for virus spread.  However, until now, universal masking has only been practiced in Asia, while WHO repeatedly said the measure was unecessary elsewhere. 

The Hungarian Parliament, meanwhile, awarded wide-ranging powers to Prime Minister Viktor Orban for an indefinite period, to fight the pandemic, including curtailing free speech and other democratic rights.  

South-East and Western Asia 

In South-East Asia, the coronavirus was increasingly disrupting the lives of those living on the socioeconomic margins. After Prime Minister Modi’s surprise lockdown announcement, India’s daily wage earners struggle under the nationwide lockdown as many are stranded in cities without food, housing, and means of getting back home, particularly vulnerable are the Muslim minority who have been victims of recent riots over amendments to the naional citizenship bill. The challenges faced by the rural Indian migrants in the megacities post-lockdown has initiated one of the largest exodus of people back into the rural areas. 

Meanwhile, in the Western Pacific Region, the International Olympic Committee (IOC) postpones the Tokyo Summer Olympics to July 23rd, 2021 to August 8th, 2021. 

Online debates also continued to swirl around the degree of China’s influence on the WHO. On Sunday, Taiwan’s Foreign Minister Joseph Wu tweeted a complaint referring a senior WHO official’s response to a question from a Hong Kong journalist, about whether WHO would reconsider Taiwan application for member state status. “Wow, can’t even utter ‘Taiwan’ in the WHO? You should set politics aside in dealing with a pandemic,” Wu wrote. Taiwan has accused WHO of ignoring its early warnings about the appearance of a novel coronavirus in mainland China, as well as brushing aside subsequent criticism that China repressed early news about the virus spread, which delayed a more systematic public health response.

Overall, Europe continued to lead with half or more of the now active COVID-19 cases worldwide, followed by the United States.  There were some 30,000 active cases in the Eastern Mediterranean Region, including heavily hit Iran.  South-East Asia was reporting nearly 3,600 active cases, and in WHO’s Africa region, there were more than 3,300 infections reported.  In the Western Pacific Region, there were some 18,095 active cases, but only about 3,000 of those were in mainland China.

Total cases of COVID-19 as of 8 p.m CET, with active case distribution globally. Numbers change rapidly.

-Tsering Lhamo contributed to this report.

Image Credits: WHO EMRO.

Health workers in full protective gear do a COVID-19 throat swab in a Addis Ababa isolation centre. But in Kampala, Uganda, doctors have no suits and they must to purchae their own masks.

CAPETOWN, South Africa – As many African countries opt for lockdowns to combat COVID-19, there is uncertainty over whether this will be enough to prevent the pandemic’s spread, or whether authorities will be able to implement this in overcrowded urban areas – as well as fears for patients with HIV, TB and other conditions that require monthly medication.

There is a sense that Africans are on the shore watching the sea drawing back before the tsunami of infections hit, overwhelming the continent’s health facilities and killing thousands of people.

In late February,  just a handful of African countries had recorded a few COVID-19 cases. Egypt, Algeria and South Africa, with a high volume of air traffic from other affected regions of the world, were hit first.

By yesterday (29 March), 4,282 cases of the virus had been recorded in 46 of the 54 African countries, according to the Africa Centres for Disease Control and Prevention (CDC).

WHO’s Director-General, Dr Tedros Adhanom Ghebreyesus recently warned the continent to “prepare for the worst”.

African countries have been struggling to reconcile measures to arrest the virus, such as travel bans, social distancing and restricting public gatherings, with the need to protect their weak economies.

More African Countries Using Lockdown Measures 

Amid the growing consensus that China’s reversal of its pandemic started from a lockdown, and this is the most effective way to reverse the pandemic, key African countries have opted for drastic  measures to contain the virus in the past few days.

Rwandans are in a 14-day lockdown which started on 22 March. Kenya has a night-time curfew and restrictions on gatherings.

South Africa went into a 21-day total lockdown on Friday.

Soweto, South Africa. Poverty and crowded conditions make lockdowns doubly difficult.

“Those countries that have acted swiftly and dramatically have been far more effective in controlling the spread of the disease,” said South African President Cyril Ramaphosa.

“While this measure will have a considerable impact on people’s livelihoods, on the life of our society and on our economy, the human cost of delaying this action would be far, far greater.”

The Democratic Republic of Congo implemented a four-day lockdown on Saturday, after the move had been delayed for a few days when the prices of essential goods spiked.

Yesterday, Nigeria’s president Muhammadu Buhari announced a 14-day lockdown for Lagos and Ogun state which comes into effect at 11pm Monday, 30 March.

Ghanians living in Accra and Kumasi face a two-week lockdown from today. Zimbabweans also face a 21-day lockdown from today, and Lesotho citizens face a 25-day lockdown. Congo-Brazzaville goes into lockdown from tomorrow (Tuesday) and eight towns in Burkina Faso will be shut down from Friday for 14 days.

However, implementing the lockdowns has proven challenging.

South Africans may only leave their homes to buy basic groceries or medical supplies and there is a ban on the sale of alcohol. The South African National Defence Force has been brought in to support the police. Already, police used rubber bullets and water cannons to disperse shoppers in Johannesburg who were refusing to stand an arm’s length apart.

Two Rwandans were reported to have been shot dead over the weekend, although that government subsequently denied that the shootings were related to the lockdown.

Observers also fear that the heavy-handed application of lockdown measures, in the African context, will deprive people of access to food and essential services, including essential medical care.

One worried Ugandan doctor who contacted Health Policy Watch related the story of an expectant mother living in a village some distance from Kampala, who had called him shortly after the country’s lockdown was announced on Monday, fearing that she was going into labour.

“She has poor obstetric history,” he said. “A few days ago, she did an ultrasound scan that revealed a breech presentation. Her expected date of delivery is 3 April. She cannot access medical services since she is in the village, in a distance not walkable to the nearest facility where she can have ceaserian section done (if necessary).

“‘I can not afford an ambulance because drivers often need fuel facilitation,’ she lamented. I was left speechless… She is opting to walk to the nearest traditional birth attendant for some magic. I felt this is worth sharing.”

 

COVID-19 simulation exercise at the Kinshasa International Airport, Democratic Republic of Congo.

Some Front-Line Health Workers Aren’t Getting PPE Supplies – Despite Massive WHO Shipments 

Meanwhile, epidemics experts are urging African governments to do whatever they can to protect the continent’s thin line of health workers. They urgently need personal protective equipment (PPE) such as masks, gloves and hand sanitiser.

“But other measures are very important such as ventilation, spacing, early triage and separation of potential cases and increased access to water and supplies,” said Amanda McClelland, senior vice-president of PreventEpidemics, part of Vital Strategies’ Resolve to Save Lives programme.

Dr Gilles van Cutsem, an infectious disease doctor and epidemiologist with Médicins sans Frontières (MSF), stressed that “there needs to be planning and preparation for screening and triage at health facilities to avoid overcrowding and saturation of hospitals, and ensure that hospitals do not become foci of transmission”.

“In Italy and China triage tents were set up outside hospitals to receive and separate patients,” added van Cutsem.

Meanwhile, HIV clinician Dr Francois Venter, deputy director of Reproductive Health and HIV Institute Johannesburg, urged those who are “mildly symptomatic” to stay away from health facilities to make sure that there is space for the very sick.

Speaking after 14 days in quarantine, Venter said he had “anticipatory anxiety” as he waited for the deluge of patients.

“I was almost disappointed that my [COVID-19] test was negative. For the first time in my life, I understand emotionally the relief that some of my gay clients expressed when they finally tested positive for HIV,” said Venter.

While the WHO has reportedly sent large consignments of PPE to various African countries, shortages are still being reported all over the continent.

There were only 60 N95masks distributed to some 280 health workers at China-Uganda Friendship Hospital near Kampala, a designated treatment facility for Covid-19 patients.  Doctors and nurses performing COVID-19 tests have to purchase their own masks, according to one staff member, assigned to the COVID-19 isolation unit. That, despite the fact a WHO African “Readiness” Checklist showed Uganda to be equipped with masks and gloves.

WHO Readiness Checklist shows Uganda equipped with PPE. Frontline health workers in Kampala isolation unit say they must buy their own masks.

The hospital staff only received gloves after threatening to go on strike – although when gloves run short, patients are also asked to purchase them in order to be examined.

When asked by Health Policy Watch about the reports of PPE shortages in Uganda’s COVID-19 units, WHO did not comment. Nor did it provide aggregate totals of PPE supplies that have been shipped to Africa until now.

However, in a press briefing Monday, WHO Emergencies Head Mike Ryan said, “”We have already sent large numbers of PPE and diagnostics to the countries. It’s not enough. We are working with World Food Programme, Jack Ma Foundation, and Africa CDC to bring in PPE.”  Jack Ma, founder of the Alibaba Group, is making a series of massive donations to regions across the world, including 1.1 million test kits, 6 million masks and 60,000 protective suits for Africa, which were due to begin distribution last week, according to Ethiopia’s Prime Minsiter, Abiy Ahmed Ali.

Donations of PPE from by the Jack Ma Foundation land in Addis Ababa last week.

McClelland recently returned from Ethiopia, Africa’s second most populous African country, and has few illusions about the massive tasks that lie ahead: “There is still much more to do in Ethiopia to test and detect cases. The extent of transmission in this country with 105 million people is not really known.”

There are two major challenges: preparing and training health workers – Ethiopia only has 19,000 – and engaging communities to change their personal behaviour to limit the spread.

Sobering new data from Imperial College predicts that 250 critical care beds will be needed per 100, 000 people if the non-pharmaceutical interventions, such as social distancing and restricting gatherings, are not successful in stemming the tide of infections.

A recent report from Nigeria estimates that the country may only have around 500 ventilators for a population of over 200-million.

Said Ryan, “The issue of ventilators is very important – but from the perspective of supporting patients, oxygen is also something we need to discuss.“Before ventilator support, what truly is lifesaving is the ability to give patients supplemental oxygen. When someone has COVID19 your lungs struggle to put oxygen in your blood. Every country in Africa has oxygen. We need to focus on getting better distribution of lifesaving oxygen. We are working to scale up the distribution of supplies and coordinate in a way that countries can expect a smooth service.”

“Micro-Isolation” Tactics Used For Ebola May Help Contain COVID-19 

While COVID-19 is a different kind of infection, with effects likely to eclipse the more deadly but less contagious diseases such as Ebola, the continent has learnt important lessons about epidemics from its experiences battling such viruses steadily, including during the 2014-2016 health emergency in West Africa, as well as the more 2018-2020 Ebola epidemic in DRC, now finally on the wane.

While trying to contain Ebola, Guinea introduced a form of community quarantine called “micro-cerclage” (micro-encirclement) to limit the movement of people in Ebola-affected areas.

Those showing symptoms of Ebola were placed in isolation while those close to them were asked to limit their movements. Limited essential movement – such as attending to crops – was allowed and was often monitored by people’s mobile phones.

Amanda McCelelland, Prevent Epidemics

Community leaders’ support for the policy was key, as were local response teams who enforced the monitoring. Affected households were also provided with food and basic toiletries.

“Microcerclage is one approach that will potentially add real value to addressing COVID-19 but this will depend on the scale of community transmission,” says McClelland, who came face-to-face with Ebola while working in the Emergency Health Unit of the International Federation of Red Cross and Red Crescent Societies.

“If clusters can be detected early and isolated then this approach could help communities to not be negatively impacted and to continue to have access to key services and resources including food and water.”

But a huge challenge is how to quarantine city dwellers. Over 20 million people live in crowded conditions in Lagos, five million live in Johannesburg and three million in Addis Ababa.

“Self-isolation and restriction of population movement on a much larger scale in some cities would stretch the resources to be able to provide food, water and services on a citywide scale,” warned McClelland.

Community Engagement Also Key 

Ebola also has negative lessons. “Without community engagement and trust, the outcomes can be devastating,” warned McClelland. “In the Ebola response, this tragically included violence against first responders. We must do everything we can to avoid this in the response to COVID-19.”

In 2019 in the DRC alone, MSF recorded more than 300 attacks on Ebola health workers, during which six people were killed and 70 wounded.

Stigmatising foreigners assumed to be infected with COVID-19 is already happening.

On 18 March, the US embassy in Ethiopia issued a security alert warning of “a rise in anti-foreigner sentiment revolving around the announcement of COVID-19”.

“Incidents of harassment and assault directly related to COVID-19 have been reported by other foreigners living within Addis Ababa and other cities throughout the country. Reports indicate that foreigners have been attacked with stones, denied transportation services, being spat on, chased on foot, and been accused of being infected with COVID-19,” according to the Embassy.

Laboratory capacity has also been improved in many Ebola-affected countries, and Nigeria in particular has made substantial improvements in combating epidemics in the last few years.

But Van Cutsem warned that the laboratory capacity of most African countries, aside from South Africa is “extremely poor”.

“Countries have to find ways to improve the capacity of their laboratories to process tests, and we need the introduction of rapid tests,” said Van Cutsem.

While some African leaders have speculated that the virus may not survive in high temperatures, McClelland simply says: “The short answer is we do not know yet. The science is still not clear. There is some evidence that, in a laboratory , the virus may be affected by warmer temperatures. But we also have transmission occurring in warm climates like Australia, the Middle East and South East Asia. Influenza transmits all year round in much of Africa and can actually be worse in dusty conditions. It is too early to assume Africa is protected due to heat and they must prepare with the same sense of urgency as other countries.”

Hopes that the pandemic may be short-lived are not shared by experts who quietly talk about the current conditions continuing for many more months.

“Settle down to this. Social isolation might be the new normal for the rest of the year. Look after your mental health, check in with people and be kind,” advises Venter.

At the same time, in Africa, where large proportions of the population live below or on the verge of poverty, ensuring people’s basic needs during the COVID-19 emergency, will still remain the most fundamental priority, said Dr Tedros Adhanom Ghebreyesus, in a brieing Monday.

“Some countries have strong social welfare systems, some countries don’t. I’m from Africa as you know, and I know some people have to work every single day to win their daily bread. And governments have to take this into account. If we are closing and limiting movement, what will happen to people who have to work on a daily basis? We don’t mean the effect as an average of GDP loss or general effect on the economy; we have to see what it means to an individual on the street.”

Kerry Cullinan is the health editor for openDemocracy 50.50, and based in South Africa.

-Updated 31 March, 2020

Image Credits: Matt-80, © WHO/Otto B., © WHO/Kabambi E., Twitter: @AbiyAhmedAli , Vital Strategies , Courtesy of Kerry Cullinan.


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(HPW/Svet Lustig): How countries rank in COVID-19 tests/per million population. Based on national test data collected by FIND (finddx.org), 28 March, 2020.

Testing: the crux of effective outbreak responses

Testing is an essential component of effective outbreak responses. Without widespread testing, we cannot know whether a disease is spreading nor take measures to appropriately respond to it. All countries should be able to test all suspected cases, they cannot fight this pandemic blindfolded, they should know where the cases are, and that is how they can take decisions,” said Dr Tedros, WHO Director General. Health Policy Watch is tracking testing trends in countries around the world, based on data from FIND’s COVID-19 tracker.

We display diagnostic capacity using two measures – cumulative testing by countries and trends showing change  

We have displayed the data using two measures: cumulative number of tests per million population, for all countries administering tests as of 28 March, and trends in selected countries over the past week.

From the cumulative data, we can see how some countries, including Iceland, Bahrain, Norway, the United Arab Emirates, and Switzerland, far outpace other nations in terms of their rate of testing, per million people. We also see how many low and middle income countries across Africa, Latin America and South-East Asia still lack any significant test capacity, even while cases are rising.  Importantly, we present testing data per million people to account for large population differences between countries.

From the trends data, we can also see how countries such as Australia, Switzerland and the United States, have very rapidly ramped up testing over just the past week, while others, such as France and Great Britain, lag further behind.

Testing Trends In Europe
Within the past week, European countries such as Switzerland and the Czech Republic have doubled and tripled their testing capacity, respectively. Switzerland, which has one of the highest per-capita rates of infection in the world, has now administered 12,639 tests per million people. Countries like France and the UK, however, have not reported any changes in testing over the past week, with only 1,548 and 1,779 tests per million , respectively, despite increasingly high infection rates.
(HPW/Svet Lustig): Trends in selected countries of WHO’s European Region. Based on national test data collected by FIND (finddx.org), 28 March, 2020.

Western Pacific, Eastern Mediterranean and Americas Regions – High Income

Australia has sharply increased its testing, with 8,134 tests per million on 28 March, double that of a week ago. While the USA has almost quadrupled its testing capacity in one week, it still has only administered a total of 2,032 tests per million, lagging behind many high-income regions.  Trends covered are in selected high income countries of the region.

(HPW/Svet Lustig): Trends in selected low- and middle-income countries of WHO’s Western Pacific (WPRO), Eastern Mediterranean (EMRO) and Americas (AMRO) regions. Based on national test data collected by FIND (finddx.org), 28 March, 2020.

African, South-East Asian and Americas Regions – Low & Middle Income  

Trends here are for selected low- and middle-income coutnries that are testing significantly. In the African continent, South Africa leads with 539 tests per million. While South Africa’s testing capacity is still low in comparison to the rest of the world, this is still approximately double compared to last week.
In Latin America, Chile has increased its testing five-fold for a cumulative total of 1209 tests per million; followed by Costa Rica, which has doubled its testing capacity to 600 tests per million. While testing capacity has almost doubled in India, as well, the country so far carried out only 20 tests per million people.
(HPW/Svet Lustig): Trends in selected low- and middle-income countries of WHO’s Americas (AMRO), African AMRO) and South East Asia (SEARO) regions. Based on national test data collected by FIND (finddx.org), 28 March, 2020.

 

Transmission electron micrograph of SARS-CoV-2 (red), the virus that causes COVID-19

Some 33 Members of the European Parliament released an open letter Friday urging top leadership in the European Commission (EC) to prohibit exclusive licensing for COVID-19 products developed with European Union (EU) grants, and demanding transparency in the research and development pipeline to ensure affordability commitments are met. 

In a separate letter signed by 37 NGOs and over 50 experts in health and patent law, public health and medicine, called on the World Health Organization and all Member States to get behind Costa Rica’s initiative to “pool” COVID-19 patent rights for essential drugs, vaccines, and technologies. The letter was posted by Knowledge Ecology International, a global patent watchdog group.

Those campaigns come right in the wake of the World Health Organization Director-General Dr Tedros Adhanom Ghebreyesus’ Twitter endorsement of Costa Rica’s call to create the “pooled rights” initiative.  

“We cannot allow patients to be refused care because of financial constraints or shortages resulting from manufacturing or supply constraints,” said the Members of the European Parliament in the letter addressed to EC President Ursula Von Der Leyen; EU Commissioner for Innovation, Research, Culture, and Youth, Mariya Gabriel; and EU Health and Food Safety Commissioner, Stella Kyriakides. 

Although the European Commission invests more than double of any private sector partner in EU-funded COVID-19 research, most of the calls for proposals so far do not seem to require companies or organizations to commit to affordability and access clauses, the MPs stated in their letter. Thus, it is even more important to enforce public oversight on the R&D process and bar exclusive licensing, they noted.

For new products, companies should be required to commit to non-exclusive licensing on any developed health technology as a precondition for receiving EU funding, said the MPs.  Granting exclusive licenses on new products could result in subsequent shortages, as only “one or very few companies” would be “allowed to produce an extremely timely medicine that is required in huge quantities worldwide,” the MPs stated.  

“From this moment forward, we require new medical tools to be immediately available once authorised for use, at an affordable price and in high enough quantities to meet global demand.”

Responding to the calls, Thomas Cueni, director-general of the International Federation of Pharmaceutical Manufacturers and Associations warned that pooling patent rights would not likely enhance the global battle against the virus. 

“While voluntary pooling of intellectual property and other assets can be a tool to stimulate R&D and facilitate access under certain conditions, its effects to address the current pandemic will likely be very limited,” warned Cueni in a statement. “Tools already exist for governments to access the medicines they need, and they are already being used in a number of cases. 

“In addition, there are established organizations in place –  such as the Medicines Patent Pool, a UN-backed initiative that uses a voluntary licensing and ‘pooled’ patent model to grant licenses to generics manufacturers – who have the expertise in licensing and managing an established pool of intellectual property assets,” Cueni added.

As one such example, AbbVie Pharmaceuticals recently announced that it would offer through the Medicines Patent Pool licenses for its lopinavir/ritonavir drug combination without patent restrictions, after the HIV treatment was identified by the World Health Organization as one of the drug combinations to be tested in a multi-country trial against COVID-19.

“Given the gravity and urgency of the COVID-19 pandemic, the biopharmaceutical industry has not wasted any time or spared any effort in using its skills, technology and resources to bring safe and effective treatments, vaccines and diagnostic to patients around the world as a matter of utmost urgency,” added Cueni, pointing to a list of IFPMA commitments on the emergency.

Civil Society Advocates Propose “Phased” Development of COVID-19 Patent Pool

However, the proposed pool of patent rights for COVID-19 technologies would, in fact, build on the successes of the Medicines Patent Pool in expanding affordable access to medicines for HIV/AIDS, tuberculosis, and hepatitis C, said Brook Baker, senior policy analyst at the Global Access Project, and a signatory on the KEI letter.

“Simply put, no exclusive rights should stand in the way of governments’ and the global community’s response to the COVID-19 pandemic,” Baker wrote in an opinion to Health Policy Watch on Costa Rica’s call to pool rights to drug development.

To build agreement around the roll-out of a COVID-19 patent pool, the KEI letter also proposes a phased approach. An initial “phase-one” agreement would establish the minimum legal basis to permit such licensing in the future, and create a process for working out the details. Hammering out which technologies to share, the terms of authorization, and possible remuneration for the pooled licenses could be done at a later date, the KEI signatories suggest. 

However, the pool for COVID-19 products should go beyond medicines patents, per se, to address regulatory test data, research data, cell lines, basic science innovations, and other intellectual property, the signatories, including some 37 NGOs and 50 experts.

Inputs to such a pool could come from governments that fund research and development or buy innovative products, as well as from universities, research institutes, charities, private companies and individuals who control rights, the letter suggests.

In parallel moves, two other large NGOs, Médecins Sans Frontières and the Treatment Action Group released separate public statements Friday calling for national governments to prepare to override patent protections as well as to take other measures, such as enacting price controls, to ensure availability of COVID-19 medicines, vaccines, and other medical tools. 

TAG threw its weight behind the MSF call, earlier in the week, for a US $5 price tag on a rapid COVID-19 test that can be used on the GeneXpert TB platform, which has thousands of diagnostics instruments in Africa, Latin America and South-East Asia.

“We know too well from our work around the world what it means to not be able to treat people in our care because a needed drug is just too expensive or simply not available,” said Dr Márcio da Fonseca, Infectious Disease Advisor at MSF’s Access Campaign in the statement.

South Africa, one of the first middle-income countries to embrace the Cepheid COVID-19 test, announced that it will begin using the new GeneXpert COVID-19 tests to leverage the large network of over 180 machines in the country to ramp up rapid testing, as total confirmed cases in the country crossed the 1000 cases threshold. The first test cartridges will be available for use in April.

Ad for generic lopinavir/ritonavir HIV drug combination, originally marketed as Kaletra by AbbVie, which relinquished its patent rights to the COVID-19 campaign

First Patient in WHO’s COVID-19 SOLIDARITY Trial Enrolled in Norway

At the University of Oslo Hospital in Norway, the first patient was enrolled Friday in WHO’s massive multi-country SOLIDARITY trial to collect data on potential COVID-19 treatments. This followed on an announcement by Prime Minister Erna Solberg of a 2.2 billion NOK (US$ 211) additional investment into the Coalition for Epidemic Preparedness Innovations (CEPI) COVID-19 vaccine development efforts. That was in addition to a 1.6 billion NOK (US$ 153.6 million) investment in the Oslo-based CEPI vaccine efforts.

“We are in a global quest for knowledge unlike anything we’ve ever seen,” said Noweigian Minister of Health Bent Høie in a press briefing. “We can save lives, protect healthcare professionals and all others from getting the disease.”  

The Norwegian SOLIDARITY trial patient will be the first to take part in this WHO-organized global effort to test four potential COVID-19 treatments under a simplified protocol, so that even low-resourced healthcare facilities could participate. The drugs to be tested include Gilead’s experimental drug remdesivir; the lopinavir/ritonavir originally developed by AbbVie Inc. for HIV/AIDs along with beta interferon; as well as the anti-malarials chloroquine or hydroxychloroquine with azithromycin. Another arm of the trial is also starting on Friday in Spain.

The SOLIDARITY Trial began as global case counts surpassed half a million, and total deaths surged over 26,000.

“These are tragic numbers,” said Dr Tedros.

Some countries are already administering the medications ad-hoc on a compassionate use basis, as well as stockpiling for future mass use. But WHO’s Dr Tedros has cautioned against widespread use of such treatments without strong evidence – following media reports of people self-medicating with the substances or ones similarly named. One man in the United States, for instance, died after ingesting chloroquine phosphate, a chemical used in aquarium cleaning, following US President Donald Trump’s endorsement of chloroquine as a treatment for COVID-19, according to the Associated Press.

“We call on individuals and countries to refrain from using therapeutics that have not been demonstrated to be effective in the treatment of COVID-19,” said Dr Tedros. “The history of medicine is strewn with examples of drugs that worked on paper, or in a test tube, but didn’t work in humans or were actually harmful.” 

In one example, he said that “during the most recent Ebola epidemic, for example, some medicines that were thought to be effective were found not to be as effective as other medicines when they were compared during a clinical trial.

“We must follow the evidence. There are no short-cuts.”

Contrary to WHO’s cautious approach, a prominent bioethicist suggested a radical approach to fast-tracking vaccine development – purposefully infecting young healthy volunteers with the virus and seeing whether the vaccine protects against infection. In a preprint paper, Director of the Center for Population–Level Bioethics (CPLB) at Rutgers University Nir Eyal suggested that despite placing participants at risk of “severe disease and death”, such a ‘human challenge’ study design could “subtract many months” from the vaccine licensure process, reducing the global burden of coronavirus morbidity and mortality.

COVID-19 cases worldwide as of Friday evening. Numbers change rapidly.

Image Credits: NIAID.

Health workers in Lecco, Lombardy, Italy in full protective gear.

No illusion.  COVID-19 is closer to us than we may imagine. And getting closer day by day. Around the world, in big cities and small centres alike, people are heading deeper into a sort of dystopian fiction, as if empty streets, latex gloves, face masks and self isolation were the new normal.

Some 1.3 billion Indians have been asked to stay home to fight the spread of the disease. One third of humanity is under Coronavirus lockdown. Never before has a virus stopped the entire world’s gears quite like this. 

The media of the entire planet is gripped by this new coronavirus, spreading a global panic – although we are also beginning to see governments step up response and engineer mass planning for worst-case scenarios. As it should be. The repercussions, however, are also moving the global health sphere into business and politics. 

The COVID-19 shockwave will end, at one point. Meanwhile, it is forcing a Copernican re-thinking of the interconnected global economy we have had in place for over three decades.

COVID-19 is not the first wake-up call for the world of the 21st century. The first seismic shock came with the terrorist attack of 9/11, followed by a global financial crisis which boiled over in 2008, with the collapse of Lehman Brothers.

Yet again, this invisible and silent virus – a minuscule RNA packet enveloped in a protein capsule – has shaped up to be an enormous stress test for globalization, shaking up all our institutional certainties as well as our individual lives. We are re-discovering just how vulnerable nations and people are. Just how fragile the globalized economy is, with its productive arrangements.

In his latest book on inequalities, Walter Scheidel reminds us that epidemics are one of the most transformative events in human history. Nothing new under the sun, basically, except that we don’t seem to learn the cogent lessons that the past, including the recent past, offers us. 

Since the start of the millennium we’ve seen a number of coronavirus species make the leap from animals to humans. The first occurred in China with SARS in 2002-2003, then in 2012 with MERS in Saudi Arabia and Jordan. Other virus specie leaps hae occurred with swine flu (H1N1) in 2009, bird flu in 2013 and 2017 (H7N9), as well as other pathogens such as Zika and Ebola (still active in Africa). For decades, experts from the science community have warned about the need to prepare for another pandemic like the 1918 Spanish flu (“the Great Influenza”), which killed at least 50 million people worldwide, but their premonitions went unheeded. 

Now that we are in it, SARS-CoV2 looks pretty much like the pathogen for which scientists had been waiting. It kills healthy adults as well as elderly people. Covid-19’s global fatality rate doubled over the past two months – up from 2.1% as of 20th January to 4.4% as of 23rd March, according to data of the World Health Organization (WHO). 

That is is much higher than 2% of the Spanish flu pandemic, although clearly, we still lack reliable evidence on how many people have been infected. The WHO recommendation (“Test, test, test”) has been key to the success in countries like South Korea, Singapore, Honk Kong and Iceland, which implemented widespread initiatives to test thousands of their inhabitants a day, early into the outbreak, thereby keeping numbers under control.

Overall, Europe’s variety of approaches, largely dependent on test kit availability or shortages as well as the limits of national health system capacity. This, in turn, has been a significant factor in the epidemiological tracking of the disease, as well as where it hit the hardest. Making testing quickly available has formed the basis of Germany’s strategy to combat the virus; COVID-19 tests have been available through the country’s statutory healthcare since January. Expansion of testing in France occurred only after lockdown, as the death toll increased. The same trend became apparent in Spain, where the death toll last week was doubling every three days.

Italy, the first country in Europe to experience a serious domestic surge of COVID-19 cases, and still the region’s major epicentre, has had to negotiate across a variety of sub-national approaches to testing, which make today’s estimates of the national mortality rate quite unreliable, as many mild or asymptomatic cases go uncounted. The lessons from Italy’s COVID-19 mistakes need to be shared widely.  However, differences in the number of people who are tested for the coronavirus and how deaths are recorded, limit the comparability of published data across even European countries to a large extent. 

What we certainly know by now is that the virus has an exponential transmission rate: one affected person may pass it on to 2-3 people, 10 people if the vector is a doctor or a nurse. The efficiency of the contagion is also  apparent among symptomless and pre-symptomatic individuals, or people with few symptoms   This means that COVID-19 is much harder to contain than SARS, which had a slower transmission rate, and only through symptomatic people. COVID-19 has already caused 10 times more cases than SARS, in just one-quarter of the time. 

When the emergency ebbs, we shall no longer recognize the landscape. Yet, in the reflections that accompany the spread of COVID-19 we may find it useful to explore several political hypotheses, which take us from globalization to its direct effects at home. Let’s try a few.

Washing hands (Photo: Fabio Fadeli)

The Sad Geopolitics of the Crisis 

Let’s start with the uncomfortable truth. While geared to prepare for war, the world is amazingly unprepared to fight viruses.

NATO, for example, has a rapid reaction force (NRF) which regularly carries out months’ long exercise programs in order to integrate and standardize all operational aspects – logistics, food and fuel provision, operational language, radio waves, etc. – across national contingents.

Nothing, nothing like that exists in the domain of health emergency and pandemic containment. The last serious simulation of a pandemic catastrophe in the US, the Dark Winter Exercise, took place in 2001. European countries are in even a worse condition. Europe doesn’t have a shred of a common health policy, so there is no joint program for tackling a health emergency. In addition, all of WHO emergency preparedness structures for identifying risks, issuing a global alert and coordinating immediate responses are, unlike NATO’s , short of funding and poorly-staffed. 

The unbelievable fact is that, while the first virus outbreak was wreaking havoc in Wuhan, European countries kept looking at China from a distance, and even with a certain degree of prejudice, cherishing the conviction that the epidemic would never really reach the Western world – no one seems to know why. Had government decision-makers seriously studied the data shared by China after WHO officially declared an international health emergency, they would have understood that the entire world was likely to have to deal with COVID-19 at different stages of the viral evolution. 

After several geopolitical slaloms and visible resistance, the WHO finally declared a COVID-19 pandemic on 11th March. Pandemic means sustained and continuous transmission of the disease, simultaneously in more than three different geographical regions. The threshold had been met, according to public health experts, weeks before the announcement.  The trajectory of the disease meant that the SARS-CoV2 virus had gained a foothold across the globe and multiplied quickly even in countries with relatively strong health systems.

While some analysts connect the WHO delay with the World Bank’s pandemic bonds mechanism, the highly due signal came in the end to rebuke and shake governments, mostly in the industrialized West, for their “alarming level of inaction”, in the words of the WHO Director General, Tedros Adhanom Ghebreyesus.  Whether because the pandemic can rattle markets and lead to more drastic travel and trade restrictions, or out of a dubious sense of political opportunism, a number of world leaders until very recently have either kept hiding or underrating the spreading capacity of COVID-19. In any case, they have delayed and still are delaying any serious containment measure. 

The WHO Director General’s preoccupation with the lack of cooperation among member states, voiced in late January on the eve of the  WHO Executive Board session (February 3-8), was  confirmed, two months into the global spread of COVID-19. Contrary to the obligations provided by the WHO International Health Regulations  (adopted in 2005, in the wake of the SARS epidemic to improve global capacity to prevent and control diseases), inter-governmental cooperation was rapidly supplanted by a viral health sovranism in dealing with the developing pandemic. That’s what we have seen happen in Europe, the cradle of the most violent COVID-19 outbreak, worldwide. Only a couple of weeks ago, most European countries were still indulging in inertia at home on how to face the disease, pretending that not much was happening. Buying time, somewhat in a state of denial.

Italy – the First Democratic Laboratory for COVID-19 Management

Donning the protective suit (Photo: Fabio Fadeli)

But time and trust are essential to good epidemic management. When Italy, the epicentre of the pandemic in Europe and the first democratic laboratory for COVID-19 management, asked for urgent medical supplies under a special European crisis mechanism, no European Union country responded. On the contrary, Germany, issued a decree to block exports of medical masks and other protective gear to Italian healthcare facilities. France, for its part, confiscated all available medical supplies by national order. Another slap in the face came from the European Central Bank (ECB) president Christine Lagarde, whose declaration implied that it was no longer ECB’s job to preserve Italy in the Euro zone. The result was the collapse of the Italian stock market, the loss of €68 billion of savings in one day, and the renewed kindling of financial malaise, alongside the viral. The impending question is whether Europe’s post-war institutional setup, grounded upon principles of solidarity and cooperation, will survive the COVID-19 pandemic.

COVID-19 is a groundbreaking test for European unity, a few weeks post Brexit. After the initial dormancy, draconian measures never before seen in peacetime Europe are forcing dramatic changes on daily life. More than 250 million people are in total or partial lockdown in the EU as Belgium and Germany have decided to follow Italy, Spain and France in closing schools and urging, or asking, people not to leave their homes. Only around mid-March, over two months after the Chinese declared their emergency outbreak in Wuhan (January 7th ), did Europe start to grasp the dimensions of the challenge. It took the European Central Bank heated internal debates before adopting a stimulus of €750 billion bond buybacks for the Eurozone to combat the economic and financial spillover unleashed by coronavirus. A much needed amount indeed, but still quite feeble if compared to Germany’s € 550 billion financial aid package and to the Trump administration’s US$ 2 trillion  stimulus to support the economy and the American families (9.5% of the national GDP). It has faced harsh criticism for its inactivity, but finally the European Commission found its footing and announced the suspension of the Stability Pact last week, much advocated for by the Italian government as coronavirus stretched the country’s defences, as well as Europe’s. Proposals asking for seizing this historical moment and launch new Covid19 credit lines, or very long maturity Eurobonds, are being voiced. Europe urgently needs a new catastrophe relief plan.  

“We’ll take the right steps, at the right time”, and “we can turn the tide of this disease in 12 weeks”, says Prime Minister Boris Johnson, with an apparent U turn from his initial – and quite controversial – strategy in the virus management. The UK government, which had sought to pursue business as usual, is moving towards more mass testing, social distancing and some school closures – shortly before Johnson himself confirmed that he had COVID-19.  

The SARS-CoV2 pandemic “could not have occurred at a worse time for the UK and its citizens” writes  Prof. Martin Mckee of the London School of Hygiene and Tropical Medicines, referring to the Brexit negotiations. Instead of doing everything possible to preserve the areas of relevant collaboration with the EU, such as health, “the UK has decided to isolate itself from European systems that have been built up over the past decade, many as a result of problems exposed by the 2009 swine flu pandemic“.  The country is now outside of the European Medicines Agency (EMA) rapid authorization mechanism for pandemic vaccines and medicines, which entails that the UK has to wait longer for these health tools then the EU member states. To worsen the picture, the UK has also withdrawn from the EU’s emergency bulk purchase mechanism for vaccines and medicines. This lever allows EU governments to enhance their market power and speed up access to vaccines and medicines during an emergency situation.  

Ultimately, as humans we are a limitless pastureland for the virus but we are, above all, a very disordered, unprepared, and yet arrogant herd. The result is considerable governance failure so far, while the WHO Director General implores us: “do not let the fire burn”. More of this is to be seen if we open a broader view beyond the borders of Europe.  What will happen, now that SARS-CoV2 creeps steadily into most African countries? The geopolitical implications may not come secondary to matters of health and safety.

Selfie in full protective gear.

Tension between Health and the Economy 

One of the reasons why the right to health is subject to so many violations lies in the fact that health cannot live in isolation. The right to health drags along with it other social and economic rights, which exist in a constant friction with economic rules and financial profits. On the other hand, disease spread implies economic losses. That’s what makes health and the economy so intertwined. With astonishing foresight, 2019 report of the World Bank Global Preparedness Monitoring Board pointed out the “very real threat of a rapidly moving, highly lethal pandemic of a respiratory pathogen” which could wipe out nearly 5% of the world’s economy. Now, with the coronavirus outbreak a reality, the OECD has warned that it could halve global economic growth this year to 1.5%, the slowest rate since 2009. It has cut its 2020 growth forecast for China to a 30-year low of 4.9%, down from 5.7% in November. Even as China slowly goes back to work, the virus continues to cause massive economic disruption. The virtual shutdown of China’s ‘factory of the world’,  decreased the supply of products and spare parts, disrupting production the world over. Low and middle income countries, especially those dependent on commodity exports and global supply chains, are particularly vulnerable in this economic havoc.

In Italy, we have been confronted far too many times over the past years with the dilemma between health and the economy (and employment) across the country. These same tensions led to the flagrant missteps in the country’s early management of COVID-19S, particularly at the regional level. No need to lecture: things are complex, and policy decisions not easy. Yet, right from the start, the highly productive valleys of Lombardy got engaged in arm wrestling with local entrepreneurs over the need to recognize and curb the contagion with rigorous public health measures and resistance to a contraction in economic activity that a health lockdown would create. Local authorities hesitated, as the contagion kept surging, and central government likewise fluctuated at the end of February. After initial containment measures, contradictory messages aimed to reassure the North’s economic exuberance (“Milano non si ferma”, Milan doesn’t stop), ended up legitimizing baseless patterns of behaviour that favoured the virus spread. 

Two different strategic approaches in tackling COVID-19 may be identified so far: Firstly, there is combat of virus spread through mass testing and social distancing measures, including the extraordinary forced isolation of communities in the Chinese and Italian model. Secondly, and arguably the flimsier approach to the contagion, places an exclusive focus on testing and treating the most affected people (the English, German, Dutch and partly French model). Of course, the containment option entails economic costs but, as Roberto Buffagni highlights, it is rooted in the legacy of ancient cultural and political values that apparently keep inspiring the decision-making style in those countries, if only by instinct.

On the other hand the laissez faire strategy, still the norm in some parts of Europe, has its roots in a pragmatic analysis which bears some sinister social selection implications. In the case of COVID-19, the more at-risk population is largely made up of elderly people, or people with other forms of chronic disease. Their loss, however painful, does not pose a threat to the functionality of the economic system, the laissez-faire theory goes. Rather the reverse. In fact, it operates with somewhat re-generational leverage, insofar as it alleviates the pension system costs alongside the costs of other social welfare structures in the country. The resulting dynamic therefore triggers off an economically expansive process “due to the legacies that, as in the great past epidemics, will enhance the liquidity and assets capacity of new generations who have a higher inclination to investments and consumption than their elders”, says Roberto Buffagni. By so doing, a government increases its economic and political operability, when compared to countries that choose the costly lockdown route. 

However, as Italians know only too well now, another critical element in the policy puzzle in either scenario, is the functionality of the health system in terms of its ability to prevent disease, treat and manage those who become ill.  And when health services are overwhelemed, an unchecked viral outbreak will ultimately lead to massive economic deaths, a toll linked also to the exasperating epidemic of precarious labour conditions, even in highly successful national economic sectors like tourism. COVID-19 has thus brought to the surface the many hidden pathologies lingering in the economic fabric of the country, untreated for too long. If the virus marks a watershed in our history, and in the history of Europe as a whole, we need to go beyond the immediate COVID-19 emergency response to advance the urgent political and economic regeneration we have long wanted to see. It’s time to work for a systemic reframing of our attitudes about health systems and services, in a post-virus world, to prompt positive changes in line with our constitutional rights. 

Health as a Common Good & the Role of the Public Health System  

We needed the SARS-CoV2 shockwave to convince Italian public opinion about the value of the national health system (Servizio Sanitario Nazionale,1978), as the main tool that secures communities and grants individuals protection from catastrophic life events. After two world wars, national health systems were gradually introduced in Europe as the most effective institutional mechanisms for sealing societies’ democratic pacts.

In Italy, the universal public health system has been instrumental in the social and economic development of the country and still today accounts for its high population life expectancy, according to Bloomberg.  The renewed awareness of the difference that a universal, free public health institution can make, is vividly present in the hardest hit countries now. Initiatives such as Spain’s to place all private hospitals under state control indefinitely should spread internationally like the virus, and generate a strong global consensus around a rights-based vision of health systems and services, which goes beyond issues of financial resources. I consider it the political point-of-no-return of the current viral crisis. In fact, this is the coronavirtue that we must seize and preserve, if we are serious about universal health coverage and sustainable development for all. 

In the name of neoliberal ideologies, and often in the name of odious debt service repayment, the development of solid health systems in the global South has been stubbornly opposed for decades, with a huge toll in the health and lives of billions of people. Most low and middle income countries are therefore now facing the coronavirus bare-handed. Years of spending cuts due to fiscal austerity policies also have undermined public health provisioning in developed economies, so that health systems have been dismantled and broken to pieces in Europe, as well. As for Italy, debt reduction and spending reviews have shrunk investments – health expenditure increased by 14.8% from 2001 to 2008, by a meagre 0.6% from 2009 to 2017.  

Despite the aging of Italian society, the national health budget  was trimmed by €25 billion between 2010 and 2012, local health units were dismantled (contracting from 642 in the 1980s to 101 in 2017), and 175 hospitals were closed down. Repeated rounds of devolution and privatization have dismembered the Italian national health system to the advantage of private insurance schemes.  Nowhere has this trend of public health system dismemberment been more apparent than in Lombardy, which has been the hardest hit by the pandemic, despite being the wealthiest region of the country.

The compelling title of the 2018 Censis-Rbm reportResentment Healthcare, Resentment for Healthcare: Scenes from an Unequal Country – illustrates the disquieting portrait of an out of control “out-of-pocket-society”. Private spending on health services increased by 9.6% from 2013 to 2017, forcing over 7 million people into debt, or into selling their properties (2.8 million people) to access their right to healthcare.  A perfect crime against common sense. Confronted with SARS-CoV2, Italy has today less than half the number of intensive care beds than Germany, or France. 

Building on Covid19’s Lessons: Policies for the Future

Health workers in Lecco, Lombardy, Italy in full protective gear.

The devastation is under our eyes. Italy’s death toll has overtaken China, with 4% of China’s population. The immediate reduction of the virus spread is no doubt the most urgent priority now to avoid the collapse of the health system, with all its implications. 

At the same time, we need to start planning now for the necessary policy changes that should be undertaken post-emergency, across the social and economic spectrum. Health-wise, more adequate financial and human resources will have to be injected into the universal health system. We need to undo the damage caused to public services in the past and we need to revise the balance of power and the rules of engagement for the private sector, including in the area of scientific and medical research. There are no reasons why health should be allowed to assert itself as a profit-extracting mechanism. 

A new governance for health will have to be set in place in Italy. National Health Services means national, i.e. centralized, and not splintered into a variety of regional strategies more or less ancillary to the temptations of the private sector. Health devolution, introduced in 2001, has not functioned. Overall, it has resulted in significant health inequalities. 

A Mirror To The World

On a small scale, Italy mirrors the health divide existing between the North and the South of the world. It has produced different and diverging approaches, multiplying inefficiencies and opportunities for corruption (in line with the global empirical evidence), and ultimately increasing costs. 

As the early stages of the virus outbreak have clearly demonstrated, health devolution responds very poorly to the complexities involved in the production of good health. That is why we need to definitively reverse those national policies that currently tolerate regimes of “differentiated autonomy”, especially in Italy’s northern economic powerhouses (Lombardy and Veneto). 

Italy is thriving in emergency conditions, for a series of structural reasons. We have the second oldest population in the world after Japan – possibly, the main cause of COVID-19 higher mortality rate in Italy. The country is the hardest hit by climate change in Europe, both for its geographical position and geographic conformation. Above all, Italy bears already a number of serious health crises that need more adequate national  policies. Antimicrobial resistance (AMR) is one good example. We are the EU country hosting the highest number incidents of antimicrobial-resistant infections. According to the European Centre for Disease Control (ECDC) and the Istituto Superiore di Sanità (ISS), Italy alone accounts for one third of all the AMR-related deaths in Europe.  Renowned virologist Ilaria Capua has aleady hinted at the potential relationship between these higher levels of AMR and higher SARS-CoV2 mortality in the country. 

Post COVID-19 will be like post-war, with its unpalatable numbers of victims, its rubble, and the need for reconstruction. Nothing will be the same anymore. But new conditions are emerging, a new historic awareness is spreading. This calls upon policymakers to redesign a stronger and better country. A stronger and better Europe. In its tragic manifestation, silent and intrusive Coronavirus is paradoxically our best chance. 

_______________________________

Nicoletta Dentico

Nicoletta Dentico is a journalist and a senior policy analyst, leading the Global Health programme of the Society for International Development (SID, www.sidint.net). She previously was director of Médecins Sans Frontières (MSF) in Italy, and she has also played an active role in the MSF campaign on access to essential medicines as well as consulting for the World Health Organization. 

Image Credits: (Fabio Fadeli).

Carlos Alvarado Quesada, President of Costa Rica

World Health Organization Director General, Dr Tedros Adhanom Ghebreyesus has welcomed the call by Costa Rica’s President, Carlos Alvarado Quesada, for WHO to launch an initiative that would “pool rights to technologies that are useful for the detection, prevention, control and treatment of the COVID-19 pandemic.”

“I welcome his initiative & call for pooled rights to COVID-19 diagnostics, drugs & vaccines, said the WHO Director General in a reply Thursday on his Twitter account to the presidential overture. “WHO is working closely with governments & agencies around the world to promote rapid R&D. These efforts are rooted in our commitment to equitable access for all.”

Alvarado’s letter, dated Monday 23 and co-signed by Costa Rica’s Health Minister, Daniel Salas, also called for the creation of a “repository of information on diagnostic tests, devices, medication or vaccines, with free access or licensing on reasonable and affordable terms, in all member countries of the Organization,” according to excerpts later posted on the presidential website and Twitter account.

Meanwhile, in another letter to the WHO Director General dated 25 March, the WHO hosted-partnership UNITAID,  offered to work with WHO and the Medicines Patent Pool, a public-private partnership that it founded, to identify “concrete steps to ensure that there will be equitable and timely access to critical health technologies and products for COVID-19 for people anywhere in the world.”

“We appreciate that several initiatives are underway or proposed that seek to address access barriers; this includes but is not limited to the proposal that has been sent to you by the President of Costa Rica about a voluntary pool of patents for COVID-19 related medicines and technology,” the UNITAID letter added.

In his letter, the Costa Rican president further urges the WHO to “develop a memorandum of understanding to share this technology, and to promote its implementation with financial support from the public and private sectors, as well as from international organizations.”

The president also asked WHO’s Global Observatory on Health Research and Development create a database on research and development activities related to COVID-19, including estimates of the costs of clinical trials and subsidies provided by governments and charities.

Extraordinary Virtual Summit of G-20 Leaders Pledges Massive Support for Global Health Response   

Meanwhile, in an Extraordinary G20 Leaders’ Summit on COVID-19, the Group of 20 most industrialized nations issued a far-reaching  set of commitments to fight the pandemic on health, economic and social fronts. Among their key health-related commitments, leaders pledged to protect the most vulnerable as well as safeguarding the global economy; expand manufacturing capacity to ensure medicines and supplies would be available widely at an affordable price; and support WHO and other global health institutions.

“We commit to take all necessary health measures and seek to ensure adequate financing to contain the pandemic and protect people, especially the most vulnerable,” the G-20 statement said at the close of a virtual one-day meeting on Thursday. “We will share timely and transparent information; exchange epidemiological and clinical data; share materials necessary for research and development; and strengthen health systems globally, including through supporting the full implementation of the WHO International Health Regulations (IHR 2005).

“We will expand manufacturing capacity to meet the increasing needs for medical supplies and ensure these are made widely available, at an affordable price, on an equitable basis, where they are most needed and as quickly as possible.”

As for support to WHO and other global health preparedness and R&D efforts, the G-20 statement said: “We will quickly work together and with stakeholders to close the financing gap in the WHO Strategic Preparedness and Response Plan. We further commit to provide immediate resources to the WHO’s COVID-19 Solidarity Response Fund, the Coalition for Epidemic Preparedness and Innovation (CEPI) and Gavi, the Vaccine Alliance, on a voluntary basis. We call upon all countries, international organizations, the private sector, philanthropies, and individuals to contribute to these efforts,”

While acknowledging the need for “urgent short-term actions” to protect front-line health workers, deliver medical supplies, diagnostics tools, medicines and vaccines, the statement also acknowledged that deeper structural changes are needed to bolster health systems, emergency preparedness strategies and spending, as well as related R&D.

“To safeguard the future, we commit to strengthen national, regional, and global capacities to respond to potential infectious disease outbreaks by substantially increasing our epidemic  preparedness spending. This will enhance the protection of everyone, especially vulnerable groups that are disproportionately affected by infectious diseases. We further commit to work together to increase research and development funding for vaccines and medicines, leverage digital technologies, and strengthen scientific international cooperation.

“We will bolster our coordination, including with the private sector, towards rapid development, manufacturing and distribution of diagnostics, antiviral medicines, and vaccines, adhering to the objectives of efficacy, safety, equity, accessibility, and affordability,” the statement added. “We ask the WHO, in cooperation with relevant organizations, to assess gaps in pandemic preparedness and report to a joint meeting of Finance and Health Ministers in the coming months, with a view to establish a global initiative on pandemic preparedness and response. This initiative will capitalize on existing programs to align priorities in global preparedness and act as a universal, efficient, sustained funding and coordination platform to accelerate the development and delivery of vaccines, diagnostics and treatments.”

In his speech at the G20 Extraordinary Leaders’ Summit on COVID-19, Dr. Tedros welcomed G20 leaders promise to “do whatever it takes to overcome the pandemic”.

“This is a global crisis that requires a global response”, he said, adding that leaders need to. “Fight, unite, ignite… with no excuses and no regrets.”

“”No country can solve this crisis alone,” he said, calling upon countries to build upon the solidarity that has so far been expressed, and exhorting them to “ignite a global movement to ensure this never happens again. “

Britain Announces £210 Million to COVID-19 Vaccine Effort 

Also today, the United Kingdom announced that it would provide some $US 254 million (£210 million) in new funding to the Oslo-based Coalition for Epidemic Preparedness Initiative (CEPI) to support the quest for rapid development of a vaccine for COVID-19, in what represents the single largest commitment so far to vaccine research.

CEPI CEO, Richard Hatchett, said the financial support “comes at a pivotal moment for a world that is in crisis. The UK has a long history of global health leadership and, today, the UK is once again stepping up as a global leader in its support CEPI and our crucial work to accelerate the development of a vaccine against COVID-19.”

The UK contribution complements pledges that have already been made by Germany, Norway, Denmark, and Finland, Hatchett said, noting it brings CEPI “closer to the $2 billion we urgently need develop a COVID-19 vaccine and we call on other world leaders to join us in our fight.”

Jeremy Farrar, Director of Wellcome Trust, welcomed the UK government pledge in a statement saying: “Support from enlightened Governments, with commitment to the global research effort is vital if we are to end this pandemic and prevent future tragedies. The pace and impact of the spread of this virus is unprecedented, our global response must be too. The research effort to rapidly advance the vaccines, treatments and diagnostics needed to save lives has been nothing short of staggering. Global support is still, however, falling seriously short – by at least $8 billion in the short-term.

US Appears Set To Overtake Italy as New Epicentre of COVID-19 Emergency 

Active cases around the world as of 2059PM CET 26 March. Right column shows cumulative case count. Numbers are rapidly changing.

The announcement of new investments in emergency response came as the United States appeared set to overtake Italy as the new centre of the COVID-19 pandemic.

There were now 521 086 reported cases of the virus worldwide, nearly 61 000 new cases since yesterday. Of all WHO regions, the European Region continued to experience the largest increase in new cases, with more than 25,000 fresh reports over the past 24 hours, ccording to WHO’s  daily Situation Report, followed by the Americas, with 11,390 new cases, and the Eastern Mediterranean region, with 2,416 new cases. In Europe, Spain is currently experiencing the highest growth in cases, having risen by approximately 10 000 cases since yesterday. In the Eastern Mediterranean region, Iran saw over 2,234 new cases. 

India Converting Railway Coaches to Hospitals 

In South-East Asia, where there were now 2344 cases, and Africa, which now had 1664 confirmed reports, government leaders were moving evermore aggressively on pre-emptive measures – while facing large, looming gaps in available hospital beds, medical supplies and services.

On Wednesday, India began a 21-day, nationwide lockdown along with announcing a massive aid bill to support its citizens during the closure. The bill aims to provide rice/lentils for ~60% of the country’s 1.3 billion people.  “No doubt this lockdown will entail an economic cost for the country, but saving the life of each and every Indian is the first priority for me,” said the Indian Prime Minister Narendra Modi, “If we are not able to manage the next 21 days, then many families will be destroyed forever. 

Mathematical modelling suggests that 300 million Indians could become infected by COVID-19, of which about four to five million could be severe, said Dr Ramanan Laxminarayan, director of the Center for Disease Dynamics, Economics and Policy, in an interview with the BBC. 

India’s dense population, which is one of the main drivers for India’s high predictions,  has not made it easy – Last wednesday, the first case of COVID-19 was reported in a slum of Mumbai inhabiting over 23,000 people in less than a square kilometre of land. Contact tracing has proved particularly difficult. 

In an attempt to alleviate an overwhelming shortage of beds in India and to prepare for a growth in COVID-19 cases, India was looking to convert its trains into hospitals.

Given that railway services in India have been suspended and the ready availability of 12 617 trains, with 24-30 coaches in each train, 10 million beds can be created “within no time”, said Sunil Kumar V, Managing Director of Asset Homes to to the Prime Minister and the authorities of the National Disaster Management Authority.

As of last Sunday, Indian National Railways had begun moving coaches to their home zones so as to prepare them for disinfection and quarantine facilities.  Meanwhile, the Indian government has said that all scheduled international commercial passenger flight services would remain closed till April 14th. 

Four fifths of countries in Africa are not Adequately Prepared for COVID-19

WHO Regional Director for Africa, Matshidiso Moeti, meanwhile said that local virus transmission still was not widespread on the continent, but time was running out to prepare.

“We still have a window of time that is narrowing. In about half of countries, we still only have imported cases. We have not yet identified that local spread is occuring,” she said, speaking at a World Economic Forum webinar on Thursday. 

She said that the draconian border closures that have been undertaken now in many African nations need to be accompanied by stronger public health interventions, including more systematic identification of cases, follow-up of contacts, and isolation of cases and contacts, as needed.

While some countries like Spain have already recommended the anti-malarial chloroquine to treat COVID-19 as part of their national outbreak response, Africa is “waiting to get robust data [from the WHO’s multi-country clinical trials] to make recommendations [about using chloroquine], said Michel Yao, Emergency Operations Programme Manager at the WHO’s Regional Office in Africa. 

“If clinical trials show the potential of the drug, we should use it. We will not recommend it formally before its impact and side effects are properly measured”, he said in the webinar. 

Only about a fifth of African countries (8/47) are adequately prepared to response, according to a WHO African Region Readiness Response Sheet. These include Algeria, Ghana, Cameroon, Kenya, Tanzania, Madagascar and Ethiopia. Another 33 countries are moderately prepared, while 7/47 countries have limited readiness status, including Benin, Namibia, Guinea Bissau and Gambia.

Among the issues identified, the assessment found that:

  • Only a quarter of African countries have full access to PCR test materials for the SARS-Cov-2 virus;  while 39/48 countries have the capacity to detect viral pathogens using an open-PCR platform, only 12/48 have access to primers (probes) specifically designed to detect SARS-Cov-2 using PCR assays.
  • Only 7/48 African countries have benefited from health worker training on Covid-19 (Angola, Botswana, Eswatini, Ethiopia, Ghana, Lesotho, Seychelles), and only 4/44 countries have districts with health facilities that benefited from training on detection and reporting on Covid-19. These include Seychelles (100), Lesotho (70), Zanzibar (36), Liberia (4);
  • There are only 9 countries in the whole African continent that have more than 50 facilities with nCoV case definition and surveillance tools, including: Algeria (100), Capo Verde (100), Cote D’ivoire (100), Mauritius (100), Seychelles (100), Togo (100), Rwanda (100) Senegal (54), Gambia(51);

However, African countries seemed better prepared in terms of biosafety, the assessment found. Some 45 countries out of 48 had stocks of personal protective equipment (PPE), although only about 30 countries have sufficient PPE for medical staff for case management and screening procedures. Some 44/48 countries reported that air and transport distribution systems are available in the country to restock supplies. 

-Svet Lustig, Tsering Llhamo and Zixuan Yang contributed to this story.